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Encyclopedia results for MHC class II

MHC class II





Encyclopedia results for MHC class II

  1. MHC class II

    Image MHC Class 2.svg thumb Schematic representation of MHC class II MHC major histocompatibility complex Class II molecules are found only on a few specialized cell types, including macrophage s, dendritic ... presented by class II molecules are derived from extracellular proteins not cytosolic as in MHC Class I class I hence, the MHC class II dependent pathway of antigen presentation is called the endocytic or exogenous pathway. Loading of class II molecules must still occur inside the cell extracellular proteins are endocytosis endocytosed , digested in lysosome s, and bound by the class II MHC molecule prior to the molecule s migration to the plasma membrane. Structure Like MHC class I molecules, class II molecules are also heterodimer s, but in this case consist of two homologous peptides, an ... Because the antigen binding groove of MHC class II molecules is open at both ends while the corresponding groove on class I molecules is closed at each end, the antigens presented by MHC class II molecules ... class II MHC is loaded with extracellular proteins, it is mainly concerned with presentation of extracellular pathogens for example, bacteria that might be infecting a wound or the blood . Class II ... due to activation of B cell s. Synthesis During synthesis of class II MHC in the endoplasmic reticulum ... chain . The nascent MHC class II protein in the rough ER has its peptide binding cleft blocked ... pathway such as those that would be loaded onto class I MHC . The invariant chain also facilitates the export of class II MHC from the ER to the golgi, followed by fusion with a late endosome ... blockage of the peptide binding cleft on the MHC molecule. An MHC class II like structure, HLA DM .... The stable class II MHC is then presented on the cell surface. Genes class wikitable Alpha Beta HLA ... Cross presentation External links MeshName Histocompatibility Antigens Class II MeshName MHC Class ... genes Category Immune system Category Glycoproteins it MHC II ...   more details



  1. MHC class I

    Image MHC Class 1.svg thumb Schematic representation of MHC class I MHC class I molecules are one of two primary classes of major histocompatibility complex MHC molecules the other one being MHC class ... by the immune system. Because MHC class I molecules present peptides derived from cytosol ic proteins, the pathway of MHC class I presentation is often called the cytosolic or endogenous pathway ... Molecules Kimball s Biology Pages, Histocompatibility Molecules ref Function Class I MHC molecules ... part of the class I MHC molecule. Thus, the function of the class I MHC is to display intracellular proteins to cytotoxic T cell s CTLs . However, class I MHC can also present peptides generated ... peptides from normal cellular protein turnover on its class I MHC, and CTLs will not be activated ... proteins, such as after viral infection, a fraction of the class I MHC will display these peptides ... the presenting cell. Alternatively, class I MHC itself can serve as an inhibitory ligand for natural killer cells NKs . Reduction in the normal levels of surface class I MHC, a mechanism employed by some ... T cells . The 1 and 2 domains fold to make up a groove for peptides to bind. MHC class I molecules bind peptides that are 8 10 amino acid in length Parham 87 . Production Image MHC Class I processing.svg ..., transport into endoplasmic reticulum by TAP complex, loading on MHC class I, and transport to the surface ... ER to meet the MHC class I molecule, whose peptide binding site is in the lumen of the ER. Translocation ... ATP consumption into the lumen of the ER. The MHC class I molecule is then, in turn, loaded ... . Calnexin acts to stabilize the class I MHC chains prior to 2m binding. Following complete assembly ... loading and colocalization. Once the peptide is loaded onto the MHC class I molecule, the complex ... of the MHC class I molecules through the secretory pathway involves several posttranslational ... Peptides that fail to bind MHC class I molecules in the lumen of the endoplasmic reticulum ER ...   more details



  1. MHC class I polypeptide-related sequence A

    PBB geneid 4276 MHC class I polypeptide related sequence A is a protein that in humans is encoded by the MICA gene . ref name pmid8022771 cite journal author Bahram S, Bresnahan M, Geraghty DE, Spies T title A second lineage of mammalian major histocompatibility complex class I genes journal Proc Natl Acad Sci U S A volume 91 issue 14 pages 6259 63 year 1994 month Aug pmid 8022771 pmc 44180 doi 10.1073 pnas.91.14.6259 ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text MICA encodes the highly polymorphic MHC HLA class I chain related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta 2 microglobulin. It is thought that MICA functions as a stress induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. ref cite web title Entrez Gene MICA MHC class I polypeptide related sequence A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 4276 accessdate ref See also MHC class I Major histocompatibility complex References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Klein J, O hUigin C title The conundrum of nonclassical major histocompatibility complex genes. journal Proc. Natl. Acad. Sci. U.S.A. volume 91 issue 14 pages 6251 2 year 1994 pmid 8022769 doi 10.1073 pnas.91.14.6251 pmc 44177 cite journal author Bahram S, Spies T title The MIC gene family. journal Res. Immunol. volume 147 issue 5 pages 328 33 year 1997 pmid 8876061 doi 10.1016 0923 2494 96 89646 5 cite journal author Blumberg RS title Current concepts in mucosal immunity. II. One size fits all nonclassical MHC molecules fulfill multiple roles in epithelial cell function. journal Am. J. Physiol. volume 274 issue 2 Pt 1 pages G227 31 year 1998 pmid 9486173 doi refend PDB Gallery geneid 4276 protein stub ...   more details



  1. Class II

    Class II may refer to Class II appliance Class II bacteriocin Class II cabinet Class II gene Class II PI 3 kinases Class II railroad Class II star MHC class II dab Long comment to avoid being listed on short pages ...   more details



  1. MHC

    MHC may refer to Biology Myosin heavy chain part of the motor protein myosin s quaternary protein structure Major histocompatibility complex a highly polymorphic region on chromosome 6 with genes particularly involved in immune functions Colleges Mars Hill College a coeducational, liberal arts college affiliated with the North Carolina Baptist Convention in Mars Hill, North Carolina, USA Mount Holyoke College a liberal arts women s college and a member of the Seven Sisters in South Hadley, Massachusetts, USA Health Managed health care Mental Health Counselor Military The US Navy hull classification symbol for Coastal Minehunter People Matthew Henry Commentary Biblical Mary Higgins Clark , American suspense author Other The Mile high club Mid Hudson Conference Milwaukee Hurling Club disambig cs MHC rozcestn k de MHC it MHC ...   more details



  1. Class II gene

    Unreferenced stub auto yes date December 2009 A class II gene is a type of gene that codes for a protein . Class II genes are transcription genetics transcribed by RNAP RNAP II . Class II genes have a promoter biology promoter that often contains a TATA box . Basal transcription of class II genes requires the formation of a preinitiation complex . They are transcribed by RNA polymerase II, include both intron and exon, and code for polypeptide. DEFAULTSORT Class Ii Gene Category Genes Category Molecular biology Genetics stub Biochem stub ...   more details



  1. File:Class II nose.jpg

    Summary Class II Nose Greek or Straight Nose from Eden Warwick, Nasology, London, Richard Bentley, 1848 PD old 100 ...   more details



  1. Class II railroad

    A Class II railroad in the United States is a mid sized freight hauling railroad, in terms of its operating revenue. As of 2006 , a railroad with revenues greater than 20.5 million but less than 277.7 million for at least three consecutive years is considered a Class II railroad. Switching and terminal railroads are excluded from Class II status. Railroads considered by the Association of American Railroads as Regional Railroads are typically Class II railroads. Criteria The Surface Transportation Board is responsible for defining the bounds of each railroad class. The bounds are typically redefined every several years, to adjust for inflation and other factors. The last major change of the upper bound for a Class II railroad was in 1992 this changed the Florida East Coast Railway from a Class I railroad to Class II. ref name FECstatus cite journal title Arrivals and Departures journal Trains magazine Trains month November year 1992 ref A previous change in 1991 prevented two railroads, Montana RailLink and Wisconsin Central Ltd. Wisconsin Central , from being classified as Class I railroads this change was made at the request of the two railroads involved, as they did not wish to take on the extra cost and paperwork associated with Class I status. ref name MRLstatus cite journal title Arrivals and Departures journal Trains magazine Trains month March year 1991 author Spriet, Ll Campbell, Cb Dyck, Dj volume 59 issue 3 pages 243 52 issn 0047 6374 pmid 1921515 format Free full text ref Changes since have been adjustments for inflation . See also Class I railroad Class III railroad List of U.S. Class II railroads References http edocket.access.gpo.gov cfr 2007 octqtr pdf 49cfr1201.pdf 49 CFR Part 1201 Railroad Companies PDF http www.stb.dot.gov stb faqs.html econ Surface Transportation Board FAQs Economic and Industry Information http www.stb.dot.gov decisions ReadingRoom.nsf UNID 7A28F3AA79ADFC1385256ED90046F575 file 34891.pdf STB Ex Parte No. 647 reflist Category Rail ...   more details



  1. Class II PI 3-kinases

    Class II PI 3 kinases are a subgroup of the enzyme family, phosphoinositide 3 kinase that share a common protein domain structure, substrate specificity and method of activation. Class II PI 3 kinases were the most recently identified class of PI 3 kinases and little is currently known about these enzymes. There are three class II PI 3 kinase isoforms expressed in mammalian cells PI3K C2 PI3K C2 PI3K C2 See also phosphoinositide 3 kinase References Stein RC 2001 Prospects for phosphoinositide 3 kinase inhibition as a cancer treatment Endocr Relat Cancer 8 237 248 http erc.endocrinology journals.org cgi content abstract 8 3 237 Foster FM, Traer CJ, Abraham SM, and Fry MJ 2003 The phosphoinositide PI 3 kinase family J Cell Sci 116 3037 3040. http jcs.biologists.org cgi content full 116 15 3037 Vanhaesebroeck B, Waterfield MD. 1999 Signaling by distinct classes of phosphoinositide 3 kinases. Exp Cell Res. 253 1 239 54. http www.ludwig.ucl.ac.uk cellsig pdf VanhaesebroeckB1999c.pdf Category EC 2.7.1 transferase stub Cell biology stub Kinases ru 3 2 ...   more details



  1. DRG Kleinlokomotive Class II

    Image deutz 57259 51.jpg thumb K f II 323 114 of the Deutsche Bundesbahn Image Deutz 57269 52.jpg thumb K f II on a rail flat German Kleinlokomotive n literally small locomotives like the DRG K II later K f II were developed as locomotive s with a low weight and driving power for light shunting duties. There were two classes, based on engine power. The Class II were engines which developed more than ... power groups DRG Class K I Class I initially 40, later 50 PS Class II up to 90 PS Image German light ... K f II in Augsburg Railway Park Image German light diesel locomotive Class 100.jpg 310 426 in Bad Salzungen File DB K f Class 323 871 4.JPG K f II at the German Steam Locomotive Museum in Neuenmarkt ... German diesel locomotives DRG Kleinlokomotive Class II Category Diesel locomotives of Germany ... over 100 new K f II engines were further developed and built after the war. In the DR over 60 ... discarded and replaced by the DR V60 project. The DB later developed a DB Class K f III K f III with up to 240 PS. In 1987, the Class 260 261 up to 1968 called V 60 engines were classified as light locomotives ... Deutsche Reichsbahn Gesellschaft power category Leistungsgruppe II, Kb K K f Kbf 4001 to 6047 br Deutsche Bundesbahn continued production of K f II up to K f 6835 br Deutsche Bundesbahn in 1968 redesignated as Class 321 324 br Deutsche Reichsbahn East Germany new models K 4002 to 4032 br Deutsche Reichsbahn East Germany in 1970 redesignated as Class 100 br Deutsche Reichsbahn East Germany in 1973, narrow gauge K redesignated as Class 199 br Deutsche Bahn AG in 1992 DR Class 100 redesignated as DBAG Class 310 Class 321 Vmax 30km h, foot brake, rebuilt into 322 324 stopped in February 1974 Class 322 Vmax 30km h, compressed air brake Class 323 324 Vmax 45km h, compressed air brake Preserved ... in the Deutsche Bundesbahn , as well as a handful of battery operated light locos, of DB Class ... scheme as Class 100 . After German reunification these became Class 310 in the DB AG. Only a few ...   more details



  1. Jingsah II class LCAC

    Infobox Ship Begin Infobox Ship Class Overview Builders Operators People s Liberation Army Navy Class before Jingsah and Payi class LCACs In commission range x present Infobox Ship Characteristics Ship type Air cushioned landing craft Ship displacement 70 t full load Ship length 22 metres Ship propulsion Turbine engines br 2 propulsion engines, 2 lift engines br 2 four bladed variable pitch propellers Ship speed 55 knots Ship armament 4 X 14.5 mm machine guns 2 twin Ship aircraft facilities The Jingsah II class LCAC is a medium size air cushioned landing craft hovercraft operated by the People s Liberation Army Navy of China. Description The Jingsah II LCAC is roughly the same size the U.S. Navy LCAC , and is designed for similar duties. It was designed as a successor to the earlier Jingsah and Payi class LCACs. The prototype was built at Dagu in 1979, and entered production in limited numbers. The prototype 452 lacked a bow door for disembarkation, and this feature may have been added to an improved version before entering production. The prototype is believed have been scrapped. Fact date April 2009 Ten are believed to be in service. Fact date April 2009 The Jingsah II class is capable of carrying 15 tons of equipment. Operators PRC People s Liberation Army Navy Specifications Crew ? Dimensions Length 22 metres Width 8 metres full load displacement 70 tons Propulsion Motors turbine engines Power 2 propulsion engines, 2 lift engines Propellers 2 four bladed variable pitch propellers Performance Speed 55 knots Range ? Military Lift 15 tons Weapons 4 X 14.5  mm machine guns 2 twin See also LCAC References reflist Saunders, Stephen RN Jane s Fighting Ships 2003 2004 ISBN 0 7106 2546 4 Ship classes of the Chinese Navy Category Ships of the People s Liberation Army Navy Category Hovercraft Category Landing craft ...   more details



  1. Dictyostelium class II RNA

    Infobox rfam Name Class II RNA image CIIRNA.png width 220 caption Class II RNA conserved secondary structure Symbol AltSymbols Rfam RNA type Cis reg Tax domain Dictyostelium discoideum CAS number EntrezGene HGNCid OMIM PDB RefSeq Chromosome Arm Band LocusSupplementaryData NOTOC The class II RNA is a ncRNA non coding RNA . This family was identified using shotgun sequencing of full length cDNA libraries of small RNAs sRNA from the social amoeba Dictyostelium discoideum . ref name Asp04 cite journal author Aspegren A, Hinas A, Larsson P, Larsson A, S derbom F title Novel non coding RNAs in Dictyostelium discoideum and their expression during development journal Nucleic Acids Res. volume 32 issue 15 pages 4646 56 year 2004 pmid 15333696 pmc 516072 doi 10.1093 nar gkh804 url http nar.oxfordjournals.org cgi pmidlookup?view long&pmid 15333696 accessdate 2010 07 22 ref The RNAs are 59 60 nucleotides in length. A Northern blot Northern blot analysis showed that this ncRNA was expressed in all stages of development and that, like Dictyostelium class I RNA , class II is strongly localised in the cytoplasm. ref name Asp04 Dictyostelium class I and II share a consensus sequence 5 CCUUACAGCAA 3 which is found in an open area of the secondary structure of both molecules. The function of this RNA is unknown. ref name Asp04 See also Dictyostelium class I RNA non coding RNA External links http www.sequenceontology.org miso current cvs term SO 0000989 Sequence Ontology page for Class II RNA References reflist Further reading refbegin 2 cite journal author Larsson P, Hinas A, Ardell DH, Kirsebom LA, Virtanen A, S derbom F title De novo search for non coding RNA genes in the AT rich genome of Dictyostelium discoideum performance of Markov dependent genome feature scoring journal Genome Res. volume 18 issue 6 pages 888 99 year 2008 month June pmid 18347326 pmc 2413156 doi 10.1101 gr.069104.107 url http www.genome.org cgi pmidlookup?view long&pmid 18347326 accessdate 2010 07 22 cite journal ...   more details



  1. Class II bacteriocin

    Pfam box Symbol Bacteriocin II Name Class II bacteriocin image PDB 2leu EBI.jpg width caption Three dimensional structure of leucocin A a type IIa bacteriocin. ref name pmid9398233 cite journal author Fregeau Gallagher NL, Sailer M, Niemczura WP, Nakashima TT, Stiles ME, Vederas JC title Three dimensional structure of leucocin A in trifluoroethanol and dodecylphosphocholine micelles spatial location of residues critical for biological activity in type IIa bacteriocins from lactic acid bacteria journal ... 60 PDB3 1cw6 A 25 60 PDB3 3leu 25 60 PDB3 1cw5 A 19 54 PDB3 1ry3 A 19 54 Class II bacteriocins are a class ... disulfide bond s are the only modification to the peptide are Class II bacteriocins. Class IIa One important and well studied class of bacteriocin s is the class IIa or pediocin like bacteriocins produced by lactic acid bacteria . All class IIa bacteriocins are produced by food associated strains ..., dairy products and vegetables. Class IIa bacteriocins are all cationic , display anti Listeria activity ... author Ennahar S, Sonomoto K, Ishizaki A title Class IIa bacteriocins from lactic acid bacteria antibacterial ... class IIa bacteriocins is involved in specific recognition of the C terminal part of cognate immunity ... Dalhus B, Fimland G, Nissen Meyer J, Johnsen L title Pediocin like antimicrobial peptides class IIa .... Sci. volume 11 issue 11 pages year 2005 pmid 16059970 doi 10.1002 psc.699 ref . Class IIa bacteriocins ... 6420.2002 pmc 134399 ref . Based on their primary structures, the peptide chains of class IIa bacteriocins ... disulfide bridge. This cationic N terminal beta sheet domain mediates binding of the class IIa bacteriocin ... ref name PUB00033829 ref name PUB00033830 . Some proteins known to belong to the class IIa bacteriocin ... curvatus curvacin A. Listeria innocua listeriocin 743A. Class IIb The class IIb bacteriocins two peptide bacteriocins require two different peptides for activity. Class IIc Other class II bacteriocins can be grouped together as Class IIc circular bacteriocins . These have a wide range of effects ...   more details



  1. Kresta II class cruiser

    facilities Helicopter deck and hangar Ship notes The Kresta II Class , Soviet Designation Project ... in Russian en icon http russian ships.info eng warships project 1134a.htm All Russian Kresta II Class Cruisers Complete Ship List Commons category Kronshtadt class cruiser ColdwarSovietShips Category Cruiser classes Category Kresta II class cruisers Category Ships of the Soviet Navy cs Projekt 1134A de Kresta II Klasse it Classe Kresta II nl Kresta II klasse ru ... were an Anti Submarine derivative of the Kresta I class cruiser . These ships had a new anti submarine ... boilers, identical to the Kresta I class. Electronics Fit Radar MR600 air search MR 310 Angara Don ... Grom SA N 1 fire control MR103 AK725 fire control Drakon RP33 fire control Ships class wikitable ... man dod 101 sys ship row rus 1134.htm Kresta Class Project 1134 at Federation of American Scientists ...   more details



  1. Ekaterina II class battleship

    convert 8 9 in mm 0 abbr on Ship notes The Ekaterina II class were a Ship class class of four pre ... beginning in 1930 by the French. Design File Ekaterina II class battleship diagrams Brasseys 1896.jpg ... 1896 center The Ekaterina II class battleships were intended to support an amphibious assault on the Bosphorus ... McLaughlin, pp. 61 62 ref General characteristics The Ekaterina II class ships were convert 331 ... s 12 inch gun mounts at the factory The main armament of the Ekaterina II class ships consisted ... thumb right 250px Ekaterina II in 1902 alt The Ekaterina II class ships were originally ... 2003 isbn 1 55750 481 4 External links Commons category Ekaterina II class battleship http ship.bsu.by ... brone brone.htm Ship histories on Black Sea Fleet ru icon Ekaterina II class battleship WWIRussianShips DEFAULTSORT Ekaterina Ii Class Battleship Category Article Feedback Pilot Category Ships of the Imperial Russian Navy Ekaterina II Class Category Victorian era battleships of Russia ja ... , showing both forward barbettes Infobox Ship Class Overview Builders Sevastopol Shipyard RoPIT , Sevastopol ... Ensign of Russia.svg 20px Imperial Russian Navy Class before Class after sclass Imperator Aleksandr II battleship 0 Subclasses ship Russian battleship Georgii Pobedonosets 2 Built range 1883 94 In commission ... Style dates New Style ref ship Russian battleship Ekaterina II 2 s crew was considered unreliable ... carried out. Ekaterina II and Chesma were both eventually sunk as target ships after being ... ships were going to be built in the class, but Georgii Pobedonosets was built to a modified Ekaterina II design when a more modern design could not be prepared in a timely manner after Sinop was launched ... of convert 4 ft m . ref McLaughlin, pp. 21, 25 ref Propulsion Ekaterina II and Chesma had two three ... of the Ekaterina II which were built by the Baltic Shipyard Baltic Works . Their total designed output ... when fired over the bow or stern. Two different guns were used Ekaterin II and Sinop had 30 caliber ...   more details



  1. Class of 1999 II: The Substitute

    Infobox Film name Class of 1999 II The Substitute image Class of 1999 2.jpg image size caption director Spiro Razatos producer writer Mark Sevi starring Sasha Mitchell music cinematography editing distributor Cinetel Films released March 29, 1994 runtime 87 minutes country United States language English budget gross preceded by Class of 1999 followed by Class of 1999 II The Substitute is a 1994 in film 1994 Direct to video film about a new teacher at a troubled inner city school, where students all are affiliated with gang s, drug s, and violence . It was directed by Spiro Razatos and starred Sasha Mitchell as renegade teacher John Bolen. The movie is a sequel to Class of 1999 , but does not contain many links to that movie except inserted footage from Flashback narrative flashback sequences, and a vague reference to previous happenings in the plot. Synopsis In this sequel to the 1990 movie Class of 1999 , the setting is still a violent future metropolis where gangs rule the hallways and themes like education and higher learning are a mere memory. Jenna McKensie is a young, sweet high school teacher who witnesses the killing of one of her students by gang member Sanders. Jenna wants to testify, so Sanders and his thugs try to intimidate her with threats and even going as far as to try to rape her. The principal cannot suspend Sanders without definite proof of wrong doing, the cops have no evidence and Jenna s boyfriend Emmett wants to deal with Sanders himself, but Jenna does not want him to do that. Jenna starts to question whether or not suspending Sanders will improve the educational system or not. Enter John Bolen, a substitute teacher who believes in extremely strict discipline. Jenna takes a liking to him and feels she has found a friend who is willing to listen to her problems. John teaches Jenna that students should not be allowed to gain control of any situation in the classroom and that she must have a firm hand when it comes to teaching students. When Sanders ...   more details



  1. MHC Martin

    update date February 2011 class infobox bordered cellpadding 4 style font size 90 width 20em align center style font size medium color ffffff background color 113366 padding 5px colspan 2 MHC Mountfield align center colspan 2 style background color white bgcolor eeeeee League Slovak Extraliga Founded 1932 bgcolor eeeeee Arena Martin Zimny tadi n City Martin, Slovakia Martin , Slovakia bgcolor eeeeee Colours blue and white bgcolor eeeeee Head coach Ladislav Spi iak MHC Mountfield is a professional ice hockey team in the Slovak Extraliga . History MedalTableTop MedalSport Ice hockey MedalCompetition Slovak Extraliga MedalBronze 2009 2010 play off MedalBronze 1992 1993 play off MedalCompetition Continental Cup MedalGold 2009 1st place MedalBottom Club was established in 1932 as Sl via Martin. Later the name was changed to Sokol, K, Z S, Hutn k, Martimex Z S, Martimex and MHC Martin 2000 2010 . Since 2010 2011 season the name is MHC Mountfield. Club played in county league, since 1970 in 1. Slovensk n rodn hokejov liga 1.SNHL . In 1992 1993 93 season hockey club advanced into Slovak Extraliga . MHC Martin played in Slovak Extraliga all seasons except 1999 2000 00 and 2004 2005 05 , which spent in 1st. Slovak National Hockey League. Woman s team MHK Martin won woman s extraliga 10 times between 1997 2009 , junior organizations make also some achievments and Hockey Club Martin deliver some players and for years also doctor MUDr. Dalim r Jan ovi , who cooperate with MHC Martin into Slovak Men s, Woman s and Junior s Ice Hockey Representation. Current squad colspan 7 big Goalkeepers ... Hutn k Z S TS 1990 1992 1993 Martimex Z S Martin Martimex Martin MHC Martin 2000 2010 MHC Mountfield ... DEFAULTSORT Mhc Martin Category Ice hockey teams in Slovakia Martin, MHC Category Ice hockey teams in Czechoslovakia Martin, MHC Category Martin, Slovakia Euro icehockey team stub Slovakia sport stub cs MHC Martin de MHC Martin fr MHC Martin it MHC Martin pl MHC Martin sk MHC Mountfield Martin ...   more details



  1. MHC restriction

    Unreferenced auto yes date December 2009 Unreferenced date May 2010 MHC restricted antigen recognition , or MHC restriction , refers to the fact that a given T cell will recognize a peptide antigen only when it is bound to a particular Major histocompatibility complex MHC molecule. Normally, as T cells are stimulated only in the presence of self MHC molecules, antigen is recognized only as peptides bound to self MHC molecules. MHC restriction is particularly important when primary lymphocytes are developing and differentiating in the thymus or bone marrow . It is at this stage that T cells die by apoptosis if they express high affinity for self antigens presented by an MHC molecule or express too low affinity for self MHC. This is ensured through two distinct developmental stages positive selection and negative selection. Developing T cells in the primary lymphoid organs thymus first express neither CD4, CD8 or TcR T cell receptor . This is referred to as double negative selection. After differentiation, the T cell expresses both CD4 , CD8 and T cell receptor TcR . This is referred to as double positive selection. It is at this stage that select T cells undergo apoptosis if they are found to select for self antigen. This is a necessary step as it prevents T cells from cascading an autoimmunity autoimmune response against its host tissues. Ultimately, the T cells differentiate and mature to express either CD4 and TcR or CD8 and TcR. At this point the T cells leave the primary lymphoid organ and enter the blood stream. Conversly, it is thought that MHC Restriction plays a pivotal role in the antiretroviral therapy used to treat HIV AIDS as it can increase the CD4 cell count thus increasing the likelihood for an immune response to be prompted. DEFAULTSORT Mhc Restriction Category Immune system Immunology stub de MHC Restriktion ...   more details



  1. Book:Imperator Aleksandr II class battleships

    saved book title Imperator Aleksandr II class battleships subtitle cover image ImperatorAleksandrII1913Reval.jpg cover color Imperator Aleksandr II class battleships Imperator Aleksandr II class battleship Imperator Aleksandr II class battleship Russian battleship Imperator Aleksandr II Imperator Aleksandr II Russian battleship Imperator Nikolai I Imperator Nikolai I Category Wikipedia books on warfare Imperator Aleksandr II class battleships ...   more details



  1. Book:Ekaterina II class battleships

    saved book title Ekaterina II class battleships subtitle cover image GeorgiyPobedonosets linkor.jpg cover color Ekaterina II class battleships Ekaterina II class battleship Ekaterina II class battleship Russian battleship Ekaterina II Ekaterina II Russian battleship Chesma 1886 Chesma Russian battleship Sinop Sinop Russian battleship Georgii Pobedonosets Georgii Pobedonosets Category Wikipedia books on warfare Ekaterina II class battleships ...   more details



  1. Jumbo Mark II Class ferry

    our fleet index.cfm?fuseaction classes Washington State Ferries class information WSF Ferry Classes ...   more details



  1. Aminoacyl tRNA synthetases, class II

    Pfam box Symbol aa tRNA synt II Name Aminoacyl tRNA synthetase, class II D, K and N Pfam PF00152 InterPro IPR004364 PROSITE PDB PDB 1asy PDB 1asz PDB 1b8a PDB 1bbu PDB 1bbw PDB 1c0a PDB 1e1o PDB 1e1t PDB 1e22 PDB 1e24 Aminoacyl tRNA synthetase, class II D, K and N EC number 6.1.1. catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two step reaction. These proteins differ widely in size and oligomeric state, and have limited sequence homology ref name PUB00007191 cite journal author Delarue M, Moras D, Poch O, Eriani G, Gangloff J title Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs journal Nature volume 347 issue 6289 pages 203 206 year 1990 pmid 2203971 ref . The 20 aminoacyl tRNA synthetases are divided into two classes, I and II. Class I aminoacyl tRNA synthetases contain a characteristic Rossman fold catalytic domain and are mostly monomeric ref name PUB00006477 cite journal author Moras D, Konno M, Shimada A, Nureki O, Tateno M, Yokoyama S, Sugiura I, Ugaji Yoshikawa Y, Kuwabara S, Lorber B, Giege R title The 2.0 A crystal structure of Thermus thermophilus methionyl tRNA synthetase ... ref . Class II aminoacyl tRNA synthetases share an anti parallel beta sheet fold flanked by alpha ... between class I and class II synthetases. In reactions catalysed by the class I aminoacyl tRNA synthetases, the aminoacyl group is coupled to the 2 hydroxyl of the tRNA, while, in class II reactions, the 3 hydroxyl site is preferred. The synthetases specific for arginine, cysteine, glutamic acid, glutamine, isoleucine, leucine, methionine, tyrosine, tryptophan and valine belong to class ..., lysine, phenylalanine, proline, serine, and threonine belong to class II synthetases ref name ..., Class Ii Category Protein domains Category Human protein families protein stub ... between class 2 aminoacyl tRNA synthetases journal Nucleic Acids Res. volume 19 issue 13 pages ...   more details



  1. Imperator Aleksandr II class battleship

    stack battleship flying penants Ship caption Imperator Aleksandr II Infobox Ship Class Overview Name Builders Operators navy Russia br navy Empire of Japan Class before sclass Ekaterina II battleship 0 Class after ship Russian battleship Dvienadsat Apostolov 2 Subclasses Imperator Nikolai I Cost 8,000,000 ... II class battleships were two pre dreadnought battleship pre dreadnoughts built for the Imperial ... was sunk as a target in 1915. Design The Imperator Aleksandr II class battleships were the first all ... m5 Propulsion The Imperator Aleksandr II class ships had two 3 cylinder Compound engine vertical ... of the Imperator Aleksandr II class. The guns labeled C are 9 inch and D are 6 inch. This shows Imperator ... armament of the Imperator Aleksandr II class ships was a pair of convert 12 in mm 0 adj on Obukhov Model 1877 30 caliber artillery caliber guns. Those in Imperator Aleksandr II were fitted in a twin ... Protection Compound armour Compound armor was used throughout the Imperator Aleksandr II class ships ... II Class Imperator Aleksandr II class battleship WWIRussianShips DEFAULTSORT Imperator Aleksandr Ii Class Battleship Category Battleship classes Category Imperator Aleksandr II class battleships ... Hide header Header caption Imperator Aleksandr II Ship type pre dreadnought battleship Ship displacement ... optimized for the ramming role. ship Russian battleship Imperator Aleksandr II 2 served in the Baltic ... minute to a modified version of the Imperator Aleksandr II design, so there were significant differences ... Aleksandr II was convert 334 ft m length at the waterline long at the waterline and convert 346 ... provided steam to the engines. The engines of the Imperator Aleksandr II were built by Baltic Shipyard ... 0.45 kg Hotchkiss Guns date 1 December 2006 accessdate 22 December 2009 ref Imperator Aleksandr II carried ... spaces and was convert 8 ft 6 in m abbr on high on Imperator Aleksandr II . convert 3 ft 6 in m ... tower had convert 8 in mm 0 adj on sides on the Imperator Aleksandr II , but they were only six ...   more details



  1. List of U.S. Class II railroads

    As of 2004 , a Class II railroad in the United States has an operating revenue greater than 20.5 million but less than 277.7 million. Current Class II railroads Alaska Railroad ref http transit safety.volpe.dot.gov publications sso CRSafetyStudy html CRSS.html ref ref http www.american rails.com alaska railroad.html ref ARR Buffalo and Pittsburgh Railroad ref Surface Transportation Board , http www.stb.dot.gov Decisions readingroom.nsf 0265f2ead72cd7eb85257497001961f4 7b01499b0bc56c07852574440058e5a9?OpenDocument GENESEE & WYOMING INC. CONTROL EXEMPTION COLUMBUS AND GREENVILLE RAILWAY COMPANY, THE CHATTOOGA AND CHICKAMAUGA RAILWAY COMPANY, AND LUXAPALILA VALLEY RAILROAD, INC. , May 15, 2008 ref BPRR Central Oregon and Pacific Railroad ref name FEC Surface Transportation Board , http www.stb.dot.gov Decisions readingroom.nsf c31258598e9102e6852574970019dd7b 2f26e8c57aaab44f85257364004c69fd?OpenDocument FORTRESS INVESTMENT GROUP LLC, ET AL. CONTROL FLORIDA EAST COAST RAILWAY, LLC , September 28, 2007 ref CORP Florida East Coast Railway ref name FEC ref http www.american rails.com florida east coast railway.html ref FEC Indiana Rail Road ref http www.american rails.com indiana rail road.html ref INRD Iowa Interstate Railroad ref Surface Transportation Board , http www.stb.dot.gov Decisions readingroom.nsf 1783820abd27cf1785257497001b4508 e41a47d8121a07ef852572480075a445?OpenDocument IOWA INTERSTATE RAILROAD, LTD. ACQUISITION OF CONTROL EXEMPTION LINCOLN & SOUTHERN RAILROAD COMPANY ... maine and atlantic railway.html ref it is class II definitely MMA New York, Susquehanna and Western ... 40 million operating revenue in 2006. This includes some companies that are not Class II carriers ... RailroadsAndStates.aspx Railroads and States , 2006, accessed July 2008 ref Former Class II railroads ... mark AR not in tl US class II Alabama Great Southern Railroad AGS , owned by Norfolk Southern Railway .... , May 9, 2001 ref References reflist Category Rail transport in the United States Class II railroads ...   more details



  1. Major histocompatibility complex, class II, DP alpha 1

    protein Name major histocompatibility complex, class II, DP alpha 1 caption image width HGNCid 4938 Symbol HLA DPA1 AltSymbols HLA DP1A EntrezGene 3113 OMIM 142880 RefSeq NM 033554 UniProt P20036 PDB ECnumber Chromosome 6 Arm p Band 21.3 LocusSupplementaryData Major histocompatibility complex, class II, DP alpha 1 , also known as HLA DPA1 , is a human gene . ref name Entrez Gene 3113 cite web title Entrez Gene HLA DPA1 major histocompatibility complex, class II, DP alpha 1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3113 accessdate ref Function The protein encoded by this gene belongs to the MHC class II HLA class II alpha chain Homology 28biology 29 Paralogy paralogues . The class II molecule is a heterodimer consisting of an alpha DPA and a beta chain DPB , both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cell s APC B lymphocytes, dendritic cells, macrophages . ref name Entrez Gene 3113 Gene structure and polymorphisms The alpha chain is approximately 33 35 kDa. It is encoded by 5 exon s, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular protein domain domains , exon 4 encodes the transmembrane protein transmembrane and the cytoplasm cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphism biology polymorphism s specifying the peptide binding specificities, resulting in up to 4 different molecules. ref name Entrez Gene 3113 See also Major histocompatibility complex Human leukocyte antigen HLA DP References reflist Surface antigens gene 6 stub NLM content ...   more details




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