protein name triosephosphateisomerase 1 caption The structure of human TPI PDB 1WYI image Beta barrel.png ..., J. R. title Free Energy Profile for the Reaction Catalyzed by TriosephosphateIsomerase journal ... of triosephosphateisomerase journal Biochemistry volume 29 issue 18 pages 4312 4317 publisher year ... TriosephosphateIsomerase DeltaG.svg Free energy changes The structure of TPI facilitates the conversion ..., L.C. title Electrophilic Catalysis in TriosephosphateIsomerase the Role of Histidine 95. journal ... of TriosephosphateIsomerase. journal Biochemistry volume 37 issue 47 pages 16828 16838 publisher ... Analysis of the Complex between TriosephosphateIsomerase and 2 Phosphoglycolate at 2.5 Resolution ..., L.C. title TriosephosphateIsomerase Requires a Positively Charged Active Site The Role of Lysine ... Isomerase deficiency TPI1 http www.proteopedia.org wiki index.php TriosephosphateIsomeraseTriosephosphateisomerase in interactive 3D at Proteopedia http www.expasy.org prosite PDOC00155 Triosephosphate ... 5.3.1.1 Chromosome 12 Arm p Band 13 LocusSupplementaryData Triose phosphate isomerase TPI or TIM ... Ribbon pastel whitebkg.jpg thumb 300px Side view of triose P isomerase monomer, active site at top center Enzymatic Reaction foward enzyme triose phosphate isomerase reverse enzyme triose phosphate isomerase substrate Dihydroxyacetone phosphate product small D small glyceraldehyde ... with a progressive, severe neurological disorder called Triose Phosphate Isomerase deficiency triose phosphate isomerase deficiency . Triose phosphate isomerase deficiency is characterized by chronic ... DATA coauthors Ov di, J. last Orosz first F. authorlink coauthors Ol h, J. title Triosephosphateisomerase deficiency facts and doubts journal IUBMB Life volume 58 issue 12 pages 703 715 publisher ... isomerase is a highly efficient enzyme, performing the reaction billions of times faster than it would ..., D.W. title On the three dimensional structure and catalytic mechanism of triose phosphate isomerase ... more details
Infobox disease Name Triosephosphateisomerase deficiency Image Caption DiseasesDB 30116 ICD10 ICD10 D 55 2 d 55 ICD9 ICD9 282.3 ICDO OMIM 190450 MedlinePlus eMedicineSubj eMedicineTopic MeshID Triosephosphateisomerase deficiency is a rare autosome autosomal dominance genetics recessive ref name Ralser et al 2006 inborn errors of metabolism metabolic disorder which was initially described in 1965. ref name Schneider et al 1965 cite journal doi 10.1056 NEJM196502042720503 last Schneider first Arthur S. coauthors William N. Valentine, Hattori M, H. L. Heins Jr year 1965 title Hereditary Hemolytic Anemia with TriosephosphateIsomerase Deficiency journal New England Journal of Medicine volume 272 issue 5 pages 229 235 pmid 14242501 ref It is a unique glycolysis glycolytic enzymopathy that is characterized by chronic haemolytic anaemia , cardiomyopathy , susceptibility to infections, severe neurological dysfunction, and, in most cases, death in early childhood. ref name Schneider 2000 cite journal last Schneider first Arthur S. year 2000 month Mar title Triosephosphateisomerase deficiency historical perspectives and molecular aspects volume 13 issue 1 pages 119 140 pmid 10916682 doi 10.1053 beha.2000.0061 url http www.sciencedirect.com science? ob ArticleURL& udi B6WBG 45FKMG0 1M& coverDate 03 2F31 2F2000& alid 513209010& rdoc 1& fmt & orig search& qd 1& cdi 6710& sort d&view c& acct ... thumb right Triosephosphateisomerase deficiency has an autosomal recessive pattern of inheritance ... and encodes the ubiquitous housekeeping enzyme triosephosphateisomerase TPI , have been discovered ... The 1591C mutation in triosephosphateisomerase TPI deficiency. Tightly linked polymorphisms and a common ... date December 20, 2006 editor1 last Janbon editor1 first Guilhem title Triose Phosphate Isomerase Deficiency ... stub de Triosephosphat Isomerase Defizienz pl Niedob r izomerazy fosfotriozowej pt Defici ncia de triose fosfato isomerase ... more details
In biochemistry , an isomerase is an enzyme that catalyzes the structural rearrangement of isomer s. Isomerases thus catalyze reactions of the form A &rarr B where B is an isomer of A. Nomenclature The names of isomerases are formed as substrate isomerase for example, enoyl CoA isomerase , or as substrate type of isomerase for example, phosphoglucomutase . Classification Isomerases have their own EC number EC classification of enzymes EC 5 . Isomerases can be further classified into six subclasses Category EC 5.1 EC 5.1 includes enzymes that catalyze racemization racemase s and epimer ization epimerase s Category EC 5.2 EC 5.2 includes enzymes that catalyze the isomerization of geometric isomerism geometric isomers cis trans isomerase s Category EC 5.3 EC 5.3 includes intramolecular oxidoreductase s Category EC 5.4 EC 5.4 includes intramolecular transferase s mutase s Category EC 5.5 EC 5.5 includes intramolecular lyase s Category EC 5.99 EC 5.99 includes other isomerases including topoisomerase s References http www.chem.qmul.ac.uk iubmb enzyme EC5 intro.html EC 5 Introduction from the Department of Chemistry at Queen Mary, University of London isomerase. Dorland s Medical Dictionary for Health Consumers. 2007. Saunders, an imprint of Elsevier, Inc 6 Nov. 2009 http medical dictionary.thefreedictionary.com isomeraseisomerase. Webster s New World College Dictionary. LoveToKnow, n.d. Web. 6 November 2009. http www.yourdictionary.com isomerase External links http www.gopubmed.org GoMeshPubMed gomeshpubmed ?tool HotTopicDirect&termAlt mesh 237535 GoPubMed Top authors, journals, places publishing on Isomerases Enzymes Isomerases Category Isomerases ar bs Izomeraza bg ca Isomerasa cs Izomer za da Isomerase de Isomerasen es Isomerasa fa fr Isom rase it Isomerasi he lt Izomeraz s nl Isomerase ja pl Izomerazy pt Isomerase ru sv Isomeras tr zomeraz zh ... more details
enzyme Name mannose isomerase EC number 5.3.1.7 CAS number 9031 25 8 IUBMB EC number 5 3 1 7 GO code 0050089 image width caption In enzymology , a mannose isomerase EC number 5.3.1.7 is an enzyme that catalysis catalyzes the chemical reaction D mannose math rightleftharpoons math D fructose Hence, this enzyme has one substrate biochemistry substrate , D mannose , and one product chemistry product , D fructose . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is D mannose aldose ketose isomerase . Other names in common use include D mannose isomerase , and D mannose ketol isomerase . This enzyme participates in fructose and mannose metabolism . References reflist 1 cite journal author Palleroni NJ and Doudoroff M date 1956 title Mannose isomerase of Pseudomonas saccharophila journal J. Biol. Chem. volume 218 pages 535&ndash 548 isomerase stub Category EC 5.3.1 Category Enzymes of unknown structure ... more details
enzyme Name retinal isomerase EC number 5.2.1.3 CAS number 9023 76 1 IUBMB EC number 5 2 1 3 GO code 0004744 image width caption In enzymology , a retinal isomerase EC number 5.2.1.3 is an enzyme that catalysis catalyzes the chemical reaction all trans retinal math rightleftharpoons math 11 cis retinal Hence, this enzyme has one substrate biochemistry substrate , all trans retinal , and one product chemistry product , 11 cis retinal . This enzyme belongs to the family of isomerase s, specifically Cis trans isomerism cis trans isomerases . The systematic name of this enzyme class is all trans retinal 11 cis trans isomerase . Other names in common use include retinene isomerase , and retinoid isomerase . This enzyme participates in retinol metabolism . References reflist 1 cite journal author HUBBARD R date 1956 title Retinene isomerase journal J. Gen. Physiol. volume 39 pages 935&ndash 62 pmid 13346046 doi 10.1085 jgp.39.6.935 issue 6 pmc 2147571 cite journal author Shichi H, Somers RL date 1974 title Possible involvement of retinylidene phospholipid in photoisomerization of all trans retinal to 11 cis retinal journal J. Biol. Chem. volume 249 pages 6570&ndash 7 pmid 4472816 issue 20 isomerase stub Category EC 5.2.1 Category Enzymes of unknown structure ... more details
enzyme Name ribose isomerase EC number 5.3.1.20 CAS number 57534 76 6 IUBMB EC number 5 3 1 20 GO code 0050261 image width caption In enzymology , a ribose isomerase EC number 5.3.1.20 is an enzyme that catalysis catalyzes the chemical reaction D ribose math rightleftharpoons math D ribulose Hence, this enzyme has one substrate biochemistry substrate , D ribose , and one product chemistry product , D ribulose . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is D ribose aldose ketose isomerase . Other names in common use include D ribose isomerase , and D ribose ketol isomerase . References reflist 1 cite journal author Izumori K, Rees AW, Elbein AD date 1975 title Purification, crystallization, and properties of D ribose isomerase from Mycobacterium smegmatis journal J. Biol. Chem. volume 250 pages 8085&ndash 7 pmid 240851 issue 20 isomerase stub Category EC 5.3.1 Category Enzymes of unknown structure ... more details
Merge Ribose 5 phosphate isomerase discuss Talk Ribose 5 phosphate isomerase Merge proposal date December 2008 protein Name ribose 5 phosphate isomerase A ribose 5 phosphate epimerase caption image width HGNCid 10297 Symbol RPIA AltSymbols EntrezGene 22934 OMIM 180430 RefSeq NM 144563 UniProt P49247 PDB ECnumber 5.3.1.6 Chromosome 2 Arm p Band 12 LocusSupplementaryData 2p11 Phosphopentose isomerase is an enzyme which converts ribulose 5 phosphate a ketose to ribose 5 phosphate an aldose . In the pentose phosphate pathway , it converts the aldose to the ketose. External links http cmgm.stanford.edu biochem200 OVERHEADS PPP.html Diagram at stanford.edu http www.ncbi.nlm.nih.gov books bv.fcgi?rid stryer.section.2848 2865 Description and mechanism click on link at nih.gov EC number 5.3.1.6 MeshName ribosephosphate isomerase biochem stub Intramolecular oxidoreductases Pentose phosphate pathway ... more details
enzyme Name glucuronate isomerase EC number 5.3.1.12 CAS number 9023 87 4 IUBMB EC number 5 3 1 12 GO code 0008880 image width caption In enzymology , a glucuronate isomerase EC number 5.3.1.12 is an enzyme that catalysis catalyzes the chemical reaction D glucuronate math rightleftharpoons math D fructuronate Hence, this enzyme has one substrate biochemistry substrate , D glucuronate , and one product chemistry product , D fructuronate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is D glucuronate aldose ketose isomerase . Other names in common use include uronic isomerase , uronate isomerase , D glucuronate isomerase , uronic acid isomerase , and D glucuronate ketol isomerase . This enzyme participates in pentose and glucuronate interconversions . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1J5S and PDB link 2Q01 . References reflist 1 cite journal author Ashwell G, Wahba AJ and Hickman J year 1960 title Uronic acid metabolism in bacteria. I. Purification and properties of uronic acid isomerase in Escherichia coli journal J. Biol. Chem. volume 235 pages 1559&ndash 1565 pmid 13794771 cite journal author KILGORE WW, STARR MP year 1959 title Catabolism of galacturonic and glucuronic acids by Erwinia carotovora journal J. Biol. Chem. volume 234 pages 2227&ndash 35 pmid 14409051 Category EC 5.3.1 Category Enzymes of known structure isomerase stub ... more details
enzyme Name arabinose 5 phosphate isomerase EC number 5.3.1.13 CAS number 9023 86 3 IUBMB EC number 5 3 1 13 GO code 0019146 image width caption In enzymology , an arabinose 5 phosphate isomerase EC number 5.3.1.13 is an enzyme that catalysis catalyzes the chemical reaction D arabinose 5 phosphate math rightleftharpoons math D ribulose 5 phosphate Hence, this enzyme has one substrate biochemistry substrate , D arabinose 5 phosphate , and one product chemistry product , D ribulose 5 phosphate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D arabinose 5 phosphate aldose ketose isomerase . Other names in common use include arabinose phosphate isomerase , phosphoarabinoisomerase , and D arabinose 5 phosphate ketol isomerase . References reflist 1 cite journal author Volk WA date 1960 title Purification and properties of phosphoarabinoisomerase from Propionibacterium pentosaceum journal J. Biol. Chem. volume 235 pages 1550&ndash 1553 isomerase stub Category EC 5.3.1 Category Enzymes of unknown structure ... more details
enzyme Name linoleate isomerase EC number 5.2.1.5 CAS number 37318 41 5 IUBMB EC number 5 2 1 5 GO code 0050058 image width caption In enzymology , a linoleate isomerase EC number 5.2.1.5 is an enzyme that catalysis catalyzes the chemical reaction 9 cis,12 cis octadecadienoate math rightleftharpoons math 9 cis,11 trans octadecadienoate Hence, this enzyme has one substrate biochemistry substrate , 9 cis,12 cis octadecadienoate , and one product chemistry product , 9 cis,11 trans octadecadienoate . This enzyme belongs to the family of isomerase s, specifically Cis trans isomerism cis trans isomerases . The systematic name of this enzyme class is linoleate Delta12 cis Delta11 trans isomerase . This enzyme is also called linoleic acid isomerase . This enzyme participates in linoleic acid metabolism . References reflist 1 cite journal author Kepler CR, Tove SB date 1967 title Biohydrogenation of unsaturated fatty acids. 3. Purification and properties of a linoleate delta 12 cis, delta 11 trans isomerase from Butyrivibrio fibrisolvens journal J. Biol. Chem. volume 242 pages 5686&ndash 92 pmid 5633396 issue 24 isomerase stub Category EC 5.2.1 Category Enzymes of unknown structure ... more details
enzyme Name chalcone isomerase EC number 5.5.1.6 CAS number 9073 57 8 IUBMB EC number 5 5 1 6 GO code 0045430 image width caption In enzymology , a chalcone isomerase EC number 5.5.1.6 is an enzyme that catalysis catalyzes the chemical reaction a chalcone math rightleftharpoons math a flavanone Hence, this enzyme has one substrate biochemistry substrate , chalcone , and one product chemistry product , flavanone . This enzyme belongs to the family of isomerase s, specifically the class of intramolecular lyases. The systematic name of this enzyme class is flavanone lyase decyclizing . This enzyme is also called chalcone flavanone isomerase . This enzyme participates in flavonoid biosynthesis . Structural studies As of late 2007, 7 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1EYP , PDB link 1EYQ , PDB link 1FM7 , PDB link 1FM8 , PDB link 1JEP , PDB link 1JX0 , and PDB link 1JX1 . References reflist 1 cite journal author Moustafa E and Wong E date 1967 title Purification and properties of chalcone flavanone isomerase from soya bean seed journal Phytochemistry journal Phytochemistry volume 6 pages 625&ndash 632 doi 10.1016 S0031 9422 00 86001 X Category EC 5.5.1 Category Enzymes of known structure isomerase stub ... more details
enzyme Name hydroxypyruvate isomerase EC number 5.3.1.22 CAS number 74812 48 9 IUBMB EC number 5 3 1 22 GO code 0008903 image width caption In enzymology , a hydroxypyruvate isomerase EC number 5.3.1.22 is an enzyme that catalysis catalyzes the chemical reaction hydroxypyruvate math rightleftharpoons math 2 hydroxy 3 oxopropanoate Hence, this enzyme has one substrate biochemistry substrate , hydroxypyruvate , and one product chemistry product , 2 hydroxy 3 oxopropanoate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is hydroxypyruvate aldose ketose isomerase . This enzyme participates in glyoxylate and dicarboxylate metabolism . References reflist 1 cite journal author de Windt FE, van der Drift C date 1980 title Purification and some properties of hydroxypyruvate isomerase of Bacillus fastidiosus journal Biochim. Biophys. Acta. volume 613 pages 556&ndash 62 pmid 7448201 issue 2 isomerase stub Category EC 5.3.1 Category Enzymes of unknown structure ... more details
enzyme Name thiocyanate isomerase EC number 5.99.1.1 CAS number 9023 71 6 IUBMB EC number 5 99 1 1 GO code 0050335 image width caption In enzymology , a thiocyanate isomerase EC number 5.99.1.1 is an enzyme that catalysis catalyzes the chemical reaction benzyl isothiocyanate math rightleftharpoons math benzyl thiocyanate Hence, this enzyme has one substrate biochemistry substrate , benzyl isothiocyanate , and one product chemistry product , benzyl thiocyanate . This enzyme belongs to the family of isomerase s, specifically those other isomerases sole sub subclass for isomerases that do not belong in the other subclasses. The systematic name of this enzyme class is benzyl thiocyanate isomerase . This enzyme is also called isothiocyanate isomerase . References reflist 1 cite journal author Virtanen AI date 1962 title On enzymic and chemical reactions in crushed plants journal Arch. Biochem. Biophys. Suppl. volume 1 pages 200&ndash 208 isomerase stub Category EC 5.99.1 Category Enzymes of unknown structure ... more details
enzyme Name S methyl 5 thioribose 1 phosphate isomerase EC number 5.3.1.23 CAS number 91608 95 6 IUBMB EC number 5 3 1 23 GO code 0046523 image width caption In enzymology , a S methyl 5 thioribose 1 phosphate isomerase EC number 5.3.1.23 is an enzyme that catalysis catalyzes the chemical reaction S methyl 5 thio alpha D ribose 1 phosphate math rightleftharpoons math S methyl 5 thio D ribulose 1 phosphate Hence, this enzyme has one substrate biochemistry substrate , S methyl 5 thio alpha D ribose 1 phosphate , and one product chemistry product , S methyl 5 thio D ribulose 1 phosphate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is S methyl 5 thio alpha D ribose 1 phosphate aldose ketose isomerase . Other names in common use include methylthioribose 1 phosphate isomerase , 1 PMTR isomerase , 5 methylthio 5 deoxy D ribose 1 phosphate ketol isomerase , S methyl 5 thio 5 deoxy D ribose 1 phosphate ketol isomerase , S methyl 5 thio 5 deoxy D ribose 1 phosphate , aldose ketose isomerase , 1 phospho 5 S methylthioribose isomerase , and S methyl 5 thio D ribose 1 phosphate aldose ketose isomerase . This enzyme participates in methionine metabolism . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1T9K and PDB link 1W2W . References reflist 1 cite journal author RH date 1984 title Characterization of a defect in the pathway for converting 5 deoxy 5 methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma journal J. Biol. Chem. volume 259 pages 6715&ndash 9 pmid 6725268 last2 Savarese first2 TM last3 Dexter first3 DL last4 Parks Jr first4 RE last5 Trackman first5 PC last6 Abeles first6 RH ... issue 20 isomerase stub Category EC 5.3.1 Category Enzymes of known structure ... more details
enzyme Name arabinose isomerase EC number 5.3.1.3 CAS number 9023 81 8 IUBMB EC number 5 3 1 3 GO code 0008790 image width caption In enzymology , an arabinose isomerase EC number 5.3.1.3 is an enzyme that catalysis catalyzes the chemical reaction D arabinose math rightleftharpoons math D ribulose Hence, this enzyme has one substrate biochemistry substrate , D arabinose , and one product chemistry product , D ribulose . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D arabinose aldose ketose isomerase . Other names in common use include D arabinose L fucose isomerase , D arabinose isomerase , L fucose isomerase , and D arabinose ketol isomerase . Structural studies As of late 2007, only one tertiary structure structure has been solved for this class of enzymes, with the Protein Data Bank PDB accession code PDB link 1FUI . References reflist 1 cite journal author Cohen SS date 1953 title Studies on D ribulose and its enzymatic conversion to D arabinose journal J. Biol. Chem. volume 201 issue 1 pages 71&ndash 84 pmid 13044776 cite journal author Green M and Cohen SS date 1956 title Enzymatic conversion of L fucose to L fuculose journal J. Biol. Chem. volume 219 issue 2 pages 557&ndash 568 pmid 13319278 isomerase stub Category EC 5.3.1 Category Enzymes of known structure ... more details
enzyme Name maleylacetoacetate isomerase EC number 5.2.1.2 CAS number 9023 75 0 IUBMB EC number 5 2 1 2 GO code 0016034 image width caption In enzymology , a maleylacetoacetate isomerase EC number 5.2.1.2 is an enzyme that catalysis catalyzes the chemical reaction 4 maleylacetoacetate math rightleftharpoons math 4 fumarylacetoacetate Hence, this enzyme has one substrate biochemistry substrate , 4 Maleylacetoacetate 4 maleylacetoacetate , and one product chemistry product , 4 fumarylacetoacetate . This enzyme belongs to the family of isomerase s, specifically Cis trans isomerism cis trans isomerases . The systematic name of this enzyme class is 4 maleylacetoacetate cis trans isomerase . Other names in common use include maleylacetoacetic isomerase , maleylacetone isomerase , and maleylacetone cis trans isomerase . This enzyme participates in tyrosine metabolism and styrene degradation . Structural studies As of late 2007, 3 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1FW1 , PDB link 2CZ2 , and PDB link 2CZ3 . References reflist 1 cite journal author EDWARDS SW, KNOX WE date 1956 title Homogentisate metabolism the isomerization of maleylacetoacetate by an enzyme which requires glutathione journal J. Biol. Chem. volume 220 pages 79&ndash 91 pmid 13319328 issue 1 cite journal author Lack L date 1961 title Enzymic cis trans isomerization of maleylpyruvic acid journal J. Biol. Chem. volume 236 pages 2835&ndash 2840 cite journal author Seltzer S date 1973 title Purification and properties of maleylacetone cis trans isomerase from vibrio 01 journal J. Biol. Chem. volume 248 pages 215&ndash 22 pmid 4692831 issue 1 isomerase stub Category EC 5.2.1 Category Enzymes of known structure ... more details
enzyme Name furylfuramide isomerase EC number 5.2.1.6 CAS number 72561 07 0 IUBMB EC number 5 2 1 6 GO code 0047907 image width caption In enzymology , a furylfuramide isomerase EC number 5.2.1.6 is an enzyme that catalysis catalyzes the chemical reaction E 2 2 furyl 3 5 nitro 2 furyl acrylamide math rightleftharpoons math Z 2 2 furyl 3 5 nitro 2 furyl acrylamide Hence, this enzyme has one substrate biochemistry substrate , E 2 2 furyl 3 5 nitro 2 furyl acrylamide , and one product chemistry product , Z 2 2 furyl 3 5 nitro 2 furyl acrylamide . This enzyme belongs to the family of isomerase s, specifically Cis trans isomerism cis trans isomerases . The systematic name of this enzyme class is 2 2 furyl 3 5 nitro 2 furyl acrylamide cis trans isomerase . It has 2 cofactor biochemistry cofactors NAD , and NADH . References reflist 1 cite journal author Tomoeda M, Kitamura R year 1977 title A cis trans isomerising activity of Escherichia coli. Isomerization from 2 2 furyl 3 cis 5 nitro 2 furyl acrylamide furylfuramide to its trans isomer journal Biochim. Biophys. Acta. volume 480 pages 315&ndash 25 pmid 12827 issue 1 Category EC 5.2.1 Category NADH dependent enzymes Category Enzymes of unknown structure isomerase stub ... more details
enzyme Name maleate isomerase EC number 5.2.1.1 CAS number 9023 74 9 IUBMB EC number 5 2 1 1 GO code 0050076 image width caption In enzymology , a maleate isomerase EC number 5.2.1.1 is an enzyme that catalysis catalyzes the chemical reaction maleate math rightleftharpoons math fumarate Hence, this enzyme has one substrate biochemistry substrate , maleate , and one product chemistry product , fumarate . This enzyme belongs to the family of isomerase s, specifically Cis trans isomerism cis trans isomerases . The systematic name of this enzyme class is maleate cis trans isomerase . This enzyme participates in butanoate metabolism and nicotinate and nicotinamide metabolism . References reflist 1 cite journal author BEHRMAN EJ, STANIER RY date 1957 title The bacterial oxidation of nicotinic acid journal J. Biol. Chem. volume 228 pages 923&ndash 45 pmid 13475371 issue 2 isomerase stub Category EC 5.2.1 Category Enzymes of unknown structure ... more details
enzyme Name maleylpyruvate isomerase EC number 5.2.1.4 CAS number 9023 77 2 IUBMB EC number 5 2 1 4 GO code 0050077 image width caption In enzymology , a maleylpyruvate isomerase EC number 5.2.1.4 is an enzyme that catalysis catalyzes the chemical reaction 3 maleylpyruvate math rightleftharpoons math 3 fumarylpyruvate Hence, this enzyme has one substrate biochemistry substrate , 3 maleylpyruvate , and one product chemistry product , 3 fumarylpyruvate . This enzyme belongs to the family of isomerase s, specifically Cis trans isomerism cis trans isomerases . The systematic name of this enzyme class is 3 maleylpyruvate cis trans isomerase . This enzyme participates in tyrosine metabolism . Structural studies As of late 2007, two tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 2NSF and PDB link 2NSG . References reflist 1 cite journal author Lack L date 1961 title Enzymic cis trans isomerization of maleylpyruvic acid journal J. Biol. Chem. volume 236 pages 2835&ndash 2840 isomerase stub Category EC 5.2.1 Category Enzymes of known structure ... more details
enzyme Name retinol isomerase EC number 5.2.1.7 CAS number 109740 80 9 IUBMB EC number 5 2 1 7 GO code 0050251 image width caption In enzymology , a retinol isomerase EC number 5.2.1.7 is an enzyme that catalysis catalyzes the chemical reaction all trans retinol math rightleftharpoons math 11 cis retinol Hence, this enzyme has one substrate biochemistry substrate , all trans retinol , and one product chemistry product , 11 cis retinol . This enzyme belongs to the family of isomerase s, specifically Cis trans isomerism cis trans isomerases . The systematic name of this enzyme class is all trans retinol 11 cis trans isomerase . This enzyme is also called all trans retinol isomerase . This enzyme participates in retinol metabolism . References reflist 1 cite journal author Bernstein PS, Law WC, Rando RR date 1987 title Isomerization of all trans retinoids to 11 cis retinoids in vitro journal Proc. Natl. Acad. Sci. U. S. A. volume 84 pages 1849&ndash 53 pmid 3494246 doi 10.1073 pnas.84.7.1849 issue 7 pmc 304538 cite journal author Bridges CD, Alvarez RA date 1987 title The visual cycle operates via an isomerase acting on all trans retinol in the pigment epithelium journal Science. volume 236 pages 1678&ndash 80 pmid 3603006 doi 10.1126 science.3603006 issue 4809 isomerase stub Category EC 5.2.1 Category Enzymes of unknown structure ... more details
enzyme Name phosphoribosylanthranilate isomerase EC number 5.3.1.24 CAS number 37259 82 8 IUBMB EC number 5 3 1 24 GO code 0004640 image width caption In enzymology , a phosphoribosylanthranilate isomerase EC number 5.3.1.24 is an enzyme that catalysis catalyzes the chemical reaction N 5 phospho beta D ribosyl anthranilate math rightleftharpoons math 1 2 carboxyphenylamino 1 deoxy D ribulose 5 phosphate Hence, this enzyme has one substrate biochemistry substrate , N 5 phospho beta D ribosyl anthranilate , and one product chemistry product , 1 2 carboxyphenylamino 1 deoxy D ribulose 5 phosphate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is N 5 phospho beta D ribosyl anthranilate aldose ketose isomerase . Other names in common use include PRA isomerase , PRAI , IGPS PRAI indole 3 glycerol phosphate , synthetase N 5 phosphoribosylanthranilate isomerase complex , and N 5 phospho beta D ribosyl anthranilate ketol isomerase . This enzyme participates in phenylalanine , tyrosine and tryptophan biosynthesis . Structural studies As of late 2007, 5 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1DL3 , PDB link 1LBM , PDB link 1NSJ , PDB link 1V5X , and PDB link 1VZW . References reflist 1 cite journal author R date 1988 title The role of the TRP1 gene in yeast tryptophan biosynthesis journal J. Biol. Chem. volume 263 pages 7868&ndash 75 pmid 3286643 last2 Luger first2 K last3 Paravicini first3 G last4 Schmidheini first4 T last5 Kirschner first5 K last6 H tter first6 R issue 16 cite journal author Creighton TE and Yanofsky C date 1970 title Chorismate to tryptophan Escherichia coli Anthranilate synthetase, PR transferase, PRA isomerase, InGP synthetase, tryptophan ... pages 2746&ndash 58 pmid 16526091 doi 10.1002 pmic.200500108 issue 9 isomerase stub Category EC 5.3.1 ... more details
Distinguish D xylose isomerase enzyme Name Glucose 6 phosphate isomerase EC number 5.3.1.9 CAS number 9001 41 6 IUBMB EC number 5 3 1 9 GO code 0004347 image Glucose 6 phosphate isomerase 1GZV wpmp.png width caption PBB geneid 2821 Glucose 6 phosphate isomerase , alternatively known as phosphoglucose isomerase or phosphohexose isomerase , is an enzyme that catalyzes the conversion of glucose 6 phosphate ... isomerase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2821 ... isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric ... significance of autocrine motility factor glucose 6 phosphate isomerase expression in human ... isomerase polypeptide journal Cancer Res. volume 56 issue 13 pages 2960 3 date 1 July 1996 ... In glycolysis Enzymatic Reaction foward enzyme Phosphoglucose isomerase reverse enzyme Phosphoglucose isomerase substrate small D small Glucose 6 phosphate product small D small Fructose 6 phosphate ... KEGG compound C05345 KEGG reaction R00771 As a glucose isomerase Enzymatic Reaction foward enzyme Phosphoglucose isomerase reverse enzyme Phosphoglucose isomerase substrate small D small Glucose ... isomerase acts as a molecular messenger. It is produced and secreted by white blood cells ... isomerase is responsible for 4 of the hemolytic anemias due to glycolytic enzyme deficiencies ... 6 phosphate isomerase deficiency. journal Baillieres Best Pract. Res. Clin. Haematol. volume 13 ... Characterization of the 5 end of the gene for human glucose phosphate isomerase GPI . journal Genomics ... author Faik P, Walker JI, Redmill AA, Morgan MJ title Mouse glucose 6 phosphate isomerase and neuroleukin ... stable variant of erythrocyte glucose phosphate isomerase associated with severe hemolytic anemia. journal ... sequence present in an intron of the glucose phosphate isomerase GPI gene in mouse and man. journal ... author Xu W, Beutler E title The characterization of gene mutations for human glucose phosphate isomerase ... more details
enzyme Name xylose isomerase EC number 5.3.1.5 CAS number 9023 82 9 IUBMB EC number 5 3 1 5 GO code 0009045 image width caption In enzymology , a xylose isomerase EC number 5.3.1.5 is an enzyme that catalysis catalyzes the chemical reaction D xylose math rightleftharpoons math D xylulose This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is D xylose aldose ketose isomerase . Other names in common use include D xylose isomerase , D xylose ketoisomerase , and D xylose ketol isomerase . This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism. The enzyme is used industrially to convert glucose to fructose in the manufacture of high fructose corn syrup . It is sometimes referred to as glucose isomerase . Structural studies As of late 2007, 73 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1A0C , PDB link 1A0D , PDB link 1A0E , PDB link 1BHW , PDB link 1BXB , PDB link 1BXC , PDB link 1CLK , PDB link 1DID , PDB link 1DIE , PDB link 1DXI , PDB link 1GW9 , PDB link 1MNZ , PDB link 1MUW , PDB link 1O1H , PDB link 1OAD , PDB link 1QT1 , PDB link 1S5M , PDB link 1S5N , PDB link 1XIA , PDB link 1XIB , PDB link 1XIC , PDB link 1XID , PDB link 1XIE , PDB link 1XIF , PDB link 1XIG , PDB link 1XIH , PDB link 1XII , PDB link 1XIJ , PDB link 1XIM , PDB link 1XIN , PDB link 1XIS , PDB link 1XLA , PDB link 1XLB , PDB link 1XLC , PDB link 1XLD , PDB link 1XLE , PDB link 1XLF , PDB link 1XLG , PDB link 1XLH , PDB link 1XLI , PDB link 1XLJ , PDB ... Xylose isomerase from Pasteurella pestis, strain A 1122 journal J. Am. Chem. Soc. volume 77 pages ..., crystallization and properties of the D xylose isomerase from Lactobacillus brevis journal Biochim. Biophys. Acta. volume 151 pages 670&ndash 80 pmid 5646045 issue 3 isomerase stub Category EC 5.3.1 ... more details
enzyme Name galactose 6 phosphate isomerase EC number 5.3.1.26 CAS number 39433 98 2 IUBMB EC number 5 3 1 26 GO code 0050044 image width caption In enzymology , a galactose 6 phosphate isomerase EC number 5.3.1.26 is an enzyme that catalysis catalyzes the chemical reaction D galactose 6 phosphate math rightleftharpoons math D tagatose 6 phosphate Hence, this enzyme has one substrate biochemistry substrate , D galactose 6 phosphate , and one product chemistry product , D tagatose 6 phosphate . This enzyme belongs to the family of isomerase s, specifically those intramolecular oxidoreductase s interconverting aldose s and ketose s. The systematic name of this enzyme class is D galactose 6 phosphate aldose ketose isomerase . This enzyme participates in galactose metabolism . References reflist 1 cite journal author de Vos WM, Boerrigter I, van Rooyen RJ, Reiche B, Hengstenberg W date 1990 title Characterization of the lactose specific enzymes of the phosphotransferase system in Lactococcus lactis journal J. Biol. Chem. volume 265 pages 22554&ndash 60 pmid 2125052 issue 36 cite journal author van Rooijen RJ, van Schalkwijk S, de Vos WM date 1991 title Molecular cloning, characterization, and nucleotide sequence of the tagatose 6 phosphate pathway gene cluster of the lactose operon of Lactococcus lactis journal J. Biol. Chem. volume 266 pages 7176&ndash 81 pmid 1901863 issue 11 isomerase stub Category EC 5.3.1 Category Enzymes of unknown structure ... more details
T1 , beta lactamase , and some interleukin s. Prolyl isomerase folding can be autocatalytic ... rate by the addition of a prolyl isomerase. Acceleration of the in vitro folding rate in mutation mutant ... the isomerization of prolines in certain sequence contexts. Assays for prolyl isomerase activity Prolyl isomerase activity was first discovered using a chymotrypsin based assay. The proteolytic enzyme ... prolyl isomerase will accelerate this latter reaction phase if it has true prolyl isomerase ... DEFAULTSORT Prolyl Isomerase Category EC 5.2.1 de Peptidyl Prolyl cis trans Isomerasen ja ... more details
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