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Encyclopedia results for Tyrosine kinase

Tyrosine kinase





Encyclopedia results for Tyrosine kinase

  1. Tyrosine kinase

    dablink Tyrosine kinases are a subclass of protein kinase , see there for the principles of protein phosphorylation Pfam box Symbol Pkinase Tyr Name Protein tyrosine kinase image PDB 1m61 EBI.jpg width caption Tyrosine protein kinase zap 70 Pfam PF07714 InterPro IPR001245 SMART TyrKc Prosite PDOC00629 ... 968 PDB3 1xkk A 712 968 PDB3 1m17 A 712 968 PDB3 1ovc A 737 976 PDB3 1yvj A 822 1095 A tyrosine kinase ... kinase serine threonine specific and tyrosine specific this domain . ref name pmid3291115 cite journal ... G title Association of Lyn tyrosine kinase with the nuclear matrix and cell cycle dependent changes in matrix associated tyrosine kinase activity journal Eur. J. Biochem. volume 236 issue 2 pages 352 ... by endotoxin in the rat a possible role for protein tyrosine kinase journal Br. J. Pharmacol. volume ... url issn ref Tyrosine kinase activity in the nucleus involves cell cycle control and properties of transcription factor s. ref name Radha 1996 In this way, in fact, tyrosine kinase activity is involved ... growth and reproduction may rely in some part on tyrosine kinase. Tyrosine kinase function has ... matrix. Furthermore, tyrosine kinase activity has been determined to be correlated to cellular ... kinase plays a role in this task, too. A protein tyrosine kinase called PTK2 pp125 is likely at hand ... tyrosine kinase associated with focal adhesions journal Proc. Natl. Acad. Sci. U.S.A. volume 89 issue ... aforementioned presence in cellular focal adhesions. The protein tyrosine kinase pp125 is one ... Schaller 1992 may be quite unique, meaning it could be a new member of the protein tyrosine kinase family. This protein tyrosine kinase is up to about 70 unique compared to some other protein tyrosine ... is, in fact, a protein tyrosine kinase. ref name Schaller 1992 Cellular proliferation, as explained in some detail above, may rely in some part on tyrosine kinase. ref name Radha 1996 Tyrosine kinase ... The contribution of the Lyn protein to the total tyrosine kinase activity within the nuclear matrix ...   more details



  1. (tyrosine 3-monooxygenase) kinase

    enzyme Name tyrosine 3 monooxygenase kinase EC number 2.7.11.6 CAS number 103537 12 8 IUBMB EC number 2 7 11 6 GO code 0050369 image width caption In enzymology , a tyrosine 3 monooxygenase kinase EC number 2.7.11.6 is an enzyme that catalysis catalyzes the chemical reaction ATP tyrosine 3 monooxygenase math rightleftharpoons math ADP phospho tyrosine 3 monooxygenase Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and tyrosine 3 monooxygenase , whereas its two product chemistry products are adenosine diphosphate ADP and phospho tyrosine 3 monooxygenase . This enzyme belongs to the family of transferase s, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in protein s protein serine threonine kinase s . The systematic name of this enzyme class is ATP tyrosine 3 monoxygenase phosphotransferase . Other names in common use include pheochromocytoma tyrosine hydroxylase associated kinase , STK4 , and tyrosine 3 monooxygenase kinase phosphorylating . This enzyme participates in mapk signaling pathway and non small cell lung cancer . References reflist 1 cite journal author Pigeon D, Drissi Daoudi R, Gros F, Thibault J date 1986 title Copurification of tyrosine hydroxylase from rat pheochromocytoma by protein kinase journal C. R. Acad. Sci. III. volume 302 pages 435&ndash 8 pmid 2872947 issue 12 cite journal author Pigeon D, Ferrara P, Gros F, Thibault J date 1987 title Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase journal J. Biol. Chem. volume 262 pages 6155&ndash 8 pmid 2883182 issue 13 Category EC 2.7.11 Category Enzymes of unknown structure enzyme stub ...   more details



  1. Tyrosine-kinase inhibitor

    A tyrosine kinase inhibitor TKI is a pharmaceutical drug that inhibits tyrosine kinase s, enzyme s responsible for the activation of signal transduction cascades through phosphorylation of various proteins . TKIs are typically used as anti cancer drugs. They are also called tyrphostins , the short name for tyrosine phosphorylation Enzyme inhibitor inhibitor , originally coined in a 1988 publication, ref cite journal author Yaish P, Gazit A, Gilon C, Levitzki A. title Blocking of EGF dependent cell proliferation by EGF receptor kinase inhibitors. year 1988 journal Science volume 242 issue 4880 pages ... Y, Levitzki A. title Tyrphostin induced inhibition of p210bcr abl tyrosine kinase activity induces ... J, Lydon NB. title Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr ... by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis ... and other tyrosine kinase inhibitors. year 2006 journal Annu Rev Biochem volume 75 pages 93 109 pmid .... See also Bcr Abl tyrosine kinase inhibitor Protein kinase inhibitor References reflist Extracellular chemotherapeutic agents Category Tyrosine kinase inhibitors de Tyrosinkinase Inhibitor es Inhibidor ... of a systematic search and discovery of small molecular weight inhibitors of tyrosine phosphorylation, which do not inhibit protein kinase s that phosphorylate serine or threonine residues and can discriminate between the kinase domains of the EGFR and that of the insulin receptor . It was further shown that in spite of the conservation of the tyrosine kinase domains one can design and synthesize tyrphostins that discriminate between even closely related protein tyrosine kinases such as EGFR ... tyrphostins as potent inhibitors of EGF receptor and ErbB2 neu tyrosine kinases. year ... pmid 8098709 ref Development of drugs Numerous tyrphostins TKIs aiming at various tyrosine kinases ... to the development of protein kinase inhibitors, especially tyrphostins TKIs. Mechanisms Tyrphostins ...   more details



  1. Non-receptor tyrosine kinase

    enzyme Name non membrane spanning protein tyrosine kinase EC number 2.7.10.2 CAS number IUBMB EC number 2 7 10 2 GO code 0004715 image width caption Non receptor tyrosine kinases or non specific protein tyrosine kinases are enzyme s that can transfer a phosphate group from Adenosine triphosphate ATP to a tyrosine residue in a protein . Non receptor tyrosine kinases are a subgroup of the larger class of tyrosine kinase s. Phosphorylation of proteins by kinases is an important mechanism in signal transduction for regulation of enzyme activity. Structural studies As of late 2007, 37 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2DM0 , PDB link 2DQ7 , PDB link 2E2B , PDB link 2E6I , PDB link 2EKX , PDB link 2GQG , PDB link 2H8H , PDB link 2HDA , PDB link 2HIW , PDB link 2HK5 , PDB link 2HWO , PDB link 2HWP , PDB link 2HYY , PDB link 2HZ0 , PDB link 2HZ4 , PDB link 2HZI , PDB link 2HZN , PDB link 2IJM , PDB link 2IN6 , PDB link 2IO6 , PDB link 2J0J , PDB link 2J0K , PDB link 2J0L , PDB link 2J0M , PDB link 2O88 , PDB link 2OF2 , PDB link 2OF4 , PDB link 2OFU , PDB link 2OFV , PDB link 2OG8 , PDB link 2OI3 , PDB link 2OIQ , PDB link 2OQ1 , PDB link 2OZO , PDB link 2QOH , PDB link 2V7A , and PDB link 2Z60 . References reflist 1 cite journal author Robinson DR, Wu YM, Lin SF date 2000 title The protein tyrosine kinase family of the human genome journal Oncogene. volume 19 pages 5548&ndash 57 pmid 11114734 doi 10.1038 sj.onc.1203957 issue 49 cite journal author Roskoski R Jr date 2004 title Src protein tyrosine kinase structure and regulation journal Biochem. Biophys. Res. Commun. volume 324 pages 1155&ndash 64 pmid 15504335 doi 10.1016 j.bbrc.2004.09.171 issue 4 enzyme stub Tyrosine kinases Intracellular signaling peptides and proteins Category EC 2.7.10 Category Enzymes of known structure ...   more details



  1. Receptor tyrosine kinase

    enzyme Name receptor protein tyrosine kinase EC number 2.7.10.1 CAS number IUBMB EC number 2 7 10 1 GO ... s, and hormone s. Of the 90 unique tyrosine kinase gene s identified in the human genome , 58 encode receptor tyrosine kinase proteins. ref name robinson1 cite journal author Robinson DR, Wu YM, Lin SF. title The protein tyrosine kinase family of the human genome journal Oncogene year 2000 volume ... Zwick, E. Bange, J. Ullrich, A. title Receptor tyrosine kinase signalling as a target for cancer ... 11566607 doi 10.1677 erc.0.0080161 ref Receptor tyrosine kinase classes Approximately 20 different ... class IX AXL receptor tyrosine kinase AXL receptor family RTK class X Leukocyte receptor tyrosine kinase ... XII Receptor tyrosine kinase like orphan receptor ROR receptor family RTK class XIII DDR1 DDR receptor ... RTK class XVI related to receptor tyrosine kinase RYK receptor family RTK class XVII MuSK protein ... growth factor or hormone . ref name Receptor tyrosine kinase signalling as a target for cancer intervention strategies cite journal author editorial title Receptor tyrosine kinase signalling ... autophosphorylation and tyrosine phosphorylation of RTK substrates. ref name Receptor tyrosine kinase ... tyrosine kinase signalling as a target for cancer intervention strategies journal Endocrine Related ... groups from targets, is known as a phosphatase . Kinase enzymes that specifically phosphorylate tyrosine ... 1 4 it lacks a cytoplasmic tyrosine kinase domain and one isoform, FGFR5 , only contains the extracellular ... autophosphorylation of specific tyrosine residues within the tyrosine kinase domain of each RET molecule .... ref name arighi cite journal author Arighi E, Borrello MG, Sariola H. title RET tyrosine kinase signaling ... Ephrin and Eph receptors are the largest subfamily of RTKs. See also Tyrosine kinase Insulin receptor Enzyme linked receptor Tyrphostins Bcr Abl tyrosine kinase inhibitors References reflist 2 External links MeshName Tyrosine Kinase Receptors EC number 2.7.10.1 Enzyme linked receptors Tyrosine ...   more details



  1. Leukocyte receptor tyrosine kinase

    PBB geneid 4058 Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene . ref name pmid2320375 cite journal author Maru Y, Hirai H, Takaku F title Human ltk gene structure ... leukocyte tyrosine kinase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... H year 1994 month Oct. title Human ltk receptor tyrosine kinase binds to PLC gamma 1, PI3 K, GAP ... The phosphatidylinositol 3 kinase pathway is required for the survival signal of leukocyte tyrosine kinase journal Oncogene volume 14 issue 25 pages 3067 72 publisher location ENGLAND issn 0950 9232 ... protein tyrosine kinase. journal Embo J. volume 10 issue 10 pages 2911 9 year 1991 pmid 1655406 doi ... of new human tyrosine kinase genes. journal Oncogene volume 5 issue 3 pages 277 82 year 1990 pmid 2156206 ... H, Kozutsumi H, Maru Y, et al. title Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble ... H, Hagiwara K, et al. title Human ltk receptor tyrosine kinase binds to PLC gamma 1, PI3 K ... motifs within leukocyte tyrosine kinase, an insulin receptor related tyrosine kinase. journal J. Biol ... journal author Snijders AJ, Ho SC, Haase VH, et al. title A lymphocyte specific Ltk tyrosine kinase ... author Ueno H, Honda H, Nakamoto T, et al. title The phosphatidylinositol 3 kinase pathway is required for the survival signal of leukocyte tyrosine kinase. journal Oncogene volume 14 issue 25 pages ... by this gene is a member of the ros insulin receptor family of tyrosine kinases whose ligand is unknown. Tyrosine specific phosphorylation of proteins is a key to the control of diverse pathways ... a putative transmembrane protein kinase devoid of an extracellular domain. journal Nature volume ... Reggiani M, Van Huijsduijnen RH title The SPOT technique as a tool for studying protein tyrosine phosphatase ... 10.1093 hmg ddh020 refend Tyrosine kinases The PBB Controls template provides controls for Protein ...   more details



  1. Megakaryocyte-associated tyrosine kinase

    PBB geneid 4145 Megakaryocyte associated tyrosine protein kinase is an enzyme that in humans is encoded ... of a novel tyrosine kinase from megakaryocytes journal J Biol Chem volume 269 issue 2 pages 1068 74 ... tyrosine kinase MATK gene and its translated product journal J Biol Chem volume ... entrez cite web title Entrez Gene MATK megakaryocyte associated tyrosine kinase url http www.ncbi.nlm.nih.gov ... to Csk tyrosine kinase and has the structural features of the CSK subfamily SRC homology SH2 .... ref name entrez Interactions Megakaryocyte associated tyrosine kinase has been shown to Protein ... The MATK tyrosine kinase interacts in a specific and SH2 dependent manner with c Kit journal J ... M, Nada S, Yamanashi Y, et al. title CSK a protein tyrosine kinase involved in regulation of src ... The MATK tyrosine kinase interacts in a specific and SH2 dependent manner with c Kit. journal J ... tyrosine kinase gene, HYL. journal Oncogene volume 9 issue 11 pages 3371 4 year 1994 pmid 7936664 ... J, et al. title Molecular cloning of a novel non receptor tyrosine kinase, HYL hematopoietic consensus tyrosine lacking kinase . journal Oncogene volume 9 issue 4 pages 1155 61 year 1994 pmid ... A, Hamaguchi I, Suda T, Yamaguchi N title Translocation of the Csk homologous kinase Chk Hyl controls activity of CD36 anchored Lyn tyrosine kinase in thrombin stimulated platelets. journal EMBO J ... kinase CHK with the diphosphorylated site Tyr568 570 of the activated c KIT in megakaryocytes ... kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells journal ... terminal src kinase csk related gene, expressed in leukocytes. journal Oncogene volume 9 issue 7 pages ... kinase CHK formerly MATK with HER 2 ErbB 2 in breast cancer cells. journal J. Biol. Chem. volume ... Price DJ, Rivnay B, Fu Y, et al. title Direct association of Csk homologous kinase CHK with the diphosphorylated ... represent the same Csk homologous kinase Chk and are regulated by stem cell factor in the megakaryoblastic ...   more details



  1. AXL receptor tyrosine kinase

    PBB geneid 558 Tyrosine protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL ... primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase journal Mol Cell Biol ... cite web title Entrez Gene AXL AXL receptor tyrosine kinase url http www.ncbi.nlm.nih.gov sites ... title summary text The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique ... entrez cite web title Entrez Gene AXL AXL receptor tyrosine kinase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 558 accessdate ref Interactions AXL receptor tyrosine kinase has been shown to Protein protein interaction interact with TENC1 . ref name pmid12470648 ... Bj rn year 2002 month Dec. title Interaction of Axl receptor tyrosine kinase with C1 TEN, a novel ... author Janssen JW, Schulz AS, Steenvoorden AC, et al. title A novel putative tyrosine kinase receptor ... A, Fiebeler A, Graham DK, et al. title Expression of axl, a transforming receptor tyrosine kinase ... tyrosine kinase, Axl, is post translationally regulated by proteolytic cleavage. journal J. Biol ... author Lee ST, Strunk KM, Spritz RA title A survey of protein tyrosine kinase mRNAs expressed in normal ... Intracellular signaling of the Ufo Axl receptor tyrosine kinase is mediated mainly by a multi substrate ... of receptor type protein tyrosine kinase genes in the human thyroid. journal Endocrinology volume ... Hafizi S, Alindri F, Karlsson R, Dahlb ck B title Interaction of Axl receptor tyrosine kinase ... tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl. journal ... Neubauer A, Burchert A, Maiwald C, et al. title Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias. journal Leuk. Lymphoma volume 25 issue ... doi cite journal author Partanen J, M kel TP, Alitalo R, et al. title Putative tyrosine kinases ...   more details



  1. Related to receptor tyrosine kinase

    PBB geneid 6259 The related to receptor tyrosine kinase RYK gene encodes the protein Ryk. The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number ... Gene RYK RYK receptor like tyrosine kinase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... tyrosine kinase related molecule with unusual kinase domain motifs journal Proc. Natl. Acad ... tyrosine kinase family members, RYK is composed of three domains, an N terminal domain, an extracellular ... domain. However, in contrast to other receptor tyrosine kinase s the C terminal domain of RYK is devoid of detectable kinase activity. ref name halford References References Further reading ... genes encoding the protein tyrosine kinase receptor related protein RYK. journal Mamm. Genome volume ... KM, Spritz RA title A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes ... segments and a tyrosine kinase catalytic domain. journal Oncogene volume 8 issue 7 pages 2009 2014 ... al. title Putative tyrosine kinases expressed in K 562 human leukemia cells. journal Proc. Natl. Acad ... homologue of a receptor related to tyrosine kinases RYK . journal Oncogene volume 8 issue ... receptor kinase isolation and analysis of expression in ovarian cancer. journal Mol. Med. volume ... RB, Ganesan TS title Functional analysis of H Ryk, an atypical member of the receptor tyrosine kinase family. journal Mol. Cell. Biol. volume 19 issue 9 pages 6427 6440 year 1999 pmid 10454588 doi pmc 84612 cite journal author Trivier E, Ganesan TS title RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF 6. journal J. Biol. Chem ... year 2007 pmid 17672918 doi 10.1186 gb 2007 8 8 r154 pmc 2374985 refend Tyrosine kinases The PBB ...   more details



  1. Tyrosine-protein kinase BLK

    PBB geneid 640 Tyrosine protein kinase BLK also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene . ref name pmid7845672 cite journal author Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE title Molecular cloning and chromosomal localization of the human homologue of a B lymphocyte specific protein tyrosine kinase blk journal Oncogene volume 10 issue 3 pages 477 86 year 1995 month Mar pmid 7845672 pmc doi ref ref name entrez cite web title Entrez Gene BLK B lymphoid tyrosine kinase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 640 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions The tyrosine protein kinase BLK has been shown to Protein protein interaction interact with UBE3A ... of the Src family tyrosine kinase Blk through E6AP mediated ubiquitination journal PNAS Proc ... author Dymecki SM, Niederhuber JE, Desiderio SV title Specific expression of a tyrosine kinase gene ... tyrosine kinase related to murine Blk. journal J. Immunol. volume 154 issue 3 pages 1265 72 year 1995 ... author Oda H, Kumar S, Howley PM title Regulation of the Src family tyrosine kinase Blk through ... product of the c cbl protooncogene is the 120 kDa tyrosine phosphorylated protein in Jurkat cells ... of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C gamma 2, microtubule associated protein kinase, GTPase activating protein, and phosphatidylinositol 3 kinase. journal Mol. Cell. Biol. volume 13 issue 9 pages ... P, et al. title In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor ... of Src family tyrosine kinases regulates functional interaction with a B cell substrate. journal ... issue 19 pages 19512 22 year 2004 pmid 14970218 doi 10.1074 jbc.M309074200 refend gene 8 stub Tyrosine ...   more details



  1. C-src tyrosine kinase

    PBB geneid 1445 C src tyrosine kinase , also known as CSK , is a human protein and gene . It includes an SH2 domain , an SH3 domain , and a tyrosine kinase domain. This protein specifically phosphorylate s Tyr 504 residue on human Lck leukocyte specific protein tyrosine kinase , which acts as a negative regulatory site . It may also act on the LYN and FYN kinases. The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions C src tyrosine kinase has been shown to Protein protein interaction interact with YTHDC1 , ref name pmid15175272 cite journal last Rafalska first Ilona authorlink coauthors Zhang Zhaiyi, Benderska Natalya, Wolff Horst, Hartmann Annette M, Brack Werner Ruth, Stamm Stefan date August 2004 title The intranuclear localization and function of YT521 B is regulated by tyrosine phosphorylation journal Hum. Mol. Genet. volume 13 issue 15 pages 1535 49 publisher location England issn 0964 6906 pmid 15175272 doi 10.1093 hmg ddh167 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref DAB2 , ref name pmid12473651 cite journal last Zhou first ... expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved ... citations yes DEFAULTSORT C Src Tyrosine Kinase Category EC 2.7.10 Category Tyrosine kinases gene ... coauthors Lee H, Bedford M T, Petrucci T, Sudol M, Lisanti M P date December 2001 title Tyrosine ... February 1999 title C terminal Src kinase associates with ligand stimulated insulin like growth factor ... M date April 2000 title Transmembrane phosphoprotein Cbp regulates the activities of Src family tyrosine ... laysummary laysource laydate quote doi 10.1084 jem.191.9.1591 pmc 2213442 ref See also Src gene Tyrosine kinase Further reading refbegin 2 PBB Further reading citations cite journal author Mustelin ... pmc 1223257 References Reflist refend PDB Gallery geneid 1445 Tyrosine kinases The PBB Controls ...   more details



  1. Bruton's tyrosine kinase

    PBB geneid 695 Bruton s tyrosine kinase or Btk is a type of kinase enzyme implicated in the primary immunodeficiency disease X linked agammaglobulinemia Bruton s agammaglobulinemia . Its exact mechanism of action remains unknown, but it plays a crucial role in B cell maturation as well as mast cell activation .... Bruton s tyrosine kinase was discovered in 1993 and is named for Dr. Ogden Bruton , who first described XLA in 1952. ref name IDF Interactions Bruton s tyrosine kinase has been shown to Protein ... of the binding site for Gqalpha on its effector Bruton s tyrosine kinase journal PNAS Proc. Natl. Acad ... L, Link G, Kawakami T, Pfizenmaier K year 1999 month Nov. title Bruton s tyrosine kinase Btk associates with protein kinase C mu journal FEBS Lett. volume 461 issue 1 2 pages 68 72 publisher location ... domain binding protein of Bruton s tyrosine kinase as BLNK functional significance of Btk SH2 domain ... with Bruton s tyrosine kinase BtK journal Biochem. Biophys. Res. Commun. volume 245 issue 2 pages ... s tyrosine kinase activity is negatively regulated by Sab, the Btk SH3 domain binding protein ... s tyrosine kinase and Bmx journal J. Biol. Chem. volume 277 issue 11 pages 9351 7 publisher location ..., Roy Ananda L year 2004 month Feb. title Mechanism of Bruton s tyrosine kinase mediated recruitment ... I by Bruton s tyrosine kinase journal Mol. Cell. Biol. volume 19 issue 7 pages 5014 24 publisher ... for Bruton s tyrosine kinase in response to B cell receptor engagement journal PNAS Proc. Natl ... 1bwn MeshName Bruton s tyrosine kinase Further reading refbegin 2 PBB Further reading citations cite ... 00008 cite journal author Uckun FM title Bruton s tyrosine kinase BTK as a dual function regulator ... box yes update summary no update citations yes DEFAULTSORT Bruton s Tyrosine Kinase Category Peripheral ... laysource laydate quote ref Protein kinase D1 , ref name pmid10561498 cite journal doi 10.1016 ... Tyrosine kinases The PBB Controls template provides controls for Protein Box Bot, please see Template ...   more details



  1. TEK tyrosine kinase

    section title summary text The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial ... related to the TIE receptor tyrosine kinase. ref cite web title Entrez Gene TEK TEK tyrosine kinase ... entrez?Db gene&Cmd ShowDetailView&TermToSearch 7010 accessdate ref Interactions TEK tyrosine kinase ... receptor tyrosine kinase. journal Oncogene volume 11 issue 10 pages 2097 103 year 1995 pmid 7478529 ... AM title Assignment of the endothelial specific protein receptor tyrosine kinase gene TEK to human ... cloning and characterization of a novel receptor protein tyrosine kinase from human placenta. journal ... mutation in the receptor tyrosine kinase TIE2. journal Cell volume 87 issue 7 pages 1181 90 year ... specific receptor tyrosine kinase Tie2. journal J. Biol. Chem. volume 273 issue 29 pages 18514 ... tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. journal ... yes DEFAULTSORT Tek Tyrosine Kinase Category Clusters of differentiation membrane protein stub fr TIE ..., Nishio H, Yancopoulos G D, Suda T date August 1998 title Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells journal Int. Immunol ... and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against ... endothelial protein tyrosine phosphatase with the angiopoietin receptor Tie 2. journal Oncogene ... geneid 7010 NLM content Tyrosine kinases Clusters of differentiation The PBB Controls template provides ...   more details



  1. Tyrosine kinase 2

    PBB geneid 7297 Non receptor tyrosine protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 ... Favera R title Identification and chromosomal mapping of new human tyrosine kinase genes journal Oncogene ... web title Entrez Gene TYK2 tyrosine kinase 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... tyrosine kinase genes journal Oncogene volume 5 issue 3 pages 277 82 year 1990 month March pmid 2156206 doi url issn ref Tyk2 was the first member of the Janus kinase JAK family that was described the other members are Janus kinase 1 JAK1 , Janus kinase 2 JAK2 , and Janus kinase 3 JAK3 . ref name ... and Interleukin 12 IL 12 signaling. Function This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinase s JAKs protein families. This protein associates with the cytoplasmic ... and tyrosine kinase 2 TYK2 . ref name pmid9759489 cite journal author Stark GR, Kerr IM, Williams ... GR, Pellegrini S title A protein tyrosine kinase in the interferon alpha beta signaling pathway ... with tyrosine kinases Jaks 1 2, and Tyk2 kinase . ref name pmid12171785 cite journal author Brasier ... SM, Esposito C, Hoit B, Dulak J, Wolfman A, Stuehr D, Larner AC title Tyk2 tyrosine kinase expression ... T, Nonoyama S, Karasuyama H title Human tyrosine kinase 2 deficiency reveals its requisite ... month December pmid 17989526 doi 10.1097 ACI.0b013e3282f1baea url issn ref Interactions Tyrosine kinase ... T, Platanias L C year 1995 month Aug. title Association of the interferon dependent tyrosine kinase ... of non receptor tyrosine kinase genes. journal Oncogene volume 5 issue 9 pages 1329 36 year 1990 ... subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. journal Mol. Cell. Biol ... 2 tyrosine kinase. journal FEBS Lett. volume 374 issue 3 pages 317 22 year 1995 pmid 7589562 doi 10.1016 ... of the interferon dependent tyrosine kinase Tyk 2 with the hematopoietic cell phosphatase. journal ... Interaction of the c cbl proto oncogene product with the Tyk 2 protein tyrosine kinase. journal Biochem ...   more details



  1. Receptor tyrosine kinase-like orphan receptor

    protein Name ROR1 receptor tyrosine kinase like orphan receptor 1 caption image width HGNCid 10256 Symbol ROR1 AltSymbols NTRKR1 EntrezGene 4919 OMIM 602336 RefSeq NM 005012 UniProt Q01973 PDB ECnumber 2.7.10.1 Chromosome 1 Arm p Band 32 LocusSupplementaryData p31 protein Name ROR2 receptor tyrosine kinase like orphan receptor 2 caption image width HGNCid 10257 Symbol ROR2 AltSymbols NTRKR2, BDB, BDB1 EntrezGene 4920 OMIM 602337 RefSeq NM 004560 UniProt Q01974 PDB ECnumber Chromosome 9 Arm q Band 22 LocusSupplementaryData In the field of molecular biology , receptor tyrosine kinase like orphan receptors RORs are a family of tyrosine kinase receptor s that are important in regulating skeletal and neuronal development, cell migration and Cell migration Cell polarity cell polarity . ROR proteins can can modulate Wnt signaling pathway Wnt signaling by sequestering Wnt signaling pathway Ligands which act on Wnt signaling Wnt ligand s. ref name pmid18848778 cite journal author Green JL, Kuntz SG, Sternberg PW title Ror receptor tyrosine kinases orphans no more journal Trends Cell Biol. volume 18 issue 11 pages 536 44 year 2008 month November pmid 18848778 doi 10.1016 j.tcb.2008.08.006 url issn ref References Reflist protein stub Tyrosine kinases Category EC 2.7.10 ...   more details



  1. Kinase tyrosine-based inhibitory motif

    context date June 2009 The term Kinase tyrosine based inhibitory motif KTIM was coined by a group of researchers from McGill University , Montreal , Canada ref name avix Abu Dayyeh I. et al.,2008. PLoS Negl Trop Dis 2 12 e305. doi 10.1371 journal.pntd.0000305 ref in 2008 to represent any ITIM like Sequence motif motif with the consensus sequence I V L SxYxxL V found in a kinase and that regulates its activity. Introduction One major way in which cells respond to stimuli is through signal transduction pathways whereby a ligand binds to a receptor causing conformational changes that lead to a cascade of events in intracellular signalling molecules that ultimately ends up in the translocation of transcription factors to the nucleus altering the expression of target genes, therefore affecting specific cellular functions. One way activation signals can be counteracted is through the triggering of different receptors bearing immunoreceptor tyrosine based inhibitory motifs ITIMs in their cytoplasmic tails. Several transmembrane receptor s are negatively regulated through recruiting cytosolic SH2 domain containing protein s such as SHP 1 to immunoreceptor tyrosine based inhibitory motif s ITIMs that they possess. Interestingly, ITIM like motifs KTIMs were shown to exist in non receptor proteins and to play a key role in their regulation. Difference between KTIM and ITIM The main difference between ITIM and KTIM is that KTIM was shown to be found in a cytosolic protein IL 1 receptor associated Kinase 1 IRAK 1 and not in a transmembrane protein such as the case with ITIMs. ref name avix KTIM function KTIMs are speculated to play a regulatory role in the negative regulation of many kinases in addition to IRAK 1, and can thus represent a novel regulatory mechanism in a wide range of cellular kinases ref name avix ref Abu Dayyeh I. et al.,2010. Dev. Comp. Immunol.,34 5 481 484, doi 10.1016 j.dci.2009.12.012 ref . The mode of action of KTIMs is similar to ITIMs and involves recruiting ...   more details



  1. Bcr-Abl tyrosine-kinase inhibitor

    Bcr Abl tyrosine kinase inhibitor TKI is the initial choice of treatment for most patients with chronic ... Rowley in 1972 and is due to fusion between Abelson Abl gene Abl tyrosine kinase gene at chromosome ... Bcr Abl and a constitutively active Bcr Abl tyrosine kinase that has been implicated in the pathogenesis of CML. Compounds have been developed that selectively inhibit this tyrosine kinase. Before the U.S. ... Druker2000 First generation Bcr Abl tyrosine kinase inhibitors Imatinib STI571 Imatinib , Gleevec ... Bcr Abl tyrosine kinase inhibitor to be used in the treatment of CML. Development File Imatinib ..., the chemical structure structure of Bcr Abl tyrosine kinase played a limited role because ... amplification . That is, the gene that encodes for the pathogenic Bcr Abl tyrosine kinase is duplicated ... on the tyrosine kinase, resulting in a loss of sensitivity to the drug. These mutations normally ... inhibit the Bcr Abl tyrosine kinase. This led to the discovery of second generation drugs. While drug ... 30 fold more potent than imatinib in inhibiting activity of the Bcr Abl tyrosine kinase and Cell ... of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia . The journal of Clinical Investigation ..., G., Furet, P., Meyer, T. and Zimmermann, J. 2002 . Imatinib a selective tyrosine kinase inhibitor ... Shawver, L. K., Slamon, D. and Ullrich, A. 2002 . Smart drugs Tyrosine kinase inhibitors in cancer ... to tyrosine kinase inhibitors in chronic myeloid leukemia and recent therapeutic strategies ... within the Abl kinase protein domain domain , over expression of Bcr Abl, increased production of transmembrane ... the Bcr Abl fusion gene encodes a constitutively activated kinase. Drug discovery that specifically targeted the ATP binding site of a single kinase was regarded as quite a challenging task since hundreds ... its activity chemistry activity as a kinase inhibitor remained the same. Subsequently, introducing ... binds to the kinase protein domain domain of Abl only when the domain adopts the inactive or closed ...   more details



  1. Tyrosine

    of protein kinase s so called receptor tyrosine kinase s . Phosphorylation of the hydroxyl group changes the activity of the target protein. A tyrosine residue also plays an important role in photosynthesis ...chembox verifiedrevid 418296962 ImageFileL1 Ref chemboximage correct ?? ImageFileL1 L tyrosine skeletal.png ImageSizeL1 120px ImageFileR1 L tyrosine 3D sticks.png ImageSizeR1 120px IUPACName Tyrosine OtherNames ... BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Tyrosine abbreviated ... essential amino acid with a polar side group. The word tyrosine is from the Greek language Greek tyri ... ce6 sci A0849873.html title Tyrosine author authorlink coauthors year 2007 work The Columbia Electronic ... www.etymonline.com index.php?term tyrosine title Tyrosine author Douglas Harper authorlink coauthors ... quote accessdate 2008 04 20 ref Functions Aside from being a proteogenic amino acid, tyrosine has ... Tyrosine, which can be synthesized in the body from phenylalanine , is found in many high protein ... Tyrosine url http www.umm.edu altmed articles tyrosine 000329.htm work University of Maryland Medical Center accessdate 2011 03 17 ref Tyrosine can also be obtained through supplementation. Biosynthesis Image Tyrosine biosynthesis2.png thumb right 400px Plant biosynthesis of tyrosine from shikimic ... transaminated using glutamic acid glutamate as the nitrogen source to give tyrosine and Alpha Ketoglutaric acid ketoglutarate . Mammals synthesize tyrosine from the essential amino acid phenylalanine ... tyrosine. Metabolism Image Tyrosine metabolism.png thumb center 500px Catecholamine hormone s produced from tyrosine metabolism. Phosphorylation and sulfation Some of the tyrosine residues can be tagged with a phosphate group phosphorylation phosphorylated by protein kinase s. In its phosphorylated state, it is referred to as phosphotyrosine . Tyrosine phosphorylation is considered to be one ... through specific antibody antibodies . Tyrosine residues may also be modified by the addition ...   more details



  1. Kinase

    pathway. Kinases are often named after their substrates. References Reflist 2 See also Protein kinase Cyclin dependent kinase Ca2 calmodulin dependent protein kinase Ca sup 2 sup calmodulin dependent protein kinase Signal transduction G protein coupled receptor Kinases Category EC 2.7.1 an Quinasa ca Quinasa cs Kin za de Kinase es Quinasa fa fr Kinase ko io Kinazo id Kinase it Chinasi he nl Kinase ja oc Quinasa pl Kinazy pt Cinase ru sr Kinaza fi Kinaasi sv Kinas uk vi Kinase zh ...   more details



  1. Tyrosine hydroxylase

    PBB geneid 7054 Tyrosine hydroxylase or tyrosine 3 monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L tyrosine to dihydroxyphenylalanine DOPA . ref name pmid8638482 cite journal author Kaufman S title Tyrosine hydroxylase journal Adv. Enzymol. Relat. Areas Mol. Biol ... ref name pmid8822146 cite journal author Nagatsu T title Tyrosine hydroxylase human isoforms, structure ... adrenaline . In humans, tyrosine hydroxylase is encoded by the TH gene . ref name pmid8822146 ... in the production of catecholamines do. Image Tyrosine hydroxylase.PNG thumb left 400px Tyrosine hydroxylase catalyzes tyrosine to dihydroxyphenylalanine br style clear left Clinical significance Tyrosine hydroxylase can be inhibited by the drug methyl para tyrosine Metirosine . This inhibition can ... L Dopa L 3,4 dyhydroxyphenylalanine which is systhesized by tyrosine hydroxylase. This drug is rarely ... . Image Dopamine.png thumb left 150px Dopamine br style clear left Tyrosine hydroxylase ..., Perheentupa J, Gustafsson J, Husebye E, Rorsman F, K mpe O title Identification of tyrosine hydroxylase ... tyrosine hydroxylase inhibitor from microbial origin journal J. Am. Chem. Soc. volume 93 issue ... of tyrosine hydroxylase by aquayamycin journal J. Antibiot. volume 21 issue 5 pages 350 3 year ... reading citations cite journal author Masserano JM, Weiner N title Tyrosine hydroxylase regulation ... of the HUMTH01 microsatellite in the Tyrosine Hydroxylase gene. journal Mol. Neurobiol. volume 26 ... TH, Park DH, Reis DJ title Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP dependent protein kinase mechanism of enzyme activation. journal Proc. Natl. Acad. Sci. U.S.A. volume 75 issue ..., mediate the phosphorylation of tyrosine hydroxylase at serine 31 in situ. journal Proc. Natl. Acad ... 48658 cite journal author Haycock JW title Phosphorylation of tyrosine hydroxylase in situ at serine ... tyrosine hydroxylase gene to 11p15 gene duplication and evolution of metabolic pathways. journal Cytogenet ...   more details



  1. Tyrosine decarboxylase

    Refimprove date April 2010 enzyme Name tyrosine decarboxylase EC number 4.1.1.25 CAS number 9002 09 9 IUBMB EC number 4 1 1 25 GO code 0004837 image width caption In enzymology , a tyrosine decarboxylase EC number 4.1.1.25 is an enzyme that catalysis catalyzes the chemical reaction L tyrosine math rightleftharpoons math tyramine CO sub 2 sub Hence, this enzyme has one substrate biochemistry substrate , L tyrosine , and two product chemistry products , tyramine and carbon dioxide . This enzyme belongs to the family of lyase s, specifically the carboxy lyases, which cleave carbon carbon bonds. The systematic name of this enzyme class is L tyrosine carboxy lyase tyramine forming . Other names in common use include L tyrosine decarboxylase , L tyrosine apodecarboxylase , and L tyrosine carboxy lyase . This enzyme participates in tyrosine metabolism and alkaloid biosynthesis. It employs one cofactor biochemistry cofactor , pyridoxal phosphate . References Reflist 1 cite journal author McGilvery RW and Cohen PP date 1948 title The decarboxylation of L phenylalanine by Streptococcus faecalis R journal J. Biol. Chem. volume 174 pages 813&ndash 816 Category EC 4.1.1 Category Pyridoxal phosphate enzymes Category Enzymes of unknown structure 4.1 enzyme stub ...   more details



  1. Tyrosine sulfation

    Tyrosine sulfation is a posttranslational modification where a sulfate group is added to a tyrosine residue of a protein molecule. Secreted proteins and extracellular parts of membrane proteins that pass through the Golgi apparatus may be sulfated. Sulfation was first discovered by Betteheim in bovine fibrinopeptide B in 1954 and later found be present in animals and plants but not in prokaryotes or in yeast. Function Sulfation plays role in strengthening protein protein interactions. Types of human proteins known to undergo tyrosine sulfation include adhesion molecules, G protein coupled receptors, coagulation factors, serine protease inhibitor s, extracellular matrix proteins, and hormones. Tyrosine O sulfate is a stable molecule and is excreted in urine in animals. No enzymatic mechanism of tyrosine sulfate desulfation is known to exist. By knock out of TPST genes in mice, it may be observed that tyrosine sulfation has effects on the growth of the mice, such as body weight, fecundity, and postnatal viability. Mechanism Sulfation is catalyzed by tyrosylprotein sulfotransferase TPST in Golgi apparatus . The reaction catalyzed by TPST is a transfer of sulfate from the universal sulfate donor 3 Phosphoadenosine 5 phosphosulfate PAPS to the side chain hydroxyl group of a tyrosine residue. Sulfation sites are tyrosine residues exposed on the surface of the protein typically surrounded ... limited evidence that the TPST genes are subject to transcriptional regulation and tyrosine O sulfate is very stable and cannot be easily degraded by mammalian sulfatases. Tyrosine O sulfation is an irreversible process in vivo . Antibody for detection of tyrosine sulfated epitopes In 2006, an article ... KL title The biology and enzymology of protein tyrosine O sulfation journal J. Biol. Chem. volume ... cgi content full 278 27 24243 cite journal author Hoffhines AJ title Detection and purification of tyrosine ... structure DEFAULTSORT Tyrosine Sulfation Category Posttranslational modification ja ...   more details



  1. Tyrosine 2,3-aminomutase

    enzyme Name tyrosine 2,3 aminomutase EC number 5.4.3.6 CAS number 9073 38 5 IUBMB EC number 5 4 3 6 GO code 0050368 image width caption Orphan date April 2009 Refimprove date April 2009 In enzymology , a tyrosine 2,3 aminomutase EC number 5.4.3.6 is an enzyme that catalysis catalyzes the chemical reaction L tyrosine math rightleftharpoons math 3 amino 3 4 hydroxyphenyl propanoate Hence, this enzyme has one substrate biochemistry substrate , L tyrosine , and one product chemistry product , 3 amino 3 4 hydroxyphenyl propanoate . This enzyme belongs to the family of isomerase s, specifically those intramolecular transferase s transferring amino groups. The systematic name of this enzyme class is L tyrosine 2,3 aminomutase . This enzyme is also called tyrosine alpha,beta mutase . This enzyme participates in tyrosine metabolism . It employs one cofactor, 5 methylene 3,5 dihydroimidazol 4 one MIO which is formed autocatalytic rearrangement of the internal tripeptide Ala Ser Gly. Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 2OHY . References reflist 1 cite journal author Kurylo Borowska Z, Abramsky T date 1972 title Biosynthesis of tyrosine journal Biochim. Biophys. Acta. volume 264 pages 1&ndash 10 pmid 5021987 issue 1 Category EC 5.4.3 Category Enzymes of known structure isomerase stub ...   more details



  1. Tyrosine aminotransferase

    protein Name tyrosine aminotransferase caption Crystallographic structure of the TAT enzyme rainbow colored ... name Karlberg PDB 3DYD cite journal author Karlberg T, Moche M, Andersson J, et al. title Human tyrosine ... Tyrosine aminotransferase or tyrosine transaminase is an enzyme present in the liver and catalyzes the conversion of tyrosine to 4 hydroxyphenylpyruvate . ref name pmid1349265 cite journal author Dietrich JB title Tyrosine aminotransferase a transaminase among others? journal Cellular and molecular ..., the tyrosine aminotransferase protein is encoded by the TAT gene . A deficiency of the enzyme in humans can result in what is known as Type II Tyrosinemia, wherein there is an abundance of tyrosine as a result of tyrosine failing to undergo an aminotransferase reaction to form 4 hydroxyphenylpyruvate ... Isolation and characterization of the human tyrosine aminotransferase gene journal Nucleic Acids Res ... by the tyrosine aminotransferase enzyme are shown below the amino acid tyrosine , the prosthetic ... . Image 3strucfinal.jpg Image DimerTAT.jpg thumb right Ribbon diagram of the tyrosine aminotransferase ... bonded to the Lys280 residue of the tyrosine aminotransferase molecule. The amine group of tyrosine ... the tyrosine in transimination. The electrons left behind from the loss of the proton move down to form .... Notice sandwich effect of the two groups to hold PLP in the correct orientation Tyrosine Aminotransferase ... Tyrosinemia is the most common metabolic disease associated with tyrosine aminotransferase. The disease results from a deficiency in hepatic tyrosine aminotransferase. ref name pmid1357662 cite journal author Natt E, Kida K, Odievre M, Di Rocco M, Scherer G title Point mutations in the tyrosine ... hyperkeratosis, mental retardation, and elevated blood tyrosine levels. ref name pmid1357662 Keratitis in Tyrosinemia type II patients is caused by the deposition of tyrosine crystals in the cornea ..., Iizuka H title Richner Hanhart syndrome report of a case with a novel mutation of tyrosine aminotransferase ...   more details



  1. FMS-like tyrosine kinase 3 ligand

    Morefootnotes article date March 2011 The Flt3l is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cell s in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady state pDC and cDC development. ref cite journal last1 Shortman first1 Ken last2 Naik first2 Shalin H. title Steady state and inflammatory dendritic cell development journal Nature Reviews Immunology volume 7 issue 1 pages 19 30 year 2006 pmid 17170756 doi 10.1038 nri1996 ref A lack of FLT3L results in low levels of DCs. References reflist Further reading cite journal last1 Robinson first1 S N last2 Chavez first2 J M last3 Pisarev first3 V M last4 Mosley first4 R L last5 Rosenthal first5 G J last6 Blonder first6 J M last7 Talmadge first7 J E title Delivery of Flt3 ligand Flt3L using a poloxamer based formulation increases biological activity in mice journal Bone Marrow Transplantation volume 31 issue 5 pages 361 9 year 2003 pmid 12634727 doi 10.1038 sj.bmt.1703816 Category Enzymes enzyme stub ...   more details




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