chembox Watchedfields changed verifiedrevid 265738700 Name Uracil ImageFile Uracil.svg ImageSize 120px ImageName Structural formula of uracil ImageFileL1 Uracil 3D balls.png ImageSizeL1 120px ImageNameL1 Ball and stick model of uracil ImageFileR1 Uracil 3D vdW.png ImageSizeR1 120px ImageNameR1 Space filling model of uracil IUPACName Pyrimidine 2,4 1 H ,3 H dione OtherNames 2 oxy 4 oxy pyrimidine, br ...&pg PA92&lpg PA92&dq Uracil boiling point&source bl&ots hn9HyffT W&sig uFAWcfhiBiFfpbctZgEWYQUnRf8&hl ... 1 NFPA F 1 NFPA R FlashPt non flammable Section8 Chembox Related OtherCpds Thymine br Cytosine Uracil .... Methylation of uracil produces thymine . ref name madsci1 It turns into thymine to protect the DNA and to improve the efficiency of DNA replication . Uracil can base pair with any of the bases ... the methyl group is repelled into a fixed position. ref name madsci1 www.madsci.org ref Uracil pairs with adenine through hydrogen bonding . Uracil is the hydrogen bond acceptor and can form two hydrogen bonds. Uracil can also bind with a ribose sugar to form the ribonucleoside uridine . When a phosphate .... et al. Principles of Biochemistry. 3rd ed. Upper Saddle River, NJ Prentice Hall, 2002. ref Uracil undergoes ... common form of uracil. Image Uracil tautomers.png left thumb Uracil tautomers Amide or lactam structure left and imide or lactim structure right br style clear left Uracil also recycles itself ... Degradation of uracil produces the substrates aspartate , carbon dioxide , and ammonia . ref name ... sup sup NH sub 4 sub sup sup CO sub 2 sub Oxidative degradation of uracil produces urea and maleic ... of diatomic oxygen and Fe sup 2 sup . Uracil is a weak acid the first site of ionization of uracil ... sub 9 sup . In the gas phase, uracil has 4 sites that are more acidic than water. ref name Lee1 Lee ... published in October 2009, NASA scientists reported having reproduced uracil from pyrimidine ... original source for uracil. ref http www.nasa.gov centers ames news features 2009 urasil.html . ref ... more details
protein Name uracil phosphoribosyltransferase FUR1 homolog S. cerevisiae caption image width HGNCid 28334 Symbol UPRT AltSymbols EntrezGene 139596 OMIM RefSeq NM 145052 UniProt Q96BW1 PDB ECnumber Chromosome X Arm q Band 13.3 LocusSupplementaryData Uracil phosphoribosyltransferase is an enzyme which creates Uridine monophosphate UMP from uracil and phosphoribosylpyrophosphate . External links MeshName Uracil phosphoribosyltransferase EC number 2.4.2.9 enzyme stub Glycosyltransferases ... more details
Tegafur uracil is a chemotherapy drug used in the treatment of cancer, primarily bowel cancer . It is also called UFT or UFUR. ref http www.cancerbackup.org.uk Treatments Chemotherapy Individualdrugs Tegafur uracil Tegafur uracil Uftoral Cancerbackup Bot generated title ref The UFT combination was developed in Japan during the 1980s using tegafur, a pro 5FU drug. UFT is approved in over 50 countries as a cancer therapy, most commonly for advanced colorectal cancer to replace 5FU, and has a low cost. sup http jjco.oxfordjournals.org cgi content full 36 4 237 sup P atients appeared strongly to prefer treatment with UFT LV over 5 FU LV. sup http www.hta.ac.uk execsumm summ732.shtml sup In Japan ... Inhibitory Flouropyrimidine drug. UFT is an oral agent with combines uracil , a competitive inhibitor of DPD, with the 5 FU prodrug tegafur in a 4 1 molar ratio. Excess uracil competes with 5 FU ... into 5 FU , a substance that kills tumor cells. The uracil causes higher amounts of 5 FU to stay inside the cells and kill them. Ftorafur is a type of antimetabolite . The uracil has also been stated ... cases of various epithelial cancers. In the UK, tegafur uracil with folinic acid is approved as first ... cancer. ref http guidance.nice.org.uk TA61 Capecitabine and tegafur uracil for metastatic ... under a variety of names including Tegafur uracil, UFT, Ftorafur, Tefudex, Ufur and Uftoral. References ... 10, September 2, 1997 Efficacy of Postoperative UFT Tegafur Uracil Plus PSK Therapies in Elderly ... 1005 16044962 Cit 1 UFT tegafur uracil in rectal cancer http annonc.oxfordjournals.org content 19 ..., J.L. Abbruzzese. Comparison of the Efficacy, Toxicity, and Pharmacokinetics of a Uracil Tegafur ... 1557 61. Ueda H, Tanaka H, Kida Y, Fukuchi H, Ichinose M. Adjuvant chemotherapy with tegafur uracil ... 1 day infusional fluorouracil leucovorin followed by metronomic chemotherapy with tegafur uracil in pretreated ... immunochemotherapy with oral Tegafur Uracil plus PSK in patients with stage II or III colorectal cancer ... more details
enzyme Name 5 amino 6 5 phosphoribosylamino uracil reductase EC number 1.1.1.193 CAS number 69020 28 6 IUBMB EC number 1 1 1 193 GO code 0008703 image width caption In enzymology , a 5 amino 6 5 phosphoribosylamino uracil reductase EC number 1.1.1.193 is an enzyme that catalysis catalyzes the chemical reaction 5 amino 6 5 phosphoribitylamino uracil NADP sup sup math rightleftharpoons math 5 amino 6 5 phosphoribosylamino uracil NADPH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are 5 amino 6 5 phosphoribitylamino uracil and nicotinamide adenine dinucleotide phosphate NADP sup sup , whereas its 3 product chemistry products are 5 amino 6 5 phosphoribosylamino uracil , nicotinamide adenine dinucleotide phosphate NADPH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 5 amino 6 5 phosphoribitylamino uracil NADP 1 oxidoreductase . This enzyme is also called aminodioxyphosphoribosylaminopyrimidine reductase . This enzyme participates in riboflavin metabolism . Structural studies As of late 2007, 7 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2AZN , PDB link 2B3Z , PDB link 2D5N , PDB link 2G6V , PDB link 2HXV , PDB link 2O7P , and PDB link 2OBC . References reflist 1 cite journal author Burrows RB, Brown GM date 1978 title Presence of Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin journal J. Bacteriol. volume 136 pages 657&ndash 67 pmid 30756 issue 2 pmc 218591 1.1.1 enzyme stub Category EC 1.1.1 Category NADPH dependent enzymes Category Enzymes of known structure it 5 amino 6 5 fosforibosilamino uracil reduttasi ja 5 6 5 ... more details
PBB geneid 7374 Uracil DNA glycosylase , also known as UNG , is a human gene ref name entrez cite web title Entrez Gene UNG uracil DNA glycosylase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... and eukaryotes and even in some DNA viruses. The first uracil DNA glycosylase DNA glycosylase was isolated ... W, Nyberg B, Sperens B title DNA N glycosidases properties of uracil DNA glycosidase from Escherichia ... updates. PBB Summary section title summary text The human gene encodes one of several uracil DNA glycosylases. One important function of uracil DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N glycosylic bond and initiating the Base excision repair base excision repair BER pathway. Uracil bases occur from cytosine deamination or misincorporation ... uracil DNA glycosylase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 7374 accessdate ref Interactions Uracil DNA glycosylase has been shown to Protein protein interaction ... R, Krokan H E year 1997 month Mar. title A sequence in the N terminal region of human uracil DNA ... involved in uracil DNA repair isoform characteristics of proteins responsible for nuclear and mitochondrial ... hybrid arrest analysis of the major human uracil DNA glycosylase. journal Nucleic Acids Res. volume ... author Muller SJ, Caradonna S title Isolation and characterization of a human cDNA encoding uracil DNA ... uracil DNA glycosylase, a highly conserved DNA repair enzyme. journal EMBO J. volume 8 issue 10 pages ... T, Krokan HE title Cell cycle regulation and subcellular localization of the major human uracil DNA ... of human uracil DNA glycosylase in complex with a protein inhibitor protein mimicry of DNA. journal ... uracil DNA glycosylase structural basis for specificity and catalysis. journal Cell volume 80 ... T, Skorpen F, Lund H, Krokan HE title Structure of the gene for human uracil DNA glycosylase and analysis ... al. title Nuclear and mitochondrial forms of human uracil DNA glycosylase are encoded by the same gene ... more details
enzyme Name uracil 5 carboxylate decarboxylase EC number 4.1.1.66 CAS number 59299 01 3 IUBMB EC number 4 1 1 66 GO code 0050382 image width caption In enzymology , a uracil 5 carboxylate decarboxylase EC number 4.1.1.66 is an enzyme that catalysis catalyzes the chemical reaction uracil 5 carboxylate math rightleftharpoons math uracil CO sub 2 sub Hence, this enzyme has one substrate biochemistry substrate , uracil 5 carboxylate , and two product chemistry products , uracil and carbon dioxide CO sub 2 sub . This enzyme belongs to the family of lyase s, specifically the carboxy lyases, which cleave carbon carbon bonds. The systematic name of this enzyme class is uracil 5 carboxylate carboxy lyase uracil forming . Other names in common use include uracil 5 carboxylic acid decarboxylase , and uracil 5 carboxylate carboxy lyase . References reflist 1 cite journal author Palmatier RD, McCroskey RP, Abbott MT date 1970 title The enzymatic conversion of uracil 5 carboxylic acid to uracil and carbon dioxide journal J. Biol. Chem. volume 245 pages 6706&ndash 10 pmid 5482775 issue 24 4.1 enzyme stub Category EC 4.1.1 Category Enzymes of unknown structure ... more details
A phosphoribosyltransferase is a type of transferase enzyme. Types include Adenine phosphoribosyltransferase Hypoxanthine guanine phosphoribosyltransferase Orotidine 5 phosphate decarboxylase Uracil phosphoribosyltransferase Glycosyltransferases Category Transferases enzyme stub ... more details
Orphan date December 2009 Saflufenacil is a relatively new herbicide of the uracil and amide class used to control annual broadleaf weeds in soybeans and maize corn . Little is known about it. External links http www.pesticideinfo.org Detail Chemical.jsp?Rec Id PC41751 http www.alanwood.net pesticides saflufenacil.html Agri stub Category Herbicides ... more details
unreferenced date November 2010 protein name dihydropyrimidine dehydrogenase caption image width HGNCid 3012 Symbol DPYD AltSymbols EntrezGene 1806 OMIM 274270 RefSeq NM 000110 UniProt PDB ECnumber 1.3.1.2 Chromosome 1 Arm p Band 22 LocusSupplementaryData Dihydropyrimidine dehydrogenase DPD is an enzyme that is involved in pyrimidine degradation. It is the initial and rate limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine . It is also involved in the degradation of the chemotherapeutic drugs 5 fluorouracil and Tegafur uracil . See also Dihydropyrimidine dehydrogenase deficiency External links enzyme stub Nucleotide metabolism de Dihydropyrimidin Dehydrogenase ... more details
Context date October 2009 The fifth type of hyper IgM syndrome has been characterized in three patients from France and Japan. The symptoms are similar to hyper IgM syndrome type 2, but the AICDA gene is intact. These three patients instead had mutations in the catalytic domain of uracil DNA glycosylase , an enzyme that removes uracil from DNA. In both type 2 and type 5 hyper IgM syndromes, the patients are profoundly deficient in IgG and IgA because the B cells can t carry out the recombination steps necessary to class switch. OMIM 608106 Immune disorders Category Immunology immunology stub ... more details
Auxotrophy is the inability of an organism to synthesize a particular organic compound required for its growth as defined by IUPAC . An auxotroph is an organism that displays this characteristic auxotrophic is the corresponding adjective. Auxotrophy is the opposite of prototrophy, which is characterized by the ability to synthesize all the compounds that the parent organism could. In genetics , a strain biology strain is said to be auxotrophic if it carries a mutation that renders it unable to synthesize an essential compound. For example a yeast mutant in which a gene of the uracil synthesis pathway for example the gene encoding yeast Orotidine 5 phosphate decarboxylase is inactivated is a uracil auxotroph. Such a strain is unable to synthesize uracil and will only be able to grow if uracil can be taken up from the environment. This is the opposite of a uracil prototroph, or in this case a wild type strain, which can still grow in the absence of uracil. Auxotrophic genetic markers are often used in molecular genetics they were famously used in George Wells Beadle Beadle and Edward Lawrie Tatum Tatum s Nobel prize winning work on the one gene one enzyme hypothesis . Researchers have used strains of E. coli auxotrophic for specific amino acids to introduce non natural amino acid analogues into proteins . For instance cells auxotrophic for the amino acid phenylalanine can be grown in media supplemented with an analogue such as para azido phenylalanine. It is important to remember that many living things, including humans, are auxotrophic for large classes of compounds required for growth and must obtain these compounds through diet see vitamin , essential amino acid , essential fatty acid . See also Autotroph Bradytroph External links http www.nature.com emboj journal v28 n21 fig tab emboj2009272a F1.html Regulation of endosomal clathrin and retromer mediated endosome to Golgi retrograde transport by the J domain protein RME 8 The EMBO Journal http www.springerlink.co ... more details
enzyme Name uracilylalanine synthase EC number 2.5.1.53 CAS number 113573 73 2 IUBMB EC number 2 5 1 53 GO code 0050471 image width caption In enzymology , an uracilylalanine synthase EC number 2.5.1.53 is an enzyme that catalysis catalyzes the chemical reaction O sub 3 sub acetyl L serine uracil math rightleftharpoons math 3 uracil 1 yl L alanine acetate Thus, the two substrate biochemistry substrates of this enzyme are O3 acetyl L serine and uracil , whereas its two product chemistry products are 3 uracil 1 yl L alanine and acetate . This enzyme belongs to the family of transferase s, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O3 acetyl L serine uracil 1 2 amino 2 carboxyethyl transferase . Other names in common use include O3 acetyl L serine acetate lyase adding uracil , isowillardiine synthase , willardiine synthase , and 3 O acetyl L serine uracil 1 2 amino 2 carboxyethyl transferase . References reflist 1 cite journal author Ahmmad MAS, Maskall CS and Brown EG date 1984 title Partial purification and properties of willardiine and synthase activity from Pisum sativum journal Phytochemistry journal Phytochemistry volume 23 pages 265&ndash 270 doi 10.1016 S0031 9422 00 80315 5 cite journal author Ikegami F, Kaneko M, Lambein F, Kuo, Y H and Murakoshi I date 1987 title Difference between uracilylalanine synthases and cysteine synthases in Pisum sativum journal Phytochemistry journal Phytochemistry volume 26 pages 2699&ndash 2704 doi 10.1016 S0031 9422 00 83575 X cite journal author Kuo, Y H and Lambein F date 1978 title Biosynthesis of the uracilylalanines willardiine and isowillardiine in higher plants journal Phytochemistry journal Phytochemistry volume 17 pages 1571&ndash 1576 doi 10.1016 S0031 9422 00 94645 4 Category EC 2.5.1 Category Enzymes of unknown structure transferase stub ... more details
UDG may refer to Universities University of Girona , a university located in the city of Girona , Spain . University of Granma , a university located in Bayamo , Cuba . University of Guadalajara , a university located in the city of Guadalajara, Jalisco Guadalajara , Mexico University of Donja Gorica , a university located in the city of Podgorica , Montenegro Others UDG band , Czech Republic Czech pop rock band from town st nad Labem . UTMC Development Group , a UK local authority led UTMC management group Unit disk graph from geometric graph theory User defined graphic on early home computer s, a small graphic created by the user and added to the character set . Uracil DNA glycosylase , an enzyme which excises uracil s from DNA disambig ... more details
UFT may stand for Unified field theory , a theory in physics United Faculty of Theology in Melbourne, Victoria United Federation of Teachers , a New York union Universidade Federal do Tocantins , a Brazilian university Tegafur Uracil , a chemotherapy drug used in the treatment of cancer Ultimate Family Tree Genealogy.com s discontinued genealogy program http freepages.genealogy.rootsweb.ancestry.com cwolfram uft.html http archiver.rootsweb.ancestry.com th index UFT disambig ... more details
DISPLAYTITLE C sub 4 sub H sub 6 sub N sub 2 sub O sub 2 sub The molecular formula C sub 4 sub H sub 6 sub N sub 2 sub O sub 2 sub molar mass 114.10 g mol may refer to Dihydrouracil , an intermediate in the catabolism of uracil Ethyl diazoacetate Muscimol , the major psychoactive alkaloid present in many mushrooms of the Amanita genus MolFormDisambig fr C4H6N2O2 ... more details
Image Rho independent terminator sequence and secondary structure conservation.jpg thumb right 200px A predicted conserved secondary structure and sequence conservation annotation for 90 bacterial Rho independent termination elements. Intrinsic termination also called Rho independent termination is a mechanism in both eukaryotes and prokaryotes that causes mRNA transcription genetics transcription to be stopped. In this mechanism, the mRNA contains a sequence that can base pair with itself to form a stem loop structure 7 20 base pairs in length that is also rich in cytosine guanine base pairs. These bases form three hydrogen bonds between each other and are therefore particularly strong. ref name Lew07 cite book last Lewin first Benjamin title Genes IX year 2007 publisher Jones and Bartlett Publishers location Sudbury, MA isbn 0 7637 4063 2 ref Following the stem loop structure is a chain of uracil residues. The bonds between uracil and adenine are very weak. A protein bound to RNA polymerase nusA binds to the stem loop structure tightly enough to cause the polymerase to temporarily stall. ref cite journal author Wilson KS, von Hippel PH title Transcription termination at intrinsic terminators the role of the RNA hairpin journal Proc. Natl. Acad. Sci. U.S.A. volume 92 issue 19 pages 8793 7 year 1995 month September pmid 7568019 pmc 41053 doi url http www.pnas.org cgi pmidlookup?view long&pmid 7568019 accessdate 2010 09 20 ref This pausing of the polymerase coincides with transcription of the poly uracil sequence. The weak Adenine Uracil bonds destabilize the RNA DNA duplex, causing it to unwind and dissociate from the RNA polymerase. ref name Lew07 Stem loop structures that are not followed by a poly Uracil sequence cause the RNA polymerase to pause, but it will typically continue transcription after a brief time because the duplex is too stable to unwind far enough to cause termination. Rho independent transcription termination is a frequent mechanism underlying th ... more details
Unreferenced date November 2006 Image Aminoallyl Uridine.gif right frame The structure of aminoallyluridine Aminoallyl nucleotides are used in post labeling of nucleic acid s to be used in microarray s. These nucleotides are formally known as 5 3 amino allyl nucleotides since the aminoallyl group is usually attached to carbon 5 of the pyrimidine ring of uracil and cytosine . They are usually abbreviated as aa , such as aa dUTP. The amine group in the aminoallyl moiety is aliphatic and thus more reactive compared to the amine groups that are directly attached to the rings aromatic of the bases. Uses The aminoallyl group in aminoallyl modified nucleotides is reactive with dyes such as the cyanine series, AnaSpec HiLyte Fluor , or Alexa Fluor dyes that also been modified to be amine reactive. A problem with this method is that the dyes react with the buffering agent usually used for storage of nucleotides. Instead a carbonate buffer is used. The DNA or RNA from a sample is copied in vitro by T7 polymerase, RT polymerase or some other polymerase except of eukaryotic origin in a mix of nucleotides in which one, typically uracil RNA and also DNA , is a mix aminoallyl NTP and normal UTP. An alternative method is using thiol reactive dyes. DEFAULTSORT Aminoallyl Nucleotide Category Nucleic acids Category Nucleotides molecular cell biology stub ... more details
Unreferenced stub auto yes date December 2009 A ribonucleotide is a nucleotide in which a purine or pyrimidine base is linked to a ribose molecule . The base may be adenine A , guanine G , cytosine C , or uracil U . Note that thymine T , which is found in deoxyribonucleotides, is not found as a ribonucleotide in living beings. Ribonucleotides have one, two, or three phosphate groups attached to the ribose sugar. Ribonucleotides include adenosine triphosphate ATP , which is the major source of energy for cell work. Nucleobases, nucleosides, and nucleotides Category RNA Category Ribosides Biochem stub de Ribonukleotide es Ribonucle tido fr Ribonucl otide it Ribonucleotide nl Ribonucleotide oc Ribonucleotid pl Rybonukleotydy ru sr Ribonukleotid ... more details
ACGT stands for the four nucleic acid bases that make up DNA . The A stands for Adenine and pairs with the T, which stands for Thymine . The C stands for Cytosine and pairs with the G, Guanine . These four nucleic acids make up a creature s genetic code, or DNA. ref name intro cite web title Introduction to Genes and DNA publisher Health Grades url http www.wrongdiagnosis.com genetics dna.htm year 2004 accessdate 2010 03 03 ref ACGU stands for the four amino acids that make up RNA . RNA pairs up the same as DNA, except that Thymine is replaced with Uracil . ref name intro References reflist genetics stub Category Acids ... more details
enzyme Name uridine phosphorylase EC number 2.4.2.3 CAS number 9030 22 2 IUBMB EC number 2 4 2 3 GO code 0004850 image width caption In enzymology , an uridine phosphorylase EC number 2.4.2.3 is an enzyme that catalysis catalyzes the chemical reaction uridine phosphate math rightleftharpoons math uracil alpha D ribose 1 phosphate Thus, the two substrate biochemistry substrates of this enzyme are uridine and phosphate , whereas its two product chemistry products are uracil and alpha D ribose 1 phosphate . This enzyme belongs to the family of glycosyltransferase s, specifically the pentosyltransferases. The systematic name of this enzyme class is uridine phosphate alpha D ribosyltransferase . Other names in common use include pyrimidine phosphorylase , UrdPase , UPH , and UPase . This enzyme participates in pyrimidine metabolism . Structural studies As of late 2007, 27 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1K3F , PDB link 1LX7 , PDB link 1RXC , PDB link 1RXS , PDB link 1RXU , PDB link 1RXY , PDB link 1RYZ , PDB link 1SJ9 , PDB link 1SQ6 , PDB link 1T0U , PDB link 1TGV , PDB link 1TGY , PDB link 1U1C , PDB link 1U1D , PDB link 1U1E , PDB link 1U1F , PDB link 1U1G , PDB link 1Y1Q , PDB link 1Y1R , PDB link 1Y1S , PDB link 1Y1T , PDB link 1ZL2 , PDB link 2HN9 , PDB link 2HRD , PDB link 2HSW , PDB link 2HWU , and PDB link 2I8A . References reflist 1 cite journal author CANELLAKIS ES date 1957 title Pyrimidine metabolism. II. Enzymatic pathways of uracil anabolism journal J. Biol. Chem. volume 227 pages 329&ndash 38 pmid 13449076 issue 1 cite journal author PAEGE LM, SCHLENK F date 1952 title Bacterial uracil riboside phosphorylase journal Arch. Biochem. Biophys. volume 40 pages 42&ndash 9 pmid 12997187 doi 10.1016 0003 9861 52 90071 4 issue 1 cite journal author Pontis H, Degerstedt G and Reichard P date 1961 title Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor jour ... more details
chembox verifiedrevid 384093002 ImageFile Dihydrouracil.svg ImageSize 120px IUPACName hexahydropyrimidine 2,4 dione OtherNames Section1 Chembox Identifiers CASNo 504 07 4 PubChem 649 SMILES C1CNC O NC1 O MeSHName Dihydrouracil Section2 Chembox Properties Formula C sub 4 sub H sub 6 sub N sub 2 sub O sub 2 sub MolarMass 114.10264 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Dihydrouracil is an intermediate in the catabolism of uracil . See also Dihydrouracil dehydrogenase NAD Dihydrouracil oxidase Dihydropyrimidinase Nucleotide metabolism intermediates Category Ureas Category Pyrimidinediones organic compound stub de Dihydrouracil ... more details
Unreferenced stub auto yes date December 2009 Drugbox Verifiedfields changed verifiedrevid 385687149 IUPAC name 5 bis 2 chloroethyl amino 1H pyrimidine 2,4 dione image uramustine.svg width 200px CAS number 66 75 1 CASNo Ref cascite ATC prefix none ATC suffix ATC supplemental PubChem 6194 ChEMBL Ref ebicite correct EBI ChEMBL 1488 DrugBank APRD00130 KEGG Ref keggcite changed kegg KEGG D06265 C 8 H 11 Cl 2 N 3 O 2 molecular weight 252.097 Gram g Mole unit mol bioavailability protein bound 5 metabolism elimination half life excretion Kidney Renal pregnancy category legal status routes of administration Uramustine International Nonproprietary Name INN or uracil mustard is a chemotherapy medication drug which belongs to the class of alkylating antineoplastic agent alkylating agent s. It is used in lymph atic malignancies such as non Hodgkin s lymphoma . It works by damaging DNA , primarily in cancer cells that preferentially take up the uracil due to their need to make nucleic acids during their rapid cycles of cell division . The DNA damage leads to apoptosis of the affected cells. Bone marrow suppression and nausea are the main side effects. Chemically it is a derivative of nitrogen mustard and uracil . Chemotherapeutic agents Category Chemotherapeutic agents Category IARC Group 2B carcinogens Category Nitrogen mustards Category Pyrimidinediones Category Organochlorides antineoplastic drug stub ... more details
enzyme Name dihydrouracil dehydrogenase NAD EC number 1.3.1.1 CAS number 9026 89 5 IUBMB EC number 1 3 1 1 GO code 0004159 image width caption In enzymology , a dihydrouracil dehydrogenase NAD EC number 1.3.1.1 is an enzyme that catalysis catalyzes the chemical reaction 5,6 dihydrouracil NAD sup sup math rightleftharpoons math uracil NADH H sup sup Thus, the two substrate biochemistry substrates of this enzyme are 5,6 dihydrouracil and nicotinamide adenine dinucleotide NAD sup sup , whereas its 3 product chemistry products are uracil , nicotinamide adenine dinucleotide NADH , and hydrogen ion H sup sup . This enzyme belongs to the family of oxidoreductase s, specifically those acting on the CH CH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 5,6 dihydrouracil NAD oxidoreductase . Other names in common use include dehydrogenase, dihydrouracil , dihydropyrimidine dehydrogenase , dihydrothymine dehydrogenase , pyrimidine reductase , thymine reductase , uracil reductase , and dihydrouracil dehydrogenase NAD . This enzyme participates in 3 metabolism metabolic pathways pyrimidine metabolism , beta alanine metabolism , and pantothenate and coa biosynthesis . References reflist 1 cite journal author CAMPBELL LL Jr date 1957 title Reductive degradation of pyrimidines. III. Purification and properties of dihydrouracil dehydrogenase journal J. Biol. Chem. volume 227 pages 693&ndash 700 pmid 13462991 issue 2 1.3 enzyme stub Category EC 1.3.1 Category NADH dependent enzymes Category Enzymes of unknown structure it Diidrouracile deidrogenasi NAD ja NAD ... more details
Encyclopedia
top
