A decamer is an oligomer composed of 10 number ten sub unit s. See also wiktionary decamer Decameron disambiguation deca , a prefix mer , an affix chemistry stub Category Oligomers ... more details
unsourced date October 2010 Other uses Mer disambiguation Mer mer and mer from Greek meros , part are affix es used in the following words. In chemistry or biochemistry Monomer Dimer Trimer Tetramer Pentamer Hexamer Heptamer Octamer Nonamer Decamer Dodecamer Oligomer Polymer Enantiomer And also Heteromer Homeomer Isomer In biology Merosity , a characteristic regarding the flower petals number in plants Metamery , a characteristic of segmented animals Category suffixes Category prefixes de mer vocab stub chem stub ... more details
About proteins the chemical compound CCl sub 4 sub Carbon tetrachloride protein Name CCL3 chemokine C C motif ligand 3 caption image width HGNCid 10627 Symbol CCL3 AltSymbols SCYA3, MIP 1 EntrezGene 6348 OMIM 182283 RefSeq NM 002983 UniProt P10147 PDB 1B50 ECnumber Chromosome 17 Arm q Band 12 LocusSupplementaryData protein Name CCL4 chemokine C C motif ligand 4 caption Molecular structure of macrophage inflammatory protein 1 oligomer. ref name urlRCSB Protein Data Bank Structure Summary for 3KKH Human macrophage inflammatory protein 1 beta decamer cite web url http www.rcsb.org pdb explore explore.do?structureId 3KKH title RCSB Protein Data Bank Structure Summary for 3KKH Human macrophage inflammatory protein 1 beta decamer format work accessdate ref image 3KKH.pdb.png width HGNCid 10630 Symbol CCL4 AltSymbols SCYA4, MIP 1 , LAG1 EntrezGene 6351 OMIM 182284 RefSeq NM 002984 UniProt P13236 PDB 1HUM ECnumber Chromosome 17 Arm q Band 21 LocusSupplementaryData q23 Macrophage Inflammatory Proteins MIP belong to the family of chemotaxis chemotactic cytokine s known as chemokine s. In humans, there are two major forms, MIP 1 and MIP 1 that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophage s after they are stimulated with bacteria l endotoxin s. ref name pmid3058856 cite journal author Sherry B, Tekamp Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A title Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta journal J. Exp. Med. volume 168 issue 6 pages 2251 9 year 1988 month December pmid 3058856 pmc 2189160 doi ref They activate human granulocyte s neutrophil s, eosinophil s and basophil s which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro inflammatory cytokines such as interleukin 1 IL 1 , Interleukin 6 IL 6 and TNF ... more details
About the SI prefix Deca disambiguation Deca Wiktionarypar deca Deca or deka ref name SP811 http physics.nist.gov Pubs SP811 sp811.html Guide for the Use of the International System of Units SI , 1995, NIST Special Publication 811 ref symbol da is a SI prefix prefix in the metric system , also a numerical prefix , denoting a factor of ten. The term is derived from the Greek language Greek meaning ten . The prefix was a part of the original metric system in 1795. It is not in very common usage, although the decapascal is occasionally used by audiologists. The decanewton is also encountered occasionally, probably because it is an SI approximation of the kilogram force . It is more commonly used in other languages in Austrian and Hungarian, deca is common and always means decagram . Before the symbol was standardized as da with the introduction of the International System of Units in 1960, various other symbols were more common, such as dk , D , and Da . 1 decametre 10 metre s 1 decalitre 10 litre s 1 decare 10 are s SI prefixes References references See also Decamer , a thing composed of ten sub units External links http www.bipm.org BIPM website Categories Category SI prefixes Interwiki be br Deka ca Deca cs Deka et Deka es Deca fa fr D ca gl Deca ko hy hi it Deca ka ... lt Deka nl Deca prefix ja no Deka nn Deka km nds Deka pl Deka pt Deca ksh Deka ru sl Deka sr vi ca ... more details
otheruses Unreferenced date October 2007 Image RAPD.JPG thumb RAPD experiment RAPD pronounced rapid stands for R andom A mplification of P olymorphic D NA. It is a type of PCR reaction, but the segments of DNA that are amplified are random. The scientist performing RAPD creates several arbitrary, short primers 8 12 nucleotides , then proceeds with the PCR using a large template of genomic DNA, hoping that fragments will amplify. By resolving the resulting patterns, a semi unique profile can be gleaned from a RAPD reaction. No knowledge of the DNA sequence for the targeted gene is required, as the primers will bind somewhere in the sequence, but it is not certain exactly where. This makes the method popular for comparing the DNA of biological systems that have not had the attention of the scientific community, or in a system in which relatively few DNA sequences are compared it is not suitable for forming a DNA databank . Because it relies on a large, intact DNA template sequence, it has some limitations in the use of degraded DNA samples. Its resolving power is much lower than targeted, species specific DNA comparison methods, such as short tandem repeats . In recent years, RAPD has been used to characterize, and trace, the phylogeny of diverse plant and animal species. Introduction RAPD markers are decamer 10 nucleotide length DNA fragments from PCR amplification of random segments of genomic DNA with single primer of arbitrary nucleotide sequence and which are able to differentiate between genetically distinct individuals, although not necessarily in a reproducible way. It is used to analyse the genetic diversity of an individual by using random primers. How It Works Unlike traditional PCR analysis, RAPD does not require any specific knowledge of the DNA sequence of the target organism the identical 10 mer primers will or will not amplify a segment of DNA, depending on positions that are complementary to the primers sequence. For example, no fragment is produced i ... more details
PBB geneid 9445 Integral membrane protein 2B is a protein that in humans is encoded by the ITM2B gene . ref name pmid9795190 cite journal author Pittois K, Deleersnijder W, Merregaert J title cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B journal Gene volume 217 issue 1 2 pages 141 9 year 1998 month Nov pmid 9795190 pmc doi 10.1016 S0378 1119 98 00354 0 ref ref name entrez cite web title Entrez Gene ITM2B integral membrane protein 2B url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9445 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text ITM2B or BRI2 is a gene located on chromosom 13. The gene is connected to Familial Danish Disease FDD and Familial British Disease FBD causing amyloid and pre filbrillar effects similar to those seen in Alzheimers Disease AD . References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Rostagno A, Tomidokoro Y, Lashley T, et al. title Chromosome 13 dementias. journal Cell. Mol. Life Sci. volume 62 issue 16 pages 1814 25 year 2005 pmid 15968464 doi 10.1007 s00018 005 5092 5 cite journal author Ernst B, Dalby MA, Dalby A title Luria testing in demented patients. journal Acta Neurol. Scand. volume 46 issue pages Suppl 43 97 8 year 1970 pmid 5466275 doi 10.1111 j.1600 0447.1970.tb01106.x cite journal author Vidal R, Frangione B, Rostagno A, et al. title A stop codon mutation in the BRI gene associated with familial British dementia. journal Nature volume 399 issue 6738 pages 776 81 year 1999 pmid 10391242 doi 10.1038 21637 cite journal author Vidal R, Revesz T, Rostagno A, et al. title A decamer duplication in the 3 region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. journal Proc. Natl. Acad. Sci. U.S.A. volume 97 issue 9 pa ... more details
PBB geneid 6720 Sterol regulatory element binding protein 1 SREBP 1 also known as sterol regulatory element binding transcription factor 1 SREBF1 is a protein that in humans is encoded by the SREBF1 gene . ref name pmid8402897 cite journal author Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS title SREBP 1, a basic helix loop helix leucine zipper protein that controls transcription of the low density lipoprotein receptor gene journal Cell volume 75 issue 1 pages 187 97 year 1993 month Nov pmid 8402897 pmc doi ref ref name pmid7759101 cite journal author Hua X, Wu J, Goldstein JL, Brown MS, Hobbs HH title Structure of the human gene encoding sterol regulatory element binding protein 1 SREBF1 and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13 journal Genomics volume 25 issue 3 pages 667 73 year 1995 month Jun pmid 7759101 pmc doi 10.1016 0888 7543 95 80009 B ref Function This gene encodes a transcription factor that binds to the sterol regulatory element 1 SRE1 , which is a decamer flanking the LDL receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum . Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix loop helix leucine zipper basic helix loop helix leucine zipper transcription factors bHLH Zip transcription factor family. This gene is located within the Smith Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. ref cite web title Entrez Gene SREBF1 sterol regulatory element binding transcription factor 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6720 acc ... more details
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