Chembox verifiedrevid 408972478 ImageFileL1 Pyridazine numbering.png ImageSizeL1 75px ImageFileR1 Pyridazine3d.png ImageSizeR1 100px IUPACName Pyridazine OtherNames 1,2 diazine, orthodiazine, oizine Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 8902 InChI 1 C4H4N2 c1 2 4 6 5 3 1 h1 4H InChIKey PBMFSQRYOILNGV UHFFFAOYAA ChEMBL Ref ebicite correct EBI ChEMBL 15719 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C4H4N2 c1 2 4 6 5 3 1 h1 4H StdInChIKey Ref stdinchicite correct chemspider StdInChIKey PBMFSQRYOILNGV UHFFFAOYSA N CASNo Ref cascite correct CAS CASNo 289 80 5 PubChem 9259 SMILES c1ccnnc1 RTECS GY2390000 Section2 Chembox Properties Formula C 4 H 4 N 2 MolarMass 80.09 g mol Appearance colorless liquid Density 1.107 g cm sup 3 sup MeltingPtC 8 BoilingPtC 208 Solubility pKa 2.10 ref Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods , Academic Press, New York, 1955. ref pKb Section3 Chembox Hazards MainHazards FlashPt Autoignition Section8 Chembox Related OtherCpds pyridine , pyrimidine , pyrazine Pyridazine is a heteroaromatic organic compound with the molecular formula C sub 4 sub H sub 4 sub N sub 2 sub , sometimes called 1,2 diazine . It contains a six membered ring with two adjacent nitrogen atoms. It is a colorless liquid with a boiling point of 208 C. Pyridazine has no household use. It is mainly used in research and industry as building block for more complex compounds. The pyridazine structure is found within a number of herbicides such as credazine , pyridafol and pyridate . It is also found within the structure of several pharmaceutical drugs such as cefozopran , cadralazine , minaprine , pipofezine , hydralazine , and cilazapril . References references Category Pyridazines de Pyridazin fr Pyridazine nl Pyridazine pt Piridazina ja sv Pyridazin ... more details
The molecular formula C sub 4 sub H sub 4 sub N sub 2 sub may refer to Pyrazine Pyridazine Pyrimidine Succinonitrile MolFormDisambig fr C4H4N2 ... more details
Distinguish Diazene Unreferenced date December 2009 Diazine refers to a group of organic compound s having the molecular formula C sub 4 sub H sub 4 sub N sub 2 sub . Each contains a benzene ring in which two of the C H fragments have been replaced by isolobal nitrogen. There are three isomer s pyrazine 1,4 diazine image pyrazine simple structure.svg pyrimidine 1,3 diazine image Pyrimidin.svg pyridazine 1,2 diazine image pyridazine simple structure.svg Category Diazines de Diazine es Diazina fr Diazine it Diazine nl Diazine ja pt Diazina ru sv Diazin zh ... more details
chembox Reference ref Merck Index , 11th Edition, 7344 . ref ImageFile Phthalazin Phthalazine.svg ImageSize 180px IUPACName Phthalazine OtherNames Benzo orthodiazine br 2,3 Benzodiazine br Benzo d pyridazine Section1 Chembox Identifiers CASNo 253 52 1 PubChem 9207 SMILES C1 CC C2C NN CC2 C1 Section2 Chembox Properties Formula C sub 8 sub H sub 6 sub N sub 2 sub MolarMass 130.15 g mol Appearance Pale yellow needles Density MeltingPt 90 91 C BoilingPt 315 317 C decomposition Solubility Miscible pKa 3.39 ref Brown, H.C., et al., in Baude, E.A. and Nachod, F.C., Determination of Organic Structures by Physical Methods , Academic Press, New York, 1955. ref Section3 Chembox Hazards MainHazards FlashPt Autoignition Phthalazine , also called benzo orthodiazine or benzopyridazine, is a heterocyclic organic compound with the molecular formula C sub 8 sub H sub 6 sub N sub 2 sub . It is isomer ic with quinoxaline , cinnoline and quinazoline . Synthesis Phthalazine can be obtained by the condensation reaction condensation of w tetrabromorthoxylene with hydrazine , or by the Redox reduction of chlorphthalazine with phosphorus and hydroiodic acid . Properties It possesses base chemistry basic properties and forms addition products with alkyl iodide s. Reactions Upon oxidation with alkaline potassium permanganate it yields pyridazine dicarboxylic acid . Zinc and hydrochloric acid decompose it with formation of orthoxylylene diamine. The keto hydro derivative phthalazone C sub 8 sub H sub 6 sub ON sub 2 sub , is obtained by condensing hydrazine with orthophthalaldehydoacid. On treatment with phosphorus oxychloride , it yields a chlorphthalazine, which with zinc and hydrochloric acid gives isoindole C sub 8 sub H sub 7 sub N , and with tin and hydrochloric acid, phthalimidine C sub 8 sub H sub 7 sub ON , the second nitrogen atom being eliminated as ammonia . References reflist 1911 Category Phthalazines ... more details
drugbox IUPAC name 3 methyl 6 3 trifluoromethyl phenyl 1,2,4 triazolo 3,4 f pyridazine image CL 218,872.svg width 140 CAS number 66548 69 4 ATC prefix ATC suffix PubChem 107950 DrugBank C 13 H 9 F 3 N 4 molecular weight 278.233 g mol bioavailability protein bound metabolism elimination half life excretion pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration CL 218,872 is a sedative and hypnotic drug used in scientific research. ref Moreau S, Coudert P, Rubat C, Gardette D, Vallee Goyet D, Couquelet J, Bastide P, Tronche P. Synthesis and anticonvulsant properties of new benzylpyridazine derivatives. Journal of Medicinal Chemistry . 1994 Jul 8 37 14 2153 60. ref ref Karolak Wojciechowska J, Lange J, Kwiatkowski W, Gniewosz M, Plenkiewicz J. Bicyclic b heteroannulated pyridazine derivatives II. Structure activity relationships in the 6 aryltriazolo 4,3 b pyridazine ligands of the benzodiazepine receptor. Bioorganic and Medicinal Chemistry . 1994 Aug 2 8 773 9. ref It has similar effects to sedative hypnotic benzodiazepine drugs such as triazolam , but is structurally distinct and so is classed as a nonbenzodiazepine hypnotic. CL 218,872 is a GABA A receptor GABA sub A sub partial agonist which is selective for the 1 subtype. ref Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ. Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. European Journal of Pharmacology . 1995 Nov 30 291 3 301 9. ref ref Araujo F, Tan S, Ruano D, Schoemaker H, Benavides J, Vitorica J. Molecular and pharmacological characterization of native cortical gamma aminobutyric acidA receptors containing both alpha1 and alpha3 subunits. Journal of Biological Chemistry . 1996 Nov 1 271 44 27902 11. ref ref Atack JR, Smith AJ, Emms ... more details
Drugbox verifiedrevid 406011923 IUPAC name 6 benzoyl 3 hydrazinyl 5 H ,6 H ,7 H ,8 H pyrido 4,3 c pyridazine image Endralazine.png CAS number 39715 02 1 ATC prefix C02 ATC suffix DB03 PubChem 47608 DrugBank KEGG Ref keggcite correct kegg KEGG D08254 chemical formula molecular weight 269.30 g mol C 14 H 15 N 5 O 1 protein bound metabolism elimination half life excretion pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL, P, POM, CD, or Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Endralazine is an antihypertensive of the hydrazine chemical class . See also Cadralazine Dihydralazine Hydralazine Nonsympatholytic vasodilatory antihypertensives Hydrazines Category Hydrazines Category Antihypertensive agents Category Amides Category Pyridazines antihypertensive stub es Endralazina ... more details
Unreferenced date December 2009 Orphan date December 2009 border 0 cellpadding 5 cellspacing 0 style margin 1em float right class wikitable colspan 3 Basic aromatic ring systems align center valign bottom Image Pyridine structure.png 67px br Pyridine Image Quinoline structure.png 119px br Quinoline Image Isoquinoline structure.png 126px br Isoquinoline align center valign bottom Image Acridine structure.png 171px br Acridine align center valign bottom Image Pyrazine structure.png 67px br Pyrazine Image Quinoxaline structure.png 119px br Quinoxaline align center valign bottom Image Imidazole structure.png 63px br Imidazole Image Benzimidazole structure.png 113px br Benzimidazole Image Purine structure.png 113px br Purine align center valign bottom Image Pyrazole structure.png 70px br Pyrazole Image Indazole structure.png 120px br Indazole align center valign bottom Image Pyrimidine structure.png 74px br Pyrimidine Image Quinazoline structure.png 126px br Quinazoline align center valign bottom Image Pyridazine structure.png 74px br Pyridazine Image Cinnoline structure.png 126px br Cinnoline Basic aromatic rings are simple aromatic ring aromatic rings in which the lone pair of electron s of a ring nitrogen atom is not part of the aromatic system and extends in the plane of the ring. This lone pair is responsible for the Base chemistry basicity of these nitrogenous base s, similar to the nitrogen atom in amine s. In these compounds the nitrogen atom is not connected to a hydrogen atom. Basic aromatic compounds get Protonation protonated and form aromatic cation s e.g. pyridinium under acid ic conditions. Typical examples of basic aromatic rings are pyridine or quinoline . Several rings contain basic as well as non basic nitrogen atoms, e.g. imidazole and purine . In non basic aromatic rings the lone pair of electron s of the nitrogen atom is delocalized and contributes to the aromatic pi electron system. In these compounds the nitrogen atom is connected to a hydrogen at ... more details
distinguish Tetrazene Image 1,2,3,4 tetrazine numbering.png thumb right 100px Structure of 1,2,3,4 tetrazine Image 1,2,4,5 tetrazine numbering.png thumb right 100px Structure of 1,2,4,5 tetrazine Tetrazine is an unstable Chemical compound compound that consists of a six membered aromatic ring containing four nitrogen atoms with the molecular formula Carbon C sub 2 sub Hydrogen H sub 2 sub Nitrogen N sub 4 sub . The name tetrazine is used in the IUPAC nomenclature nomenclature of derivatives of this compound. Three core ring isomer s exist 1,2,3,4 tetrazines , 1,2,3,5 tetrazines and 1,2,4,5 tetrazines . 1,2,3,4 tetrazines 1,2,3,4 Tetrazines are often isolated fused to an aromatic ring system and are stabilized as the dioxide derivatives. 1,2,4,5 tetrazine 1,2,4,5 Tetrazines are very well known and myriad 3,6 disubstituted 1,2,4,5 tetrazines are known. ref see United States Patent 6645325 ref These materials are of use in the area of energetic chemistry. The compound 3,6 di 2 pyridyl 1,2,4,5 tetrazine ref Datasheet http www.sigmaaldrich.com catalog search ProductDetail ALDRICH 403547 Link ref has two pyridine substituents and is of importance as a reagent in Diels Alder reaction s. It reacts with norbornadiene in a sequence of one DA reactions and two retro DA reactions to cyclopentadiene and a pyridazine with exchange of an acetylene unit Image DielsAlderCycloadditionDTP.png 500px reaction of norbornadiene with 3,6 di 2 pyridyl 1,2,4,5 tetrazine With norbornadiene fused to an arene the reaction stops at an intermediary stage ref Bond Screening in Benzonorbornadienes The Role of 7 Substituents in Governing the Facial Selectivity for the Diels Alder Reaction of Benzonorbornadienes with 3,6 Di 2 pyridyl s Tetrazine . Ronald N. Warrener and Peter A. Harrison Molecules journal Molecules 2001 , 6, 353 369 http www.mdpi.org molecules papers 60400353.pdf Online Article ref See also 6 membered rings with one nitrogen atom pyridine s 6 membered rings with two nitrogen atoms ... more details
Bazinaprine 3 2 morpholino ethyl amino 4 cyano 6 phenylpyridazine , also referred to as SR 95191 , is a monoamine oxidase inhibitor which is believed to be useful for the treatment of depression mood depression . The drug strongly inhibits type A monoamine oxidase , but only weakly inhibits type B. The effects of the drug are reversible in vivo , but not in vitro . ref name 88newderivative cite journal last Kan first JP coauthors Steinberg R, Leclercq J, Worms P, Biziere K. title Monoamine oxidase inhibiting properties of SR 95191, a new pyridazine derivative, in the rat evidence for selective and reversible inhibition of monoamine oxidase type A in vivo but not in vitro. journal Journal of Neurochemistry year 1988 month April volume 50 issue 4 pages 1137 44 pmid 3346672 url http www.ncbi.nlm.nih.gov pubmed 3346672 accessdate 7 February 2011 ref In studies, the chemical has been shown to not interact in vivo with other neurotransmitter or drug receptor sites. ref name 87MAOI cite journal last Kan first JP coauthors Kan JP, Steinberg R, Mouget Goniot C, Worms P, Bizi re K. title SR 95191, a selective inhibitor of type A monoamine oxidase with dopaminergic properties. II. Biochemical characterization of monoamine oxidase inhibition. journal The Journal of Pharmacology and Experimental Theraputics year 1987 month January volume 240 issue 1 pages 251 8 pmid 3100771 url http www.ncbi.nlm.nih.gov pubmed 3100771 accessdate 7 February 2011 ref References reflist pharma stub Category Monoamine oxidase inhibitors Category Antidepressants ... more details
TPA may refer to Science and medicine Texas Pharmacy Association , the voice of pharmacy and pharmacists in Texas Tissue plasminogen activator tPA , a fibrinolytic enzyme in biochemistry and medicine Toronto Paramedic Association , a group of paramedics based in Toronto Transpalatal arch , an orthodontic device Two photon absorption 12 O tetradecanoylphorbol 13 acetate Tetradecanoylphorbol Acetate , a tumor promoter employed in biomedical research Computing u t u rans u p u arency u a u dapter, part of an image scanner Chemistry Terephthalic acid , an aromatic acid and monomer for Aramid Tissue plasminogen activator tPA , a fibrinolytic enzyme in biochemistry and medicine TPA 023 , 7 1,1 Dimethylethyl 6 2 ethyl 2H 1,2,4 triazol 3 ylmethoxy 3 2 fluorophenyl 1,2,4 triazolo 4,3 b pyridazine, an experimental anxiolytic drug 12 O tetradecanoylphorbol 13 acetate Tetradecanoylphorbol Acetate , a tumor promoter employed in biomedical research Television Televis o P blica de Angola , the state owned TV station in Angola initials in Portuguese Television Programs of America , a television production company of the 1950s Transport Tampa International Airport IATA code Tanzania Ports Authority Toronto Parking Authority , a corporation owned by the City of Toronto that operates municipal parking lot Toronto Port Authority , a Canadian agency that manages port operations Traffic Pattern Altitude, an altitude on which airfield traffic pattern is flown Other TaxPayers Alliance , a British free market lobby group Tempe Preparatory Academy , a preparatory secondary school in Arizona, USA Thickened pyrophoric agent , an incendiary weapon Third party access , a competition principle regarding natural resources Third party administrator , financial transaction administrator that handles retirement plans, health insurance, self insurance Tonne s per annum Tons per acre, wine grape production term for estimating yield wine yield TPA Flight 028 , the second album by Canadian indie rock gro ... more details
Drugbox verifiedrevid 408802699 IUPAC name 1,2 dihydro 1,5 dimethyl 2 phenyl 3 H pyrazol 3 one image Phenazone.svg width 200 UNII Ref fdacite correct FDA UNII T3CHA1B51H InChI 1 C11H12N2O c1 9 8 11 14 13 12 9 2 10 6 4 3 5 7 10 h3 8H,1 2H3 InChIKey VEQOALNAAJBPNY UHFFFAOYAS ChEMBL Ref ebicite correct EBI ChEMBL 277474 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C11H12N2O c1 9 8 11 14 13 12 9 2 10 6 4 3 5 7 10 h3 8H,1 2H3 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey VEQOALNAAJBPNY UHFFFAOYSA N CAS number 60 80 0 CASNo Ref cascite correct CAS ATC prefix N02 ATC suffix BB01 ATC supplemental ATC S02 DA03 PubChem 2206 DrugBank DB01435 ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 2121 KEGG Ref keggcite correct kegg KEGG D01776 C 11 H 12 N 2 O 1 molecular weight 188.226 g mol synonyms analgesine, antipyrine bioavailability metabolism elimination half life excretion pregnancy category legal status routes of administration smiles O C2 C C N N2c1ccccc1 C C Phenazone International Nonproprietary Name INN , phenazon , antipyrine United States Adopted Name USAN , or analgesine is an analgesic and antipyretic . It was first synthesized by Ludwig Knorr in 1883. ref Cite journal doi 10.1016 S1366 0071 97 80033 2 title The early history of non opioid analgesics year 1997 last1 Brune first1 K journal Acute Pain volume 1 pages 33 ref It is formed by reducing diortho dinitrodiphenyl with sodium amalgam and methyl alcohol , or by heating diphenylene ortho dihydrazine with hydrochloric acid to 150 C. It crystal lizes in needles which melt at 156 C. Potassium permanganate oxidize s it to pyridazine tetracarboxylic acid. Adverse effects Possible adverse effects include fact date December 2009 Allergy to pyrazolone s Nausea Agranulocytosis Hepatotoxicity See also Propyphenazone A B Otic Drops , ear drops combined with benzocaine to relieve pain and remove cerumen References Reflist Analgesics Otologicals Category Analgesics Category Py ... more details
unreferenced date February 2011 drugbox Verifiedfields changed verifiedrevid 399716938 IUPAC name 1 S ,9 S 9 2 S 1 ethoxy 1 oxo 4 phenylbutan 2 yl amino 10 oxo octahydro 1 H pyridazino 1,2 a 1,2 diazepine 1 carboxylic acid image Cilazapril.svg ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 50830 InChI 1 C22H31N3O5.H2O c1 2 30 22 29 18 13 12 16 8 4 3 5 9 16 23 17 10 6 14 24 15 7 11 19 21 27 28 25 24 20 17 26 h3 5,8 9,17 19,23H,2,6 7,10 15H2,1H3, H,27,28 1H2 t17 ,18 ,19 m0. s1 InChIKey JQRZBPFGBRIWSN YOTVLOEGBC smiles O C OCC C H N C H 2C O N1N CCC C H 1C O O CCC2 CCc3ccccc3.O StdInChI Ref stdinchicite correct chemspider StdInChI 1S C22H31N3O5.H2O c1 2 30 22 29 18 13 12 16 8 4 3 5 9 16 23 17 10 6 14 24 15 7 11 19 21 27 28 25 24 20 17 26 h3 5,8 9,17 19,23H,2,6 7,10 15H2,1H3, H,27,28 1H2 t17 ,18 ,19 m0. s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey JQRZBPFGBRIWSN YOTVLOEGSA N CAS number 88768 40 5 CAS supplemental 92077 78 6 ATC prefix C09 ATC suffix AA08 PubChem 56329 DrugBank KEGG Ref keggcite changed kegg KEGG D07699 C 22 H 33 N 3 O 6 molecular weight 435.514 g mol bioavailability protein bound metabolism elimination half life excretion pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S8 legal UK POM legal US OTC Rx only legal status routes of administration Oral Cilazapril is a pyridazine angiotensin converting enzyme inhibitor ACE inhibitor used for the treatment of hypertension and congestive heart failure . It is branded as Inhibace in Canada, Zapril in New Zealand, Vascace and Dynorm in Europe. According to http www.drugs.com drugs.com who have a partnership with the http www.fda.gov NewsEvents Newsroom PressAnnouncements ucm212844.htm US Food & drug Administration none of these are currently available in the United States as of May 2010. References Cilazapril monograph. Lexi Comp Online, Lexi Drugs Online, Lexi Comp Inc. Hudson, OH. Available at http crlonline.com crlonline . ... more details
drugbox IUPAC name 7 Cyclobutyl 6 2 ethyl 2H 1,2,4 triazol 3 ylmethoxy 3 phenyl 1,2,4 triazolo 4,3 b pyridazine image TP 13.png CAS number ATC prefix ATC suffix PubChem DrugBank C 19 H 19 N 7 O 1 molecular weight 361.400 g mol smiles C5CCC5c3cc2nnc c4ccccc4 n2nc3OCc1ncnn1C bioavailability protein bound metabolism elimination half life excretion pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration TP 13 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. It is a subtype selective partial agonist at GABA A receptor GABA sub A sub receptor s, binding selectively to GABA sub A sub receptor complexes bearing 2 and 3 subunits. ref McCabe C, Shaw D, Atack JR, Street LJ, Wafford KA, Dawson GR, Reynolds DS, Leslie JC. Subtype selective GABAergic drugs facilitate extinction of mouse operant behaviour. Neuropharmacology . 2004 Feb 46 2 171 8. PMID 14680756 ref It has modest anticonvulsant activity although less than that of diazepam , ref Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR. Differential contribution of GABA A receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands. Journal of Psychopharmacology . 2007 Jun 21 4 384 91. PMID 17092983 ref and its main effect is likely to be selective anxiolytic action, as seen with other related 2 3 preferring agonists such as L 838,417 . References references Anxiolytics Category Anxiolytics Category Ethers Category Triazoles Category Triazolopyridazines nervous system drug stub ... more details
chembox verifiedrevid 414056174 ImageFile Hexazine.svg ImageSize 220px ImageFile2 Hexazine3.png ImageSize2 220px IUPAC Hexazine OtherNames Hexaazabenzene Section1 Chembox Identifiers CASNO 7616 35 5 PubChem 11966278 SMILES n1 nn nn n1 InChI 1S N6 c1 2 4 6 5 3 1 InChIKey YRBKSJIXFZPPGF UHFFFAOYSA N Section2 Chembox Properties Formula N sub 6 sub MolarMass 84.0402 g mol Hexazine also known as hexaazabenzene is a hypothetical allotrope of nitrogen composed of 6 nitrogen atoms arranged in a ring like structure analogous to that of benzene . It would be the final member of the azabenzene azine series, having all of the methylidyne groups of the benzene molecule replaced with nitrogen atoms. The two last members of this series, hexazine and pentazine, have not been observed, although all other members of the azine series have such as pyridine , pyrimidine , pyridazine , pyrazine , 1,3,5 triazine and tetrazine . Stability The hexazine molecule bears a structural similarity to the very stable benzene molecule. Like benzene, it has been calculated that hexazine is likely an aromatic molecule. Despite this, it has yet to be synthesized. In fact, it has been predicted computationally that the hexazine molecule is highly unstable. It has been suggested that this predicted instability is caused by the lone pair s on the nitrogen atoms, which may repel each other electrostatically and or cause electron donation to sigma antibonding molecular orbital orbitals . ref cite journal author J. Fabian and E. Lewars year 2004 title Azabenzenes azines The nitrogen derivatives of benzene with one to six N atoms Stability, homodesmotic stabilization energy, electron distribution, and magnetic ring current a computational study url http pubs.nrc cnrc.gc.ca rp rppdf v03 178.pdf journal Canadian Journal of Chemistry volume 82 issue 1 pages 50 69 doi 10.1139 v03 178 ref See also Azide Octaazacubane Nitrogen allotrope with formula N sub 8 sub Pentazole Tetranitrogen Nitrogen allotrope with formul ... more details
drugbox verifiedrevid 402884937 IUPAC name 2 4 Chlorophenyl 5,6 dihydro 1 benzothepino 5,4 c pyridazin 3 2H one 7 oxide image Y 23684 2d skeletal.png ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 169332 StdInChI Ref stdinchicite correct chemspider StdInChI 1S C18H13ClN2O2S c19 13 5 7 14 8 6 13 21 17 22 11 12 9 10 24 23 16 4 2 1 3 15 16 18 12 20 21 h1 8,11H,9 10H2 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey WHMCSFWQVGJBGM UHFFFAOYSA N smiles Clc4ccc N1 N C2 C C C1 O CCS O c3ccccc23 cc4 CAS number 118288 67 8 ATC prefix ATC suffix PubChem 195253 DrugBank C 18 H 13 Cl 1 N 2 O 2 S 1 molecular weight 356.826 g mol bioavailability protein bound metabolism elimination half life excretion pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Y 23684 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. ref Nakao T, Obata M, Kawakami M, Morita K, Tanaka H, Morimoto Y, Takehara S, Yakushiji T, Tahara T. Studies on the synthesis of condensed pyridazine derivatives. IV. Synthesis and anxiolytic activity of 2 aryl 5,6 dihydro 1 benzothiepino 5,4 c pyridazin 3 2H ones and related compound. Chemical and Pharmaceutical Bulletin Tokyo . 1991 Oct 39 10 2556 63. ref ref Nakao T, Obata M, Yamaguchi Y, Marubayashi N, Ikeda K, Morimoto Y. Synthesis and biological activities of optical isomers of 2 4 chlorophenyl 5,6 dihydro 1 benzothiepino 5,4 c pyridazin 3 2H one 7 oxide. Chemical and Pharmaceutical Bulletin Tokyo . 1992 Jan 40 1 117 21. ref It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. Y 23684 is a nonselective partial agonist at GABA A receptor GABA sub A sub Receptor biochemistry receptor s. It has ... more details
component 5 H Indane Indeno 1,2 c pyridazine pyridazin 5 ones ref name pmid17034132 ref name pmid17910428 ... E, Thull U, Testa B, Altomare C title Synthesis and monoamine oxidase inhibitory activity of new pyridazine ... more details
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