PBB geneid 4609 Myc c Myc codes for a protein that binds to the DNA of other genes and is therefore a transcription factor . When a gene like Myc is altered to cause cancer, the cancerous version of the gene ... oncogene . The Myc gene is located on chromosome 8 in the human and encodes for a transcription ... transcription factor, Myc also functions to regulate global chromatin structure by regulating .... title N Myc regulates a widespread euchromatic program in the human genome partially independent of its ... year 2008 pmid 19047142 pmc 2637654 doi 10.1158 0008 5472.CAN 08 1961 ref A mutated version of Myc is found in many cancers which causes Myc to be persistently expressed. This leads to the unregulated ... of cancer . A common translocation which involves Myc is t 8 14 is involved in the development of Burkitt s Lymphoma . A recent study demonstrated that temporary inhibition of Myc selectively kills ... Modelling Myc inhibition as a cancer therapy journal Nature volume 455 issue 7213 pages 679 683 publisher ... ref Discovery Myc gene was first discovered in Burkitt s lymphoma patients. In Burkitt s lymphoma, cancer ... oncogene v Myc . Thus, the newfound cellular gene was named c Myc. Structure Myc protein belongs to Myc family of transcription factors, which also includes N Myc and L Myc genes. Myc family of transcription factors contain bHLH LZ basic Helix Loop Helix Leucine Zipper domain. Myc protein, through ... Max, another bHLH transcription factor. Myc mRNA contains an IRES internal ribosome entry site ... viral infection. Molecular Function Myc protein is a transcription factor that activates ... expression of Miz 1 target genes. In addition, myc has a direct role in the control of DNA replication ... Dalla Favera title Non transcriptional control of DNA replication by c Myc journal Nature volume 448 ... ref Myc is activated upon various mitogen mitogenic signal s such as Wnt signalling pathway Wnt ... of its target genes, Myc activation results in numerous biological effects. The first to be discovered ... more details
A myc tag is a polypeptide protein tag derived from the c myc gene product that can be added to a protein using recombinant DNA technology. It can be used for affinity chromatography , then used to separate recombinant, overexpressed protein from wild type protein expressed by the host organism. It can also be used in the isolation of protein complexes with multiple subunits. A myc tag can be used in many different assays that require recognition by an antibody . If there is no antibody against the studied protein, adding a myc tag allows one to follow the protein with an antibody against the Myc epitope. Examples are cellular localization studies by immunofluorescence or detection by SDS PAGE protein electrophoresis. The peptide sequence of the myc tag is N EQKLISEEDL C 1202 Da . It can be fused to the C terminus and the N terminus of a protein. It is advisable not to fuse the tag directly behind the signal peptide of a secretory protein, since it can interfere with translocation into the secretory pathway . A monoclonal antibody against the myc epitope , named 9E10, is available from the non commercial Developmental Studies Hybridoma Bank ref http dshb.biology.uiowa.edu c myc Developmental Studies Hybridoma Bank 9E10 ref . See also Polyhistidine tag , a different tag used in similar ways References references Category Biochemistry ... more details
PBB geneid 4613 V myc myelocytomatosis viral related oncogene, neuroblastoma derived avian , also known ... of the MYC family of transcription factor s and encodes a protein with a basic helix loop helix basic ... bHLH protein in order to bind DNA. ref cite web title Entrez Gene MYCN v myc myelocytomatosis viral ... C, Brodeur GM title Preferential amplification of the paternal allele of the N myc gene in human neuroblastomas ... 10.1038 ng0693 191 url issn ref Interactions N Myc has been shown to Protein protein interaction interact ... protein that forms a sequence specific DNA binding complex with Myc journal Science journal Science ... Myc journal Oncogene volume 18 issue 15 pages 2489 98 publisher location ENGLAND issn 0950 9232 ... laydate quote ref N Myc is also stabilized by Aurora A which protects it from degradation. ref Stabilization of N Myc Is a Critical Function of Aurora A in Human Neuroblastoma Cancer Cell, Volume ..., Holger Christiansen, Bernd Berwanger, Martin Eilers ref See also Myc References reflist Further ... of the transcription factors of the Myc Max Mad network. journal Gene volume 277 issue 1 2 ... strand opposite to N myc. journal Cell Growth Differ. volume 3 issue 6 pages 385 90 year 1992 ... of the acidic central region of the N myc protein by casein kinase II. journal Eur. J. Biochem ... GW, Armstrong BC, Battey JF title N myc mRNA forms an RNA RNA duplex with endogenous antisense ... a sequence specific DNA binding complex with Myc. journal Science volume 251 issue 4998 pages ... G, Boyd JP, et al. title N myc amplification in multiple homogeneously staining regions in two human ... Sequence of a germ line N myc gene and amplification as a mechanism of activation. journal Oncogene ... JM title Nucleotide sequence of the human N myc gene. journal Proc. Natl. Acad. Sci. U.S.A. volume ... author Michitsch RW, Melera PW title Nucleotide sequence of the 3 exon of the human N myc gene. journal ... of the protein encoded by the human N myc oncogene. journal Science volume 232 issue ... more details
Orphan date December 2007 Automatically added by User SoxBot. If this is an error, please contact User Soxred93 C myc mRNA is a type of Messenger RNA mRNA that serves as a template for the Myc MYC protein which is implicated in the rapid growth of cancer cancer cells . This mRNA is a topic of ongoing research to investigate the viability of preventing cancer growth by cleaving or degrading the c myc mRNA. ref cite journal last Lee first Chow H. authorlink Chow H. Lee coauthors Dan Sparanese title CRD BP shields c myc and MDR 1 RNA from endonucleolytic attack by a mammalian endoribonuclease journal ScienceDirect volume 35 issue 4 pages 1209 1221 date 31 January 2007 doi 10.1093 nar gkl1148 pmid 17264115 pmc 1851641 ref References references Category RNA Category Molecular biology ... more details
PBB geneid 9111 N myc interactor also known as N myc and STAT interactor is a protein that in humans is encoded by the NMI gene . ref name pmid8668343 cite journal author Bao J, Zervos AS title Isolation and characterization of Nmi, a novel partner of Myc proteins journal Oncogene volume 12 issue 10 pages 2171 6 year 1996 month Aug pmid 8668343 pmc doi ref ref name pmid9989503 cite journal author Zhu M, John S, Berg M, Leonard WJ title Functional association of Nmi with Stat5 and Stat1 in IL 2 and IFNgamma mediated signaling journal Cell volume 96 issue 1 pages 121 30 year 1999 month Mar pmid 9989503 pmc doi 10.1016 S0092 8674 00 80965 4 ref ref name entrez cite web title Entrez Gene NMI N myc ... 9111 accessdate ref Function NMYC interactor NMI interacts with N Myc NMYC and Myc CMYC two members of the oncogene Myc family , and other transcription factors containing a bZIP domain Zip , Basic ... RL, Meyerdierks A, Hagemeier M, B ttger EC, Naumovski L title Interferon inducible Myc STAT interacting ... November pmid 10950963 doi 10.1074 jbc.M006975200 url issn ref Myc , ref name pmid11916966 cite journal author Li H, Lee TH, Avraham H title A novel tricomplex of BRCA1, Nmi, and c Myc inhibits c Myc induced human telomerase reverse transcriptase gene hTERT promoter activity in breast cancer journal ... localization of Myc interacting protein Nmi. journal J. Interferon Cytokine Res. volume 18 issue 9 ... RL, Naumovski L title Subcellular localization of interferon inducible Myc stat interacting protein ... Bannasch D, Weis I, Schwab M title Nmi protein interacts with regions that differ between MycN and Myc ... Chen J, Shpall RL, Meyerdierks A, et al. title Interferon inducible Myc STAT interacting protein Nmi ... author Li H, Lee TH, Avraham H title A novel tricomplex of BRCA1, Nmi, and c Myc inhibits c Myc induced ... with the N myc interacting protein Nmi. journal J. Mol. Biol. volume 353 issue 5 pages 1033 42 ... induced apoptosis is enhanced by Myc and involves PKCdelta signaling. journal Int. J. Cancer volume ... more details
Rfam box acc RF00261 description L myc internal ribosome entry site IRES abbreviation IRES L myc avg length 183.20 avg identity 47.00 type Cis reg IRES se PMID 14730027 , INFERNAL ss Published PMID 14730027 release 10.0 The L myc internal ribosome entry site IRES is an Cis regulatory element RNA element present in the Five prime untranslated region 5 UTR of the mRNA of L myc that allows cap independent translation. L myc undergoes translation via the internal ribosome entry site and bypasses the typical eukaryotic cap dependent translation pathway 1 . The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis. References reflist 1 1 cite journal last Jopling first CL coauthors Spriggs KA, Mitchell SA, Stoneley M, Willis AE year 2004 title L Myc protein synthesis is initiated by internal ribosome entry journal RNA volume 10 pages 287&ndash 298 pmid 14730027 doi 10.1261 rna.5138804 issue 2 pmc 1370540 External links Rfam id RF00261 name L myc internal ribosome entry site IRES Category Cis regulatory RNA elements molecular cell biology stub ... more details
Orphan date February 2009 Rfam box acc RF00226 description n myc internal ribosome entry site IRES abbreviation IRES n myc avg length 267.60 avg identity 50.00 type Cis reg IRES se PMID 11419940 ss Predicted PFOLD release 10.0 The N myc internal ribosome entry site IRES is an cis regulatory element RNA element found in the n myc gene. The myc family of genes when expressed are known to be involved in the control of cell growth, differentiation and apoptosis. n myc mRNA has an alternative method of translation via an internal ribosome entry site where ribosome s are recruited to the IRES located in the 5 UTR thus bypassing the typical eukaryotic cap dependent translation pathway. ref cite journal last Jopling first CL coauthors Willis AE year 2001 title N myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells journal Oncogene volume 20 pages 2664&ndash 2670 pmid 11420678 doi 10.1038 sj.onc.1204404 issue 21 ref References reflist 1 External links Rfam id RF00226 name n myc internal ribosome entry site IRES Category Cis regulatory RNA elements molecular cell biology stub ... more details
Rfam box acc RF00216 description c myc internal ribosome entry site IRES abbreviation IRES c myc avg length 263.80 avg identity 81.00 type Cis reg IRES se PMID 11419940 ss Published PMID 11419940 release 10.0 The c myc internal ribosome entry site IRES is an Cis regulatory element RNA element present in the Five prime untranslated region 5 UTR of the mRNA of C myc and allows cap independent translation. The mammalian c myc gene is a proto oncogene which is required for cell proliferation, transformation and death. c myc mRNA has an alternative method of translation via internal ribosome entry where ribosomes are recruited to the IRES located in the 5 UTR thus bypassing the typical eukaryotic cap dependent translation pathway. ref cite journal last Le Quesne first JP coauthors Stoneley M, Fraser GA, Willis AE year 2001 title Derivation of a structural model for the c myc IRES journal J Mol Biol volume 310 pages 111&ndash 126 pmid 11419940 doi 10.1006 jmbi.2001.4745 issue 1 ref References reflist External links Rfam id RF00216 name c myc internal ribosome entry site IRES Category Cis regulatory RNA elements molecular cell biology stub ... more details
Summary This is the official flag of the Manila Yacht Club MYC . Licensing Non free logo History of File Ph myc.gif 2007 06 24T11 22 47Z User Lovebus Lovebus User talk Lovebus Talk Special Contributions Lovebus contribs 106 bytes nowiki This is the official flag of the Manila Yacht Club MYC . nowiki 2007 06 24T11 22 47Z User Lovebus Lovebus User talk Lovebus Talk Special Contributions Lovebus contribs 360x216 2474 bytes ... more details
Mariscal Sucre Airport airport codes MYC SVBS is an airport near Maracay , Venezuela . External links WAD SVBS coord 10.24998 67.64942 type airport region VE D source ourairports.com data display title Category Airports in Venezuela Venezuela airport stub ... more details
Refimprove date January 2011 class infobox bordered style width 15em text align left font size 95 style font size larger Manly Yacht Club colspan 2 style text align center Image Myc burgee.png 200px br Burgee Founded 1950 Clubhouse East Esplanade, Manly, NSW, 2095 Country AUS Website http www.myc.org.au Manly Yacht Club MYC is a sailing club in the suburb of Manly, New South Wales Manly on the Northern Beaches Sydney Northern Beaches of Sydney , in the state of New South Wales , Australia . The club races a keelboat fleet and a dinghy fleet Citation needed date January 2011 . The keelboat fleet Yacht racing races as two divisions on Sundays inshore on Port Jackson Sydney harbour and on Friday Twilight Series during summer Citation needed date January 2011 . There is also a short offshore series. vague date January 2011 A branch of Sailability , which states its purpose to be an organisation facilitating sailing for everyone, regardless of age or ability , ref cite web url http www.sailability.org title Sailability official website accessdate 2011 02 09 ref , is integrated with MYC and operates a fleet of eight Access dinghies. Citation needed date January 2011 MYC is volunteer organisation affiliated with Yachting Australia . Citation needed date January 2011 Location The club is located on the water front on the eastern peninsular of Manly, New South Wales Manly . The club has a deep water jetty and storage for dinghies. Citation needed date January 2011 The clubhouse is available for hire and is used for wedding and parties Citation needed date February 2011 . Training The Big Blue is the official sailing school at MYC and offers sail training adults and juniors in keel boats and dinghies. Citation needed date January 2011 References reflist External links http www.myc.org.au Manly Yacht Club Geolinks AUS suburbscale long 151.2854 lat 33.80315 http www.manlysailability.com.au Manly Sailability Category Yacht clubs in Australia Category Sport in Sydney de Manly Yac ... more details
was published in Nature 2004 , MYC Inactivation Uncovers Pluripotent Differentiation and Tumor Dormancy ..., Robert D. Cardiff, et al. MYC Inactivation Uncovers Pluripotent Differentiation and Tumor Dormancy ... how MYC expression induces cancer in mice and the effect of its inactivation in those tumors. She showed that removing MYC expression kills the tumor. But more importantly, she showed that MYC reprograms the tumor cells. When MYC expression is taken away from the tumor cells, they are released ... Felsher D. W.Tumor dormancy and MYC inactivation pushing cancer to the brink of normalcy. Cancer Res ... Felsher D. W.Tumor dormancy and MYC inactivation pushing cancer to the brink of normalcy. Cancer Res ... analysis of a MYC overexpressing tumor cell following MYC inactivation. Cancer Res. 2008 Jul 1 68 13 5132 42. ref The MYC protein in cancers correlates with poor prognosis and is a difficult therapeutic target. To find alternative downstream targets of MYC, Dr. Shachaf defined levels of MYC ... profile of MYC dependent tumor cells using microarray analysis, mass spectrometry, cell antibody ... of HMG CoAReductase by Atorvastatin Prevents and Reverses MYC Induced Tumorigenesis. Equal contributionBlood ..., Nolan GP, Plevritis SK and Felsher DW. Systematic molecular analysis of a MYC overexpressing tumor cell following MYC inactivation. Cancer Res. 2008 Jul 1 68 13 5132 42. ref The statin inhibited signaling pathways required for the tumor generating activities of the MYC oncogene. This study is an important ... more details
Infobox Airport name El Libertador nativename small Base A rea Libertador image IATA MYC ICAO SVBL type Military owner oper Venezuelan Air Force location Maracay , Venezuela elevation f 1,450 elevation m 442 coordinates coord 10 10 50 N 067 33 40 W region VE type airport website metric rwy y r1 number 09 27 r1 length m 3,170 r1 length f 10,400 r1 surface Concrete footnotes Source DAFIF ref name WAD http www.worldaerodata.com wad.cgi?airport SVBL Airport information for SVBL from DAFIF effective October 2006 ref ref name GCM GCM MYC source DAFIF ref El Libertador Air Base lang es Base A rea Libertador airport codes MYC SVBL is a military airport and base for the Venezuelan Air Force . It is located in Maracay , a city in central Venezuela and the capital of the States of Venezuela state of Aragua state Aragua . Facilities The air base resides at an elevation of convert 1450 ft 0 above mean sea level . It has one runway designated 09 27 with a concrete surface measuring convert 3170 x 48 m ft 0 . ref name WAD References references External links NWS current SVBL ASN MYC Category Airports in Venezuela Category Aragua state es Base a rea Libertador ru ... more details
PBB geneid 4610 L myc 1 proto oncogene protein is a protein that in humans is encoded by the MYCL1 gene . ref name pmid8978772 cite journal author Speleman F, Van Camp G, Van Roy N title Reassignment of MYCL1 ... name entrez cite web title Entrez Gene MYCL1 v myc myelocytomatosis viral oncogene homolog 1, lung ... N, Minna J, Kennett RH title The human L myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines detection by monoclonal antibodies specific to two myc homology box sequences .... title Max a helix loop helix zipper protein that forms a sequence specific DNA binding complex with Myc ... of Max on E box vs initiator element mediated regulation by c Myc journal Oncogene volume 18 issue ... Function and regulation of the transcription factors of the Myc Max Mad network. journal Gene volume ... Ikegaki N, Minna J, Kennett RH title The human L myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines detection by monoclonal antibodies specific to two myc homology ... L myc gene reveal a complex pattern of alternative mRNA processing. journal Mol. Cell. Biol. volume ... J, Fedorko J, et al. title The human L myc gene encodes multiple nuclear phosphoproteins from alternatively ... doi pmc 365511 cite journal author DePinho RA, Hatton KS, Tesfaye A, et al. title The human myc gene family structure and activity of L myc and an L myc pseudogene. journal Genes Dev. volume 1 issue ..., Fitch WM title Myc and Max molecular evolution of a family of proto oncogene products and their dimerization ... vs initiator element mediated regulation by c Myc. journal Oncogene volume 18 issue 15 pages 2489 ... Y, et al. title L myc genotype is associated with different susceptibility to lung cancer in smokers ... journal author Suzuki H, Yamashiro K title L myc restriction fragment length polymorphism and histological ... Allelic deletions of Rb and L myc in urine sediments from patients with bladder tumors or carcinoma ... author Wu R, Lin L, Beer DG, et al. title Amplification and overexpression of the L MYC proto ... more details
PBB geneid 26292 C Myc binding protein is a protein that in humans is encoded by the MYCBP gene . ref name pmid9797456 cite journal author Taira T, Maeda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi Ariga SM, Ariga H title AMY 1, a novel C MYC binding protein that stimulates transcription activity of C MYC journal Genes Cells volume 3 issue 8 pages 549 65 year 1998 month Dec pmid 9797456 pmc doi 10.1046 j.1365 2443.1998.00206.x ref ref name entrez cite web title Entrez Gene MYCBP c myc binding protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 26292 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The MYCBP gene encodes a protein that binds to the N terminal region of MYC MIM 190080 and stimulates the activation of E box dependent transcription by MYC. supplied by OMIM ref name entrez cite web title Entrez Gene MYCBP c myc binding protein url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 26292 accessdate ref Interactions MYCBP has been shown to Protein protein interaction interact with AKAP1 , ref name pmid12223483 cite journal last Yukitake first Hiroshi authorlink coauthors .... title AMY 1, a c Myc binding protein, is localized in the mitochondria of sperm by association with S AKAP84 ... ref name pmid12223483 and Myc . ref name pmid9797456 cite journal doi 10.1046 j.1365 2443.1998.00206.x ... M, Tamai K, Iguchi Ariga S M, Ariga H year 1998 month Aug. title AMY 1, a novel C MYC binding protein that stimulates transcription activity of C MYC journal Genes Cells volume 3 issue 8 pages 549 65 ... reading citations cite journal author Furusawa M, Ohnishi T, Taira T, et al. title AMY 1, a c Myc binding ... Ariga SM, et al. title AMY 1 associate of Myc 1 localization to the trans Golgi network through ... cite journal author Sedoris KC, Thomas SD, Miller DM title c myc promoter binding protein regulates ... more details
PBB geneid 4149 Protein max also known as myc associated factor X is a protein that in humans is encoded ... ref ref name entrez cite web title Entrez Gene MAX MYC associated factor X url http www.ncbi.nlm.nih.gov ... with other family members, which include MXD1 Mad , MXI1 Mxl1 and Myc . Myc is an oncogene ... for some of them is unknown. ref name entrez cite web title Entrez Gene MAX MYC associated factor ... have a repressive function. In contrast, Myc contains a transactivation domain but cannot homodimerize. However Myc can heterodimerize with Max to form heterodimers that can both bind DNA and transactivate. The transcriptionally active Max Myc dimer promotes cell proliferation as well as apoptosis . ref name pmid8193530 cite journal author Amati B, Land H title Myc Max Mad a transcription factor ... MYC and MAX journal Oncogene volume 22 issue 6 pages 819 25 publisher location England issn 0950 ... R N year 1993 month Jan. title Mad a heterodimeric partner for Max that antagonizes Myc transcriptional ... the suppressive effects of Mad family members on c myc journal Oncogene volume 16 issue 9 pages 1149 ... K year 2003 month Jan. title X ray structures of Myc Max and Mad Max recognizing DNA. Molecular ... regulation by c Myc journal Oncogene volume 18 issue 15 pages 2489 98 publisher location ENGLAND ... laysummary laysource laydate quote ref SPAG9 , ref name pmid12391307 N Myc , ref name pmid2006410 ... DNA binding complex with Myc journal Science journal Science volume 251 issue 4998 pages 1211 7 publisher ... pmid10229200 Myc , ref name pmid17353931 cite journal last Ewing first Rob M authorlink coauthors ... month Jan. title The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c Myc ... The novel ATM related protein TRRAP is an essential cofactor for the c Myc and E2F oncoproteins ... J, Yu J, Kalpana G V year 1999 month May. title c MYC interacts with INI1 hSNF5 and requires the SWI ... title The Myc Max Mad network and the transcriptional control of cell behavior. journal Annu. Rev. Cell ... more details
may also repress the transcriptional activity of the proto oncogene c Myc. Alternatively spliced transcript ... interact with Myc . ref name pmid9792694 cite journal last Mori first K authorlink coauthors Maeda Y, Kitaura H, Taira T, Iguchi Ariga S M, Ariga H year 1998 month Nov. title MM 1, a novel c Myc associating protein that represses transcriptional activity of c Myc journal J. Biol. Chem. volume 273 ... S, Nishihara H, Iguchi Ariga S M, Nagashima K, Ariga H year 2001 month Nov. title MM 1, a c Myc ... cite journal author Fujioka Y, Taira T, Maeda Y, et al. title MM 1, a c Myc binding protein, is a candidate ... author Watanabe K, Ozaki T, Nakagawa T, et al. title Physical interaction of p73 with c Myc and MM1, a c Myc binding protein, and modulation of the p73 function. journal J. Biol. Chem. volume 277 issue ... activities of MM 1 isoforms toward c Myc. journal J. Cell. Biochem. volume 97 issue 1 pages ... more details
the boats docked at the MYC basin for fear that the Japanese soldiers might use them to launch ... to liberate Manila . The US Army occupied the Club and in March 1947, MYC was able to secure the property ... more details
Orphan date February 2009 PBB geneid 84864 MYC induced nuclear antigen is a protein that in humans is encoded by the MINA gene . ref name pmid12091391 cite journal author Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H title A novel myc target gene, mina53, that is involved in cell proliferation journal J Biol Chem volume 277 issue 38 pages 35450 9 year 2002 month Sep pmid 12091391 pmc doi 10.1074 jbc.M204458200 ref ref name entrez cite web title Entrez Gene MINA MYC induced nuclear antigen url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 84864 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Bonaldo MF, Lennon G, Soares MB title Normalization and subtraction two approaches to facilitate gene discovery. journal Genome Res. volume 6 issue 9 pages 791 806 year 1997 pmid 8889548 doi 10.1101 gr.6.9.791 cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences. journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Teye K, Tsuneoka M, Arima N, et al. title Increased expression of a Myc target gene Mina53 in human colon cancer. journal Am. J. Pathol. volume 164 issue 1 pages 205 16 year 2004 pmid 14695334 doi pmc 1602225 cite journal author Ota T, Suzuki Y, Nishikawa T, et al. title Complete sequencing and characterization of 21,243 full length human cDNAs. journal Nat. Genet. volume 36 issue 1 pages 40 5 year 2004 pmid 14702039 ... pmc 1356129 cite journal author Teye K, Arima N, Nakamura Y, et al. title Expression of Myc target ... of the myc target gene Mina53 in advanced renal cell carcinoma. journal Pathol. Int. volume 57 ... more details
Orphan date February 2009 PBB geneid 10260 C myc promoter binding protein is a protein that in humans is encoded by the DENND4A gene . ref name pmid8056341 cite journal author Stasiv YZ, Mashkova TD, Chernov BK, Sokolova IV, Itkes AV, Kisselev LL title Cloning of a cDNA encoding a human protein which binds a sequence in the c myc gene similar to the interferon stimulated response element journal Gene volume 145 issue 2 pages 267 72 year 1994 month Sep pmid 8056341 pmc doi 10.1016 0378 1119 94 90018 3 ref ref name pmid12906859 cite journal author Semova N, Kapanadze B, Corcoran M, Kutsenko A, Baranova A, Semov A title Molecular cloning, structural analysis, and expression of a human IRLB, MYC promoter binding protein new DENN domain containing protein family emerges small star, filled journal Genomics volume 82 issue 3 pages 343 54 year 2003 month Aug pmid 12906859 pmc doi 10.1016 S0888 7543 03 00103 4 ref ref name entrez cite web title Entrez Gene DENND4A DENN MADD domain containing 4A pmid 10260 ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Ewing RM, Chu P, Elisma F, et al. title Large scale mapping of human protein protein interactions by mass spectrometry. journal Mol. Syst. Biol. volume 3 issue pages 89 year 2007 pmid 17353931 doi 10.1038 msb4100134 pmc 1847948 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The status, quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal Genome Res. volume 14 issue 10B pages 2121 7 year 2004 pmid 15489334 doi 10.1101 gr.2596504 pmc 528928 cite journal author Jin J, Smith FD, Stark C, et al. title Proteomic, functional, and domain based analysis of in vivo 14 ... with c Myc to regulate Y box binding protein 1 expression. journal J. Biol. Chem. volume 277 issue ... more details
genetics transcription activation. TRRAP a central role in MYC c Myc transcription activation, and also participates in cell transformation by MYC. It is required for p53 TP53 , E2F1 and E2F4 mediated ... c Myc interacting nuclear cofactor for oncogenic transformation journal Mol. Cell. Biol. volume ... Tesfai Jerusalem, Evrard Yvonne A, Dent Sharon Y R, Martinez Ernest date May 2003 title c Myc ... 10.1016 S0092 8674 01 00450 0 ref Myc , ref name pmid9708738 cite journal last McMahon first S B ... ATM related protein TRRAP is an essential cofactor for the c Myc and E2F oncoproteins journal Cell ... TRRAP recruits the histone acetyltransferase hGCN5 to c Myc journal Mol. Cell. Biol. volume 20 ... The novel ATM related protein TRRAP is an essential cofactor for the c Myc and E2F oncoproteins ... hGCN5 to c Myc. journal Mol. Cell. Biol. volume 20 issue 2 pages 556 62 year 2000 pmid 10611234 ... acetyltransferase recruitment and Myc dependent oncogenesis. journal Genes Dev. volume 15 issue ... BAF53 forms distinct nuclear complexes and functions as a critical c Myc interacting nuclear cofactor ... and TRRAP independent transcriptional activation by Myc family oncoproteins. journal Mol. Cell ... cite journal author Liu X, Tesfai J, Evrard YA, et al. title c Myc transformation domain ... more details
Orphan date February 2009 PBB geneid 4150 Myc associated zinc finger protein is a protein that in humans is encoded by the MAZ gene . ref name pmid1567856 cite journal author Pyrc JJ, Moberg KH, Hall DJ title Isolation of a novel cDNA encoding a zinc finger protein that binds to two sites within the c myc promoter journal Biochemistry volume 31 issue 16 pages 4102 10 year 1992 month May pmid 1567856 pmc doi 10.1021 bi00131a029 ref ref name pmid1502157 cite journal author Bossone SA, Asselin C, Patel AJ, Marcu KB title MAZ, a zinc finger protein, binds to c MYC and C2 gene sequences regulating transcriptional initiation and termination journal Proc Natl Acad Sci U S A volume 89 issue 16 pages 7452 6 year 1992 month Sep pmid 1502157 pmc 49728 doi 10.1073 pnas.89.16.7452 ref ref name entrez cite web title Entrez Gene MAZ MYC associated zinc finger protein purine binding transcription factor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 4150 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions MAZ gene has been shown to Protein protein interaction interact with BPTF ref name pmid10727212 cite journal doi 10.1021 bi992211q ... year 2000 month Mar. title Fetal Alz 50 clone 1 FAC1 protein interacts with the Myc associated zinc ... H, Song J, Shiga T, Fearon E, Murata T, Yokoyama K K year 2001 month Sep. title Interaction of Myc ... of a human gene for Myc associated zinc finger protein MAZ . journal J. Biol. Chem. volume 273 ... and transcriptional activities of MAZ, a myc associated zinc finger protein, are regulated by casein ... 1 FAC1 protein interacts with the Myc associated zinc finger protein ZF87 MAZ and alters its transcriptional ... 10.1021 bi992211q cite journal author Ugai H, Li HO, Komatsu M, et al. title Interaction of Myc associated ... D, Rizzoli R, et al. title Functional importance of Myc associated zinc finger protein for the human ... more details
Infobox Disease Name Feingold syndrome Image Caption DiseasesDB 33706 ICD10 ICD9 ICDO OMIM 164280 MedlinePlus eMedicineSubj eMedicineTopic MeshID Feingold syndrome also called oculodigitoesophagoduodenal syndrome is a rare autosomal dominant hereditary disorder . It is named after Murray Feingold , an American physician who first described the syndrome in 1975. Until 2003, at least 79 patients have been reported worldwide ref Teszas et al. 2006 Expanding the clinical spectrum of MYCN related Feingold syndrome Am J Med Genet Part A 140A 2254 2256 ref Characteristics Feingold syndrome is marked by various combinations of microcephaly , limb malformations , esophagus esophageal and duodenum duodenal atresia s, and sometimes learning disability or mental retardation ref Celli et al. 2003 Feingold syndrome clinical review and genetic mapping Am J Med Genet Part A 122 4 294 300 ref . Genetics and cause Image Autodominant.jpg thumb right Feingold Syndrome is inherited in an autosomal dominant fashion. Feingold syndrome is caused by mutations in the N Myc neuroblastoma derived V myc avian myelocytomatosis viral related oncogene MYCN which is located on the short arm of chromosome 2 2p24.1 . Diagnosis and treatment The diagnosis is based on the following clinical findings microcephaly clinodactyly and shortness of index and little fingers syndactyly of 2nd & 3rd and 4th & 5th toe short palpebrae palpebral fissures esophageal and or duodenal atresia References reflist 2 External links http www.ncbi.nlm.nih.gov bookshelf br.fcgi?book gene&part feingold GeneReview NIH UW entry on Feingold syndrome Transcription factor coregulator deficiencies DEFAULTSORT Feingold Syndrome Category Autosomal dominant disorders Category Syndromes Category Transcription factor deficiencies pl Zesp Feingolda ... more details
Encyclopedia
top
