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Encyclopedia results for insulin like growth factor

insulin like growth factor





Encyclopedia results for insulin like growth factor

  1. Insulin-like growth factor

    Image 3GF1 Insulin Like Growth Factor Nmr 10 01.png thumb ILGF The insulin like growth factors IGFs are protein s with high Homology biology sequence similarity to insulin . IGFs are part of a complex ... ligand s IGF 1 and IGF 2 , a family of six high affinity Insulin like growth factor binding protein IGF binding proteins IGFBP 1 6 , as well as associated Insulin like growth factor binding protein IGFBP ... referred to as the Growth Hormone IGF1 Axis. Insulin like growth factor 1 IGF 1 is mainly secreted by the liver as a result of stimulation by growth hormone GH . IGF 1 is important for both the regulation ... death apoptosis . Insulin like growth factor 2 IGF 2 is thought to be a primary growth factor required for early development while IGF 1 expression is required for achieving maximal growth. Gene ... LL last3 Rogers first3 I last4 Holly first4 JM last5 Alspac Study first5 Team title Association of Insulin like Growth Factor I and Insulin like Growth Factor Binding Protein 3 with Intelligence Quotient ... 2 are regulated by a family of proteins known as the Insulin like growth factor binding protein ... title Insulin like growth factor I receptors are overexpressed and predict a low risk in human breast ... title Deafferentation induced increases in hippocampal insulin like growth factor 1 messenger RNA expression ... like growth factor 1 Insulin like growth factor 2 Growth hormone treatment HGH controversies Insulin ... doi 10.1101 gad.867301 ref that are insulin like or IGF 1 like , whereas in the mammals insulin like proteins comprise only 7 members insulin , IGF s, relaxin s, EPIL , and relaxin like factor Citation ... cite journal author Scarth JP year 2006 title Modulation of the growth hormone insulin like growth ... the insulin receptor. Like the insulin receptor, the IGF 1 receptor is a receptor tyrosine kinase ... may be an anabolic factor for bone . Since at high concentrations it is capable of activating the insulin ... cite journal author Cohen P, Peehl DM, Lamson G, Rosenfeld RG year 1991 title Insulin like ...   more details



  1. Insulin-like growth factor II IRES

    Rfam box acc RF00483 description Insulin like growth factor II IRES abbreviation IRES IGF2 avg length 117.50 avg identity 91.00 type Cis reg IRES se Moxon SJ ss Published PMID 11903044 release 10.0 The insulin like growth factor II IGF II internal ribosome entry site IRES is found in the 5 UTR of Insulin like growth factor 2 IGF II leader 2 mRNA . This cis regulatory element RNA element allows cap independent translation of the mRNA and it is thought that this family may facilitate a continuous IGF II production in rapidly dividing cells during development. ref cite journal last Pedersen first SK coauthors Christiansen J, Hansen TO, Larsen MR, Nielsen FC year 2002 title Human insulin like growth factor II leader 2 mediates internal initiation of translation journal Biochem J volume 363 pages 37&ndash 44 pmid 11903044 doi 10.1042 0264 6021 3630037 issue Pt 1 pmc 1222448 ref References reflist 1 External links Rfam id RF00483 name Insulin like growth factor II IRES http iresite.org IRESite web.php?page view&entry id 337 IRESite page for IGF2 leader2 Category Cis regulatory RNA elements molecular cell biology stub ...   more details



  1. Insulin-like growth factor 2

    PBB geneid 3481 Insulin like growth factor 2 IGF 2 is one of three protein hormone s that share structural similarity to insulin . Gene structure In humans, the IGF2 gene is located on chromosome 11p15.5 ... its effects by binding to the Insulin like growth factor 1 receptor IGF 1 receptor . IGF2 may also bind to the Insulin like growth factor 2 receptor IGF 2 receptor also called the cation independent ... Wiedeman syndrome See also Insulin like growth factor 2 receptor Insulin like growth factor II IRES Interactions Insulin like growth factor 2 has been shown to Protein protein interaction interact ... B, H ning S, Ackmann M, Zapf J, Blum W, Braulke T year 2001 month Dec. title Transferrin binds insulin like growth factors and affects binding properties of insulin like growth factor binding protein ... Twigg first S M authorlink coauthors Baxter R C year 1998 month Mar. title Insulin like growth factor ... surface binding of insulin like growth factor binding protein 3 journal J. Biol. Chem. volume 273 ... . ref name pmid11749962 References reflist External links MeshName Insulin Like Growth Factor ... IN title Insulin like growth factor II IGF II . journal Int. J. Biochem. Cell Biol. volume 30 issue ... AA, Yakar S, Gewolb IH, et al. title Insulin like growth factor I receptor signal transduction at the interface ... author Kalli KR, Conover CA title The insulin like growth factor insulin system in epithelial ovarian ... 1034 cite journal author Wood AW, Duan C, Bern HA title Insulin like growth factor signaling in fish ... no update citations yes DEFAULTSORT Insulin Like Growth Factor 2 Category Peptide hormones Category Growth factors biochem stub he IGF 2 ru IGF2 .... Function The major role of IGF2 is as a growth promoting hormone during gestation . In the process ..., placental development and fetal growth. journal Horm. Res. volume 65 Suppl 3 issue pages 50 8 year 2006 pmid 16612114 doi 10.1159 000091506 refend PDB Gallery geneid 3481 Growth factors Hormones The PBB ...   more details



  1. Insulin-like growth factor-binding protein

    Pfam box Symbol IGFBP Name Insulin like growth factor br binding protein image PDB 1boe EBI.jpg width caption Structure of the IGF binding domain of the insulin like growth factor binding protein 5 IGFBP 5 . ref name pmid9822601 cite journal author Kalus W, Zweckstetter M, Renner C, et al. title Structure of the IGF binding domain of the insulin like growth factor binding protein 5 IGFBP 5 implications for IGF and IGF I receptor interactions journal EMBO J. volume 17 issue 22 pages 6558 72 year 1998 month November pmid 9822601 pmc 1171003 doi 10.1093 emboj 17.22.6558 url ref Pfam PF00219 InterPro IPR000867 SMART SM00121 PROSITE PDOC00194 SCOP 1boe TCDB OPM family OPM protein PDB PDB2 1boe , PDB2 1h59 The Insulin like growth factor binding protein also known as IGFBP serves as a carrier protein for Insulin like growth factor 1 IGF 1 . ref name pmid10605625 cite journal author Hwa V, Oh Y, Rosenfeld RG title The insulin like growth factor binding protein IGFBP superfamily journal Endocr. Rev. volume 20 issue 6 pages 761 87 year 1999 month December pmid 10605625 doi 10.1210 er.20.6.761 url issn ref Function Approximately 98 of IGF 1 is always bound to one of 6 binding proteins IGF BP . IGFBP 3, the most abundant protein, accounts for 80 of all IGF binding. IGF 1 binds to IGFBP 3 in a 1 1 molar ratio. IGF BP also binds to IGF 1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF 1. This is important because proliferating IGF 1 IGF BP complex allow growth of the femur and the muscle. IGF binding proteins IGFBPs are proteins of 24 to 45 ... title Potentiation of insulin like growth factor I IGF I activity by an antibody supportive evidence ... MeshName Insulin like growth factor binding proteins biochemistry stub Carrier proteins Category ... author Clemmons DR, Busby WH, Arai T, Nam TJ, Clarke JB, Jones JI, Ankrapp DK title Role of insulin like growth factor binding proteins in the control of IGF actions journal Prog. Growth Factor Res ...   more details



  1. Insulin-like growth factor 1

    PBB geneid 3479 Insulin like growth factor 1 IGF 1 also known as somatomedin C or mechano growth factor ... CJ, Sussenbach JS title The human gene encoding insulin like growth factor I is located on chromosome ... human insulin like growth factor I precursor journal Nature volume 306 issue 5943 pages 609 11 ... to its specific receptor, the Insulin like growth factor 1 receptor , abbreviated as IGF1R , present ... to a second protein called Insulin like growth factor 2 IGF 2 . IGF 2 also binds the IGF 1 receptor ... insulin like growth factor 1 implies, IGF 1 is structurally related to insulin, and is even ... cite journal author Velcheti V, Govindan R title Insulin like growth factor and lung cancer journal ..., Insulin like growth factor 1 receptor IGFR , its binding does not interfere with IGF 1 function ... DF, Digicaylioglu M title Intranasal delivery of erythropoietin plus insulin like growth factor I for acute ... Insulin like growth factor 1 has been shown to bind and interact with all the IGF 1 Binding Proteins ... growth despite profound disruptions in the circulating insulin like growth factor system journal ... ref name pmid9497324 cite journal author Twigg SM, Baxter RC title Insulin like growth factor IGF binding ... title Structural determinants of ligand and cell surface binding of insulin like growth factor binding ... like growth factor II to insulin like growth factor binding proteins 1 6 journal J. Biol. Chem. volume ... insulin like growth factor binding protein 4 journal J. Biol. Chem. volume 273 issue 36 pages ... and characterization of insulin like growth factor binding protein IGFBP 7. Recombinant human mac25 ... D title Insulin like growth factor I compartmentalization within the somatotropic axis? journal News ... author Winn N, Paul A, Musar A, Rosenthal N title Insulin like growth factor isoforms in skeletal ... Galloway E, Torres Aleman I title Role of insulin like growth factor I signaling in neurodegenerative ... Conti E, Carrozza C, Capoluongo E, et al. title Insulin like growth factor 1 as a vascular protective ...   more details



  1. Insulin-like growth factor 1 receptor

    PBB geneid 3480 The Insulin like Growth Factor 1 IGF 1 Receptor is a transmembrane receptor transmembrane ..., Beitner Johnson D, Roberts CT title Molecular and cellular aspects of the insulin like growth factor ... C, Hofmann F, Krystal GW title The insulin like growth factor I receptor kinase inhibitor, NVP ADW742 ... D, Knowlden JM, Williams S, Wakeling AE, Nicholson RI title Insulin like growth factor I receptor ... R, Brewster SF, Macaulay VM title Expression of the type 1 insulin like growth factor receptor is up ..., Bell RH, Hurtado Coll A, Fazli L, Gleave ME, Cox ME title Increased insulin like growth factor I receptor ... AM, Voelker MA, Sternberg H, Timiras PS title Insulin like growth factor 1 receptor immunoreactive ... . Interactions Insulin like growth factor 1 receptor has been shown to Protein protein interaction ... with the insulin like growth factor I receptor journal Biochem. Biophys. Res. Commun. volume ... month Aug. title Localization of the insulin like growth factor I receptor binding sites for the SH2 ... ligand induced ubiquitination and stability of the insulin like growth factor I receptor journal ... interaction of the insulin like growth factor I receptor with IRS 1, Shc, and Grb10 journal ... of phosphatidylinositol 3 kinase with insulin like growth factor 1 signaling proteins journal ... kinase associates with ligand stimulated insulin like growth factor I receptor journal J. Biol. Chem ... 2001 month Aug. title Association of insulin like growth factor 1 receptor with EHD1 and SNAP29 journal ... of c Cbl as a new ligase for insulin like growth factor I receptor with distinct roles from ... of SHC and the insulin receptor substrate 1 IRS 1 with the insulin like growth factor I IGF I receptor ... K year 2001 month Nov. title Direct interaction of insulin like growth factor 1 receptor with leukemia ... T A year 1997 month Apr. title 14 3 3 epsilon interacts with the insulin like growth factor I receptor ... IH, et al. title Insulin like growth factor I receptor signal transduction at the interface between ...   more details



  1. Insulin-like growth factor 2 receptor

    A, Francke U title Chromosomal mapping of the gene for the type II insulin like growth factor .... Interactions Insulin like growth factor 2 receptor has been shown to Protein protein interaction ... cite journal author O Dell SD, Day IN title Insulin like growth factor II IGF II . journal ... 2725 98 00048 X cite journal author Hawkes C, Kar S title The insulin like growth factor II mannose ... 1370435 doi 10.1002 ijc.2910500210 cite journal author Zhou J, Bondy C title Insulin like growth factor ... JC, Standring DN, et al. title Insulin like growth factor II receptor as a multifunctional binding protein ..., Voutilainen R title Insulin like growth factor binding proteins in the human adrenal gland. journal ... of heterozygosity on 6q at the mannose 6 phosphate insulin like growth factor II receptor locus in human ... like growth factor II binding site to amino acids 1508 1566 in repeat 11 of the mannose 6 phosphate insulin like growth factor II receptor. journal J. Biol. Chem. volume 270 issue 25 pages 14975 82 ... of insulin like growth factor II receptor in human pancreatic cancer. journal Pancreas volume ... EI, Vorum H, et al. title Mannose 6 phosphate insulin like growth factor II receptor targets ... refend External links MeshName Insulin Like Growth Factor II Receptor PDB Gallery geneid 3482 Clusters of differentiation Growth factor receptors Category Receptors Category Clusters of differentiation ... cation dependent mannose 6 phosphate receptor In the fields of biochemistry and cell biology , the insulin like growth factor 2 receptor IGF2R , also called the cation independent mannose 6 phosphate ... ref IGF2R is a multifunctional protein receptor biochemistry receptor that binds insulin like growth factor 2 IGF2 at the plasma membrane cell surface and mannose 6 phosphate M6P tagged proteins in the trans ... T, Neville Golden J, Maxwell M title Expression of insulin like growth factors I and II and their receptor ... factor like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions. journal ...   more details



  1. Growth factor-like domain

    Pfam box Symbol APP CU bd Name Amyloid precursor N terminal image 1mwp gfld.png width 200 caption The GFLD region of amyloid precursor protein Pfam PF02177 InterPro IPR008154 SMART SM00006 PROSITE SCOP 1mwp TCDB PDB PDB2 1mwp , PDB2 1owt , PDB2 2fjz , PDB2 2fk1 , PDB2 2fk2 , PDB2 2fk3 , PDB2 2fkl , PDB2 2fma A growth factor like domain GFLD is a protein domain structurally related to epidermal growth factor , which has a high binding affinity for the epidermal growth factor receptor . As structural domains within larger proteins, GFLD regions commonly bind calcium ion s. A subtype present in the N terminus N terminal region of the amyloid precursor protein is a member of the heparin binding class of GFLDs and may itself have growth factor function, particularly in promoting neuron al development. References Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. 1999 . Crystal structure of the N terminal, growth factor like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6 4 327 31. protein stub Category Protein domains ...   more details



  1. Heparin-binding EGF-like growth factor

    PBB geneid 1839 Heparin binding EGF like growth factor HB EGF is a member of the epidermal growth factor ... binding EGF like growth factor journal Cytokine Growth Factor Rev. year 2004 volume 15 issue 1 ... EGF like growth factor that mediates cell migration journal EMBO J. volume 20 issue 13 pages 3342 50 ... form of heparin binding EGF like growth factor a unique role for proHB EGF in cell survival ... of heparin binding EGF like growth factor. Multiple forms, primary structure, and glycosylation ... increases transcription of the heparin binding epidermal growth factor like growth factor gene in vascular ... Diphtheria toxin binds to the epidermal growth factor EGF like domain of human heparin binding EGF like growth factor diphtheria toxin receptor and inhibits specifically its mitogenic activity. journal ... factor like growth factor is an autocrine growth factor for human keratinocytes. journal J. Biol ..., Funatomi H, Friess H, et al. title Induction and expression of heparin binding EGF like growth factor ... within heparin binding EGF like growth factor that mediate interaction with heparin. journal J ... encoding the human heparin binding epidermal growth factor like growth factor diphtheria toxin receptor ... EGF like growth factor stimulates chemotaxis but not proliferation. journal EMBO J. volume 16 ... EGF like growth factor expression increases selectively in bladder smooth muscle in response to lower ... extracellular domain of CD9 and the epidermal growth factor EGF like domain of heparin binding EGF like growth factor for up regulation of binding and activity. journal J. Biol. Chem. volume ... Duque JL, Adam RM, Mullen JS, et al. title Heparin binding epidermal growth factor like growth factor ... form of heparin binding EGF like growth factor a unique role for proHB EGF in cell survival ... growth factor has been shown to Protein protein interaction interact with NRD1 , ref name pmid11432822 ... factor secreted by macrophage like cells that is related to EGF. journal Science volume 251 issue ...   more details



  1. Growth factor

    A growth factor is a naturally occurring substance capable of stimulating cellular growth , ref DorlandsDict three 000038554 growth factor ref proliferation and cellular differentiation . Usually it is a protein or a steroid hormone . Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling molecules between cells. Examples are cytokine ... differentiation, while fibroblast growth factor s and vascular endothelial growth factor s stimulate blood vessel differentiation angiogenesis . Growth factors versus cytokines Growth factor is sometimes ... development and in the mature organism. While growth factor implies a positive effect on cell division ... growth factor proteins tend to occur as members of larger families of structurally and evolution arily ... factor BDNF Epidermal growth factor EGF Erythropoietin EPO Fibroblast growth factor FGF Glial ... colony stimulating factor GM CSF Growth differentiation factor 9 GDF9 Hepatocyte growth factor HGF Hepatoma derived growth factor HDGF Insulin like growth factor IGF Migration stimulating factor Myostatin GDF 8 Nerve growth factor NGF and other neurotrophins Platelet derived growth factor PDGF Thrombopoietin TPO Transforming growth factor alpha TGF Transforming growth factor beta TGF Tumour necrosis factor alpha TNF Vascular endothelial growth factor VEGF Wnt Signaling Pathway placental growth factor PlGF Foetal Bovine Somatotrophin FBS IL 1 Cofactor for IL 3 and IL 6. Activates T cells. IL 2 T cell growth factor. Stimulates IL 1 synthesis. Activates B cells and NK cells. IL 3 Stimulates production of all non lymphoid cells. IL 4 Growth factor for activated B cells, resting ... Ig synthesis. Growth factor for plasma cells. IL 7 Growth factor for pre B cells. Stimulates ... Genome Organisation Growth factor receptor Mitogen References reflist External links MeshName Growth ... cell biology cells . They often promote cell differentiation and maturation, which varies between growth ...   more details



  1. Fibroblast growth factor receptor

    The fibroblast growth factor receptors are, as their name implies, Receptor biochemistry receptors that bind to members of the fibroblast growth factor family of proteins. Structure The fibroblast growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. These receptors bind fibroblast growth factor s, members of the largest family of growth factor ligands, comprising 22 members. ref name ornitz cite journal author Ornitz DM. and Itoh, N. title Fibroblast growth factors journal Genome Biol. year 2001 volume 2 issue 3 pages REVIEWS 3005 pmid 11276432 doi 10.1186 gb 2001 2 3 reviews3005 pmc 138918 ref The natural gene splicing alternate splicing of four fibroblast growth factor receptor FGFR genes results in the production of over 48 different ... of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co receptor binding ... Specificity of the Fibroblast Growth Factor Family. journal JBC volume 271 issue 25 pages 15292 15297 ... al. title Identification of a new fibroblast growth factor receptor, FGFR5 journal Gene year 2001 ... superfamily FGFR1 to FGFR4 . Gene FGFR1 see also Fibroblast growth factor receptor 1 CD331 Gene FGFR2 see also Fibroblast growth factor receptor 2 CD332 Gene FGFR3 see also Fibroblast growth factor receptor 3 CD333 Gene FGFR4 see also Fibroblast growth factor receptor 4 CD334 Gene FGFR6 References ... Growth factor receptors Tyrosine kinases DEFAULTSORT Fibroblast Growth Factor Receptor Category ... all share the common extracellular region composed of three immunoglobulin Ig like domains D1 D3 ..., and Gallagher JT. title Receptors for fibroblast growth factors journal Immunol. Cell. Biol. year ... Ig like domains D1, D2, and D3 present a stretch of acid ic amino acid s the acidic box between D1 ... like domains D2 and D3 are sufficient for FGF binding. Each receptor can be activated by several FGFs ...   more details



  1. Placental growth factor

    PBB geneid 5228 Placental growth factor is a protein that in humans is encoded by the PGF gene . ref name entrez cite web title Entrez Gene PGF placental growth factor, vascular endothelial growth factor ... mRNAs coding for the angiogenic factor, placenta growth factor PlGF , are transcribed from a single ... doi url issn ref Placental growth factor PGF is a member of the VEGF vascular endothelial growth ... url issn ref Clinical significance Placental growth factor expression within human atherosclerosis ... A, Collen D, Martin JF, Carmeliet P, Zachary IC title Placental growth factor promotes atherosclerotic ... cite journal author Shibuya M title Vascular endothelial growth factor dependent and independent ... A, Collen D, Martin JF, Carmeliet P, Zachary IC title Placental growth factor promotes atherosclerotic ... name pmid18452647 cite journal author Shibuya M title Vascular endothelial growth factor dependent ... reading refbegin 2 cite journal author Luttun A, Tjwa M, Carmeliet P title Placental growth factor PlGF ..., placenta growth factor PlGF , are transcribed from a single gene of chromosome 14. journal Oncogene ... J, et al. title Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity ... S, Weich HA title A heparin binding form of placenta growth factor PlGF 2 is expressed in human umbilical ... O, et al. title Assignment of vascular endothelial growth factor VEGF and placenta growth factor PLGF ... D, Ribatti D, et al. title Placenta growth factor 1 is chemotactic, mitogenic, and angiogenic ... Vuorela P, Hatva E, Lymboussaki A, et al. title Expression of vascular endothelial growth factor and placenta growth factor in human placenta. journal Biol. Reprod. volume 56 issue 2 pages 489 94 year ... Placenta growth factor identification and characterization of a novel isoform generated by RNA ... growth factor placenta growth factor receptor Flt 1 required for binding and structural stability ... cite journal author Landgren E, Schiller P, Cao Y, Claesson Welsh L title Placenta growth factor ...   more details



  1. Epidermal growth factor receptor

    of c Cbl as a new ligase for insulin like growth factor I receptor with distinct roles ... Adams TE, McKern NM, Ward CW title Signalling by the type 1 insulin like growth factor receptor interplay ... geneid 1956 The epidermal growth factor receptor EGFR ErbB 1 HER1 in humans is the Cell membrane cell surface receptor biochemistry receptor for members of the epidermal growth factor family EGF family ... Herbst RS title Review of epidermal growth factor receptor biology journal Int. J. Radiat. Oncol. Biol ... url ref The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily ... JCI32278 url ref Epidermal Growth Factor was discovered by Stanley Cohen biochemist Stanley Cohen ... or Medicine in 1986. Function EGFR epidermal growth factor receptor exists on the cell surface and is activated by binding of its specific ligand s, including epidermal growth factor and TGF alpha transforming growth factor TGF note, a full list of the ligands able to activate EGFR and other ... heterodimerization with other family members such as EGFR. Upon activation by its growth factor ligands ... growth factor receptor journal Nature volume 311 issue 5985 pages 483 5 year 1984 pmid 6090945 doi ..., Funahashi A, Kitano H title A comprehensive pathway map of epidermal growth factor receptor signaling ... growth factor receptor journal J Clin Invest. volume 116 issue 7 pages 1878 1885 year 2006 pmid 16778986 ... DA title Activating mutations in the epidermal growth factor receptor underlying responsiveness of non ... LV, Johnson BE title Impact of epidermal growth factor receptor and KRAS mutations on clinical ... epithelial cell line HaCaT were incubated with anti epithelial growth factor receptor EGFR antibody ... inhibitor, a T knot protein, is an epidermal growth factor antagonist that inhibits tumor ... copyright status removed Image Egfr inhibitor diagram.jpg Interactions Epidermal growth factor ... growth factor receptor in androgen sensitive prostate cancer cells journal Steroids volume ...   more details



  1. Platelet-derived growth factor

    Pfam box Symbol PDGF Name Platelet derived growth factor PDGF image width caption Pfam PF00341 InterPro ... In molecular biology , platelet derived growth factor PDGF is one of the numerous growth factor s, or protein .... In chemical terms, platelet derived growth factor is protein dimer dimeric glycoprotein composed ... journal author Hannink M, Donoghue DJ title Structure and function of platelet derived growth factor ... on platelet derived growth factor journal EMBO J. volume 11 issue 12 pages 4251 4259 year 1992 ... derived growth factor PDGF receptor activation by PDGF AB journal J. Biol. Chem. volume 266 issue ... Aaronson SA title Chimeric alpha and beta platelet derived growth factor PDGF receptors define three ... terminal domain of alpha platelet derived growth factor alpha PDGF receptor for PDGF focus forming ... U title Vascular endothelial growth factor B, a novel growth factor for endothelial cells journal ... growth factor, VEGF C, is a ligand for the Flt4 VEGFR 3 and KDR VEGFR 2 receptor tyrosine kinases ... in angiogenesis and endothelial cell growth, and placenta growth factor PlGF which is also ... mRNAs coding for the angiogenic factor, placenta growth factor PlGF , are transcribed from a single ... of the first growth factor s characterized, ref cite journal author Paul D, Lipton A, Klinger I ... pmc 389008 ref and has led to an understanding of the mechanism of many growth factor biochemical ... title An antibody reactive with domain 4 of the platelet derived growth factor beta receptor allows ... Family members Human genes encoding proteins that belong to the platelet derived growth factor family include C fos induced growth factor FIGF PDGFA PDGFB PDGFC PDGFD Placental growth factor PGF Vascular endothelial growth factor VEGF VEGF41 Vascular endothelial growth factor B VEGFB Vascular endothelial growth factor C VEGFC See also Platelet activating factor Platelet derived growth factor receptor ... MeshName platelet derived growth factor eMedicineDictionary platelet derived growth factor Signaling ...   more details



  1. Growth factor receptor

    A growth factor receptor is a Receptor biochemistry receptor which binds to growth factor . ref MeshName Growth Factor Receptors ref These receptors may use the JAK STAT signaling pathway JAK STAT , MAP kinase , and Phosphoinositide 3 kinase PI3 kinase pathways. ref name HoffbrandMoss2006 cite book author1 A. V. Hoffbrand author2 P. A. H. Moss author3 J. E. Pettit title Essential haematology url http books.google.com books?id IFFL 1YNy oC&pg PA6 accessdate 28 November 2010 year 2006 publisher Wiley Blackwell isbn 9781405136495 pages 6 ref References reflist Growth factor receptors Category Receptors biochem stub ...   more details



  1. Epidermal growth factor

    url issn ref Heparin binding EGF like growth factor HB EGF TGF alpha transforming growth factor TGF Amphiregulin AR Epiregulin EPR Epigen Betacellulin BTC neuregulin 1 NRG1 neuregulin ...PBB geneid 1950 Epidermal growth factor or EGF is a growth factor that plays an important role in the regulation of cell growth , cell growth proliferation , and Cellular differentiation differentiation by binding to its receptor Epidermal growth factor receptor EGFR . Human EGF is a 6045 dalton unit ... pmid2186024 cite journal author Carpenter G, Cohen S title Epidermal growth factor journal The Journal ... growth factor receptor biology journal International Journal of Radiation Oncology, Biology, Physics ... ref Biological Sources Epidermal growth factor can be found in human platelets, macrophages, urine, saliva ... affinity to epidermal growth factor receptor EGFR on the plasma membrane cell surface and stimulating ... RA, Knaver DJ, Cunningham DD title Epidermal growth factor immunoreactive material in the central ... are potential substances for this purpose. Interactions Epidermal growth factor has been shown to Protein protein interaction interact with Epidermal growth factor receptor ref name pmid12093292 cite ... growth factor in ErbB 2 ErbB 3 binding studied by phage display journal Biochemistry volume ... of the epidermal growth factor EGF receptor in amphiregulin and EGF mitogenic signaling journal J. Biol ... growth factor http www.ebi.ac.uk biomodels main static pages.do?page ModelMonth 252FAugust2006 ... citations cite journal author Boonstra J, Rijken P, Humbel B, et al. title The epidermal growth factor ... cite journal author Dvorak B title Epidermal growth factor and necrotizing enterocolitis journal ... cite journal author Howell WM title Epidermal growth factor gene polymorphism and development ... member of the EGF like domain EGF family of proteins . Members of this protein family have highly ... ref name dreux cite journal author Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA title The epidermal growth ...   more details



  1. Fibroblast growth factor

    of growth factor s involved in angiogenesis , wound healing , and embryonic development ... fibroblast growth factor journal Biochemistry volume 35 issue 7 pages 2086 94 year 1996 month February ... Members FGF1 through FGF10 all bind fibroblast growth factor receptor s FGFRs . FGF1 is also known as acidic , and FGF2 is also known as basic fibroblast growth factor . Members FGF11 , FGF12 , FGF13 .... ref cite journal author Olsen SK, Garbi M. et al. title Fibroblast growth factor FGF homologous ... growth factor receptor family has 4 members, FGFR1 , FGFR2 , FGFR3 , and FGFR4 . The FGFRs consist ... growth factor, KGF binds only to FGFR2b KGFR . The signaling complex at the cell surface is believed ... and either one or two heparan sulfate chains. History Fibroblast growth factor was found in pituitary ... in 1974 . ref cite journal author Gospodarowicz D title Localisation of a fibroblast growth factor ... named acidic fibroblast growth factor FGF1 and basic fibroblast growth factor FGF2 . These proteins ... M, Chen Y., et al. title Nuclear activities of basic fibroblast growth factor potentiation of low ... title Promiscuity of fibroblast growth factor receptors ref Promiscuous refers to the biochemistry ... development , ref cite journal author B ttcher RT, Niehrs C. title Fibroblast growth factor signaling ... author Borland C.Z., Schutzman J.L. and Stern M.J. title Fibroblast growth factor signaling in Caenorhabditis ... cells into tube like structures. They thus promote angiogenesis , the growth of new blood ... endothelial growth factor VEGF or platelet derived growth factor PDGF . ref cite journal author ... also known as Keratinocyte Growth Factor s KGF and KGF2, respectively stimulate the repair of injured ... stimulating factor G CSF granulocyte macrophage colony stimulating factor GM CSF nerve growth factor NGF neurotrophins erythropoietin EPO thrombopoietin TPO myostatin GDF 8 Growth Differentiation factor ... technology.php FGF1 in Cosmetic Products Signaling proteins DEFAULTSORT Fibroblast Growth Factor ...   more details



  1. Transforming growth factor

    Transforming growth factor sometimes referred to as Tumor growth factor , or TGF is used to describe two classes of polypeptide growth factor s, TGF&alpha and TGF beta TGF&beta . The name Transforming Growth Factor is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor biochemistry receptor mechanism biology mechanisms . Furthermore, they do not always induce cellular transformation , and are not the only growth factors that induce cellular transformation. Types TGF&alpha is upregulated in some human cancer s. It is produced in macrophage s, brain cells, and keratinocyte s, and induces epithelium epithelial development. TGF beta TGF exists in three known subtypes in humans, TGF&beta 1, TGF&beta 2, and TGF&beta 3. These are upregulated in Marfan s syndrome ref name dysregmarfan Circulating transforming growth factor beta in Marfan syndrome. Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De Backer J, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC GenTAC Consortium. Circulation. 2009 Aug 11 120 6 526 32. Epub 2009 Jul 27. PMID 19635970 ref ref name popmarfan http sciencenow.sciencemag.org cgi content full 2008 625 3?etoc Inhibiting TGF to help Marfan ref and some human cancers, and play crucial roles in tissue regeneration , cell differentiation , embryonic development , and regulation of the immune system . Isoforms of transforming growth factor beta TGF 1 are also thought to be involved in the pathogenesis of pre eclampsia . TGF&beta ...?search TGF Tumor growth factor TGF citations http www.ihop net.org UniPub iHOP gs 125537.html ... MeshName Transforming Growth Factors Signaling proteins Category Growth factors Category Signal transduction cs Transformuj c r stov faktor de Transforming growth factor fr Transforming growth factor ... in a specific cell culture system, rat kidney fibroblasts. Application of the transforming growth factors ...   more details



  1. Hematopoietic growth factor

    Unreferenced date January 2009 Orphan date February 2009 Hematopoietic growth factor is a group of proteins that causes blood cells to grow and mature . External links http www.cancer.gov Templates db alpha.aspx?CdrID 44960 Hematopoietic growth factor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Blood cells med stub ...   more details



  1. Transforming growth interacting factor

    Transforming growth interacting factor TGIF is a potential repressor of TGF pathways in myometrial cells. ref name Yen Ping Cite journal author Yen Ping Ho J, Man WC, Wen Y, Polan ML, Shih Chu Ho E, Chen B title Transforming growth interacting factor expression in leiomyoma compared with myometrium journal Fertil. Steril. volume issue pages year 2009 month June pmid 19524896 doi 10.1016 j.fertnstert.2009.05.001 url pmc 2888713 ref Expression of TGIF is increased in uterine leiomyoma compared with myometrium. ref name Yen Ping References Reflist Category TGF domain ...   more details



  1. Keratinocyte growth factor

    The Keratinocyte Growth Factor KGF , also known as FGF7 , is a growth factor present in the epithelialization phase of wound healing . In this phase, keratinocytes are covering the wound, forming the epithelium . KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b FGFR2b . ref name pmid18575591 cite journal author Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A title Silencing of keratinocyte growth factor receptor restores 5 fluorouracil and tamoxifen efficacy on responsive cancer cells journal PLoS ONE volume 3 issue 6 pages e2528 year 2008 pmid 18575591 pmc 2424182 doi 10.1371 journal.pone.0002528 url http www.plosone.org article info doi 10.1371 journal.pone.0002528 ref For signalling to occur, a dimer is required between two FGF FGFR complexes that is linked together by a molecule of heparin. There are 23 known FGFs, and 4 FGF receptor s. FGF FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner. FGF10 is also known as Keratinocyte growth factor 2 . ref name urliHOP Information Hyperlinked over Proteins FGF10 cite web url http www.ihop net.org UniPub iHOP gs 88201.html title iHOP Information Hyperlinked over Proteins FGF10 format work accessdate ref See also Palifermin References reflist External links http www personal.umich.edu lpt fgf 1fq9 files side.jpg http www personal.umich.edu lpt fgf 1fq9.htm Category Growth factors medicine stub Growth factors ...   more details



  1. Growth differentiation factor

    Growth differentiation factors GDFs are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in development. ref name herpin cite journal author Herpin A, Lelong C, Favrel P title Transforming growth factor beta related proteins an ancestral and widespread superfamily of cytokines in metazoans journal Dev Comp Immunol volume 28 issue 5 pages 461 85 year 2004 pmid 15062644 doi 10.1016 j.dci.2003.09.007 ref Types Several members of this subfamily have been described, and named GDF1 through GDF15. GDF1 is chiefly expressed in the nervous system and functions in left right patterning and mesoderm induction biology induction during ... of left right patterning in mice by growth differentiation factor 1 journal Nat Genet volume 24 issue ... O Keeffe G, Dockery P, Sullivan A title Effects of growth differentiation factor 5 on the survival ... author Buxton P, Edwards C, Archer C, Francis West P title Growth differentiation factor 5 GDF 5 and skeletal ... J, Scott J, Rasmussen C, Swahn M, Hsueh A, Hovatta O title Growth differentiation factor 9 promotes the growth, development, and survival of human ovarian follicles in organ culture journal J Clin ... N, Jenkins N, Gilbert D, Copeland N, Reddi A, Lee S title Growth differentiation factor 10 a new member of the transforming growth factor beta superfamily related to bone morphogenetic protein 3 journal Growth Factors volume 12 issue 2 pages 99 109 year 1995 pmid 8679252 doi 10.3109 08977199509028956 ... C title Growth differentiation factor 11 signals through the transforming growth factor beta receptor ... S, Esquela A, Koniaris L title Growth differentiation factor 15 macrophage inhibitory cytokine ... T, Lee S title Characterization of growth differentiation factor 15, a transforming growth factor ... 213X 6 43 pmc 1609107 ref GDF8 is now officially known as myostatin and controls the growth of muscle ... TGF beta superfamily member. Nature journal Nature 1997 387 83 90. PMID 9139826. ref GDF9 , like GDF3 ...   more details



  1. Hepatocyte growth factor

    PBB geneid 3082 Hepatocyte growth factor scatter factor HGF SF is a paracrine cellular growth, motility and morphogen morphogenic factor . It is secreted by mesenchymal cell s and targets and acts primarily upon epithelial cell s and endothelial cell s, but also acts on haematopoiesis haemopoietic progenitor cells . It has been shown to have a major role in embryonic organ development, in adult organ regeneration and in wound healing. ref cite book title Proteoglycans structure, biology and molecular ... growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto oncogenic c Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi functional cytokine on cells of mainly .... ref cite web title Entrez Gene HGF hepatocyte growth factor hepapoietin A scatter factor url ... Interactions Hepatocyte growth factor has been shown to Protein protein interaction interact with C ... Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor journal ... T title Structure and function of hepatocyte growth factor. journal Prog. Growth Factor Res. volume ... H, Nakamura T title Hepatocyte growth factor from diagnosis to clinical applications. journal Clin ... 9 cite journal author Skibinski G title The role of hepatocyte growth factor c met interactions in the immune ... al. title Hepatocyte growth factor scatter factor and prostate cancer a review. journal Histol. Histopathol ... refend PDB Gallery geneid 3082 See also growth factor hepatocyte growth factor receptor HGFR External links MeshName Hepatocyte growth factor Category Growth factors Category Developmental genes ... with growth factors and morphogens editor Iozzo, M, V. year 2000 publisher Marcel Dekker ... Ware LB, Matthay MA title Keratinocyte and hepatocyte growth factors in the lung roles in lung development ... yes update citations yes es Factor de crecimiento de hepatocitos id Faktor pertumbuhan hepatosit it HGF ...   more details



  1. Nerve growth factor receptor

    Nerve growth factor receptors are a group of growth factor receptor s which specifically bind to neurotrophin s. There are two classes of receptors, p75 and the Trk family of Tyrosine kinase s receptors. p75 is a low affinity neurotrophin receptor , to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase x only applies to this receptor. ref MeshName Nerve Growth Factor Receptor p75 ref The Trk receptor Trk family include TrkA , TrkB , and TrkC , and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins. NGF binds to TrkA, BDNF and NT 4 bind to TrkB and NT 3 binds to TrkC . In addition NT 3 also binds to and activates TrkA and TrkB but it does so less efficiently. Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis . TrkA, B, and C receptors TrkA is a receptor tyrosine kinase meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling . There are other related Trk receptors TrkB and TrkC , and there are other neurotrophic factors structurally related to NGF BDNF , NT 3 , and NT 4 TrkA mediates the effects of NGF TrkB binds and is activated by BDNF , NT 4 , and NT 3 TrkC binds and is activated only by NT 3 LNGFR receptor The other NGF receptor, the LNGFR , for Low affinity nerve growth factor receptor , commonly known as p75 , plays a less clear role. LNGFR binds and serves as a sink for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity since they have a higher microconcentration of the neurotrophin. However ... basalis of postmortem Alzheimer s brains. References reflist External links MeshName Nerve Growth Factor Receptors Growth factor receptors Category Receptors biochem stub ...   more details



  1. Vascular endothelial growth factor

    Vascular endothelial growth factor VEGF is a signal protein produced by cells that stimulates vasculogenesis ... growth factor family of cystine knot growth factors. They are important signaling protein s involved ... is VEGF A . Other members are Placenta growth factor PlGF , VEGF B , VEGF C and VEGF D . The latter ... Angharad M. last4 Cross first4 Michael J. title Vascular endothelial growth factor receptor 2 Structure .... title Serum concentrations of vascular endothelial growth factor D in angiosarcoma patients journal ... Expression of Vascular Endothelial Growth Factor in Kidney Leads to Progressive Impairment of Glomerular ... growth factor VEGF production by human luteinized granulosa cells in vitro journal Fertil. Steril ... Endothelial Growth Factors Proteopedia Vascular Endothelial Growth Factor the Vascular Endothelial Growth Factor Structure in Interactive 3D Further reading refbegin 2 PBB Further reading citations ... endothelial growth factor expression during the postnatal development of the rat visual cortex ... growth factor in angiogenesis journal Acta Haematol. volume 106 issue 4 pages 148 56 year 2002 pmid ... F, et al. title Vascular endothelial growth factor and its receptors in multiple myeloma ... cite journal author Caldwell RB, Bartoli M, Behzadian MA, et al. title Vascular endothelial growth factor ... permeability factor vascular endothelial growth factor in angiogenesis a historical review ... endothelial growth factor in cancer journal Cytokine Growth Factor Rev. volume 16 issue 1 pages ... author Matsumoto T, Mugishima H title Signal transduction via vascular endothelial growth factor ... W title Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative ... T, Murphy RF, Agrawal DK title Immunomodulatory role of vascular endothelial growth factor and angiopoietin ... aspects and binding strategies of vascular endothelial growth factor in renal cell carcinoma journal ... TD. title Depolymerized hyaluronan induces vascular endothelial growth factor, a negative ...   more details




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