known as L Phenylalanine Mustard, or L PAM, melphalan is a phenylalanine derivative of mechlorethamine ... T, Mary JY, Hulin C, et al. title Melphalan and prednisone plus thalidomide versus melphalan and prednisone ... dosing varies by purpose and route of administration as well as patient weight. Melphalan Prescribing Information http www.celgene.com pdfs AlkeranPI Tablet.pdf Melphalan Patient Information http www.nlm.nih.gov medlineplus druginfo meds a682220.html Melphalan Material Safety Data Sheet MSDS ... Hair loss Interstitial pneumonitis Rash pruritus Itching Irreversible bone marrow failure due to melphalan ... ru simple Melphalan sl Melfalan ... more details
wiktionarypar beam Beam may refer to Beam structure , a construction element Beam nautical , the most extreme width or breadth of a nautical vessel, or a point alongside the ship at the mid point of its length A narrow, propagating stream of particles or energy Charged particle beam Cathode ray , or electron beam Light beam Beam music , a connection line in musical notation Balance beam gymnastics , a piece of gymnastics equipment BEAM robotics , an automatically moving machine based on analog electronics Beam search , a search algorithm Beam Software , a computer game developer BEAM.TV , a global distribution network Blaster Beam , a musical instrument BEAM, an aggressive chemotherapy regimen involving the use of Carmustine BCNU Carmustine , Etoposide , Cytarabine Ara C Cytarabine , and Melphalan BEAM, neuroimaging brain electrical activity mapping BEAM, the virtual machine at the core of the Erlang programming language Erlang programming language Beam, operate the Transporter Star Trek Transporter in the fictional Star Trek series See also Beam theory , a means of calculating the load carrying and deflection characteristics of beams Battle of the Beams , radio countermeasures used against navigational system used by the Luftwaffe during WWII Jim Beam , a popular brand of American whiskey The Beam disambiguation disambig ang B am da Trave de Beam ja pt Trave simple Beam tl Beam th ... more details
This is a list of specific Wiktionary pharmacological agent pharmacologic agents that are known to be of use in the treatment of cancer , otherwise known as Wiktionary chemotherapeutic agent chemotherapeutic agents . This list is organized by type of agent, though the subsections are not necessarily definitive and are subject to revision. Each drug is listed once at present , though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing. Expand list date August 2008 Alkylating agents Cyclophosphamide Mechlorethamine Chlorambucil Melphalan Anthracyclines article on anthracycline s Daunorubicin Doxorubicin Epirubicin Idarubicin Mitoxantrone Valrubicin Cytoskeletal disruptors Paclitaxel Docetaxel Epothilones article on epothilone s Inhibitors of topoisomerase II Etoposide Teniposide Tafluposide Nucleotide analogs and precursor analogs Azacitidine Azathioprine Capecitabine Cytarabine Doxifluridine Fluorouracil Gemcitabine Mercaptopurine Methotrexate Tioguanine formerly Thioguanine Peptide antibiotics Bleomycin Platinum based agents Carboplatin Cisplatin Oxaliplatin Retinoids All trans retinoic acid Vinca alkaloids and derivatives Vinblastine Vincristine Vindesine Vinorelbine Full alphabetical listing All trans retinoic acid Azacitidine Azathioprine Bleomycin Carboplatin Capecitabine Cisplatin Chlorambucil Cyclophosphamide Cytarabine Daunorubicin Docetaxel Doxifluridine Doxorubicin Epirubicin Epothilone Etoposide Fluorouracil Gemcitabine Hydroxyurea requires categorization Idarubicin Imatinib Mechlorethamine Mercaptopurine Methotrexate Mitoxantrone Oxaliplatin Paclitaxel Pemetrexed Teniposide Tioguanine Valrubicin Vinblastine Vincristine Vindesine Vinorelbine Category Chemotherapeutic agents cs Cytostatika de Zytostatikum fr Agent chimioth rapeutique nl Chemotherapie Klassieke cytostatica pl Leki cytostatyczne ru sl Zdravila z delovanjem na novotvorbe ... more details
Percutaneous Hepatic Perfusion PHP is a regionalized, minimally invasive approach to cancer treatment currently undergoing Phase II and Phase III clinical trial clinical testing . PHP treats a variety of hepatic tumors by isolating the liver and exposing the organ anatomy organ to high dose chemotherapy . As demonstrated in clinical trials, patients treated by PHP can tolerate much higher doses of chemotherapeutic agents than those receiving traditional systemic chemotherapy without increased toxicity toxicities . Procedure Using a system of catheters and Filter chemistry filters , PHP isolates the liver from the circulatory system and infuses a chemotherapeutic agent directly to the liver via the Common hepatic artery hepatic artery . The venous effluent from the liver is then filtered outside of the body and the filtered blood is returned into the jugular vein . PHP is a repeatable procedure and can be performed in an operating room or a radiology suite under local anesthesia local or general anesthesia . See also Delcath Systems, Inc. References http home.businesswire.com portal site google index.jsp?ndmViewId news view&newsId 20070626005495&newsLang en Business Wire http www.homelanddefensestocks.com insiderscorner Articles 071207.asp InvestorIdeas.com http www.delcath.com Delcath Systems, Inc. Pingpank, James F. Phase I Study of Hepatic Arterial Melphalan Infusion and Hepatic Venous Hemfiltration Using Percutaneously Placed Catheters in Patients with Unresectable Hepatic Malignancies. J Clin Oncol 23 3456 3474. Seidel, Geoffrey D. Part I Regional Chemotherapy Clinical Studies in Nontraditional Clinical Settings. 10.1188 06.CJON.338 344. Category Oncology Category Hepatology Category Cancer treatments oncology stub ... more details
CFU GEMM is a colony forming unit that generates myeloid cells. CFU GEMM cells are multipotential progenitor cell s. ref name pmid7679010 cite journal author Carow CE, Hangoc G, Broxmeyer HE title Human multipotential progenitor cells CFU GEMM have extensive replating capacity for secondary CFU GEMM an effect enhanced by cord blood plasma journal Blood volume 81 issue 4 pages 942 9 year 1993 month February pmid 7679010 doi url http www.bloodjournal.org cgi pmidlookup?view long&pmid 7679010 ref ref name pmid3332164 cite journal author Roodman GD, LeMaistre CF, Clark GM, Page CP, Newcomb TF, Knight WA title CFU GEMM correlate with neutrophil and platelet recovery in patients receiving autologous marrow transplantation after high dose melphalan chemotherapy journal Bone Marrow Transplant. volume 2 issue 2 pages 165 73 year 1987 month August pmid 3332164 doi url ref The GEMM stands for granulocyte , erythrocyte , monocyte , megakaryocyte . ref name urlHem I WBC Morphology and Physiology cite web url http www.clt.astate.edu wwilliam hem i wbc morphology and physiology.htm title Hem I WBC Morphology and Physiology work accessdate 2008 12 30 Dead link date October 2010 bot H3llBot ref CFU GEMM gives rise to CFU GM . It has been suggested that eosinophil s do not derive from the common myeloid progenitor. ref name pmid19114669 cite journal author Mori Y, Iwasaki H, Kohno K, et al. title Identification of the human eosinophil lineage committed progenitor revision of phenotypic definition of the human common myeloid progenitor journal J. Exp. Med. volume 206 issue 1 pages 183 93 year 2009 month January pmid 19114669 doi 10.1084 jem.20081756 url http www.jem.org cgi pmidlookup?view long&pmid 19114669 pmc 2626675 ref References reflist 2 Blood Blood physiology Human cell types derived primarily from mesoderm Category Microbiology medicine stub ca CFU GEMM ... more details
trials phase I II with defibrotide plus melphalan , prednisone , and thalidomide in patients with multiple ... toxicity of melphalan. However, is too early for any definitive results at that stage. Cautions ... by manufacturer cite web url http rx.onconews.org news Melphalan.html title Melphalan profile and news ... more details
. Another regimen termed VMCP VBAP uses alternating vincristine, melphalan M , cyclophosphamide ... may increase benefit from conventional therapy and high dose melphalan may prolong progression ... been recently used, alone or in combination with conventional chemotherapeutics like melphalan or cyclophosphamide ... more details
valign top Alkeran melphalan palliative treatment of multiple myeloma and for the palliation of non resectable epithelial carcinoma of the ovary 01 17 1964 GlaxoSmithKline valign top Alkeran melphalan ... more details
for a longer time than some of the other alkylating agents. Examples include melphalan and chlorambucil ... Uramustine or uracil mustard Melphalan Chlorambucil Ifosfamide Nitrosourea s Carmustine Lomustine Streptozocin ... more details
with melphalan and prednisone. Recent studies among this population ref cite journal author San Miguel, J.F. et al. year 2008 title Bortezomib plus Melphalan and Prednisone for Initial Treatment ... regimens. Treatment with bortezomib, melphalan and prednisone had an estimated overall survival of 83 at 30 months, lenalidomide plus low dose dexamethasone an 82 survival at 2 years and melphalan, prednisone ... disease include re treatment with the original agent, use of other agents such as melphalan, cyclophosphamide ... more details
, carboplatin , alkylating agents cyclophosphamide , ifosfamide , melphalan , topoisomerase II ... European Neuroblastoma Study Group ENSG1 enrolled 167 children and randomized to melphalan autologous ... better 5 year event free survival for stage 4 over 1 year old in melphalan transplant group versus ... J, Cotterill SJ, Germond SM, Imeson J, de Kraker J, Jones DR title High dose melphalan in the treatment ... respectively with non aggressive surgical approach, no radiotherapy, and melphalan only autologous ... LI carboplatin, etoposide, melphalan, with local irradiation ref name Autologous Stem Cell Transplantation ... followed by transplant randomization to CEM carboplatin, etoposide, melphalan or BuMel busulfan, melphalan ... more details
Fertility preservation is the effort to help cancer patients retain their fertility , or ability to procreate. Research into how cancer affects reproductive health and preservation options are growing, sparked in part by the increase in the survival rate of cancer patients. Indications Fertility preservation procedures are indicated when it s predicted that there will be exposure to a cause of infertility , mainly cancer treatment . Cancer treatment Chemotherapy and radiation treatments for cancer and other serious illnesses can affect reproductive health. The regimens that threaten ovarian and testicular function are mainly radiation therapy to the pelvic area and some types of chemotherapy . Chemotherapies with high risk include procarbazine and alkylating drug s such as cyclophosphamide , ifosfamide, busulfan, melphalan, chlorambucil and chlormethine. ref name Brydoy cite journal author Bryd y M, Foss SD, Dahl O, Bj ro T title Gonadal dysfunction and fertility problems in cancer survivors journal Acta Oncol volume 46 issue 4 pages 480 9 year 2007 pmid 17497315 doi 10.1080 02841860601166958 url http informahealthcare.com doi pdf 10.1080 02841860601166958 ref Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and carboplatin. ref name Brydoy On the other hand, therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, antibiotics such as bleomycinand dactinomycin and antimetabolites such as methotrexate, mercaptopurine and 5 fluoruracil. ref name Brydoy These regimens attack rapidly dividing cells in the body, including healthy cells like sperm and those belonging to the ovarian follicle egg . Depending on the dose and duration of administration, these therapies can have varying effects on reproductive health. Surgery involving reproductive tissue affects reproductive function and fertility. For many cancer patients, the decrease or loss of reproductive function is temporary many men and ... more details
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