Summary 3d model of a thymidinetriphosphate molecule. Created by Michael Str ck mstroeck on date of upload. Released under the GFDL. Licensing GFDL self with disclaimers migration relicense ... more details
respectively dTMP, dTDP or dTTP deoxythymidine mono di or triphosphate . It exists in solid ... just called thymidine. Thymidine is listed as a chemical teratogen. ref The following list of chemicals ..., 7th Ed., by N. Irving Sax and Richard J. Lewis. ref Modified analogs of thymidine Iododeoxyuridine ... cycle . tritium Tritiated thymidine is commonly used in cell proliferation assays. The thymidine is incorporated ... thymidine analog that is often used for the detection of proliferating cells in living tissues ... ca Timidina de Desoxythymidin es Timidina fr D soxythymidine it Timidina lt Timidinas nl Thymidine ... more details
enzyme Name thymidine triphosphatase EC number 3.6.1.39 CAS number 37367 74 1 IUBMB EC number 3 6 1 39 GO code 0050339 image width caption In enzymology , a thymidine triphosphatase EC number 3.6.1.39 is an enzyme that catalysis catalyzes the chemical reaction dTTP H sub 2 sub O math rightleftharpoons math dTDP phosphate Thus, the two substrate biochemistry substrates of this enzyme are dTTP and water H sub 2 sub O , whereas its two product chemistry products are dTDP and phosphate . This enzyme belongs to the family of hydrolase s, specifically those acting on acid anhydrides in phosphorus containing anhydrides. The systematic name of this enzyme class is dTTP nucleotidohydrolase . Other names in common use include thymidinetriphosphate nucleotidohydrolase , dTTPase , and deoxythymidine 5 triphosphatase . This enzyme participates in pyrimidine metabolism . References reflist 1 cite journal author Dahlmann N date 1982 title Human serum thymidinetriphosphate nucleotidohydrolase purification and properties of a new enzyme journal Biochemistry. volume 21 pages 6634&ndash 9 pmid 6297538 doi 10.1021 bi00269a004 issue 26 hydrolase stub Category EC 3.6.1 Category Enzymes of unknown structure ... more details
url ref There is a feed back regulation of the action of thymidine kinase in the cell thymidinetriphosphate ...enzyme Name Thymidine kinase EC number 2.7.1.21 IUBMB EC number 2 7 1 21 CAS number 9002 06 6 GO code 0004797 image 2B8T.png width caption Crystal structure of a tetrameric protein tetramer of thymidine ... in complex with thymidine space filling model , carbon white, oxygen red, nitrogen blue . ref name ... Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations ... Thymidine kinase image width caption Pfam PF00265 Pfam clan CL0023 InterPro IPR001267 SMART PROSITE ... Name Thymidine kinase 1 Thymidine kinase 1, soluble caption image width HGNCid 11830 Symbol Thymidine ... 2.7.1.21 Chromosome 17 Arm q Band 23.2 LocusSupplementaryData 25.3 protein Name Thymidine kinase 2, mitochondrial ... NM 004614 UniProt O00142 PDB ECnumber 2.7.1.21 Chromosome 16 Arm Band LocusSupplementaryData Thymidine kinase is an enzyme , a phosphotransferase a kinase 2 deoxythymidine kinase, ATP thymidine 5 phosphotransferase, EC number 2.7.1.21 . ref name pmid3939993 cite journal author Kit S title Thymidine ... function of thymidine kinase journal Biochem. Soc. Trans. volume 25 issue 1 pages 303 8 year ... genetic information for expression of viral thymidine kinases. Thymidine kinase catalyses the reaction Thd ATP TMP ADP where Thd is thymidine deoxythymidine , Adenosine triphosphate ATP is energy rich adenosine 5 triphosphate, Thymidine monophosphate TMP is deoxythymidine 5 phosphate and Adenosine diphosphate ADP is adenosine 5 diphosphate. Thymidine kinases have a key function in the synthesis of deoxyribonucleic ... of degradation of DNA from food and from dead cells. Thymidine kinase is required for the action ... . History The incorporation of thymidine in DNA was demonstrated around 1950. ref name pmid14824173 ... cite journal author Bollum FJ, Van Potter R title Incorporation of thymidine into deoxyribonucleic acid ... of deoxyribonucleic acid by extracts of mammalian cells. IV. The phosphorylation of thymidine ... more details
enzyme Name thymidine phosphorylase EC number 2.4.2.4 CAS number 9030 23 3 IUBMB EC number 2 4 2 4 GO code 0009032 image width caption In enzymology , a thymidine phosphorylase EC number 2.4.2.4 is an enzyme that catalysis catalyzes the chemical reaction thymidine phosphate math rightleftharpoons math thymine 2 deoxy alpha D ribose 1 phosphate Thus, the two substrate biochemistry substrates of this enzyme are thymidine and phosphate , whereas its two product chemistry products are thymine and 2 deoxy alpha D ribose 1 phosphate . Thymidine phosphorylase is involved and used in the diagnosis of mitochondrial neurogastrointestinal encephalomyopathy MNGIE . This enzyme belongs to the family of glycosyltransferase s, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine phosphate deoxy alpha D ribosyltransferase . Other names in common use include pyrimidine phosphorylase , thymidine orthophosphate deoxyribosyltransferase , animal growth regulators, blood platelet derived endothelial cell , growth factors , blood platelet derived endothelial cell growth factor , deoxythymidine phosphorylase , gliostatins , pyrimidine deoxynucleoside phosphorylase , and thymidine phosphate deoxy D ribosyltransferase . This enzyme participates in 3 metabolism metabolic pathways purine metabolism , pyrimidine metabolism , and bladder cancer . Structural studies As of late 2007, 6 tertiary structure structures have been solved for this class of enzymes, with Protein Data Bank PDB accession codes PDB link 1AZY , PDB link 1OTP , PDB link 1TPT , PDB link 1UOU , PDB link 2J0F , and PDB link 2TPT . References reflist 1 cite journal author FRIEDKIN M, ROBERTS D date 1954 title The enzymatic synthesis of nucleosides. I. Thymidine phosphorylase in mammalian tissue journal ... M and Seidenberg J date 1964 title Deoxyribosyl transfer. I. Thymidine phosphorylase and nucleoside ... pyrimidine deoxyribosyltransferase activity of three partially purified thymidine phosphorylases journal ... more details
chembox ImageFile DTMP chemical structure.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo 365 07 1 PubChem 1139 SMILES MeSHName Thymidine monophosphate Section2 Chembox Properties Formula C sub 10 sub H sub 15 sub N sub 2 sub O sub 8 sub P MolarMass 322.209 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxythymidine monophosphate , also known as 5 thymidylic acid , thymidylate , TMP , or less commonly, dTMP , is a nucleotide that is found in DNA . It is an ester of phosphoric acid with the nucleoside thymidine . TMP consists of a phosphate Functional group group , the pentose sugar deoxyribose , and the nucleobase thymine . As a substituent , it takes the form of the prefix thymidylyl . See also Nucleoside Nucleotide DNA RNA Oligonucleotide External links Nucleobases, nucleosides, and nucleotides Category Nucleotides biochem stub ca Timidilat es Timidilato fr Thymidine monophosphate nl Thymidinemonofosfaat ja sr Timidin monofosfat zh ... more details
chembox ImageFile dTDP chemical structure.png ImageSize 197 IUPACName 2R,3S,5R 3 hydroxy br 5 5 methyl 2,4 dioxopyrimidin br 1 yl oxolan 2 yl methyl phosphono hydrogen phosphate OtherNames Section1 Chembox Identifiers CASNo 1861 44 5 PubChem 164628 SMILES CC1 CN C O NC1 O C H 2C C H C H O2 COP O O OP O O O O MeSHName Section2 Chembox Properties Formula C sub 10 sub H sub 16 sub N sub 2 sub O sub 12 sub P sub 2 sub MolarMass 402.19 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxythymidine diphosphate , abbreviated TDP , is a nucleotide . It is an ester of pyrophosphoric acid with the nucleoside thymidine . TDP consists of the pyrophosphate Functional group group , the pentose sugar ribose , and the nucleobase thymine . clear See also Nucleoside Nucleotide DNA RNA Oligonucleotide Thymidine diphosphate glucose dTDP glucose External links Nucleobases, nucleosides, and nucleotides Category Nucleotides biochem stub ca Difosfat de timidina nl Thymidinedifosfaat ja sr Timidin difosfat zh ... more details
unreferenced date February 2007 Nucleoside triphosphate NTP is a nucleoside with three phosphate s. Natural nucleoside triphosphates include adenosine triphosphate ATP , guanosine triphosphate GTP , cytidine triphosphate CTP , thymidinetriphosphate TTP and uridine triphosphate UTP . These terms refer to those nucleoside triphosphates that contain ribose. The nucleoside triphosphates containing deoxyribose take prefix deoxy in their names and small d in their abbreviations deoxyadenosine triphosphate dATP , deoxyguanosine triphosphate dGTP , deoxycytidine triphosphate dCTP , deoxythimidine triphosphate dTTP and deoxyuridine triphosphate . Check the entry nucleotide for table and description of these compounds. Apart from d ATP, d GTP, d CTP, d TTP and d UTP, there are other less abundant NTPs, such as intermediates of nucleotide metabolism, but also rare natural nucleotides or even artificial nucleotides . The rare NTP are tautomeric forms of the NTPs. They cause mismatched base pairing during DNA replication. For example, a tautomeric form of cytosine is capable of forming 3 h bonds with adenine, and it will spontaneously revert to its original cytosine form, causing a mismatch. By a similar token, the deamination of cytosine leads to uracil, whereas a deamination of a commonly encountered in eukaryotes 5 methylcytosine will lead to thymine. However, the 5 to 3 DNA replication ensures that these mismatched bases are excised. Nucleotide derivatives are of unparalleled importance for current natural life forms, as they are building blocks of nucleic acid s and have thousands of other roles in cell metabolism and regulation. ATP is a major source of cellular energy. GTP is a very frequent cofactor of enzymes and proteins. NTPs generally provide energy and phosphate group for phosphorylations. Generally nucleoside s are nucleotide s e.g. adenine, guanine, cytosine... that lack ... triphosphate NTP . The nucleotides that contain a ribose sugar are the monomers of RNA and those ... more details
chembox ImageFile Ara CTP.svg ImageSize IUPACName OtherNames Ara CTP, Cytarabine triphosphate, br Cytosine arabinoside triphosphate Reference ref name pubchem http pubchem.ncbi.nlm.nih.gov summary summary.cgi?cid 25774 Ara CTP Compound Summary , PubChem . ref Section1 Chembox Identifiers CASNo 13191 15 6 PubChem 25774 SMILES C1 CN C O N C1N C2C C C O2 COP O O OP O O OP O O O O O MeSHName Arabinofuranosylcytosine triphosphate Section2 Chembox Properties Formula C sub 9 sub H sub 16 sub N sub 3 sub O sub 14 sub P sub 3 sub MolarMass 483.156323 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Arabinofuranosylcytosine triphosphate is a nucleotide that inhibits the protein biosynthesis synthesis of DNA . It is the biologically active form of cytarabine . ref name pubchem References reflist Nucleobases, nucleosides, and nucleotides Category Nucleotides Category Pyrimidones organic compound stub ... more details
Unreferenced stub auto yes date December 2009 Chembox verifiedrevid 413100674 ImageFile Uridintriphosphat2.svg ImageSize IUPACName 2R,3S,4R,5R 5 2,4 dioxopyrimidin 1 yl 3,4 dihydroxyoxolan 2 yl methyl hydroxy phosphonooxyphosphoryl hydrogen phosphate OtherNames Section1 Chembox Identifiers CASNo 63 39 8 CASNo Ref cascite PubChem 1181 SMILES MeSHName Uridine triphosphate Section2 Chembox Properties Formula C sub 9 sub H sub 15 sub N sub 2 sub O sub 15 sub P sub 3 sub MolarMass 484.141 Appearance Density MeltingPt BoilingPt Section3 Chembox Hazards Solubility MainHazards FlashPt Autoignition Uridine 5 triphosphate UTP is a pyrimidine nucleotide , consisting of the organic base uracil linked to the 1 carbon of the ribose sugar, and esterified with tri phosphoric acid at the 5 position. Its main role is as substrate for the synthesis of RNA during transcription genetics transcription . Role in metabolism UTP also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of Adenosine Triphosphate ATP , but more specific. When UTP activates a substrate, UDP substrate is usually formed and inorganic phosphate is released. UDP glucose enters the synthesis of glycogen . UTP is used in the metabolism of galactose , where the activated form UDP galactose is converted to UDP glucose. UDP glucuronate is used to conjugate bilirubin to a more water soluble bilirubin diglucuronide . See also CTP synthase Nucleobases, nucleosides, and nucleotides DEFAULTSORT Uridine Triphosphate Category Nucleotides Category Gene expression Category Metabolism Category Pyrimidinediones Biochem stub ca Trifosfat d uridina cs Uridintrifosf t da Uridintrifosfat de Uridintriphosphat es Uridina trifosfato fr Uridine triphosphate it Uridintrifosfato nl Uridinetrifosfaat ja sr Uridin trifosfat zh ... more details
Guanosine 5 triphosphate GTP is a purine nucleotide . It can act as a substrate for the synthesis ... sugar and three phosphate s, with the nucleobase attached to the 1 and the triphosphate moiety attached ... in metabolic reactions, like that of adenosine triphosphate ATP , but more specific. It is used ... triphosphate ATP , since GTP is readily converted to ATP. ref name Stryer cite book last ..., Ph.D. ref cGTP cyclic guanosine triphosphate redirects here Cyclic guanosine triphosphate cGTP helps ... References references Nucleobases, nucleosides, and nucleotides DEFAULTSORT Guanosine Triphosphate ... de Guanosintriphosphat es Guanos n trifosfato eo Guanosina trifosfato fr Guanosine triphosphate ... more details
, Grisar T & Bettendorff L. 2004 Thiamine triphosphate, a new signal required for optimal growth of Escherichia ... Ref4 Cooper JR, Itokawa Y & Pincus JH. 1969 Thiamine triphosphate deficiency in subacute necrotizing ..., of adenosine thiamine triphosphate AThTP . In mammals , ThTP is hydrolyzed by a specific thiamine ... 11827967 url http www.jbc.org content 277 16 13771.long ref History Thiamine triphosphate ThTP was chemically synthesized in 1948 at a time when the only organic triphosphate known was ATP. ref Velluz ... s yeast. ref Kiessling K. H. 1953 Thiamine triphosphate in baker s yeast Nature 172 1187 1188 ... phosphorylation unphosphorylated . ref Yusa T. 1962 Studies on thiamine triphosphate II. Thiamine triphosphate ... more details
Unreferenced auto yes date December 2009 Expert subject Chemistry date November 2008 Chembox verifiedrevid 413276035 ImageFile Desoxycytidintriphosphat protoniert.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct CAS CASNo 2056 98 6 PubChem 65091 SMILES C1C C OC1N2C CC NC2 O N COP O O OP O O OP O O O O Section2 Chembox Properties Formula C sub 9 sub H sub 16 sub N sub 3 sub O sub 13 sub P sub 3 sub MolarMass 467.156923 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxycytidine triphosphate dCTP is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction . e.g. A chemical equation can be written that represents the process DNA sub n sub dCTP DNA sub n sub C PP sub i sub That is, dCTP has the PP sub i sub pyrophosphate cleaved off and the Deoxycytidine monophosphate dCMP is incorporated into the DNA strand at the 3 end. Subsequent hydrolysis of the PP sub i sub drives the equilibrium of the reaction toward the right side, i.e. incorporation of the nucleotide in the growing DNA chain. It is stored at 20 degrees Celsius . See also DNA Replication Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxycytidine Triphosphate Category Molecular biology Category Nucleotides Biochemistry stub ca Trifosfat de desoxicitidina de Desoxycytidintriphosphat nl Deoxycytidinetrifosfaat sr Dezoksicitidin trifosfat zh ... more details
Chembox verifiedrevid 399891141 ImageFile Desoxyguanosintriphosphat protoniert.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers InChI 1 C10H13N5O4.3H3O4P c11 10 13 8 7 9 18 14 10 12 3 15 8 6 1 4 17 5 2 16 19 6 3 1 5 2,3 4 h3 6,16 17H,1 2H2, H3,11,13,14,18 3 H3,1,2,3,4 t4 ,5 ,6? m0... s1 InChIKey LOQVEVDWWPCIJG OKGDMBFWBZ SMILES1 OP O O O.OP O O O.OP O O O.N C3 N c2c ncn2C1C C H O C H CO O1 C O N3 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C10H13N5O4.3H3O4P c11 10 13 8 7 9 18 14 10 12 3 15 8 6 1 4 17 5 2 16 19 6 3 1 5 2,3 4 h3 6,16 17H,1 2H2, H3,11,13,14,18 3 H3,1,2,3,4 t4 ,5 ,6? m0... s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey LOQVEVDWWPCIJG OKGDMBFWSA N CASNo PubChem 65103 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 19969413 SMILES C1C C OC1N2C NC3 C2NC NC3 O N COP O O OP O O OP O O O O Section2 Chembox Properties Formula C sub 10 sub H sub 16 sub N sub 5 sub O sub 13 sub P sub 3 sub MolarMass 507.181023 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxyguanosine triphosphate ref Lehninger4th ref dGTP is a nucleotide precursor used in cells for DNA replication DNA synthesis . The substance is used in the polymerase chain reaction technique, in sequencing , and in cloning . It is also the competitor of inhibition onset by acyclovir in the treatment of Herpes simplex virus HSV virus . ref name pmid6285704 cite journal author Furman PA, Lambe CU, Nelson DJ title Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1 journal Am. J. Med. volume 73 issue 1A pages 14 7 year 1982 month July pmid 6285704 doi url issn ref References reflist 2 Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxyguanosine Triphosphate Category Nucleotides Organic compound stub ca Trifosfat de desoxiguanosina de Desoxyguanosintriphosphat nl Deoxyguanosinetrifosfaat sr Dezoksiguanozin tr ... more details
The crystal structure of sodium triphosphate, Na5P3O10, phase I journal Acta Crystallographica volume .... last2 Corbridge first2 D. E. C. title The crystal structure of sodium triphosphate, Na5P3O10, phase ... Many related di , tri , and polyphosphates are known including the cyclic triphosphate P sub 3 sub ... agent . Image TriphosphateChelate.png thumb 180px left chelation of a metal cation by triphosphate ..., which in moderate amounts are nutritious. For example, Adenosine triphosphate ATP , a related derivative of triphosphate, is essential for life. Thus, the toxicity of polyphosphates is low, as the lowest ... more details
Orphan date January 2010 Chembox verifiedrevid 399339634 ImageFile 7,8 Dihydroneopterin triphosphate.png ImageSize 200px IUPACName OtherNames DHNTP Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 108735 InChI 1 C9H16N5O13P3 c10 9 13 7 5 8 17 14 9 12 3 1 11 7 6 16 4 15 2 25 29 21,22 27 30 23,24 26 28 18,19 20 h4,6,15 16H,1 2H2, H,21,22 H,23,24 H2,18,19,20 H4,10,11,13,14,17 t4 ,6 m1 s1 InChIKey DGGUVLXVLHAAGT XINAWCOVBB SMILES1 O P O O OP O O OP O O OC C H O C H O C 1 N C 2C O N C NC 2NC 1 N StdInChI Ref stdinchicite correct chemspider StdInChI 1S C9H16N5O13P3 c10 9 13 7 5 8 17 14 9 12 3 1 11 7 6 16 4 15 2 25 29 21,22 27 30 23,24 26 28 18,19 20 h4,6,15 16H,1 2H2, H,21,22 H,23,24 H2,18,19,20 H4,10,11,13,14,17 t4 ,6 m1 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey DGGUVLXVLHAAGT XINAWCOVSA N CASNo 17088 65 2 PubChem SMILES O C1C2 C NCC C H C H COP OP OP O O O O O O O O O N2 NC N N1 Section2 Chembox Properties C 9 H 16 N 5 O 13 P 3 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition 7,8 Dihydroneopterin triphosphate DHNTP is an intermediate in tetrahydrobiopterin biosynthesis . References Unreferenced date September 2009 Reflist DEFAULTSORT Dihydroneopterin triphosphate, 7,8 Category Organophosphates Category Pteridines organic compound stub ja 7,8 ... more details
Orphan date February 2009 chembox verifiedrevid 402880365 ImageFile xanthosine triphosphate.png ImageSize 200px IUPACName 2 R ,3 S ,4 R 5 2,6 dioxo 3 H purin 9 yl 3,4 dihydroxy 2 tetrahydrofuranyl methyl hydroxy phosphonooxyphosphoryl hydrogen phosphate OtherNames Section1 Chembox Identifiers InChI 1 C10H12N4O6.3H3O4P c15 1 3 5 16 6 17 9 20 3 14 2 11 4 7 14 12 10 19 13 8 4 18 3 1 5 2,3 4 h2 3,5 6,9,15 17H,1H2, H2,12,13,18,19 3 H3,1,2,3,4 t3 ,5 ,6 ,9 m1... s1 InChIKey BKBQKVXTMZOVRH CYCLDIHTBT StdInChI Ref stdinchicite correct chemspider StdInChI 1S C10H12N4O6.3H3O4P c15 1 3 5 16 6 17 9 20 3 14 2 11 4 7 14 12 10 19 13 8 4 18 3 1 5 2,3 4 h2 3,5 6,9,15 17H,1H2, H2,12,13,18,19 3 H3,1,2,3,4 t3 ,5 ,6 ,9 m1... s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey BKBQKVXTMZOVRH CYCLDIHTSA N CASNo 6253 56 1 PubChem 121887 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 19980202 SMILES OP O O O.OP O O O.OP O O O.O C3Nc2c ncn2 C H 1O C H CO C H O C H 1O C O N3 Section2 Chembox Properties Formula C sub 10 sub H sub 15 sub N sub 4 sub O sub 15 sub P sub 3 sub MolarMass 524.17 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Xanthosine 5 triphosphate XTP is a nucleotide that is not produced by and has no known function in living cells. Uses of XTP are, in general, limited to experimental procedures on enzymes that bind other nucleotides. See also Xanthosine Xanthosine monophosphate Nucleobases, nucleosides, and nucleotides Category Nucleotides Category Purines organic compound stub biochemistry stub ... more details
chembox verifiedrevid 407447572 Name Adenosine triphosphate ImageFile Adenosintriphosphat protoniert.svg ImageName Skeletal formula of ATP ImageFile1 ATP xtal 3D balls.png ImageName1 Ball and stick model, based on x ray diffraction data ImageFile2 Atp exp.qutemol ball.png ImageSize2 180px ImageName2 Space filling model with hydrogen atoms omitted IUPACName 2 R ,3 S ,4 R ,5 R 5 6 aminopurin 9 yl 3,4 dihydroxyoxolan 2 yl methyl hydroxyphosphonooxyphosphoryl hydrogen phosphate OtherNames adenosine 5 tetrahydrogen triphosphate Section1 Chembox Identifiers UNII Ref fdacite correct FDA UNII 8L70Q75FXE InChI 1 C10H16N5O13P3 c11 8 5 9 13 2 12 8 15 3 14 5 10 7 17 6 16 4 26 10 1 25 30 21,22 28 31 23,24 27 29 18,19 20 h2 4,6 7,10,16 17H,1H2, H,21,22 H,23,24 H2,11,12,13 H2,18,19,20 t4 ,6 ,7 ,10 m1 s1 SMILES ... salt br decomposes Density 1.04 g cm sup 3 sup disodium salt pKa 6.5 Adenosine 5 triphosphate ... groups triphosphate . The phosphoryl groups, starting with the group closest to the ribose ... of adenosine 5 triphosphate to adenosine 5 diphosphate url http www.jbc.org cgi reprint 261 ... produces two molecules of carbon dioxide , one molecule of the ATP equivalent guanosine triphosphate ... colwidth 35em External links http www.cliffsnotes.com WileyCDA CliffsReviewTopic Adenosine Triphosphate ATP .topicArticleId 8741,articleId 8593.html CliffNotes Adenosine Triphosphate ATP http pubchem.ncbi.nlm.nih.gov summary summary.cgi?cid 5957 PubChem entry for Adenosine Triphosphate http www.genome.jp dbget bin www bget?cpd C00002 KEGG entry for Adenosine Triphosphate Nucleobases, nucleosides, and nucleotides Enzyme cofactors Neurotransmitters good article DEFAULTSORT Adenosine Triphosphate ... trifosfato eo Adenozina trifosfato eu Adenosin trifosfato fa fr Ad nosine triphosphate ... triphosphate sk Adenoz ntrifosf t sl Adenozin trifosfat sr sh Adenozin trifosfat su Ad nosin trifosfat fi Adenosiinitrifosfaatti sv Adenosintrifosfat th Adenosine triphosphate tr Adenozin ... more details
enzyme Name ADP thymidine kinase EC number 2.7.1.118 CAS number 82114 39 4 IUBMB EC number 2 7 1 118 GO code 0047628 image width caption In enzymology , an ADP thymidine kinase EC number 2.7.1.118 is an enzyme that catalysis catalyzes the chemical reaction ADP thymidine math rightleftharpoons math AMP thymidine 5 phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine diphosphate ADP and thymidine , whereas its two product chemistry products are adenosine monophosphate AMP and thymidine 5 phosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ADP thymidine 5 phosphotransferase . Other names in common use include ADP dThd phosphotransferase , and adenosine diphosphate thymidine phosphotransferase . References reflist 1 cite journal author Falke D, Labenz J, Brauer D, Muller WE date 1982 title Adenosine diphosphate thymidine 5 phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus induced deoxypyrimidine kinase journal Biochim. Biophys. Acta. volume 708 pages 99&ndash 103 pmid 6293576 issue 1 enzyme stub Kinases Category EC 2.7.1 Category Enzymes of unknown structure ... more details
enzyme Name AMP thymidine kinase EC number 2.7.1.114 CAS number 60440 28 0 IUBMB EC number 2 7 1 114 GO code 0047667 image width caption In enzymology , an AMP thymidine kinase EC number 2.7.1.114 is an enzyme that catalysis catalyzes the chemical reaction AMP thymidine math rightleftharpoons math adenosine thymidine 5 phosphate Thus, the two substrate biochemistry substrates of this enzyme are adenosine monophosphate AMP and thymidine , whereas its two product chemistry products are adenosine and thymidine 5 phosphate . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is AMP thymidine 5 phosphotransferase . This enzyme is also called adenylate nucleoside phosphotransferase . References reflist 1 cite journal author Falke D, Labenz J, Brauer D, Muller WE date 1982 title Adenosine diphosphate thymidine 5 phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus induced deoxypyrimidine kinase journal Biochim. Biophys. Acta. volume 708 pages 99&ndash 103 pmid 6293576 issue 1 cite journal author Falke D, Nehrbass W, Brauer D, Muller WE date 1981 title Adenylic acid deoxythymidine 5 phosphotransferase evidence for the existence of a novel herpes simplex virus induced enzyme journal J. Gen. Virol. volume 53 pages 247&ndash 55 pmid 6267178 doi 10.1099 0022 1317 53 2 247 issue Pt 2 enzyme stub Category EC 2.7.1 Category Enzymes of unknown structure ... more details
PBB geneid 7083 Thymidine kinase 1, soluble gene name TK1 , is a human thymidine kinase . ref cite web title Entrez Gene Thymidine kinase 1, soluble url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... updates. PBB Summary section title summary text Interactions Thymidine kinase 1 has been shown ... D Y authorlink coauthors Chang Z F year 2001 month Jun. title Interaction of human thymidine kinase ... WP1601 highlight Thymidine kinase 1 References reflist Further reading refbegin 2 PBB Further ... in the promoter of the human thymidine kinase gene required for the G1 S regulated transcription ... Sadava D, Bernard B title Transition from cytosolic to mitochondrial thymidine kinase during development ... Co purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity ... of the human thymidine kinase gene. journal Gene volume 52 issue 2 3 pages 267 77 year 1987 pmid 3301530 ... thymidine kinase. Purification and physical characterization of the enzyme from HeLa cells journal ... JA, Kelly TJ title Genetic analysis of the human thymidine kinase gene promoter journal Mol. Cell ... HD, Deininger PL title Human thymidine kinase gene molecular cloning and nucleotide sequence ... title Localization and ordering of acid alpha glucosidase GAA and thymidine kinase TK1 by fluorescence ... phosphorylation of human thymidine kinase journal J. Biol. Chem. volume 273 issue 20 pages 12095 ... JF, Kristensen T, et al. title Valine, not methionine, is amino acid 106 in human cytosolic thymidine ... author Huang DY, Chang ZF title Interaction of human thymidine kinase 1 with p21 Waf1 journal Biochem ... 1221910 cite journal author Fujiwaki R, Hata K, Moriyama M, et al. title Clinical value of thymidine ... Thymidine kinase in epithelial ovarian cancer relationship with the other pyrimidine pathway enzymes ... detection of cytosolic thymidine kinase and proliferating cell nuclear antigen in breast cancer journal ... sequence of thymidine kinase 1 in breast and colorectal cancer journal Int. J. Biol. Markers volume ... more details
Pfam box Symbol Herpes TK Name Thymidine kinase from herpesvirus image PDB 1kim EBI.jpg width caption Structure of thymidine kinase from herpesvirus. ref name pmid9715911 cite journal author Champness JN, Bennett MS, Wien F, et al. title Exploring the active site of herpes simplex virus type 1 thymidine kinase by X ray crystallography of complexes with aciclovir and other ligands journal Proteins volume 32 issue 3 pages 350 61 year 1998 month August pmid 9715911 doi 10.1002 SICI 1097 0134 19980815 32 3 350 AID PROT10 3.0.CO 2 8 url ref Pfam PF00693 InterPro IPR001889 SMART PROSITE SCOP 1kin TCDB OPM family OPM protein PDB PDB3 1e2p B 56 330 PDB3 1e2j B 56 330 PDB3 1vtk 56 330 PDB3 1of1 B 56 330 PDB3 1e2l A 56 330 PDB3 1e2k A 56 330 PDB3 1p7c A 56 330 PDB3 1e2m B 56 330 PDB3 1ki6 A 56 330 PDB3 1e2h B 56 330 PDB3 3vtk 56 330 PDB3 1e2n A 56 330 PDB3 1e2i B 56 330 PDB3 2vtk 56 330 PDB3 1osn C 19 299 PDB3 1p72 A 32 309 PDB3 1p75 B 32 309 PDB3 1p73 D 32 309 PDB3 1p6x A 32 309 Thymidine kinase from herpesvirus is a protein family sub family of thymidine kinase s. ref name pmid7552712 cite journal author Brown DG, Visse R, Sandhu G, Davies A, Rizkallah PJ, Melitz C, Summers WC, Sanderson MR title Crystal structures of the thymidine kinase from herpes simplex virus type 1 in complex with deoxythymidine and ganciclovir journal Nat. Struct. Biol. volume 2 issue 10 pages 876 81 year 1995 month October pmid 7552712 doi 10.1038 nsb1095 876 url issn ref Its presence in herpesvirus infected cells is used to activate a range of antivirals against herpes infection , and thus specifically target the therapy towards infected cells only. Such antivirals include Purine analogue s of guanine Aciclovir , Famciclovir , Ganciclovir , Penciclovir , Valaciclovir , Valganciclovir Vidarabine Pyrimidine analogue s of uridine Idoxuridine , Trifluridine Brivudine References Reflist DNA antivirals Category Protein domains protein stub ... more details
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