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immunosuppression





Encyclopedia results for immunosuppression

  1. Immunosuppression

    on immunosuppression. Dr. Murray and his team are credited with the first successful human kidney .... Irrelevant to immunosuppression because that transplant was between indentical twins see Kidney transplantation Pathogenic See Immunodeficiency Immunosuppression is a common aim of many bacterial virulence ... fr Immunosuppression it Immunodepressione pl Immunosupresja pt Imunosupress o ru ...   more details



  1. Immunosuppression-associated Kaposi sarcoma

    Infobox disease ICD10 ICD10 C 46 c 45 ICD9 ICD9 176 ICDO ICDO 9140 3 Immunosuppression associated Kaposi sarcoma resembles that of classic Kaposi sarcoma however, the site of presentation is more variable. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 600 See also Kaposi sarcoma Skin lesion References reflist Vascular tumors DEFAULTSORT Immunosuppression Associated Kaposi Sarcoma Category Dermal and subcutaneous growths oncology stub Dermal growth stub ...   more details



  1. BCG-oma

    Unreferenced date February 2007 A BCG oma is an abscess caused by the bacille Calmette Gu rin BCG strain of Mycobacterium bovis . It follows incorrect Pharmaceutical drug Administration administration of BCG subcutaneous injection or administration in the context of immunosuppression . It is treated as for any Mycobacterium bovis infection isoniazid and rifampicin for nine months . DEFAULTSORT Bcg Oma Category Infectious diseases Disease stub ...   more details



  1. HIV disease-related drug reaction

    HIV disease related drug reactions present in HIV infected patients, especially those with helper T cell counts between 25 and 200, immunosuppression that increases the risk for the development of adverse reactions to medications. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 131 See also HIV Skin lesion List of cutaneous conditions References reflist Cutaneous condition stub Category Drug eruptions ...   more details



  1. VZV immune globulin

    orphan date September 2010 VZV varicella zoster virus globulin is an immune system medication that is used mostly for Immunosuppression immunosuppressed patients. It shortens the course of Cutaneous conditions cutaneous disease and may protect against its dissemination. ref name Essential Neurology, 2005 Wilkinson, Iain and Lennox, Graham June 2005 . Essential Neurology 4th ed. . Wiley Blackwell. p. 263 ISBN 978 1 4051 1867 5. ref Varicella zoster virus is a virus in humans that causes chickenpox and Herpes zoster shingles . References Reflist Neuroscience stub Category Medical treatments ...   more details



  1. IBD

    IBD may stand for In business Independent Bicycle Dealers , a small bicycle business Interest bearing debt , a debt that the debtor needs to pay interest on Investment banking Core investment banking activities Investment Banking Division , a department of an investment bank Investor s Business Daily , a national newspaper in the United States Integrated Brand Development , develop brands through strategic planning, Research, PR, Corporate Identity, advertising, events and interactive media in India In science and medicine Identity by descent , a genetics term Inclusion Body Disease , a destructive virus occurring in boid snakes Infectious bursal disease , a poultry disease causing immunosuppression Inflammatory bowel disease , a group of inflammatory conditions of the large intestine Iodobenzene dichloride , a reagent used in organic chemistry Other uses Institute of Brewing and Distilling , an international organisation for brewing disambig it IBD nl IBD ja IBD ...   more details



  1. Chicken anaemia virus

    Chicken anaemia virus , or CAV , is a virus that causes anaemia , bone marrow atrophy , and severe immunosuppression in poultry . Clinical signs of CAV infection are predominantly found in young chicks due to horizontal transmission from hatchmates or vertical transmission from the breeder hens whose maternal antibodies are not yet present after exposure. The disease is rare today because of the widespread practice of vaccinating breeders, but the subclinical form of the disease is ubiquitous. ref cite journal author Sommer F, Cardona C title Chicken anemia virus in broilers dynamics of the infection in two commercial broiler flocks journal Avian Dis. volume 47 issue 4 pages 1466 73 year 2003 pmid 14708998 doi 10.1637 7048 ref The vaccine has the ATCvet code ATCvet I01 AD04 . References Reflist Category Poultry diseases Category Animal virology veterinary med stub ja ...   more details



  1. Immunotoxicology

    Unreferenced stub auto yes date December 2009 Orphan date December 2009 Immunotoxicology sometimes abbreviated as ITOX is the study of immune dysfunction resulting from exposure of an organism to a xenobiotic . The immune dysfunction may take the form of immunosuppression or alternatively, allergy , autoimmunity or any number of inflammatory based diseases or pathologies. Because the immune system plays a critical role in host resistance to disease as well as in normal homeostasis of an organism, identificantion of immunotoxic risk is significant in the protection of human, animal and wildlife health. In the non adult embryo , fetus , neonate , juvenile organism juvenile , adolescent this study is referred to as Developmental Immunotoxicology commonly abbreviated as DIT . For most toxicants examined to date, the developing immune system exhibits a heightened sensitivity compared with that of an adult. For this reason, DIT screening has applications to human, animal and wildlife health protection. See also Journal of Immunotoxicology Category Toxicology Category Immunology med toxic stub Immunology stub ...   more details



  1. Onygenales

    Taxobox name Eurotiales image Coccidioides immitis microscopy.jpg image caption Coccidioides immitis regnum Fungi divisio Ascomycota classis Eurotiomycetes ordo Onygenales subdivision ranks Families subdivision Ajellomycetaceae br Arachnomycetaceae br Arthrodermataceae br Ascosphaeraceae br Gymnoascaceae br Onygenaceae The Onygenales are an order biology order of Ascomycetes , within the eurotiomycetes Ascomycetes . The Onygenales are important as emerging human pathogen s because of the rising rates of immunosuppression due to live organ transplant, HIV AIDS, and autoimmune disorders such as Lupus erythematosus . References C.J. Alexopolous, Charles W. Mims, M. Blackwell, Introductory Mycology, 4 sup th sup ed. John Wiley and Sons, Hoboken NJ, 2004 ISBN 0 471 52229 5 Category Eurotiomycetes Eurotiomycetes stub de Onygenales es Onygenales fr Onygenales nl Onygenales ...   more details



  1. Streptomyces tsukubaensis

    Refimprove date March 2008 Expert subject Microbiology date March 2008 italictitle Taxobox regnum Bacteria phylum Actinobacteria classis Actinobacteria ordo Actinomycetales familia Streptomycetaceae genus Streptomyces species S. tsukubaensis binomial Streptomyces tsukubaensis binomial authority Streptomyces tsukubaensis is a species of actinobacteria . It produces the immunosuppression immunosuppressive medication drug tacrolimus . ref name DrugDiscovToday2005 Pritchard cite journal author Pritchard D title Sourcing a chemical succession for cyclosporin from parasites and human pathogens. journal Drug Discov Today volume 10 issue 10 pages 688 91 year 2005 pmid 15896681 doi 10.1016 S1359 6446 05 03395 7 Supports source organism, but not team information ref References reflist Category Actinomycetales bacteria stub es Streptomyces tsukubaensis ...   more details



  1. Immunosuppressant

    Refimprove date April 2008 main Immunosuppressive drug An immunosuppressant is any substance that performs immunosuppression of the immune system . They may be either exogenous, as immunosuppressive drug s, or endogenous, as ,e. g., testosterone . ref cite journal last Fimmel coauthors Zouboulis CC year 2005 title Influence of physiological androgen levels on wound healing and immune status in men journal Aging Male volume 8 pages 166&ndash 174 pmid 16390741 doi 10.1080 13685530500233847 first S issue 3 4 ref When the immune system function is suppressed, there is an increased susceptibility to infectious diseases and cancers. The term immunotoxin is also sometimes used incorrectly to label undesirable immunosuppressants, such as various pollutants . Polychlorinated biphenyls PCB and the herbicide DDT are immunosuppressants. fact date May 2009 Uses Immunosuppressants may be prescribed when a normal immune response is undesirable, such as in autoimmune diseases . After an organ transplantation , the body will nearly always reject the new organ s due to differences in human leukocyte antigen haplotype s between the donor and recipient. As a result, the immune system detects the new tissue as hostile , and attempts to remove it by attacking it with recipient leukocytes , resulting in the death of the tissue. Immunosuppressants are applied as a countermeasure the side effect is that the body becomes more vulnerable to infections and malignancy, much like in an advanced HIV infection. See also Immunosuppression Immunosuppressive drug BK virus more dangerous to the immunosuppressed References reflist Immunosuppressants Category Immunosuppressants medicine stub es Inmunosupresor sr Imunosupresant zh ...   more details



  1. Post-transplant lymphoproliferative disorder

    of Immunosuppression immunosuppressant medication, ref name urlHematopathology cite web url ...   more details



  1. BK virus

    ref Treatment The cornerstone of therapy is reduction in immunosuppression. A recent surge in BKVN correlates ... were preserved in 8 8 individuals managed with reduction in immunosuppression while graft loss occurred ... treatment option behind reduction of immunosuppression. Leflunomide in BKVN The rationale ...   more details



  1. Immune reconstitution inflammatory syndrome

    meningitis may be local or systemic immunosuppression induced by the cryptococcal infection which ...   more details



  1. Pathogenesis

    The pathogenesis of a disease is the mechanism biology mechanism by which the disease is caused. The term can also be used to describe the origin and development of the disease and whether it is acute medical acute , chronic medical chronic or recurrent . The word comes from the Greek language Greek pathos , disease , and genesis , creation . Types of pathogenesis include microbe microbial infection , inflammation , malignancy and Necrosis tissue breakdown . Most diseases are caused by multiple pathogenetical processes together. For example, certain cancer s arise from dysfunction of the immune system skin tumor s and lymphoma after a renal transplant , which requires immunosuppression . ref cite book last Fox first Alvin title General aspects of bacterial pathogenesis year 2010 publisher Microbiology and Immunology On line Textbook location University of South Carolina School of Medicine url http pathmicro.med.sc.edu fox bact path.htm ref Often, a potential etiology is identified by epidemiology epidemiological observations before a pathology pathological link can be drawn between the cause and the disease. References reflist Further reading Haugan, Salomon Avian Influenza Etiology, Pathogenesis and Interventions Public Health in the 21st Century. Nova Science Pub Inc. January 30, 2010 ISBN 1607418460, ISBN 978 1607418467 Category Pathology Pathology stub bg cs Patogeneze de Pathogenese es Patog nesis fr Pathogen se id Patogenesis it Patogenesi hu Patogenezis nl Pathogenese pl Patogeneza pt Patog nese ru sk Patogen za sv Patogenes th tr Patogenez uk ...   more details



  1. Seroconversion

    Seroconversion is the development of detectable specific antibodies to microorganism s in the blood plasma blood serum as a result of infection or immunization . Serology the testing for antibodies is used to determine antibody positivity. Prior to seroconversion, the blood test is seronegative for the antibody after seroconversion, the blood test is seropositive for the antibody. The word is often used in reference to blood testing for anti HIV antibodies. In particular, seroconverted has been used to refer to the process of having become HIV positive. ref http www.avclub.com content node 92431 ref ref http www.thestranger.com seattle SavageLove?oid 6064090 ref Syn date December 2010 Seroreversion is the opposite of seroconversion. This is when the tests can no longer detect antibody antibodies in a patient s serum. ref Tantalo et al., JID 2005 191 Treponema pallidum strain specific differences in neuroinvasion and clinical phenotype in a rabbit model ref Background The immune system maintains an immunological memory against past pathogens to facilitate early detection and to confer protective immunity against a Challenge dechallenge rechallenge rechallenge . This explains why many childhood diseases never recur in adulthood and when they do, it generally indicates immunosuppression or failure of a vaccine . In the initial primary infection phase of the infection, immunoglobulin M IgM antibodies are produced and as these levels drop and become undetectable immunoglobulin G IgG levels rise and remain detectable. Upon reinfection, IgM antibodies usually do not rise again but IgG levels will increase. Thus an elevated IgM titre indicates recent primary infection, while the presence of IgG suggests past infection or immunization . References reflist Use dmy dates date December 2010 Category Serology de Serokonversion fr S roconversion id Serokonversi pt Seroconvers o ...   more details



  1. Ghon focus

    Image TB CXR.jpg frame right 100px Visible cavities in later stage tuberculosis Ghon focuses are smaller. A Ghon focus is a primary lesion caused by mycobacterium tuberculosis mycobacterium bacilli tuberculosis developed in the lung of a previously uninfected individual. It is named for Anton Ghon 1866 1936 , an Austrian people Austrian pathologist . It is a small area of granulomatous inflammation, only detectable by chest X ray if it calcifies or grows substantially see tuberculosis radiology ref name Robbins Kumar, Vinay Abbas, Abul K. Fausto, Nelson & Mitchell, Richard N. 2007 . Robbins Basic Pathology 8th ed. . Saunders Elsevier. pp. 516 522 ISBN 978 1 4160 2973 1 ref . Typically these will heal, but in some cases, especially in immunosuppression immunosuppressed patients, it will progress to miliary tuberculosis so named due to the granulomas resembling millet seeds on a chest X ray ref name Robbins . The classical location for primary infection is surrounding the lobar fissures, either in the upper part of the lower lobe or lower part of the upper lobe ref name Robbins . If the Ghon focus also involves infection of adjacent lymphatics and hilar lymph nodes, it is known as the Ghon s complex or primary complex. When it undergoes fibrosis and calcification it is called RANKE COMPLEX. ref name Robbins ref http www.smbs.buffalo.edu pth600 IMC Path y2case y2ans10.htm ref . References reflist Gram positive actinobacteria diseases Category Tuberculosis Category Histopathology es Foco de Ghon pathology stub ...   more details



  1. Aplidine

    Image Aplidine Dehydrodidemnin B structure.jpg thumb Chemical structure of Aplidine Aplidine , also known as Dihydrodidemnin B , is a compound extracted from the Ascidiacea ascidian Aplidium albicans . ref Cragg, G.M. and Newman, D.J., The Journal of Natural Products 2004 , 67 8 , 1216 1238. ref It is currently undergoing clinical trial testing. Chemical structure See Didemnins Aplidine is a cyclic depsipeptide , meaning it is a Cyclic molecule cyclic peptide in which there is one or more ester bond in place of one or more of a peptide bond. Its chemical structure is very close to that of Didemnins Didemnin B , the only difference being that the Lactic acid lactate residue in Didemnin B is present in the Oxidation Redox reactions in biology oxydized pyruvate version. Pharmacological activity Like all didemnin compounds, it exhibits Antineoplastic antitumor , Antiviral drug antiviral and Immunosuppression immunosuppressive activities. It shows promise in shrinking tumors in pancreatic, stomach, bladder, and prostate cancers. ref Garrison, Tom. u Oceanography An Invitation to Marine Science u . 4th ed. United States Brooks Cole. 2002. 98. ref ref name Total Synthesis and Biological Evaluation of Tamandarin B Analogues Adrio, J. et al . The Journal of Organic Chemistry 2007 , 72 14 , 5129 5138. ref As of 2007, it was undergoing multicenter Clinical trial Phase II phase II clinical trials . ref name Total Synthesis and Biological Evaluation of Tamandarin B Analogues In July 2003, Aplidine was granted the orphan drug status by the European Medicines Agency for treating acute lymphoblastic leukemia . ref http www.emea.europa.eu pdfs human comp opinion 037804en.pdf ref References references Category Oceanography ocean stub organic chem stub ...   more details



  1. Friend virus

    Taxobox Color parameter is not needed automatically assigned name Friend virus virus group vi familia Retroviridae subfamilia Orthoretrovirinae genus Gammaretrovirus species Murine leukemia virus subdivision ranks Serotype subdivision Friend virus The Friend virus is a strain of murine leukemia virus identified by Charlotte Friend in 1956. The virus infects adult immunocompetent mice and is a well established model for studying genetic resistance to infection by an Immunosuppression immunosuppressive retrovirus . The Friend virus has been used for both immunotherapy and vaccines . It is a member of the retroviridae group of viruses, with its nucleic acid being ssRNA . Vaccination Experiments have shown that it is possible to protect against Friend virus infection with several types of vaccines, including attenuated virus es, viral proteins, peptides , and recombinant vaccinia vectors expressing the Friend virus gene. In a study of vaccinated mice, it was possible to identify the immunological epitopes required for protection against the virus, thus determining the types of immunological responses necessary or required for protection against it. The research discovered protective epitopes that were localized to F MuLV gag and env proteins. This was achieved using recombinant vaccinia viruses expressing the 74 and 76 genes of FV. Implications Friend virus models showed valuable information regarding genetic resistance to retroviral disease. A particular gene of interest is the Rfv 3 gene, which cause susceptibility to suppression of the FV specific anitbody response. The greater understanding by which the mechanisms work may aid in the development of immunotherapies and vaccines that may be applicable to human diseases. References http www.pnas.org cgi content full 94 15 7811 Immunity to retroviral infection The Friend virus model http www.nap.edu readingroom.php?book biomems&page cfriend.html DEFAULTSORT Friend Virus Retroviruses Category Retroviruses es Friend virus ...   more details



  1. Malakoplakia

    Infobox Disease Name PAGENAME Image Michaelis Gutmann bodies very high mag cropped.jpg Caption Micrograph showing the characteristic finding of malakoplakia Michaelis Gutmann bodies . H&E stain . Width 225 DiseasesDB 29128 ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj derm eMedicineTopic 872 MeshID D008287 Malakoplakia is a rare inflammatory condition which makes its presence known as a papule , plaque or genital ulcer ulceration that usually affects the genitourinary tract . ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 274 However, it may also be associated with other bodily organs. It was initially described in the early 1900s as soft yellowish plaques found on the mucosa of the urinary bladder . Microscopically it is characterized by the presence of foamy histiocyte s with basophil ic inclusions called Michaelis Gutmann body Michaelis Gutmann bodies . It usually involves gram negative bacteria. ref name ChengBostwick2006 cite book author1 Liang Cheng author2 David G. Bostwick title Essentials of anatomic pathology url http books.google.com books?id B LUwWcqspoC&pg PA1180 accessdate 15 May 2010 year 2006 publisher Springer isbn 9781588294616 pages 1180 ref Causes Malakoplakia is thought to result from the insufficient killing of bacteria by macrophage s. Therefore, the partially digested bacteria accumulate in macrophages and leads to a deposition of iron and calcium . The impairment of bactericide bactericidal activity manifests itself as the formation of an ulcer dermatology ulcer , plaque or papule. Malakoplakia is associated with patients with a history of immunosuppression due to lymphoma , diabetes mellitus , renal transplant ation, or because of long term Pharmacotherapy therapy with systemic corticosteroid s. Treatment Today, antibiotics are used for treatment of malakop ...   more details



  1. Anthony Hollander

    Anthony Hollander born 4 February 1964 is Professor of Rheumatology and Tissue Engineering at the University of Bristol . On 19 November 2008 it was reported that an artificially grown organ had been successfully transplanted into a woman, Claudia Castillo, a breakthrough in which Hollander played a key role. In 2009, Biddy Baxter , the editor of the children s television programme Blue Peter published a selection of children s letters received by the Blue Peter team. Amongst them was a letter from Hollander who had written in 1973 that he wanted to become a doctor. He said that he owes his career to Miss Baxter If her letter had shown any hint of ridicule or disbelief I might perhaps never have trained to become a medical scientist or been driven to achieve the impossible dream, and really make a difference to a human being s life. ref cite news url http www.dailymail.co.uk news article 1130479 How boy 9 wrote Blue Peter predicting illustrious future scientist 35 years ago.html title How boy, 9, wrote to Blue Peter predicting his illustrious future as top scientist... 35 years ago publisher Daily Mail date 2009 01 28 ref References Reflist External links http esciencenews.com articles 2008 11 19 first.trachea.transplant.without.immunosuppression First trachea transplant without immunosuppression Eureka Science News http www.bristol.ac.uk cellmolmed staff hollander.html Prof. Anthony Hollander webpage DEFAULTSORT Hollander, Anthony Category British scientists Category 1960s births Category Living people UK med bio stub ...   more details



  1. Tinea incognito

    Refimprove date December 2008 Tinea incognito is a fungal infection mycosis of the skin caused by the presence of a topical Immunosuppressive drug immunosuppressive agent . The usual agent is a topical corticosteroid topical steroid . As the skin fungal infection has lost some of the characteristic features due to suppression of inflammation , it may have a poorly defined border, skin atrophy, telangiectasia , and florid growth. Occasionally, secondary infection with bacteria occurs with concurrent pustule s and impetigo . ref Habif, T. P. 1995 Clinical Dermatology . Mosby, 3rd ed. pp. 41 42. ref Diagnosis Clinical suspicion arises especially if the eruption is on the Human foot feet , ankle , Human leg legs , or groin . A history of topical steroid or immunosuppressive agent is noted. Confirmation is with a Excoriation skin scraping and microscopic exam with potassium hydroxide solution . Characteristic hyphae are seen running through the Squamous epithelium squamous epithelial cells . Fungal Cell culture culture is not necessary, but might be considered if the patient is using a combination antifungal and topical steroid product. Cause The use of a topical steroid is the most common cause. Frequently, a combination topical steroid and antifungal cream is prescribed by a physician. These combinations include Betamethasone betamethasone dipropionate and clotrimazole trade name Lotrisone and triamcinolone acetonide and clotrimazole . In area of open skin, these combinations are acceptable in treating fungal infection of the skin. Unfortunately, in area where the skin is occluded groin, buttock crease, Axilla armpit , the immunosuppression by the topical steroid might be significant enough to cause tinea incognito to occur even in the presence of an effective antifungal. Treatment The removal of the offending topical steroid or immunosuppressive agent. Treatment with a topical antifungal is adequate. If the tinea incognito is extensive, treatment with a systemic antif ...   more details



  1. Khodadoust line

    Orphan date February 2011 Expert subject Ophthalmology date January 2010 A Khodadoust Line or chronic focal transplant reaction is a medical sign that indicates a complication of corneal graft surgery on the eye. ref http emedicine.medscape.com article 1193505 overview Corneal Graft Rejection on eMedicine ref This medical condition is similar to organ rejection after an organ transplant , except that it involves immunological rejection of a transplanted cornea rather than an internal organ. A Khodadoust line is made up of mononuclear cells white blood cells . These cells appear at the vascularized edge of the recently transplanted cornea. If untreated, the line of white blood cells will move across and damage the endothelial cells of the cornea over the space of several days. Treatment Prompt treatment by immunosuppression can prevent further damage. ref cite web url http www.atlasophthalmology.com atlas photo.jsf ?node 6888&locale en title Atlas of Ophthalmology publisher Atlasophthalmology.com date accessdate 2011 01 02 ref References reflist External links http www.redatlas.org fr index.htm? RAPages A A077.htm cite journal author Ficker LA, Kirkness CM, Steele AD, Rice NS, Gilvarry AM title Intraocular surgery following penetrating keratoplasty the risks and advantages journal Eye volume 4 issue 5 pages 693 7 year 1990 pmid 2282943 cite journal author Khodadoust AA, Karnama Y, Stoessel KM, Puklin JE title Pars planitis and autoimmune endotheliopathy journal American Journal of Ophthalmology volume 102 issue 5 pages 633 9 year 1986 month November pmid 3777084 cite journal author Khodadoust AA, Silverstein AM title Induction of corneal graft rejection by passive cell transfer journal Investigative Ophthalmology volume 15 issue 2 pages 89 95 year 1976 month February pmid 1357 url http www.iovs.org cgi pmidlookup?view long&pmid 1357 Eye pathology Category Diseases of the eye and adnexa Category Medical signs disease stub ...   more details



  1. Vanishing bile duct syndrome

    refimprove date April 2010 Vanishing bile duct syndrome is a loose collection of diseases which leads to of the injury to hepatic bile ducts and eventual ductopenia . ref cite journal author Reau NS, Jensen DM title Vanishing bile duct syndrome journal Clin Liver Dis volume 12 issue 1 pages 203 17, x year 2008 month February pmid 18242505 doi 10.1016 j.cld.2007.11.007 url ref Etiology Congenital Developmental In fetal and neonatal life the ductal plates are remodeled. The malformations can be atretic or fibrocystic. Atretic causes Extrahepatic bile duct atresia Fibrocystic causes Autosomal recessive polycystic kidney disease Congential hepatic fibrosis Caroli s disease Von Meyenburg complex Chromosomal associations Trisomy 17, 18 and 21 Genetic associations Cystic fibrosis Alpha 1 antitryspin deficiency Trihydroxycoprostanic acidemia Byler s disease Immunologic associations Bile duct injury and loss can result from autoimmune destruction. T cells recognize biliary epithelial cell antigens causing injury and eventual atresia. Other causes Primary biliary cirrhosis Primary sclerosing cholangitis Hodgkin s disease Chronic graft versus host disease Drugs Toxins Ischemia Clinical presentation The presentation is dependant upon the underlying etiology. The course can be rapid or chronic. Symptoms Fatigue Anorexia Abdominal pain Weight loss Pruritis Signs Hyperlipidemia Malabsorption Fat soluble vitamin deficiencies Elevated alkaline phosphatase Elevated gamma glutamyltransferase Elevated conjugated bilirubin Treatment Treatment is dependent upon the underlying etiology. Treatment is supportive as it is not possible to induce regrowth of lost ducts. Medical therapies Ursodeoxycholic acid Immunosuppression General consensus is that more studies are needed before this can be considered Organ transplant References Reflist External links http www.utdol.com patients content topic.do?topicKey 1kvvp.E6r b5ok&source HISTORY Uptodate Hepatic ductopenia and vanishing bile duct syndr ...   more details



  1. Immunosuppressive drug

    rabbit serum. Polyclonal antibodies affect all lymphocytes and cause general immunosuppression, possibly ... can cause excessive immunosuppression. Although CD3 antibodies act more specifically than polyclonal ... mofetil based immunosuppression changes the frequency and phenotype of CD4 FoxP3 regulatory t cells ... to assess the amount of immunosuppression achieved using drugs in this category. ref http www.isotechnika.com ... . Opioids Prolonged use of opioid s may cause immunosuppression of both innate and adaptive immunity ... reported being 10 to 100 times more potent than Ciclosporin See also Immunosuppression Immunosuppressant ... Accessed on 21 August 2005. http www.emedicine.com ped topic2848.htm Immunosuppression ... asked questions about immunosuppression in renal transplatation for a layman. Accessed on 21 August ...   more details




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