File Kinesin walking.gif thumb Animation of kinesin walking on a microtubule Image Kinesin cartoon.png thumb The kinesin dimer attaches to, and moves along, microtubules. Image Motility of kinesin en.png thumb Diagram illustrating motility of kinesin. A kinesin is a protein belonging to a class of motor ... of the kinesin family vary in shape but the typical kinesin is a protein protein dimer dimer molecule ... the kinesin dimer. Cargo binds to the light chain. Kinesin motor domain Pfam box Symbol Kinesin motor domain Name Kinesin motor domain image Kinesin motor domain 1BG2.png width caption Crystallographic structure of the human kinesin motor domain depicted as a rainbow colored cartoon N terminus blue ... journal author Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD title Crystal structure of the kinesin ... The head is the signature of kinesin and its amino acid sequence is well conserved among various kinesins ... in the motion of the kinesin. Several structural elements in the head, including a central beta ... cite journal author Schnitzer MJ, Block SM title Kinesin hydrolyses one ATP per 8 nm step journal ... pulls the cargo along. ref name Mather cite journal author Mather WH, Fox RF title Kinesin s Biased ..., Milligan RA, Vale RD title A structural change in the kinesin motor protein that drives motility ... as anterograde transport . Kinesin 14 family proteins, such as Drosophila NCD, budding yeast KAR3, and Arabidopsis ... et al cite journal author Ambrose JC,Li W, Marcus A, Ma H, Cyr R title A minus end directed kinesin ... soma . This is known as retrograde transport . Proposed mechanisms of movement Kinesin accomplishes .... In the hand over hand mechanism, the kinesin heads step past one another, alternating the lead position. In the inchworm mechanism, one kinesin head always leads, moving forward a step ... author Yildiz A, Tomishige M, Vale RD, Selvin PR title Kinesin Walks Hand Over Hand journal Science ... name Asbury cite journal author Asbury CL title Kinesin world s tiniest biped journal Current Opinion ... more details
The Kinesin 8 Family are a subfamily of the molecular motor proteins known as kinesin s. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP hydrolysis ATP hydrolysis created energy. The Kinesin 8 family has been shown to play an important role in chromosome alignment during mitosis . Kinesin 8 family members KIF18A in humans ref name Mayr cite journal author Mayr MI, H mmer S, Bormann J, et al. title The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression journal Curr Biol. volume 17 issue 6 pages 488 98 year 2007 month Mar pmid 17346968 doi 10.1016 j.cub.2007.02.036 ref and Kip3 in yeast ref name Gupta cite journal author Gupta ML, Carvalho P, Roof DM, Pellman D title Plus end specific depolymerase activity of Kip3, a kinesin 8 protein, explains its role in positioning the yeast mitotic spindle journal Nat Cell Biol. volume 8 issue 9 pages 913 23 year 2006 month Sep pmid 16906148 doi 10.1038 ncb1457 ref have been shown to be in vivo plus end directed microtubule depolymerizers. During prometaphase of mitosis , the microtubules attach to the kinetochores of sister chromatids . Kinesin 8 is thought to play some role in this process, as knockdown of this protein via siRNA produces a phenotype of sister chromatids that are unable to align properly see External Links . ref name Mayr ref name Stumpff cite journal author Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L title The kinesin 8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment journal Dev Cell volume 14 issue 2 pages 252 62 year 2008 month Feb pmid 18267093 doi 10.1016 j.devcel.2007.11.014 pmc 2267861 ref References reflist External links http www.pubmedcentral.nih.gov picrender.fcgi?artid 2267861&blobname NIHMS40734 supplement 03.mov Video Illustrations of Kinesin 8 depletion Category Motor proteins ... more details
Refimprove date August 2010 Wikify date August 2010 The Kinesin 13 Family are a subfamily of motor proteins known as kinesin s. Most kinesins transport materials or cargo around the cell while traversing along microtubule polymer tracks with the help of ATP hydrolysis ATP hydrolysis created energy. They are easily identified by their three typical structural components including a highly conserved structural domain, catalytic core, and microtubule binding sites. The kinesin 13 family, unlike other kinesins, has an internally positioned motor domain. They were initially named KIF M because of the unique location of their catalytic core in the middle of the polypeptide between the N terminal globular domain and the C terminal stalk but they are truly special due to their versatile nature. The Kinesin 13 family s molecular mechanism is less understood than other classes of kinesins which have their motor domains at one end of the molecule or the other. They are capable of traveling to both the minus and plus ends of microtubules whereas most motors are unidirectional. Thus they can catalytically polymerization depolymerize a microtubule from both ends making it a very efficient process. The exact mechanism of Kinesin 13 activated microtubule depolymerization remains unclear, however, recent biochemical and structural studies revealed some more detailed class specific features enabling researchers to formulate the following model. Refer to Figure 6 in referenced Ogawa article for illustrated description. The protein first contacts the side wall of a microtubule. This is not a stable interaction because the convex surface of the catalytic core does not fit to the flat surface of the straight microtubule protofilament . Steric hindrance between the molecule neck and adjacent protofilament further inhibits full contact between protein and the microtubule and only facilitates one dimensional diffusion along the microtubule. At this time, The protein s nucleotide binding pocket ... more details
Catastrophin , or KIF2, is a Microtubule microtubal motor protein which causes destabilization, ie. increases dynamic instability, of the microtubule plus end. It is specifically a kinesin like protein with a motor domain situated in the middle portion of its heavy chain. See also Microtubule associated protein Kinesin Category Motor proteins biochem stub ... more details
A light chain is the small polypeptide subunit of a protein complex . More specifically, it can refer to Immunoglobulin light chain Ferritin light chain Myosin light chain Kinesin light chain Dynein light chain Light chain may also refer to Mail armour disambig ... more details
A heavy chain is the large polypeptide subunit of a protein complex , such as a motor protein e.g. myosin , kinesin , or dynein or antibody or immunoglobulin . It commonly refers to the immunoglobulin heavy chain . Category Protein complexes biology stub ca Cadena pesant es Cadena pesada id Rantai berat ... more details
PBB geneid 3831 Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene . ref name ... A, White B, Siciliano MJ, Lachman LB title Cloning and genetic characterization of the human kinesin ..., Philp AV, McGrail M, Gindhart JG, Goldstein LS title Kinesin dependent axonal transport is mediated ... KNS2 kinesin 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3831 ... PBB Controls to Stop updates. PBB Summary section title summary text Conventional kinesin is a tetrameric ... chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N terminal domain, and six tetratricopeptide repeat TPR ... complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named " kinesin 2" , this gene is not a member of the kinesin 2 kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different ... of these variants has not been determined. ref name entrez cite web title Entrez Gene KNS2 kinesin ... Nov. title Kinesin dependent axonal transport is mediated by the sunday driver SYD protein journal ... chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 journal Biochemistry ... L S year 1998 month Jun. title Two kinesin light chain genes in mice. Identification and characterization ... Sep. title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants journal ..., Hirokawa N title Analysis of the kinesin superfamily insights into structure and function. journal ... cite journal author Goedert M, Marsh S, Carter N title Localization of the human kinesin light chain ... Y, Brown A, Clark J title Human kinesin light beta chain gene DNA sequence and functional characterization ... AA, et al. title A specific light chain of kinesin associates with mitochondria in cultured cells ... author Rahman A, Friedman DS, Goldstein LS title Two kinesin light chain genes in mice. Identification ... more details
PBB geneid 3798 Kinesin heavy chain isoform 5A is a protein that in humans is encoded by the KIF5A gene . ref name pmid9858832 cite journal author Hamlin PJ, Jones PF, Leek JP, Bransfield K, Lench NJ, Aldersley MA, Howdle PD, Markham AF, Robinson PA title Assignment of GALGT encoding beta 1, 4N acetylgalactosaminyl transferase GalNAc T and KIF5A encoding neuronal kinesin D12S1889 to human chromosome band 12q13 by assignment to ICI YAC 26EG10 and in situ hybridization. medjph stjames.leeds.ac.uk journal ... cite web title Entrez Gene KIF5A kinesin family member 5A url http www.ncbi.nlm.nih.gov sites entrez ... summary text This gene encodes a member of the kinesin family of proteins. Members of this family ... cite web title Entrez Gene KIF5A kinesin family member 5A url http www.ncbi.nlm.nih.gov sites entrez .... title Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins ... coauthors Kamal A, Roberts E A, Goldstein L S year 1999 month Sep. title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants journal J. Cell Biol. volume 146 issue 6 pages ... author Fichera M, Lo Giudice M, Falco M, et al. title Evidence of kinesin heavy chain KIF5A involvement ... and localization of a conventional kinesin motor expressed exclusively in neurons. journal Neuron ... gr.6.9.791 cite journal author Rahman A, Friedman DS, Goldstein LS title Two kinesin light chain ... author Rahman A, Kamal A, Roberts EA, Goldstein LS title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. journal J. Cell Biol. volume 146 issue 6 pages 1277 88 year 1999 ... Y, et al. title KIF5C, a novel neuronal kinesin enriched in motor neurons. journal J. Neurosci. volume ... Y, et al. title Glutamate receptor interacting protein GRIP1 directly steers kinesin to dendrites ... journal author Reid E, Kloos M, Ashley Koch A, et al. title A kinesin heavy chain KIF5A mutation in hereditary ... M, et al. title Beta dystrobrevin interacts directly with kinesin heavy chain in brain. journal ... more details
to fulfill their function. For example, kinesin deficiencies have been identified as cause for Charcot ... microfilament s through interaction with actin . Microtubule motors such as dynein and kinesin move ... motors KinesinKinesin s are a group of related motor proteins that use a microtubule track along which ... of kinesin. Fourteen distinct kinesin families are known, with some additional kinesin like ... Y, Hirokawa N title Analysis of the kinesin superfamily insights into structure and function journal ... issue 9 ref Genomic representation of kinesin motors ref name Vale Fungus Fungi yeast 6 Plant ... than kinesin and myosin motors. Dynein facilitates the movement of cilia and flagella . Compared to 15 ... a larger number of different kinesins. Many of these plant specific kinesin groups are specialized ... plate and ultimately the new cell wall requires kinesin like motor proteins. ref name Smith cite journal ... division is kinesin like calmodulin binding protein KCBP , which is unique to plants and part kinesin ... ASN title Origin and evolution of kinesin like calmodulin binding protein journal Plant Physiology ... more details
Unreferenced auto yes date December 2009 about the WWII Polish political organization Home Political Representation the Finnish police agency Keskusrikospoliisi an airport in Denmark Karup Airport KRP stands for kinesin related proteins . bimC is a subfamily of KRPs and its function is to separate the duplicated centrosomes during mitosis . DEFAULTSORT Krp Category Proteins Biochem stub ... more details
chembox ImageFile1 Monastrol.2D.png ImageSize1 150px ImageFile2 Monastrol.3D.png ImageSize2 150px IUPACName ethyl 4 3 hydroxyphenyl 6 methyl 2 sulfanylidene 3,4 dihydro 1H pyrimidine 5 carboxylate OtherNames Monastrol Section1 Chembox Identifiers CASNo PubChem 2987927 SMILES CCOC O C1 C NC S NC1C2 CC CC C2 O C InChI 1S C14H16N2O3S c1 3 19 13 18 11 8 2 15 14 20 16 12 11 9 5 4 6 10 17 7 9 h4 7,12,17H,3H2,1 2H3, H2,15,16,20 Section2 Chembox Properties Formula C sub 14 sub H sub 16 sub N sub 2 sub O sub 3 sub S MolarMass 292.35344 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Monastrol is a discovered by manish soni and Tim Mitchison . Monastrol was shown to inhibit kinesin 5, a motor protein . ref cite journal title Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype Based Screen author Thomas U. Mayer, Tarun M. Kapoor, Stephen J. Haggarty, Randall W. King, Stuart L. Schreiber, Timothy J. Mitchison journal Science year 1999 volume 286 issue 5441 pages 971 974 url http www.biochem.wisc.edu courses biochem704 Reading Mayer1999.pdf pmid 10542155 doi 10.1126 science.286.5441.971 ref Mechanism of action Monastrol binds to a long loop that is specific to the Eg5 kinesin family, and allosterically inhibits ATPase activity of the kinesin ref cite journal author Maliga Z, Kapoor TM, Mitchison TJ title Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5 journal Chem. Biol. volume 9 issue 9 pages 989 96 year 2002 month September pmid 12323373 doi 10.1016 S1074 5521 02 00212 0 url ref References reflist 2 Category Pharmacology pharma stub ... more details
PBB geneid 3799 Kinesin 1 heavy chain is a protein that in humans is encoded by the KIF5B gene . ref ... G, Vale RD title Cloning and expression of a human kinesin heavy chain gene interaction of the COOH ... ref ref name entrez cite web title Entrez Gene KIF5B kinesin family member 5B url http www.ncbi.nlm.nih.gov ... chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 journal Biochemistry ... A authorlink coauthors Friedman D S, Goldstein L S year 1998 month Jun. title Two kinesin light chain ... E A, Goldstein L S year 1999 month Sep. title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants journal J. Cell Biol. volume 146 issue 6 pages 1277 88 publisher location ... dependent interaction of kinesin light chain 2 and the 14 3 3 protein journal Biochemistry volume ... N, Vale RD title Cloning and localization of a conventional kinesin motor expressed exclusively in neurons ... 94 90314 X cite journal author Kull FJ, Sablin EP, Lau R, et al. title Crystal structure of the kinesin ... DS, Goldstein LS title Two kinesin light chain genes in mice. Identification and characterization ... disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear ... Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. journal J. Cell Biol. volume ... journal author Ong LL, Lim AP, Er CP, et al. title Kinectin kinesin binding domains and their effects ..., a novel neuronal kinesin enriched in motor neurons. journal J. Neurosci. volume 20 issue 17 pages ... receptor interacting protein GRIP1 directly steers kinesin to dendrites. journal Nature volume ... MA, Speicher DW, Shiekhattar R title The motor protein kinesin 1 links neurofibromin and merlin in a common ... E, Douglas MW, Cunningham AL title The heavy chain of conventional kinesin interacts with the SNARE ... Beta dystrobrevin interacts directly with kinesin heavy chain in brain. journal J. Cell. Sci. volume ... receptor, p180, interacts with kinesin heavy chain, KIF5B. journal Biochem. Biophys. Res ... more details
PBB geneid 9371 Kinesin like protein KIF3B is a protein that in humans is encoded by the KIF3B gene . ref name pmid9205841 cite journal author Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O title Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro journal DNA Res volume 4 issue 2 pages 141 50 year 1997 month Sep pmid 9205841 pmc doi 10.1093 dnares 4.2.141 ref ref name entrez cite web title Entrez Gene KIF3B kinesin family member 3B url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9371 accessdate ... as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis ... movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. ref name entrez cite web title Entrez Gene KIF3B kinesin family ... coupling between Rab4 and the motor protein kinesin journal Mol. Cell. Biol. volume 23 issue 14 ..., Hirokawa N title KIF3A B a heterodimeric kinesin superfamily protein that works as a microtubule plus ... along microtubules and associates with kinesin superfamily motor KIF3. journal EMBO J. volume 17 issue ... 29 cells cloning of ser thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu ... motor kinesin II in vertebrate retina. journal Exp. Eye Res. volume 69 issue 5 pages 491 503 ... and the kinesin superfamily. journal Nat. Cell Biol. volume 4 issue 4 pages 323 7 year 2002 pmid ... links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella ... Rab4 and the motor protein kinesin. journal Mol. Cell. Biol. volume 23 issue 14 pages 4892 900 year ... T, Jimbo T, et al. title Role of the kinesin 2 family protein, KIF3, during mitosis. journal ... journal author Wu Y, Dai XQ, Li Q, et al. title Kinesin 2 mediates physical and functional interactions ... more details
Orphan date February 2009 PBB geneid 147700 Kinesin light chain 3 is a protein that in humans is encoded by the KLC3 gene . ref name entrez cite web title Entrez Gene KLC3 kinesin light chain 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 147700 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain KHC and two kinesin light chain KLC molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. ref name entrez cite web title Entrez Gene KLC3 kinesin light chain 3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 147700 accessdate ref Interactions KLC3 has been shown to Protein protein interaction interact ... year 2002 month Apr. title Phosphorylation dependent interaction of kinesin light chain 2 and the 14 ... FA title Rat kinesin light chain 3 associates with spermatid mitochondria. journal Dev. Biol. volume ... of kinesin light chain with outer dense fibers in a microtubule independent fashion. journal J. Biol ... A, Itagaki C, et al. title Phosphorylation dependent interaction of kinesin light chain 2 and the 14 ... 10.1021 bi015946f cite journal author Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA title Kinesin ... Rahman A, Kamal A, Roberts EA, Goldstein LS title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. journal J. Cell Biol. volume 146 issue 6 pages 1277 88 year 1999 pmid 10491391 ... LS title Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins ... more details
PBB geneid 11004 Kinesin like protein KIF2C is a protein that in humans is encoded by the KIF2C gene . ref name pmid9434124 cite journal author Kim IG, Jun DY, Sohn U, Kim YH title Cloning and expression of human mitotic centromere associated kinesin gene journal Biochim Biophys Acta volume 1359 issue 3 pages 181 6 year 1998 month Feb pmid 9434124 pmc doi ref ref name entrez cite web title Entrez Gene KIF2C kinesin family member 2C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 11004 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a member of kinesin like protein family. Most proteins of this family are microtubule dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein acts to regulate microtubule dynamics in cells and is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation. ref name entrez cite web title Entrez Gene KIF2C kinesin family member 2C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 11004 accessdate ref References ... M, Kaneshiro K, Hirokawa N title All kinesin superfamily protein, KIF, genes in mouse and human. journal ... Mitotic centromere associated kinesin is important for anaphase chromosome segregation. journal J ... affect the subcellular distribution of mitotic centromere associated kinesin MCAK . journal Cell Biol ... associated kinesin. journal J. Biol. Chem. volume 276 issue 37 pages 34753 8 year 2001 pmid 11466324 ... author Ganem NJ, Compton DA title The KinI kinesin Kif2a is required for bipolar spindle assembly ... M, Ovechkina Y, et al. title MCAK, a Kin I kinesin, increases the catastrophe frequency of steady ... G, Kalaidzidis Y, et al. title The depolymerizing kinesin MCAK uses lattice diffusion to rapidly ... more details
Orphan date February 2009 PBB geneid 10749 Kinesin like protein KIF1C is a protein that in humans is encoded by the KIF1C gene . ref name pmid9685376 cite journal author Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R title Characterization of KIF1C, a new kinesin like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum journal J Biol Chem volume 273 issue 32 pages 20267 75 year 1998 month Sep pmid 9685376 pmc doi 10.1074 jbc.273.32.20267 ref ref name entrez cite web title Entrez Gene KIF1C kinesin family member 1C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10749 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions KIF1C has been shown to Protein protein interaction interact with PTPN21 ref name pmid9685376 cite journal last Dorner first C authorlink coauthors Ciossek T, M ller S, M ller P H, Ullrich A, Lammers R year 1998 month Aug. title Characterization of KIF1C, a new kinesin like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum journal J. Biol. Chem. volume 273 issue 32 pages 20267 75 publisher location UNITED STATES issn 0021 9258 pmid 9685376 bibcode oclc id url language format accessdate laysummary laysource laydate quote doi 10.1074 jbc.273.32.20267 ref and YWHAG . ref name pmid10559254 cite journal last Dorner first C authorlink coauthors Ullrich A, H ring H U, Lammers R year 1999 month Nov. title The kinesin like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14 3 3 family journal J. Biol. Chem. volume 274 issue 47 pages 33654 60 publisher location UNITED ... HU, Lammers R title The kinesin like motor protein KIF1C occurs in intact cells as a dimer and associates ... author Kopp P, Lammers R, Aepfelbacher M, et al. title The kinesin KIF1C and microtubule plus ends ... more details
PBB geneid 3800 Kinesin heavy chain isoform 5C is a protein that in humans is encoded by the KIF5C gene . ref name pmid7514426 cite journal author Niclas J, Navone F, Hom Booher N, Vale RD title Cloning and localization of a conventional kinesin motor expressed exclusively in neurons journal Neuron volume 12 issue 5 pages 1059 72 year 1994 month Jun pmid 7514426 pmc doi 10.1016 0896 6273 94 90314 X ref ref name entrez cite web title Entrez Gene KIF5C kinesin family member 5C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3800 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Engelender S, Sharp AH, Colomer V, et al. title Huntingtin associated protein 1 HAP1 interacts with the p150Glued subunit of dynactin. journal Hum. Mol. Genet. volume 6 issue 13 pages 2205 12 year 1998 pmid 9361024 doi 10.1093 hmg 6.13.2205 cite journal author Nagase T, Ishikawa K, Miyajima N, et al. title Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. journal DNA Res. volume 5 issue 1 pages 31 9 year 1998 pmid 9628581 doi 10.1093 dnares 5.1.31 cite journal author Xia Ch, Rahman A, Yang Z, Goldstein LS title Chromosomal localization reveals three kinesin heavy chain genes in mouse. journal Genomics volume 52 issue 2 pages 209 13 year 1998 pmid 9782088 doi 10.1006 geno.1998.5427 cite journal author Junco A, Bhullar B, Tarnasky HA, van der Hoorn FA title Kinesin light chain KLC3 expression in testis is restricted to spermatids. journal ... of a novel gene family of coiled coil domain proteins association in vivo and in vitro with kinesin ... 1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF 1 as an adaptor protein in the anterograde ... more details
PBB geneid 3797 Kinesin like protein KIF3C is a protein that in humans is encoded by the KIF3C gene . ref name pmid9480755 cite journal author Sardella M, Navone F, Rocchi M, Rubartelli A, Viggiano L, Vignali G, Consalez GG, Sitia R, Cabibbo A title KIF3C, a novel member of the kinesin superfamily sequence, expression, and mapping to human chromosome 2 at 2p23 journal Genomics volume 47 issue 3 pages 405 8 year 1998 month Apr pmid 9480755 pmc doi 10.1006 geno.1997.5123 ref ref name entrez cite web title Entrez Gene KIF3C kinesin family member 3C url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3797 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Davidovic L, Jaglin XH, Lepagnol Bestel AM, et al. title The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules. journal Hum. Mol. Genet. volume 16 issue 24 pages 3047 58 year 2008 pmid 17881655 doi 10.1093 hmg ddm263 cite journal author Kimura K, Wakamatsu A, Suzuki Y, et al. title Diversification of transcriptional modulation large scale identification and characterization of putative alternative promoters of human genes. journal Genome Res. volume 16 issue 1 pages 55 65 year 2006 pmid 16344560 doi 10.1101 gr.4039406 pmc 1356129 cite journal author Gerhard DS, Wagner L, Feingold EA, et al. title The status, quality, and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC . journal ... and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles. journal ... Yang Z, Goldstein LS title Characterization of the KIF3C neural kinesin like motor from mouse ... localization of a novel human gene that encodes a kinesin related protein highly similar to mouse ... more details
PBB geneid 10112 Kinesin like protein KIF20A is a protein that in humans is encoded by the KIF20A gene . ref name pmid11416179 cite journal author Miki H, Setou M, Kaneshiro K, Hirokawa N title All kinesin superfamily protein, KIF, genes in mouse and human journal Proc Natl Acad Sci U S A volume 98 issue 13 pages 7004 11 year 2001 month Jun pmid 11416179 pmc 34614 doi 10.1073 pnas.111145398 ref ref name pmid10806357 cite journal author Lai F, Fernald AA, Zhao N, Le Beau MM title cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin like gene journal Gene volume 248 issue 1 2 pages 117 25 year 2000 month Jul pmid 10806357 pmc doi 10.1016 S0378 1119 00 00135 9 ref ref name entrez cite web title Entrez Gene KIF20A kinesin family member 20A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10112 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions KIF20A has been shown to Protein protein interaction interact with RAB6A . ref name pmid9438855 cite journal last Echard first A authorlink coauthors Jollivet F, Martinez O, Lacap re J J, Rousselet A, Janoueix Lerosey I, Goud B year 1998 month Jan. title Interaction of a Golgi associated kinesin like protein with Rab6 journal Science journal Science volume 279 issue 5350 pages 580 5 publisher location UNITED STATES issn 0036 8075 ... of a Golgi associated kinesin like protein with Rab6. journal Science volume 279 issue 5350 pages ... journal author Hill E, Clarke M, Barr FA title The Rab6 binding kinesin, Rab6 KIFL, is required ... pmc 310948 cite journal author Nagura M, Nagao Y, Takita J, et al. title The kinesin superfamily ... Neef R, Preisinger C, Sutcliffe J, et al. title Phosphorylation of mitotic kinesin like protein ... Taniuchi K, Nakagawa H, Nakamura T, et al. title Down regulation of RAB6KIFL KIF20A, a kinesin involved ... more details
PBB geneid 3833 Kinesin like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene . ref name pmid8276466 cite journal author Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T, Abe K, et al. title Cloning of a new kinesin related gene located at the centromeric end of the human MHC region journal Immunogenetics volume 39 issue 3 pages 194 200 year 1994 month Feb pmid 8276466 pmc doi ref ref name entrez cite web title Entrez Gene KIFC1 kinesin family member C1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3833 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Miki H, Setou M, Kaneshiro K, Hirokawa N title All kinesin superfamily protein, KIF, genes in mouse and human. journal Proc. Natl. Acad. Sci. U.S.A. volume 98 issue 13 pages 7004 11 year 2001 pmid 11416179 doi 10.1073 pnas.111145398 pmc 34614 cite journal author Janitz K, Wild A, Beck S, et al. title Genomic organization of the HSET locus and the possible association of HLA linked genes with immotile cilia syndrome ICS . journal Immunogenetics volume 49 issue 7 8 pages 644 52 year 1999 pmid 10369922 doi 10.1007 s002510050660 cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences. journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Neef R, Preisinger C, Sutcliffe J, et al. title Phosphorylation of mitotic kinesin like protein 2 by polo like kinase 1 is required for cytokinesis. journal J. Cell Biol. volume ... Analysis of the weak interactions of ADP Unc104 and ADP kinesin with microtubules and their inhibition ... more details
PBB geneid 3796 Kinesin like protein KIF2A is a protein that in humans is encoded by the KIF2A gene . ref name pmid9177777 cite journal author Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D title Identification of a novel human kinesin related gene HK2 by the cDNA differential display technique journal Genomics volume 42 issue 1 pages 67 73 year 1997 month Jul pmid 9177777 pmc doi 10.1006 geno.1997.4720 ref ref name entrez cite web title Entrez Gene KIF2A kinesin heavy chain member 2A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3796 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Kinesins, such as KIF2, are microtubule associated motor proteins. For background information on kinesins, see MIM 148760. supplied by OMIM ref name entrez cite web title Entrez Gene KIF2A kinesin heavy chain member 2A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3796 accessdate ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Manning AL, Ganem NJ, Bakhoum SF, et al. title The kinesin 13 proteins Kif2a, Kif2b, and Kif2c MCAK have distinct roles during mitosis in human cells. journal Mol. Biol. Cell volume 18 issue 8 pages 2970 9 year 2007 pmid 17538014 doi 10.1091 mbc.E07 02 0110 pmc 1949365 cite journal author Schepis A, Stauber T, Krijnse Locker J title Kinesin 1 plays multiple roles during the vaccinia virus life cycle. journal Cell. Microbiol. volume 9 issue 8 pages 1960 73 year 2008 pmid 17394562 doi 10.1111 j.1462 5822.2007.00927.x cite journal author Li C, Zheng Y, Qin W, et al. title A family based association study of kinesin heavy chain member 2 gene KIF2 and schizophrenia. journal Neurosci. Lett. volume 407 issue 2 pages ... doi 10.1101 gr.2596504 pmc 528928 cite journal author Ganem NJ, Compton DA title The KinI kinesin ... more details
PBB geneid 9493 Kinesin like protein KIF23 is a protein that in humans is encoded by the KIF23 gene . ref name pmid1406973 cite journal author Nislow C, Lombillo VA, Kuriyama R, McIntosh JR title A plus end directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles journal Nature volume 359 issue 6395 pages 543 7 year 1992 month Nov pmid 1406973 pmc doi 10.1038 359543a0 ref ref name entrez cite web title Entrez Gene KIF23 kinesin family member 23 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9493 accessdate ref Function The protein encoded by this gene is a member of kinesin like protein family. This family includes microtubule dependent molecular motors that transport organelle s within cells and move chromosomes during cell division . This protein has been shown to cross bridge antiparallel microtubule s and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different protein isoform isoform s. ref name entrez cite web title Entrez Gene KIF23 kinesin family member 23 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... RA title Arf proteins bind to mitotic kinesin like protein 1 MKLP1 in a GTP dependent fashion journal ... N title All kinesin superfamily protein, KIF, genes in mouse and human. journal Proc. Natl ... protein kinase and interacts with a kinesin like protein, CHO1 MKLP 1. journal Mol. Cell. Biol ... BE, Walker RA title Nuclear localization of C terminal domains of the kinesin like protein MKLP 1 ... kinesin like protein 1 MKLP1 in a GTP dependent fashion. journal Cell Motil. Cytoskeleton volume ... require a kinesin like protein RhoGAP complex with microtubule bundling activity. journal ... cite journal author Kuriyama R, Gustus C, Terada Y, et al. title CHO1, a mammalian kinesin like protein ... T, Kuriyama R, Erikson RL title Molecular interactions of Polo like kinase 1 with the mitotic kinesin ... more details
PBB geneid 11127 Kinesin like protein KIF3A is a protein that in humans is encoded by the KIF3A gene . ref name pmid1054846 cite journal author Stanley SM title A theory of evolution above the species level journal Proc Natl Acad Sci USA volume 72 issue 2 pages 646 50 year 1975 month Jun pmid 1054846 pmc 432371 doi 10.1073 pnas.72.2.646 ref ref name entrez cite web title Entrez Gene KIF3A kinesin family member 3A url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 11127 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions KIF3A has been shown to Protein protein interaction interact with MAP3K10 . ref name pmid9427749 cite journal last Nagata first K i authorlink coauthors Puls A, Futter C, Aspenstrom P, Schaefer E, Nakata T, Hirokawa N, Hall A year 1998 month Jan. title The MAP kinase kinase kinase MLK2 co localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 journal EMBO J. volume 17 issue 1 pages 149 58 publisher location ENGLAND issn 0261 4189 pmid 9427749 doi 10.1093 emboj 17.1.149 ... Aizawa H, Sekine Y, Takemura R, et al. title Kinesin family in murine central nervous system. journal ... kinesin superfamily protein that works as a microtubule plus end directed motor for membrane organelle ... and associates with kinesin superfamily motor KIF3. journal EMBO J. volume 17 issue 1 pages ... LS title Characterization of the KIF3C neural kinesin like motor from mouse. journal Mol. Biol ... T, Yagi A, Isobe K title Interaction between GADD34 and kinesin superfamily, KIF3A. journal Biochem ... the tumour suppressor APC and the kinesin superfamily. journal Nat. Cell Biol. volume 4 issue 4 ... author Brown CL, Maier KC, Stauber T, et al. title Kinesin 2 is a motor for late endosomes and lysosomes ... 0854.2005.00347.x cite journal author Haraguchi K, Hayashi T, Jimbo T, et al. title Role of the kinesin ... more details
PBB geneid 3835 Kinesin like protein KIF22 is a protein that in humans is encoded by the KIF22 gene . ref name pmid8599929 cite journal author Tokai N, Fujimoto Nishiyama A, Toyoshima Y, Yonemura S, Tsukita S, Inoue J, Yamamota T title Kid, a novel kinesin like DNA binding protein, is localized to chromosomes and the mitotic spindle journal EMBO J volume 15 issue 3 pages 457 67 year 1996 month Apr pmid 8599929 pmc 449964 doi ref ref name pmid11416179 cite journal author Miki H, Setou M, Kaneshiro K, Hirokawa N title All kinesin superfamily protein, KIF, genes in mouse and human journal Proc Natl Acad Sci U S A volume 98 issue 13 pages 7004 11 year 2001 month Jun pmid 11416179 pmc 34614 doi 10.1073 pnas.111145398 ref ref name entrez cite web title Entrez Gene KIF22 kinesin family member 22 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 3835 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text The protein encoded by this gene is a member of kinesin like protein family. This family of proteins are microtubule dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. ref name entrez Interactions KIF22 has been shown to Protein protein interaction interact with SIAH1 . ref name pmid11146551 cite journal last Germani first A authorlink coauthors Bruzzoni Giovanelli H, Fellous A, Gisselbrecht S, Varin Blank N, Calvo F year 2000 month Dec. title SIAH 1 interacts with alpha tubulin and degrades the kinesin ... tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. journal Oncogene volume ... LK, Gettemeier T, Chinnadurai G title A nuclear kinesin like protein interacts with and stimulates ... more details
PBB geneid 64837 Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene . ref name pmid9624122 cite journal author Rahman A, Friedman DS, Goldstein LS title Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins journal J Biol Chem volume 273 issue 25 pages 15395 403 year 1998 month Jul pmid 9624122 pmc doi 10.1074 jbc.273.25.15395 ref ref name entrez cite web title Entrez Gene KLC2 kinesin light chain 2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 64837 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions KLC2 has been shown to Protein protein interaction interact with MAPK8IP3 ref name pmid11106729 cite journal unused data DUPLICATE DATA pmid 11106727 last Bowman first A B authorlink coauthors Kamal A, Ritchings B W, Philp A V, McGrail M, Gindhart J G, Goldstein L S year 2000 month Nov. title Kinesin dependent axonal transport is mediated by the sunday driver SYD protein journal Cell volume 103 issue 4 pages 583 94 publisher location UNITED STATES issn 0092 8674 pmid 11106729 bibcode oclc id url language format accessdate laysummary laysource laydate quote doi 10.1016 S0092 8674 00 00162 8 ref and KIF5B . ref name pmid9624122 cite journal last Rahman first A authorlink coauthors Friedman D S, Goldstein L S year 1998 month Jun. title Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins journal J. Biol. Chem. volume 273 issue 25 pages 15395 403 publisher location UNITED STATES issn 0021 9258 pmid ... A, Roberts E A, Goldstein L S year 1999 month Sep. title Defective kinesin heavy chain behavior in mouse kinesin light chain mutants journal J. Cell Biol. volume 146 issue 6 pages 1277 88 publisher ... Bowman AB, Kamal A, Ritchings BW, et al. title Kinesin dependent axonal transport is mediated by the sunday ... more details
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