Infobox disease Name Thrombocytopenia Image Caption DiseasesDB 27522 ICD10 ICD10 D 69 6 d 65 , ICD10 ... 000586 eMedicineSubj eMedicineTopic MeshID D013921 Thrombocytopenia thrombopenia in short is the presence ... indicate disease. One common definition of thrombocytopenia is a platelet count below 50,000 ... anywhere on the body from a traumatic injury. A person with thrombocytopenia may also complain of malaise, fatigue and general weakness with or without accompanying blood loss . In acquired thrombocytopenia ... virus viral or bacterial infection Dengue fever can cause thrombocytopenia by direct infection of bone ... Congenital amegakaryocytic thrombocytopenia CAMT Thrombocytopenia absent radius syndrome Fanconi anemia ... of thrombocytopenia, pale blue leuckocyte inclusions, and giant platelets Grey platelet syndrome Alport ... SLE Post transfusion purpura Neonatal alloimmune thrombocytopenia NAITP Splenic sequestration ... and immunological platelet destruction HIV associated thrombocytopenia ref name pmid11914001 cite journal author Scaradavou A title HIV related thrombocytopenia journal Blood Rev. volume 16 issue 1 ... retrieve pii S0268960X01901882 ref Medication induced Thrombocytopenia inducing medications include ... chemotherapy drugs H2 blocker s and Proton pump inhibitor s have shown increased Thrombocytopenia symptoms ..., Pantoprazole Induced Thrombocytopenia url http www.theannals.com cgi content abstract 40 4 758 .... Heparin induced thrombocytopenia HIT is the classic example of this phenomenon. In HIT, the heparin ... explain why severe thrombocytopenia is not a common feature of HIT. Abciximab induced thrombocytopenia. More extensive lists of thrombocytopenia inducing medications are available. ref name urlmoon.ouhsc.edu ... K, Maekawa T. 2005. Viper Agkistrodon halys blomhoffii mamushi bite with remarkable thrombocytopenia ... or peripheral destruction. Thrombocytopenia in hospitalized alcoholics may be caused by splenomegaly ... tests to determine the platelet count and clotting function may also be done. In severe thrombocytopenia ... more details
unreferenced date February 2010 Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 O 99 1 o 94 ICD9 ICD9 649.3 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Gestational thrombocytopenia is a primarily benign condition of pregnancy of uncertain significance, believed to be related to idiopathic thrombocytopenic purpura . There are 5 criteria mild and asymptomatic thrombocytopenia no evidence of fetal thrombocytopenia development late in pregnancy no history of thrombocytopenia outside of pregnancy spontaneous resolution once the child is delivered References http emedicine.medscape.com article 272867 overview http www.haematologica.org cgi reprint 82 3 341.pdf http qjmed.oxfordjournals.org cgi content abstract 84 1 593 Pathology of pregnancy, childbirth and the puerperium Category Maternal disorders predominantly related to pregnancy ... more details
Infobox Disease Name Fetal and Neonatal Alloimmune Thrombocytopenia Image Caption DiseasesDB 33767 ICD10 ICD10 P 61 0 p 50 ICD9 ICD9 776.1 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 3256 eMedicine mult eMedicine2 med 3480 MeshName MeshNumber Neonatal Alloimmune Thrombocytopenia NAITP or NAIT or NAT for short or fetal and neonatal alloimmune thrombocytopenia , FNAIT , feto maternal alloimmune thrombocytopenia , FMAITP or FMAIT is a disease that affects fetus es and neonates newborns . Genetic ... ref Porcelijn L, Van den Akker ES, Oepkes D. Fetal thrombocytopenia Review . Semin Fetal Neonatal ... data patho GB uk NAIT.pdf work Orphanet Encyclopedia title Fetal and Neonatal Alloimmune Thrombocytopenia ... Diagnosis of Neonatal Alloimmune Thrombocytopenia Using Allele Specific Oligonucleotide Probes ... in pregnancy for fetal or neonatal alloimmune thrombocytopenia systematic review. BJOG 2010 Jul 8. Epub ahead of print ref Signs and Symptoms Frequently, the thrombocytopenia is mild and the affected .... In case of severe thrombocytopenia, the neonates may exhibit hemorrhagic complication at or a few ... pregnancy in up to 50 of cases, and the affected fetuses may develop severe thrombocytopenia 50,000 L very early during pregnancy. Usually, the thrombocytopenia increases as gestation progresses. In utero ... the effects of NAIT in infants and reduce the severity of thrombocytopenia. The most common treatment .... ref cite web url http www.emedicine.com med topic3256.htm work eMedicine title Immune Thrombocytopenia ... and neonatal alloimmune thrombocytopenia safe and effective. BJOG 2007 Apr 114 4 469 73. ref In some ... cases it has been shown to reduce the severity of thrombocytopenia in some. Also it is suspected ... thrombocytopenia 30x10 sup 9 sup L is the transfusion of compatible platelets i.e. platelets from a donor who, like the mother lacks the causative antigen . Additionally if the thrombocytopenia ... Neonatal Alloimmune Thrombocytopenia Category Blood disorders Category Obstetrics Category Pediatrics ... more details
Infobox Disease Name Congenital amegakaryocytic thrombocytopenia Image Caption DiseasesDB ICD10 ICD9 ICD9 287.33 , ICD9 287.5 ICDO OMIM 604498 MedlinePlus eMedicineSubj eMedicineTopic MeshID Congenital amegakaryocytic thrombocytopenia CAMT is a rare inherited disorder. ref name pmid11133753 cite journal author Ballmaier M, Germeshausen M, Schulze H, et al. title c mpl mutations are the cause of congenital amegakaryocytic thrombocytopenia journal Blood volume 97 issue 1 pages 139 46 year 2001 month January pmid 11133753 doi 10.1182 blood.V97.1.139 url http www.bloodjournal.org cgi pmidlookup?view long&pmid 11133753 ref ref name pmid16470591 cite journal author Germeshausen M, Ballmaier M, Welte K title MPL mutations in 23 patients suffering from congenital amegakaryocytic thrombocytopenia the type of mutation predicts the course of the disease journal Hum. Mutat. volume 27 issue 3 pages 296 year 2006 month March pmid 16470591 doi 10.1002 humu.9415 ref ref name pmid18240171 cite journal author Rose MJ, Nicol KK, Skeens MA, Gross TG, Kerlin BA title Congenital amegakaryocytic thrombocytopenia the diagnostic importance of combining pathology with molecular genetics journal Pediatr Blood Cancer volume 50 issue 6 pages 1263 5 year 2008 month June pmid 18240171 doi 10.1002 pbc.21453 ref Presentation The primary manifestations are thrombocytopenia and megakaryocytopenia , or low numbers of platelets and megakaryocytes. There is an absence of megakaryocytes in the bone marrow with no associated ... author Freedman MH, Estrov Z title Congenital amegakaryocytic thrombocytopenia an intrinsic hematopoietic ... mpl gene in congenital amegakaryocytic thrombocytopenia journal Proc. Natl. Acad. Sci. date 1999 volume ... thrombocytopenia journal Blood. date 2001 volume 97 pages 139 46 doi 10.1182 blood.V97.1.139 pmid ... M, Strauss G, Welte K, Ballmaier M title Congenital amegakaryocytic thrombocytopenia a retrospective ... External links http www.marrowfailure.cancer.gov index.html Amegakaryocytic Thrombocytopenia research ... more details
Severe fever with thrombocytopenia syndrome SFTS is an emerging infectious disease recently discovered in northeast and central China. SFTS cause high fatality rate of 12 and as high as 30 in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia low platelet count , leucopenia low white blood cell count , and elevated liver enzyme level. SFTS occurs in rural areas from March to November and a majority of cases are from April to July. In 2009 Xue jie Yu and colleagues isolated the SFTS virus SFTSV from SFTS patients blood. SFTSV is a Phlebovirus in the family of Bunyaviridae. The life cycle of the SFTSV most likely involves arthropod vectors and animal hosts. Humans are accidental hosts and play no role in the life cycle of the SFTSV. SFTSV has been detected from Haemaphysalis longicornis ticks. The transmission routine of SFTSV is unknown, but person to person transmission either plays no role or at least is not an important routine of transmission of SFTSV. 1 edit References1. Xue jie Yu et al. Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China. N Engl J Med. 2011 Mar 16. Epub ahead of print Retrieved from http www.nejm.org doi full 10.1056 NEJMoa1010095 Category Arthropod borne viral fevers and viral haemorrhagic fevers Category Bunyaviruses Category Insect borne diseases Category Zoonoses fr Syndrome de fi vre s v re avec thrombocytop nie ... more details
Infobox Disease Name Heparin induced thrombocytopenia Image PBB Protein PF4 image.jpg Alt Caption A schematic drawing of platelet factor 4, which when bound to heparin leads to an immune response in HIT ... eMedicineSubj article eMedicineTopic 1357846 MeshID Not coded Heparin induced thrombocytopenia HIT is the development of thrombocytopenia a low platelet count , due to the administration of various ... thrombocytopenia and thrombosis HITT . HIT is caused by the formation of abnormal antibody antibodies ... journal author Ahmed I, Majeed A, Powell R title Heparin induced thrombocytopenia diagnosis and management ... induced thrombocytopenia a historical perspective journal Blood volume 112 issue 7 pages 2607 16 year ... thrombocytopenia . However, it is generally not low enough to lead to an increased risk of bleeding ... name Ahmed ref name Warkentin2006 HIT antibodies have been found in individuals with thrombocytopenia ... RM, Kelton JG year 2008 title A spontaneous prothrombotic disorder resembling heparin induced thrombocytopenia ... of blood clots the platelet count falls as a result, leading to thrombocytopenia. ref name Ahmed ..., but only a proportion of these develop thrombocytopenia or thrombosis. ref name Ahmed This has been ... induced thrombocytopenia journal Br. J. Haematol. volume 133 issue 3 pages 259 69 year 2006 ... heparin turn out to have HIT. The timing, severity of the thrombocytopenia, the occurrence ... 1 497 ref Thrombocytopenia 2 points if the fall in platelet count is 50 of the previous value, or the lowest ... induced thrombocytopenia a critical review journal Arch Intern Med volume 164 issue 4 pages 361 ... occurred together with thrombocytopenia was reported in 1969 ref cite journal author Natelson EA, Lynch EC, Alfrey CP, Gross JB title Heparin induced thrombocytopenia. An unexpected response ... author Rhodes GR, Dixon RH, Silver D title Heparin induced thrombocytopenia with thrombotic and hemorrhagic ... between two forms of heparin induced thrombocytopenia type 1 mild, non immune mediated and self limiting ... more details
CAMT may refer to Center for Arts Management and Technology Thrombocytopenia Congenital Amegakaryocytic Thrombocytopenia Commission on Accreditation of Medical Transport Systems disambig ... more details
NAIT stands for North American Islamic Trust , an organization in Plainfield, Indiana, that owns Islamic properties Northern Alberta Institute of Technology Neonatal alloimmune thrombocytopenia National Association of Industrial Technology disambig ... more details
HITT can refer to Heparin induced thrombocytopenia , a type of disease HITT Production , a Turkey Turkish record label People Bryan Hitt , the drummer of American rock band REO Speedwagon Jack Hitt , an American author John Hitt , the president of the University of Central Florida disambig ... more details
Multifocal lymphangioendotheliomatosis also known as Congenital cutaneovisceral angiomatosis with thrombocytopenia, ref name Bolognia and Multifocal Lymphangioendotheliomatosis with thrombocytopenia ref name Bolognia cite book author Rapini, Ronald P. Bolognia, Jean L. Jorizzo, Joseph L. title Dermatology 2 Volume Set publisher Mosby location St. Louis year 2007 pages isbn 1 4160 2999 0 oclc doi accessdate ref presents at birth with hundreds of red brown plaques as large as several centimeters. ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 596 See also Skin lesion List of cutaneous conditions References reflist Dermal growth stub Vascular tumors Category Dermal and subcutaneous growths ... more details
Taxobox Color parameter is not needed automatically assigned name Phleboviruses virus group v ordo Unassigned familia Bunyaviridae genus Phlebovirus SFTSV is a Phlebovirus in the family of Bunyaviridae . ref Xue jie Yu et al. Fever with thrombocytopenia asshociated with a novel Bunyavirus in China. N Engl J Med. 2011 Mar 16. Epub ahead of print ref It appears to be more closely related to the Uukuniemi virus serogroup than to the Sandfly fever group. It may be the prototype of a new serogroup within the Phlebovirus genus as it is only distantly related to both the existing serogroups. The clinical condition it causes is known as severe fever with thrombocytopenia syndrome SFTS . SFTS is an emerging infectious disease recently described in northeast and central China. SFTS has a fatality rate of 12 and as high as 30 in some areas. The major clinical symptoms of SFTS are fever, vomiting, diarrhea, multiple organ failure, thrombocytopenia low platelet count , leucopenia low white blood cell count and elevated liver enzyme levels. History In 2009 Xue jie Yu and colleagues isolated the SFTS virus SFTSV from SFTS patients blood. ref Xue jie Yu et al. Fever with thrombocytopenia associated with a novel Bunyavirus in China. N Engl J Med. 2011 Mar 16. Epub ahead of print ref Life cycle The life cycle of the SFTSV is not yet known but seems most likely to involve arthropod vectors and mammaliam hosts including cat s, mouse mice , hedgehog s, weasle s, possum s and yak s. Humans appear to be accidental hosts and play no role in the life cycle of the SFTSV. SFTSV has been detected from the ixoid tick , Haemaphysalis longicornis . The transmission routine of SFTSV is unknown, but person to person transmission either plays no role or at least is not an important routine of transmission of SFTSV. Epidemiology This virus has been found in Anhui , Henan , Hubei , Jiangsu , Liaoning and Shandong . SFTS occurs in rural areas from March to November and a majority of cases are from Apri ... more details
Infobox disease Name TAR Syndrome br Thrombocytopenia br with Absent Radius Image Caption DiseasesDB 29769 ICD10 ICD10 Q 87 2 q 80 ICD9 ICD9 287.33 ICDO OMIM 274000 MedlinePlus eMedicineSubj eMedicineTopic MeshID TAR Syndrome Thrombocytopenia with Absent radius is a rare genetic disorder which is characterized by the absence of the Radius bone radius bone in the forearm, and a dramatically reduced platelet count. This syndrome may occur as a part of the 1q21.1 deletion syndrome Presentation Symptoms of thrombocytopenia , or a lowered platelet count, leads to bruising and potentially life threatening hemorrhage . Other common links between people with TAR seem to include heart problems, kidney problems, knee joint problems, frequently lactose intolerance and often thumb hypoplasia File Chromosome 1 to 1q21.1.jpg thumb right 500px The structure of 1q21.1 Treatment Treatments range from platelet transfusions to surgery aimed at normalizing the appearance of the arm, which is much shorter and clubbed. There is some controversy surrounding the role of surgery. The infant mortality rate has been curbed by new technology, including platelet transfusions, which can even be performed in utero . The critical period is the first year of life. For most people with TAR, platelet counts improve as they grow out of childhood. Genetics Genetic research is underway. A 2007 research article identified a region of chromosome 1, 1q21.1, containing 11 genes including HFE2 , LIX1L , PIAS3 , ANKRD35 , ITGA10 , RBM8A , PEX11B , POLR3GL , TXNIP , and GNRR2 , that is heterozygously deleted in thirty of thirty patients with TAR. ref cite journal author Klopocki E, Schulze H, Strauss G, et al. title Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia ... index.html Thrombocytopenia Absent Radii research study of Inherited Bone Marrow ... NCBI NIH UW entry on Thrombocytopenia Absent Radius Syndrome Myeloid hematologic disease Multiple ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 M 31 1 m 30 ICD9 ICD9 446.6 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Thrombotic microangiopathies are a category of pathologies that result in thrombosis in capillaries and arterioles . ref DorlandsDict five 000066226 thrombotic microangiopathy ref This process leads to thrombocytopenia and a variety of other symptoms such as anemia , purpura , renal failure some , schistocytes fragmented blood cells severed by fibrin products and ischemic injury to cells. Categories Bacterial toxins are the primary cause of one category of thrombotic microangiopathy known as HUS or hemolytic uremic syndrome . The other major category is TTP or thrombotic thrombocytopenic purpura caused by autoimmune or hereditary dysfunctions that activate the coagulation cascade or the complement system . Some sources group TTP and HUS together ref http www.merck.com mmpe sec11 ch133 ch133g.html ref , while other sources express skepticism about their common pathophysiology. ref http www.emedicine.com emerg topic579.htm ref Presentation The clinical presentation typically includes fever , microangiopathic hemolytic anemia see schistocytes in a blood smear , renal failure , thrombocytopenia , neurological manifestations. See also microangiopathy References reflist pathology stub Myeloid hematologic disease Systemic vasculitis Category Histopathology Category Systemic connective tissue disorders ... more details
Unreferenced stub auto yes date December 2009 Cytopenia is a reduction in the number of blood cell s. It takes a number of forms Low red blood cell count resulting in anemia . Low white blood cell count leukopenia or neutropenia because neutrophil s make up at least half of all white cells, they are almost always low in leukopenia . Low platelet count thrombocytopenia . Low granulocyte count granulocytopenia Pathology granulocytopenia Low red blood cell, white blood cell, and platelet counts pancytopenia . See also Polycythemia , the opposite of cytopenia Category Hematology Med stub de Zytopenie it Citopenia ... more details
HIC may refer to Habitat International Coalition Head impact criterion , a measure of the likelihood of head injury generated by crash tests Henry Ian Cusick , an actor Heparin induced thrombocytopenia , a complication of heparin used post surgery. HiC , a C compiler and integrated development environment Hipparcos Input Catalogue , an astronomical catalogue Hot in Cleveland , a TV series United Nations Humanitarian Information Centers Hydrophobic Interaction Chromatography , a chemistry technique Hic may refer to The onomatopoeia for the sound made when hiccup ing See also Hi C disambiguation disambig ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 Y43.3 ICD9 ICD9 E933.1 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Hydroxyurea dermopathy is caused by chronic use of hydroxyurea for chronic myelogenous leukemia , thrombocytopenia, or psoriasis, and presents with skin lesion s characteristic of dermatomyositis . ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 135 See also Skin lesion List of cutaneous conditions References reflist Cutaneous condition stub External causes of morbidity and mortality Category Drug eruptions ... more details
syndrome WAS , X linked thrombocytopenia XLT , and X linked congenital neutropenia XLN . Sequence ... grading of severity ref name Jin cite doi 10.1182 blood 2003 05 1592 ref 0.5 intermittent thrombocytopenia 1.0 thrombocytopenia and small platelets microthrombocytopenia 2.0 microthrombocytopenia ... WASp . It was later discovered that the disease X linked thrombocytopenia XLT was also due to WASp mutations ... linked thrombocytopenia XLT and X linked congenital neutropenia XLN http www.primaryimmune.org publications ... more details
Infobox disease Name Griscelli syndrome type 2 Image Alt Caption DiseasesDB ICD10 ICD9 ICDO OMIM 607624 MedlinePlus eMedicineSubj eMedicineTopic MeshID GeneReviewsID GeneReviewsName Griscelli syndrome type 2 also known as Partial albinism with immunodeficiency is a rare autosomal recessive syndrome characterized by variable pigmentary dilution, hair with silvery metallic sheen, frequent pyogenic infections, neutropenia , and thrombocytopenia . ref name Andrews James, William Berger, Timothy Elston, Dirk 2005 . Andrews Diseases of the Skin Clinical Dermatology . 10th ed. . Saunders. ISBN 0 7216 2921 0. ref rp 866 See also Griscelli syndrome References reflist Cutaneous condition stub Pigmentation disorders Deficiencies of intracellular signaling peptides and proteins Category Disturbances of human pigmentation ... more details
Thrombopoiesis refers to the process of thrombocyte generation. ref MeshName Thrombopoiesis ref ref name pmid14443744 Cite journal author SCHULMAN I, PIERCE M, LUKENS A, CURRIMBHOY Z title Studies on thrombopoiesis. I. A factor in normal human plasma required for platelet production chronic thrombocytopenia due to its deficiency journal Blood volume 16 issue pages 943 57 year 1960 month July pmid 14443744 doi url http www.bloodjournal.org cgi pmidlookup?view long&pmid 14443744 ref Thromobocytes are ligations of the cytoplasm from megakaryocytes . A single megakaryocyte can give rise to thousands of thrombocytes. The term thrombocytopoiesis is sometimes used to emphasize the cellular nature. Thrombopoietin stimulates thrombopoiesis. References Reflist Blood physiology ca Trombocitog nesi es Trombopoyesis fr Thrombocytopo se Category Coagulation system medicine stub ... more details
Italic title Taxobox color lightgrey name Anaplasmataceae regnum Bacterium Bacteria phylum Proteobacteria classis Alpha Proteobacteria ordo Rickettsiales familia Anaplasmataceae genus Ehrlichia binomial Ehrlichia canis binomial authority Donatien and Lestoquard 1935 Moshkovski 1945 Ehrlichia canis is a species of Ehrlichia ref name pmid12873028 cite journal author Heeb HL, Wilkerson MJ, Chun R, Ganta RR title Large granular lymphocytosis, lymphocyte subset inversion, thrombocytopenia, dysproteinemia, and positive Ehrlichia serology in a dog journal J Am Anim Hosp Assoc volume 39 issue 4 pages 379 84 year 2003 pmid 12873028 doi url http www.jaaha.org cgi pmidlookup?view long&pmid 12873028 ref affecting dogs of all ages. References reflist Category Rickettsiales bacteria stub ... more details
expert date June 2010 morefootnotes date June 2010 Infobox Disease Name Phlegmasia cerulea dolens Image Caption DiseasesDB 32484 ICD10 ICD9 ICDO OMIM MedlinePlus 000200 eMedicineSubj med eMedicineTopic 2767 MeshID Phlegmasia cerulea dolens literally painful blue edema is an uncommon severe form of deep venous thrombosis which results from extensive Thrombosis thrombotic occlusion blockage by a blood clot of the major and the Arteriovenous anastomosis collateral veins of an extremity. It is characterized by sudden severe pain, swelling, cyanosis and edema of the affected limb. There is a high risk of massive pulmonary embolism , even under anticoagulation . Foot gangrene may also occur. An underlying malignancy is found in 50 of cases. This phenomenon was discovered by Jonathan Towne , a vascular surgeon in Milwaukee , who was also the first to report the white clot syndrome Now called HIT Heparin induced thrombocytopenia . Two of their HIT patients developed Phlegmasia cerulea dolens that went on to become gangrenous ref Heparin Induced Thrombocytopenia By Theodore E. Warkentin, Andreas Greinacher, Published 2004, ISBN 0824756258 ref . See also Phlegmasia alba dolens References references Cite journal title Images in Clinical Medicine Phlegmasia Cerulea Dolens last Barham first Kalleen coauthors Tina Shah date 2007 01 18 journal The New England Journal of Medicine volume 356 issue 3 pages e3 pmid 17229945 doi 10.1056 NEJMicm054730 DEFAULTSORT Phlegmasia Cerulea Dolens Category Inflammations Category Angiology disease stub de Phlegmasia coerulea dolens es Flegmasia cerulea dolens tr Phlegmasia coerulea dolens ... more details
drugbox type mab image mab type mab source zu o target CD154 CAS number 220651 94 5 ATC prefix none ATC suffix PubChem DrugBank chemical formula molecular weight bioavailability protein bound metabolism elimination half life excretion pregnancy AU pregnancy US pregnancy category legal AU legal CA legal UK legal US legal status routes of administration Ruplizumab trade name Antova is a humanize d monoclonal antibody intended for the treatment of rheumatic disease s like systemic lupus erythematosus and lupus nephritis . A study showed that the drug was associated with life threatening thromboembolism s, ref cite journal pmid 15046525 year 2004 last1 Liossis first1 SN last2 Sfikakis title Costimulation blockade in the treatment of rheumatic diseases volume 18 issue 2 pages 95 102 journal BioDrugs clinical immunotherapeutics, biopharmaceuticals and gene therapy first2 PP ref while another study only found thrombocytopenia . ref cite journal doi 10.1093 rheumatology kei118 pmid 16188945 year 2006 last1 Nakamura first1 M last2 Tanaka first2 Y last3 Satoh first3 T last4 Kawai first4 M last5 Hirakata first5 M last6 Kaburaki first6 J last7 Kawakami first7 Y last8 Ikeda first8 Y last9 Kuwana first9 M title Autoantibody to CD40 ligand in systemic lupus erythematosus association with thrombocytopenia but not thromboembolism volume 45 issue 2 pages 150 6 journal Rheumatology Oxford, England ref References reflist immunosuppressants Monoclonals for immune system monoclonal antibody stub antineoplastic drug stub ... more details
Onyalai is a form of thrombocytopenia that affects some of the population in areas of central Africa . ref name Onyalai cite web url http www.itg.be evde 45 Haematologyp6.htm title Onyalai work accessdate ref Onyalai exhibits similarities to idiopathic thrombocytopenic purpura ITP but differs in pathogenesis . The affected age range is from less than a year to 70 years and seems to not be gender specific in the same manner as ITP. Cases generally peak between 11 and 20 years old. Although the cause of onyalai is not known at this time, inadequate nutrition and or the consumption of tainted food are suspected. ref name Onyalai Signs and symptoms Onyalai is an acute disease that results in the development of hematoma on oral mucous membranes . Hemorrhagic lesion s may develop on the skin, including on the soles of the foot feet . ref name Onyalai The patient does not initially appear to be in distress, which may result in a delay of diagnosis. As the disease progresses, hematuria and melena will develop. Epistaxis , petechiae and ecchymoses are common symptoms, as are subconjunctival bleeding and menorrhagia . On average, bleeding will persist for approximately eight days, and may reoccur. ref name Onyalai Approximately 80 percent of cases will exhibit chronic thrombocytopenia. Periodic episodes of acute hemorrhage are also possible and may be severe, possibly leading to shock circulatory shock and death . ref name Onyalai References reflist Category Blood disorders circulatory stub Disease stub ... more details
FDA for prophylaxis or treatment of thrombosis in patients with heparin induced thrombocytopenia HIT ... Use in the Management of Heparin Induced Thrombocytopenia. Am J Cardiovasc Drugs 2009 9 4 261 82. http ... thrombocytopenia Argatroban is used as an anticoagulant in individuals with thrombosis and heparin induced thrombocytopenia. Often these individuals require long term anticoagulation. If warfarin is chosen .... title Transitioning from argatroban to warfarin therapy in patients with heparin induced thrombocytopenia ... more details
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