journal author Rubinsztein DC title The roles of intracellular protein degradation pathways in neurodegeneration ... 796 802 year 2006 month October pmid 17051206 doi 10.1038 nature05293 accessdate 2009 06 20 ref Neurodegeneration ... journal author Thompson LM title Neurodegeneration a question of balance journal Nature volume 452 ... are a cause or a result of neurodegeneration. ref name rubinsztein autophagy lysosome ... confined macroautophagy gene knockouts develop intraneuronal aggregates leading to neurodegeneration. ref name rubinsztein chaperone mediated autophagy defects may also lead to neurodegeneration ... rubinsztein Mitochondrial dysfunction The most common form of cell death in neurodegeneration is through ... disease leading to neurodegeneration is likely, at least on some level, to involve all of these functions ... apoptosis, and necrosis causes different kinds of aponecrosis ref name bredesen . PCD and neurodegeneration ... pathways in neurodegeneration. Different diseases may enter these pathways at different points ..., cell death in neurodegeneration is due to apoptosis and most commonly through the intrinsic mitochondrial ... pmid 18333761 doi 10.1146 annurev.neuro.30.051606.094302 accessdate 2009 06 20 ref Neurodegeneration ... E title Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer ..., but the findings are significant because they implicate cells other than neuron cells in neurodegeneration ... doi 10.1038 nn0507 535 accessdate 2009 06 20 ref Aging and neurodegeneration The greatest risk ... proline rich peptide PRP 1 offers neuroprotective effects and can prevent neurodegeneration in hippocampus ... in neurodegeneration. Both of these options involve very complex pathways that we are only beginning ... more details
likely to reduce further neurodegeneration in AD. References Bedalov A, Simon JA 2004 . NAD ... and neurodegeneration. Science. 296, 868 871. Pillai JB, Isbatan A, Imai SI, Gupta MP 2005 . Poly ADP ... more details
Infobox disease Name Pantothenate kinase associated neurodegeneration Image Pantetheine structure.png Caption Pantetheine DiseasesDB 29462 ICD10 ICD10 G 23 0 g 20 ICD9 ICD9 333.0 ICDO OMIM 234200 MedlinePlus 001225 eMedicineSubj neuro eMedicineTopic 151 MeshID D006211 GeneReviewsID pkan GeneReviewsName Pantothenate Kinase Associated Neurodegeneration Pantothenate kinase associated neurodegeneration PKAN , also known as neurodegeneration with brain iron accumulation 1 NBIA1 and formerly called Hallervorden Spatz syndrome use of this eponym is discouraged due to Drs. Julius Hallervorden and Hugo Spatz s affiliation with the Nazi regime and the ethically unacceptable manner in which they obtained some autopsy specimens ref whonamedit doctor 535 ref ref whonamedit doctor 1063 ref , is a degenerative disease of the brain that can lead to parkinsonism , dystonia, dementia, and ultimately death. Neurodegeneration in PKAN is accompanied by an excess of iron that progressively builds up in the brain. Symptoms Symptoms typically begin in childhood and are progressive, often resulting in death by early adulthood. Symptoms of PKAN begin before middle childhood, and most often are noticed before ten years of age. Symptoms include dystonia repetitive uncontrollable muscle contractions that may cause jerking or twisting of certain muscle groups dysphagia & dysarthria due to muscle groups involved ... was named pantothenate kinase associated neurodegeneration or PKAN by Zhou et al. 2001 ref ... phenotype and genotype of pantothenate kinase associated neurodegeneration journal Neurology volume ... mutations in the PANK2 gene in a Chinese patient with atypical pantothenate kinase associated neurodegeneration ... DEFAULTSORT Pantothenate Kinase Associated Neurodegeneration Category Extrapyramidal and movement disorders Category Vitamin, coenzyme, and cofactor metabolism disorders de Neurodegeneration ... Spatz pl Choroba Hallervordena Spatza simple Pantothenate kinase associated neurodegeneration ... more details
Orphan date September 2010 Transneuronal degeneration is the Neurodegeneration death of neurons resulting from the disruption of Afferent neuron input from or Efferent neuron output to other nearby neuron s. ref http medical dictionary.thefreedictionary.com transneuronal degeneration ref References Reflist External links http www.ncbi.nlm.nih.gov pubmed 18245781 Category Neuroscience Neuroscience stub ... more details
neurodegeneration PKAN , formerly Hallervorden Spatz syndrome. Alternative splicing, involving ... pkan GeneReviews NCBI NIH UW entry on Pantothenate Kinase Associated Neurodegeneration Further ... doi Cite journal author Hayflick SJ title Neurodegeneration with brain iron accumulation from ... neurodegeneration. journal Neurology volume 58 issue 11 pages 1673 4 year 2002 pmid 12058097 ... in pantothenate kinase associated neurodegeneration, localizes to mitochondria. journal Hum. Mol. Genet ... J title Clinical heterogeneity of neurodegeneration with brain iron accumulation Hallervorden Spatz syndrome and pantothenate kinase associated neurodegeneration. journal Mov. Disord. volume 19 issue ... accumulation in pantothenate kinase associated neurodegeneration. journal Ann. N. Y. Acad. Sci. volume ... brothers with pantothenate kinase associated neurodegeneration. journal Mov. Disord. volume 20 issue ... Y, Ohmori H, et al. title Pantothenate kinase associated neurodegeneration initially presenting ... Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation ... mutations in the PANK2 gene in a Chinese patient with atypical pantothenate kinase associated neurodegeneration ... kinase associated neurodegeneration. journal Neurology volume 64 issue 10 pages 1810 2 ... with pantothenate kinase associated neurodegeneration evidence for a founder effect. journal Neurogenetics ... more details
Orphan date September 2008 Peter Calabresi is Director of the Johns Hopkins Multiple Sclerosis MS Center and an Associate Professor of Neurology . Calabresi was recently awarded a five year MS center grant from the National MS Society for the study of mechanisms of neurodegeneration and strategies for neuroprotection in MS. Education His education includes a Bachelor of Science B.S. from Yale College in 1984 and an Doctor of Medicine M.D. from Brown University in 1988. External links http www.neuro.jhmi.edu profiles calabresi.html www.neuro.jhmi.edu profiles calabresi.html DEFAULTSORT Calabresi, Peter Category Living people Category Year of birth missing living people Category American neurologists US med bio stub ... more details
The Wolfson Centre for Age Related Diseases CARD is based at the Guy s Hospital campus of King s College London , England . It is made up of three research groups including the Receptors and Signalling Group, the Neurorestoration Group and Neurodegeneration and Clinical Trials Group. The centre is directed by Professor Pat Doherty ref cite web title CARD Staff Wolfson Centre for Age Related Diseases CARD King s College London publisher King s College London date 2006 06 28 url http www.kcl.ac.uk schools biohealth research wolfson cardstaff.html accessdate 2006 12 09 archiveurl http web.archive.org web 20061009000758 http kcl.ac.uk schools biohealth research wolfson cardstaff.html archivedate 2006 10 09 ref . References reflist External links http www.kcl.ac.uk schools biohealth research wolfson Official Website King s College London med org stub Category King s College London Category Medical research institutes Category Research institutes in England ... more details
Pantothenate kinase PanK CoaA is the first enzyme in the Coenzyme A biosynthetic pathway. It phophorylates pantothenate Vitamin B5 vitamin B sub 5 sub to form 4 phosphopantothenate. Types Three distinct types of PanK has been identified PanK I found in bacteria , PanK II mainly found in eukaryotes, but also in the Staphylococci and PanK III, also known as CoaX found in bacteria . Eukaryotic PanK II enzymes often occur as different isoforms, such as PanK1, PanK2, PanK3 and PanK4. Genes Gene PANK1 , Gene PANK2 , Gene PANK3 , Gene PANK4 . PANK2 is associated with Pantothenate kinase associated neurodegeneration , formerly called Hallervorden Spatz syndrome. External links MeshName Pantothenate kinase EC number 2.7.1.33 enzyme stub Kinases Metabolism of vitamins, coenzymes, and cofactors Category EC 2.7.1 de Pantothenatkinase fr Pantoth nate kinase ja ... more details
Infobox Disease Name Aceruloplasminemia Image Caption DiseasesDB 30055 ICD10 ICD10 E 83 1 e 70 ICD9 ICD9 275.0 ICDO OMIM 604290 MedlinePlus eMedicineSubj eMedicineTopic MeshID Aceruloplasminemia is an autosomal recessive ref cite journal pmid 7708681 year 1995 month March author Harris, Zl Takahashi, Y Miyajima, H Serizawa, M Macgillivray, Rt Gitlin, Jd title Aceruloplasminemia molecular characterization of this disorder of iron metabolism volume 92 issue 7 pages 2539 43 issn 0027 8424 pmc 42253 journal Proceedings of the National Academy of Sciences of the United States of America doi 10.1073 pnas.92.7.2539 ref disorder of iron metabolism characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus . Iron accumulates in the pancreas , liver and brain . Accumulation in the eye may lead to retinal degeneration . The disease is caused by mutation s in the ceruloplasmin gene . ref cite journal pmid 7539672 year 1995 month March author Yoshida, K Furihata, K Takeda, S Nakamura, A Yamamoto, K Morita, H Hiyamuta, S Ikeda, S Shimizu, N Yanagisawa, N title A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans volume 9 issue 3 pages 267 72 doi 10.1038 ng0395 267 journal Nature genetics ref Aceruloplasminemia belongs to the group of genetic disorders called neurodegeneration with brain iron accumulation NBIA . Image autorecessive.svg thumb right Aceruloplasminemia has an autosomal recessive pattern of inheritance . References Reflist External Links http www.ncbi.nlm.nih.gov books NBK1493 GeneReviews NCBI NIH UW entry on Aceruloplasminemia http www.ncbi.nlm.nih.gov omim 117700,604290,117700,604290 OMIM entries on Aceruloplasminemia See also Human iron metabolism Iron overload disorder Mineral metabolic pathology Category Inborn errors of metal metabolism Category Hepatology Category Autosomal recessive disorders Category Iron metabolism genetic disorder stub de Acaeruloplasmin mie fr Ac rul oplasmin mie ... more details
Refimprove date December 2009 A degenerative disease , also called neurodegenerative disease, is a disease in which the function or structure of the affected biological tissue tissues or Organ anatomy organs will progressively deteriorate over time, whether due to normal bodily wear or lifestyle choices such as exercise or eating habits. ref http www.nlm.nih.gov medlineplus degenerativenervediseases.html Degenerative Nerve Diseases ref Degenerative diseases are often contrasted with infectious diseases . Some Examples of Degenerative Diseases Amyotrophic Lateral Sclerosis ALS , e.g., Lou Gehrig s Disease Alzheimer s disease Parkinson s Disease Multiple system atrophy Niemann Pick disease Atherosclerosis Progressive supranuclear palsy Cancer Tay Sachs Disease Diabetes Heart Disease Keratoconus Inflammatory bowel disease Inflammatory Bowel Disease IBD Prostatitis arthritis Osteoarthritis Osteoporosis Rheumatoid Arthritis Huntington s Disease Chronic traumatic encephalopathy See also Aging Disease Life extension Neurodegeneration Senescence Progressive disease References Reflist DEFAULTSORT Degenerative Disease Category Diseases and disorders ar es Enfermedad degenerativa fa fr Maladie d g n rative hr Degenerativne bolesti ms Penyakit degeneratif nl Degeneratieve ziekte pl Choroby zwyrodnieniowe pt Doen a degenerativa sl Degenerativna bolezen sv Degenerativ sjukdom th zh ... more details
Primary sources date January 2010 italictitle Infobox journal title Journal of NeuroVirology editor K. Khalili discipline Neuroscience , Virology abbreviation publisher Informa Informa Healthcare country United Kingdom UK frequency Bimonthly history 1974 present openaccess website http www.informapharmascience.com jnv link1 link1 name link2 link2 name RSS atom JSTOR OCLC LCCN CODEN ISSN 1355 0284 eISSN 1528 2443 The Journal of NeuroVirology is a medical journal that publishes Review journal review articles on the molecular biology, immunology, genetics, epidemiology, and pathogenesis of CNS disorders with the goal of bridging the gap between basic and clinical studies, and enhancing translational research in neurovirology. It is published by Informa Informa Healthcare . The Journal of NeuroVirology is the official journal of the International Society of Neurovirology. Core areas Encephalopathies Infectious diseases Virus induced neurodegeneration Molecular biology Immunology Genetics External links http www.informahealthcare.com jnv Journal of NeuroVirology http www.isnv.org International Society of Neurovirology Category Publications established in 1974 Category Neuroscience journals ... more details
File Sally Temple.jpg thumb Dr. Temple Please add back when a picture is available Sally Temple is a developmental neuroscientist in Albany, New York . She is Scientific Director of http www.nstemcell.org The Neural Stem Cell Institute and Professor of Neuroscience and Neuropharmacology at Albany Medical College . ref name NYNSCI http www.nynsci.org core singlePers ?pers id 21 NYNSCI ref ref http www.amc.edu research CNN cnnresearcher.cfm?ID 139 AMC ref In 2008, Dr. Temple was awarded the MacArthur Fellows Program MacArthur Fellowship , a no strings attached grant intended to supplement the winner s potential for creativity. ref cite web url http www.macfound.org site c.lkLXJ8MQKrH b.4536877 k.1412 Meet the 2008 Fellows.htm title Meet the 2008 Fellows author The John D. and Catherine T. MacArthur Foundation accessdate 2008 09 23 ref She received education at Cambridge University , University College London , and Columbia University . ref name NYNSCI Dr. Temple is an innovator in the field of stem cells , specifically neural stem cells , which are potentially applicable in cell replacement therapy for ailments like spinal cord injury and neurodegeneration . References Reflist Category MacArthur Fellows ... more details
neurodegeneration. Therapeutic and prophylactic ophthalmologic lens for pseudophakic eyes and or eyes suffering neurodegeneration. Illumination system with a therapeutic and prophylactic filter for healthy eyes, pseudophakic eyes and or eyes suffering neurodegeneration. Components of prevention for healthy eyes and of therapy and prophylaxis for pseudophakic eyes and or eyes suffering neurodegeneration ... more details
, and pantothenate kinase associated neurodegeneration PKAN , primarily affect the brain and the basal ... center Pantothenate kinase associated neurodegeneration PKAN align left PANK2 align left autosomal recessive ... more. ref name Medpedia2010 Management Currently, no treatment slows the neurodegeneration in neuroacanthocytosis ... neurodegeneration details Pantothenate kinase associated neurodegeneration Pantothenate kinase associated neurodegeneration PKAN is a disease characterized by brain iron accumulation and progressive ... onset occurs much later and is less severe. Pantothenate kinase associated neurodegeneration was formerly ... War II. ref name GHR PKAN Onset and incidence Pantothenate kinase associated neurodegeneration usually ... neurodegeneration is inherited in an autosomal recessive pattern meaning that both copies of the gene ... responsible for Pantothenate kinase associated neurodegeneration is known as PANK2. This gene .... This causes the symptoms that are present in Pantothenate kinase associated neurodegeneration to occur ... neurodegeneration when they have the following manifestations Dystonia and rigidity of movements ... name GeneReviews PKAN Management Most of the treatment for Pantothenate kinase associated neurodegeneration ... kinase associated neurodegeneration but certain drugs such as alpha tocopherol and idebenone ... condition pantothenatekinaseassociatedneurodegeneration Pantothenate Kinase associated Neurodegeneration ... bookshelf br.fcgi?book gene&part pkan Pantothenate Kinase Associated Neurodegeneration ... Kinase associated Neurodegeneration. Genetics Home Reference. October 2006. 3 March 2010. http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book gene&part pkan Pantothenate Kinase Associated Neurodegeneration ... more details
UBB 1 is shorthand for Ubiquitin B 1, a frameshifted mutant arising from the Ubiquitin B gene. ref name pmid9422699 cite journal author van Leeuwen FW, de Kleijn DP, van den Hurk HH, Neubauer A, Sonnemans MA, Sluijs JA, K yc S, Ramdjielal RD, Salehi A, Martens GJ, Grosveld FG, Peter J, Burbach H, Hol EM title Frameshift mutants of beta amyloid precursor protein and ubiquitin B in Alzheimer s and Down patients journal Science volume 279 issue 5348 pages 242 7 year 1998 month January pmid 9422699 doi 10.1126 science.279.5348.242 url issn ref UBB 1 is thought to arise from molecular misreading, a poorly understood process. Molecular misreading introduces dinucleotide deletions e.g. GA, GU into mRNA transcripts. These deletions are not present in genomic DNA . UBB 1 has been observed in the hallmarks of Alzheimer s Disease , as well as other tauopathies and in polyglutamine diseases e.g.Huntington s disease but not in synucleinopathies e.g.Parkinson s disease . Since its discovery it has been shown in vitro and in vivo that UBB 1 inhibits the proteasome and gives rise to downstream effects e.g. a behavioral phenotype impaired contextual memory . In non neuronal cells UBB 1 also accumulates suggesting a functional role in non neuronal diseases. ref name pmid20173331 cite journal author Dennissen FJ, Kholod N, Steinbusch HW, Van Leeuwen FW title Misframed proteins and neurodegeneration a novel view on Alzheimer s and Parkinson s diseases journal Neurodegener Dis volume 7 issue 1 3 pages 76 9 year 2010 pmid 20173331 doi 10.1159 000285510 url issn ref References Reflist DEFAULTSORT Ubb 1 Category Genetics ... more details
Orphan date February 2009 Sticky mouse is a murine mutant possessing a defective alanyl tRNA synthetase AARS ref name pmid16906138 cite journal author Roy H, Ibba M title Molecular biology sticky end in protein synthesis journal Nature journal Nature volume 443 issue 7107 pages 41 2 year 2006 month September pmid 16906138 doi 10.1038 nature05002 ref and therefore used in investigational studies into mechanisms of neuronal degeneration. Its most immediately obvious symptom is a sticky secretion on the mouse s fur thus the name however, it is accompanied by lack of muscle control, ataxia , alopecia , loss of Purkinje cell s in the cerebellum , and eventually, death. Sticky mouse is one of several animal mutants that are known to have problems in mRNA translation and are used in studies. ref name pmid17680008 cite journal author Scheper GC, van der Knaap MS, Proud CG title Translation matters protein synthesis defects in inherited disease journal Nat. Rev. Genet. volume 8 issue 9 pages 711 23 year 2007 month September pmid 17680008 doi 10.1038 nrg2142 ref See also Wasted mouse wst EEF1A2 defect Harlequin mouse Reeler RELN defect Shaking rat Kawasaki RELN defect References reflist 2 External links http www.nature.com nature journal v443 n7107 edsumm e060907 16.html A sticky wicket editor s summary, Nature, 2006 http videocast.nih.gov Summary.asp?File 15141 Forward Genetics Reveals Novel Mechanisms of Neurodegeneration free online videolecture by Ackerman SL. June 2009 http www.hhmi.org news ackerman20060809.html Sticky mice lead to discovery of new cause of neurodegenerative disease Howard Hughes Medical Institute, 2006 http www.hhmi.org research investigators ackerman bio.html Susan L. Ackerman bio at the Institute site Category Animal diseases Category Mice veterinary med stub ... more details
Deleted image removed Image Atg4 wiki.jpg thumb 220px right Schematic drawing of Atg4b. The color codes for the secondary structure elements are alpha helix , cyan beta strand s, magenta loops, salmon. The active site residues Y54, C74, W142, R229, D278 and H280 are shown in ball and stick representation. The coordinates and structure factors have been deposited in the RCSB PDB accession code 2D1I . Autophagin 1 Atg4 Apg4 is a unique cysteine protease responsible for the cleavage of the carboxyl terminus of Atg8 Apg8 Aut7, a reaction essential for its lipidation during autophagy ref Development by self digestion molecular mechanisms and biological functions of autophagy by Levine B, Klionsky DJ. in Dev Cell. 2004 Apr 6 4 463 77. Review. ref . Human Atg4 homologues cleave the carboxyl termini of the three human Atg8 homology biology homologues , microtubule associated protein light chain 3 LC3 , GABARAP, and GATE 16 ref HsAtg4B HsApg4B autophagin 1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule associated protein light chain 3 and GABAA receptor associated protein phospholipid conjugates byTanida I, Sou YS, Ezaki J, Minematsu Ikeguchi N, Ueno T, Kominami E. in J Biol Chem. 2004 Aug 27 279 35 36268 76 ref . The rapid advancement in our understanding of the mechanisms and regulation of autophagy has placed this process in the center of current research in major human disorders ref Autophagy in sickness and in health by Cuervo AM. in Trends Cell Biol. 2004 Feb 14 2 70 7. ref . The future challenge is to develop easy methods to separately manipulate the activity of each of the autophagic pathways. This would allow researchers to further understand their contribution to disease such as cancer , neurodegeneration , infectious disease , muscular disorders and possibly will provide therapeutic tools. See also Autophagy Apoptosis Ubiquitin References references Cysteine proteases Category EC 3.4.22 Category Posttranslational modificati ... more details
orphan date August 2010 Floppy trunk syndrome abbreviated FTS , also known as flaccid trunk paralysis is a condition that causes trunk paralysis in elephant s. The paralysis is caused by Neurodegeneration degeneration of peripheral nerves , which begins at the base of the trunk. ref name NS cite news url http www.newscientist.com article mg13618470.700 lead in lake blamed for floppy trunks .html title Lead in lake blamed for floppy trunks last Cole first Mary date 14 November 1992 publisher NewScientist accessdate 2009 06 25 ref FTS has been observed in the northwest of Zimbabwe , ref name NS the Satara area of Kruger National Park , and Forthergill in Lake Kariba . The condition interferes with the elephant s ability to drink and feed. ref cite news url http www.slate.com id 30038 title Touched by a Tabloid last Mendelsohn first Jennifer date 9 June 1999 publisher Slate accessdate 2009 06 25 ref Research is being conducted to ascertain the cause of the illness. It is suspected to be a Neurotoxin toxin from the plant genera Boerhavia or Indigofera . ref name BMSE cite book last Fowler first Murray coauthors Mikota, Susan title Biology, Medicine, and Surgery of Elephants editor Murray E. Fowler, Susan K. Mikota publisher Wiley, John & Sons, Incorporated date September 2006 pages 441 isbn 9780813806761 url http books.google.com books?id oCpiZA61tyQC&lpg RA1 PA441&ots 2IHdN9o39h&dq floppy 20trunk 20syndrome&pg RA1 PA441 ref Heliptrompium ovalifolium , a plant native to Nigeria , is speculated to be the cause. ref cite book last Schmelzer first G. H title Medicinal plants publisher Plant Resources of Tropical Africa pages 323 isbn 9057822040 url http books.google.com books?id 7FJqgQ3 tnUC&lpg PT323&ots QsLAtHX5J3&dq floppy 20trunk 20syndrome&pg PT323 v onepage&q &f false accessdate 12 November 2009 ref References reflist External links http www.wildcast.net 2008 11 15 floppy trunk video Floppy trunk syndrome video veterinary med stub Category Elephants Category Diseases ... more details
The European Biological Inorganic Chemistry Conference , or EUROBIC as it is most commonly called, is a biannual conference on Bioinorganic chemistry founded in 1992. The conference is held in Europe but attracts scientists from all over the world. EUROBIC was the result of a merger of the Swiss Italian SIMBIC conference and the French German SAMBAS conference. The aim is to create a forum and promote collaboration between scientists in the highly multidisciplinary field of Biological Inorganic Chemistry, ranging from biology to inorganic chemistry . EUROBIC usually span over five days and include around a hundred oral presentations and a few hundred poster presentations. Oral presentations are divided into plenary lectures 1 hour that are joint for the entire conference and parallel sessions including keynote lectures 30 min , session lectures 25 min and oral lectures 15 minutes . Since 1994 EUROBIC 2 , the European Medal for Bio Inorganic Chemistry , also called the EUROBIC award, is presented in conjunction with the conference, customary as part of the closing ceremony. EUROBIC Conferences to date 2010 EUROBIC 10 Thessaloniki, Greece 2008 EUROBIC 9 Wroclaw, Poland 2006 EUROBIC 8 Aveiro, Portugal 2004 EUROBIC 7 Garmisch Partenkirchen, Germany 2002 EUROBIC 6 Lund, Sweden 2000 EUROBIC 5 Toulouse, France 1998 EUROBIC 4 Seville, Spain 1996 EUROBIC 3 Noordwijkerhout, The Netherlands 1994 EUROBIC 2 Firenze, Italy 1992 EUROBIC 1 Newcastle, United Kingdom Topics covered Metals in Medicine Therapeutic and Diagnostic Agents Bioinspired Catalysis Biomimetic Systems Metal Trafficking Metals and Oxidative Stress Metals and Nucleic Acids Chemical and Biological Aspects Metal Based Environmental Chemistry Metal Related Diseases Metals and Neurodegeneration Computational Aspects and Metal Containing Molecules Chemical Bioinformatics Metals Light and Life Metalloproteins Structure Function Correlation in Metal Containing Biomolecules Bioinspired Coordination Chemistry Biopharmaceu ... more details
Julius Hallervorden October 21, 1882 May 29, 1965 was a German physician and neuroscientist . In 1938, he became the head of the Neuropathology Department of the Kaiser Wilhelm Society Kaiser Wilhelm Institute for Brain Research . He was a member of the Nazi Party , and admitted to knowningly performing much of his controversial research on the brains of executed prisoners. Along with Hugo Spatz , he is credited with the discovery of Hallervorden Spatz syndrome now more commonly referred to as Pantothenate kinase associated neurodegeneration . ref cite journal title Eponyms and the Nazi Era Time to Remember and Time For Change last Strous first Rael D. coauthor Morris C. Edelman work Israel Medical Association Journal year 2007 month March volume 9 issue 3 pages 207 214 url http www.ima.org.il imaj ar07mar 24.pdf accessdate 2010 11 01 ref ref cite journal title Julius Hallervorden s wartime activities implications for science under dictatorship last Shevell first Michael coauthor J ergen Peiffer work Pediatr Neurol year 2001 month August volume 2 pages 162 165 url http www.ncbi.nlm.nih.gov pubmed 11551747 accessdate 2010 11 01 ref See also List of medical eponyms with Nazi associations References reflist Persondata name Hallervorden, Julius alternative names short description place of birth place of death date of birth October 21, 1882 date of death May 29, 1965 DEFAULTSORT Hallervorden, Julius Category 1882 births Category 1965 deaths Category Nazi human experimentation Category Nazi physicians germany med bio stub de Julius Hallervorden pl Julius Hallervorden ... more details
Hugo Spatz September 2, 1888 January 27, 1969 was a German Neuropathology neuropathologist . In 1937, he was appointed director of the Kaiser Wilhelm Society Kaiser Wilhelm Institute for Brain Research . He was a member of the Nazi Party , and admitted to knowningly performing much of his controversial research on the brains of executed prisoners. Along with Julius Hallervorden , he is credited with the discovery of Hallervorden Spatz syndrome now more commonly referred to as Pantothenate kinase associated neurodegeneration . ref cite journal title Eponyms and the Nazi Era Time to Remember and Time For Change last Strous first Rael D. coauthor Morris C. Edelman work Israel Medical Association Journal year 2007 month March volume 9 issue 3 pages 207 214 url http www.ima.org.il imaj ar07mar 24.pdf accessdate 2010 12 09 ref ref cite web url http www.whonamedit.com doctor.cfm 1063.html title Hugo Spatz publisher Who Named It? accessdate 2010 12 09 ref See also List of medical eponyms with Nazi associations References reflist Persondata name Spatz, Hugo alternative names short description place of birth place of death date of birth September 2, 1888 date of death January 27, 1969 DEFAULTSORT Spatz, Hugo Category 1888 births Category 1969 deaths Category Nazi human experimentation Category Nazi physicians germany med bio stub de Hugo Spatz pl Hugo Spatz ... more details
Infobox journal title Neural Regeneration Research cover editor Kwok Fai So, Xiao Ming Xu discipline Neurology , neuroscience , neural stem cell s former names abbreviation Neural Regener. Res. publisher Publishing House of Neural Regeneration Research country China frequency Twice monthly history 2006 present openaccess Yes license impact impact year website http www.nrronline.org link1 http www.crter.org sites MainSite List 2 2442.html link1 name Online archive link2 link2 name JSTOR OCLC 173468424 LCCN CODEN NRREBM ISSN 1673 5374 eISSN 1876 7958 Neural Regeneration Research is a Peer review peer reviewed scientific journal covering research on neuroregeneration and stem cell s. Topics covered include neural stem cell s, nerve tissue engineering , gene therapy , neurodegeneration neurodegenerative diseases , and traditional Chinese medicine . It was established in 2006 and the Editor in chief editors in chief are Kwok Fai So University of Hong Kong and Xiao Ming Xu Indiana University Bloomington Indiana University . The journal publishes the following types of papers research and reports, techniques and methods, investigation and analysis, meta analysis, evidence based case reports, commentaries review, and case reports. ref cite web url http oa.crter.org nrren ch first menu.aspx?parent id 2008111280152001 title Instructions to Authors for Neural Regeneration Research in 2010 format work accessdate 2010 12 26 ref Abstracting and indexing The journal is abstracted and indexed in BIOSIS Previews , Chemical Abstracts Service Chemical Abstracts , EMBASE Excerpta Medica , Institute of Scientific & Technical Information of China , Chinese Science Citation Database , Scopus , and the Science Citation Index Science Citation Index Expanded . ref cite web url http oa.crter.org nrren ch first menu.aspx?parent id 2008111280139001 title Introduction to Journal of Neural Regeneration Research format work accessdate 2010 12 26 ref References Reflist External links Official http ... more details
PBB geneid 101 Disintegrin and metalloproteinase domain containing protein 8 is an enzyme that in humans is encoded by the ADAM8 gene . ref name pmid9126482 cite journal author Yoshiyama K, Higuchi Y, Kataoka M, Matsuura K, Yamamoto S title CD156 human ADAM8 expression, primary amino acid sequence, and gene location journal Genomics volume 41 issue 1 pages 56 62 year 1997 month May pmid 9126482 pmc doi 10.1006 geno.1997.4607 ref ref name entrez cite web title Entrez Gene ADAM8 ADAM metallopeptidase domain 8 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 101 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a member of the ADAM a disintegrin and metalloprotease domain family. Members of this family are membrane anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell cell and cell matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration. ref name entrez cite web title Entrez Gene ADAM8 ADAM metallopeptidase domain 8 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 101 accessdate ref See also Cluster of differentiation References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Yamamoto S, Higuchi Y, Yoshiyama K, et al. title ADAM family proteins in the immune system. journal Immunol. Today volume 20 issue 6 pages 278 84 year 1999 pmid 10354553 doi 10.1016 S0167 5699 99 01464 4 cite journal author Schlomann U, Rathke Hartlieb S, Yamamoto S, et al. title Tumor necrosis factor alpha induces a metalloprotease disintegrin, ADAM8 CD 156 implications for neuron glia interactions during neurodegeneration. journal J. Neurosci. volume ... more details
Infobox Disease Name PAGENAME Image Gray672.png Caption Diagram of the principal fasciculi of the spinal cord. In subacute combined degeneration of spinal cord, the combined refers to the fact that the dorsal column s and lateral corticospinal tract s are both affected, in contrast to tabes dorsalis which is selective for the dorsal columns. DiseasesDB 12591 ICD10 ICD10 G 32 0 g 30 , ICD10 E 53 8 e 50 ICD9 ICD9 336.2 , ICD9 266.2 ICDO OMIM MedlinePlus 000723 eMedicineSubj eMedicineTopic MeshID D052879 Subacute combined degeneration of spinal cord , also known as Ludwig Lichtheim Lichtheim s disease, ref WhoNamedIt synd 492 ref ref L. Lichtheim. Zur Kenntnis der pernici sen An mie. Verhandlungen des Deutschen Kongress f r innere Medizin, 1889, 6 84 96. 42 1887. ref refers to degeneration of the posterior and lateral columns of the spinal cord as a result of vitamin B12 deficiency vitamin B sub 12 sub deficiency most common , vitamin E deficiency or Friedrich s ataxia . It is usually associated with pernicious anemia . Presentation The pathological findings of subacute combined degeneration consist of patchy losses of myelin in the dorsal and lateral columns. Patients present with weakness of legs, arms, trunk, tingling and numbness that progressively worsens. Vision changes and change of mental state may also be present. Bilateral spastic paresis may develop and pressure, vibration and touch sense are diminished. A positive Babinski sign may be seen. Prolonged deficiency of vitamin B12 vitamin B sub 12 sub leads to irreversible nervous system damage. If someone is deficient in vitamin B sub 12 sub and folic acid, the vitamin B sub 12 sub deficiency must be treated first to avoid precipitating subacute combined degeneration of the cord. Treatment Therapy with vitamin B sub 12 sub results in partial to full recovery, depending on the duration and extent of neurodegeneration . References reflist External links http www.neuropathologyweb.org chapter8 chapter8Nutritional. ... more details
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