of inosine metabolism has led to advances in immunotherapy in recent decades. Inosinemonophosphate is oxidised by the enzyme inosinemonophosphate dehydrogenase , yielding xanthosine monophosphate ... drug that acts as an inhibitor of inosinemonophosphate dehydrogenase. It is used in the treatment ... deficiency resulting from IMD inhibition. Reactions Adenine is converted to adenosine or inosinemonophosphate IMP , either of which, in turn, is converted into inosine I , which pairs with Adenine A , cytosine C , and uracil U . Purine nucleoside phosphorylase intraconverts inosine and hypoxanthine . Inosine is also an intermediate in a chain of purine nucleotides reactions required for muscle ... of farmed fish . For example, inosine and inosine 5 monophosphate have been reported as specific feeding .... Fish., 50 645 651. ref The main problem of using inosine and or inosine 5 monophosphate as feeding ... to modulate inosine , causing knock out of viral load. See also Inosinemonophosphate dehydrogenase ... of administration Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring also known as a ribofuranose via a N sub 9 sub glycosidic bond . Inosine is commonly found in tRNA ... title Inosine supplementation has no effect on aerobic or anaerobic cycling performance journal ... author1 McNaughton L author2 Dalton B author3 Tarr J author separator , ref It has been shown that inosine ... title Secondary degeneration reduced by inosine after spinal cord injury in rats journal Spinal Cord .... ref cite journal title Inosine induces axonal rewiring and improves behavioral outcome after ... NCT00067327 Treatment of Multiple Sclerosis Using Over the Counter Inosine Full Text View ClinicalTrials.gov ... primer molecular biology primer s for polymerase chain reaction , inosine is useful in that it will indiscriminately ... efficiency. Fitness Despite lack of clinical evidence that it improves muscle development, inosine remains an ingredient in some fitness supplements. Feeding Stimulant Inosine has also been found to be an important ... more details
enzyme Name inosine kinase EC number 2.7.1.73 CAS number 37237 46 0 IUBMB EC number 2 7 1 73 GO code 0008906 image width caption In enzymology , an inosine kinase EC number 2.7.1.73 is an enzyme that catalysis catalyzes the chemical reaction ATP inosine math rightleftharpoons math ADP IMP Thus, the two substrate biochemistry substrates of this enzyme are adenosine triphosphate ATP and inosine , whereas its two product chemistry products are adenosine diphosphate ADP and IMP . This enzyme belongs to the family of transferase s, specifically those transferring phosphorus containing groups phosphotransferase s with an alcohol group as acceptor. The systematic name of this enzyme class is ATP inosine 5 phosphotransferase . Other names in common use include inosine guanosine kinase , and inosine kinase phosphorylating . This enzyme participates in purine metabolism . References reflist 1 cite journal author Pierre KJ, LePage GA date 1968 title Formation of inosine 5 monophosphate by a kinase in cell free extracts of Ehrlich ascites cells in vitro journal Proc. Soc. Exp. Biol. Med. volume 127 pages 432&ndash 40 pmid 5645030 issue 2 enzyme stub Category EC 2.7.1 Category Enzymes of unknown structure ... more details
enzyme Name inosine nucleosidase EC number 3.2.2.2 CAS number 9030 95 9 IUBMB EC number 3 2 2 2 GO code 0047724 image width caption In enzymology , an inosine nucleosidase EC number 3.2.2.2 is an enzyme that catalysis catalyzes the chemical reaction inosine H sub 2 sub O math rightleftharpoons math D ribose hypoxanthine Thus, the two substrate biochemistry substrates of this enzyme are inosine and water H sub 2 sub O , whereas its two product chemistry products are D ribose and hypoxanthine . This enzyme belongs to the family of hydrolase s, specifically those glycosylases that hydrolyse N glycosyl compounds. The systematic name of this enzyme class is inosine ribohydrolase . Other names in common use include inosinase , and inosine guanosine nucleosidase . This enzyme participates in purine metabolism . References reflist 1 cite journal author KOCH AL date 1956 title Some enzymes of nucleoside metabolism of Escherichia coli journal J. Biol. Chem. volume 223 pages 535&ndash 49 pmid 13376622 issue 1 cite journal author Tarr HLA date 1955 title Fish muscle riboside hydrolases journal Biochem. J. volume 59 pages 386&ndash 391 hydrolase stub Category EC 3.2.2 Category Enzymes of unknown structure ... more details
chembox ImageFile Inosine pranobex.png ImageSize 150px IUPACName 9 2 R ,3 R ,4 S ,5 R 3,4 dihydroxy 5 hydroxymethyl oxolan 2 yl 3 H purin 6 one 4 acetamidobenzoic acid 1 dimethylamino propan 2 ol OtherNames Isoprinosine Methisoprinol Section1 Chembox Identifiers ChemSpiderID 16736312 InChI1 1 C10H12N4O5.C9H9NO3.C5H13NO c15 1 4 6 16 7 17 10 19 4 14 3 13 5 8 14 11 2 12 9 5 18 1 6 11 10 8 4 2 7 3 5 8 9 12 13 1 5 7 4 6 2 3 h2 4,6 7,10,15 17H,1H2, H,11,12,18 2 5H,1H3, H,10,11 H,12,13 5,7H,4H2,1 3H3 t4 ,6 ,7 ,10 m0.. s1 InChIKey1 PBJNZCQJMWVIRT MDQYBHOLBR CASNo 36703 88 5 PubChem 37510 KEGG D01995 SMILES CN C CC C O.OC O c1ccc NC C O cc1.Oc3ncnc2c3ncn2 C H 1O C H CO C H O C H 1O Section2 Chembox Properties Formula C sub 52 sub H sub 78 sub N sub 10 sub O sub 17 sub MolarMass 1115.23 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Inosine pranobex Isoprinosine or Methisoprinol is a combinatinon of inosine , acetamidobenzoic acid , and dimethylaminoisopropanol used as an antiviral drug . Inosine pranobex has no effect on viral cells itself. It acts as a powerful immunostimulant . It is most commonly used to treat the rare measles complication subacute sclerosing panencephalitis in conjunction with intrathecal interferon therapy, with promising results. pharma stub Category Antivirals fr Inosine pranobex ja pl Pranobeks inozyny ... more details
chembox ImageFile Xanthosine monophosphate.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo 523 98 8 PubChem 122280 SMILES MeSHName Xanthosine monophosphate Section2 Chembox Properties Formula C sub 10 sub H sub 13 sub N sub 4 sub O sub 9 sub P MolarMass 364.206 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Xanthosine monophosphate is an intermediate in purine metabolism , formed from Inosine monophosphate IMP , and forming Guanosine monophosphate GMP . It is a ribonucleoside monophosphate . Clinical significance Xanthylic acid can be used in quantitative measurements of the inosine monophosphate dehydrogenase enzyme activities in purine metabolism, as recommended to ensure optimal thiopurine therapy for children with acute lymphoblastic leukaemia ALL . ref name pmid16725387 cite journal author Khalil PN, Erb N, Khalil MN, Escherich G, Janka Schaub GE title Validation and application of a high performance liquid chromatographic based assay for determination of the inosine 5 monophosphate dehydrogenase activity in erythrocytes journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. volume 842 issue 1 pages 1 7 year 2006 month September pmid 16725387 doi 10.1016 j.jchromb.2006.04.040 url http linkinghub.elsevier.com retrieve pii S1570 0232 06 00373 4 ref See also Ribonucleoside monophosphate Xanthosine References reflist Nucleotide metabolism intermediates Category Nucleotides Category Purines biochem stub ja fi Ksantosiinimonofosfaatti ... more details
by the ATP synthase during oxidative phosphorylation AMP can be converted into inosinemonophosphate ... adenosine monophosphate, are formed. AMP can be regenerated to ATP as follows AMP ATP 2 ADP adenylate ... monophosphate can be converted to uric acid , which is excreted from the body. cAMP AMP can also exist as a cyclic structure known as cyclic adenosine monophosphate cyclic AMP or cAMP . Within ... monofosfato fr Ad nosine monophosphate ko hr Adenozin monofosfat it Adenosina monofosfato ... sv Adenosinmonofosfat tr Adenozin monofosfat uk ur Adenosine monophosphate zh ... more details
monophosphate . Another common shorthand for the molecule is uridylate the deprotonated form of the molecule ... uridylyl . Biosynthesis Uridine monophosphate is formed from Orotidine 5 monophosphate orotidylic ... decarboxylase function is carried out by the protein UMP synthase . ref http www.pubmedcentral.nih.gov articlerender.fcgi?artid 1715274 Analysis of UMP synthase gene and mRNA structure in hereditary orotic aciduria fibroblasts Bot generated title ref Defective UMP synthase can result ... fed supplements of uridine monophosphate, choline, and docosahexaenoic acid DHA were found to have ... ref Uridine Monophosphate in Foods In brain research studies such as those mentioned in this article, uridine monophosphate is used as a convenient delivery compound for uridine . Uridine is the active ... drugs. This is not so. Uridine monophosphate is a major component of RNA . Any food rich in RNA ... RNA Oligonucleotide Pyrimidine biosynthesis Ribonucleoside monophosphate Nucleobases, nucleosides ... biochem stub ca Monofosfat d uridina da Uridinmonofosfat de Uridinmonophosphat fr Uridine monophosphate ... more details
A purine or pyrimidine ribonucleoside monophosphate NMP ref name Scavennec82 cite journal author Scavennec J, Maraninchi D, Gastaut JA, Carcassonne Y, Cailla HL title Purine and Pyrimidine Ribonucleoside Monophosphate Patterns of Peripheral Blood and Bone Marrow Cells in Human Acute Leukemias journal Cancer Res. volume 42 issue 4 pages 1326 30 year 1982 pmid 6277481 month April url http cancerres.aacrjournals.org content 42 4 1326.full.pdf html ref is an ester of phosphoric acid with a purine or pyrimidine nucleoside . Purine ribonucleoside monophosphates The purine ribonucleoside monophosphates are adenosine and guanosine ribonucleosides with the monophosphate at the 2 , 3 , 4 or 5 carbon position on the ribose ring. Adenosine monophosphate AMP occurring in ribonucleic acid RNA is 5 AMP. Guanosine monophosphate GMP occurring in RNA is 5 GMP. Xanthosine monophosphate XMP, or 5 XMP is an intermediate in purine metabolism formed from inosinemonophosphate IMP, or 5 IMP . 2 AMP, 3 AMP and 5 ... can form isoguanosine triphosphate. ref name Switzer Like the other monophosphates, isoguanosine monophosphate ... ribonucleoside monophosphates are cytidine and uridine ribonucleosides with the monophosphate at the 2 , 3 , 4 or 5 carbon position in the ribose ring. Cytidine monophosphate CMP occurring in RNA is 5 CMP. Uridine monophosphate UMP occurring in RNA is 5 UMP. Isocytidine monophosphate iso C possibly in RNA, forming a base pair with isoguanosine monophosphate iso G , may have been a component of primitive ... cytidine 3 5 monophosphate concentrations in peripheral blood cells may be characteristic of acute leukemias ... of cyclic cytidine 3 5 monophosphate, cyclic guanosine 3 5 monophosphate, and cyclic adenosine 3 5 monophosphate ... 1981 volume 41 issue 8 pages 3222 7 pmid 6265079 ref Cyclic cytidine 3 5 monophosphate levels are low ... Scavennec Low cyclic adenosine 3 5 monophosphate concentrations are associated with leukemic disease ... Y, Cailla HL title Purine and Pyrimidine Ribonucleoside Monophosphate Patterns of Peripheral ... more details
Unreferenced date October 2006 Chembox verifiedrevid 400825361 ImageFile DAMP chemical structure.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 12079 InChI 1 C10H14N5O6P c11 9 8 10 13 3 12 9 15 4 14 8 7 1 5 16 6 21 7 2 20 22 17,18 19 h3 7,16H,1 2H2, H2,11,12,13 H2,17,18,19 t5 ,6 ,7 m0 s1 InChIKey KHWCHTKSEGGWEX RRKCRQDMBS StdInChI Ref stdinchicite correct chemspider StdInChI 1S C10H14N5O6P c11 9 8 10 13 3 12 9 15 4 14 8 7 1 5 16 6 21 7 2 20 22 17,18 19 h3 7,16H,1 2H2, H2,11,12,13 H2,17,18,19 t5 ,6 ,7 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey KHWCHTKSEGGWEX RRKCRQDMSA N CASNo Ref cascite correct CAS CASNo 653 63 4 PubChem 621 SMILES c1nc c2c n1 n cn2 C H 3C C H C H O3 COP O O O O N MeSHName Deoxyadenosine monophosphate Section2 Chembox Properties Formula C sub 10 sub H sub 14 sub N sub 5 sub O sub 6 sub P MolarMass 331.222 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Context article date October 2009 Deoxyadenosine monophosphate , also known as deoxyadenylate , or dAMP , is a derivative of the common nucleic acid AMP, or adenosine monophosphate , in which the OH hydroxyl group on the 2 carbon on the nucleotide s pentose has been removed hence the deoxy part of the name . The monophosphate of the name indicates that two of the phosphoryl groups of ATP have been removed, most likely by hydrolysis . Deoxyadenosine monophosphate is abbreviated dAMP. See also Nucleic acid DNA metabolism Cofactor biochemistry Cofactor Guanosine Cyclic AMP cAMP Adenosine Triphosphate ATP Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxyadenosine Monophosphate Category Nucleotides Biochemistry stub ca Monofosfat de desoxiadenosina fr D soxyad nosine monophosphate nl Deoxyadenosinemonofosfaat ja sr Dezoksiadenozin monofosfat zh ... more details
Unreferenced date March 2008 chembox ImageFile dTMP chemical structure.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo 365 07 1 PubChem 1139 SMILES MeSHName deoxyThymidine monophosphate Section2 Chembox Properties Formula C sub 10 sub H sub 15 sub N sub 2 sub O sub 8 sub P MolarMass 322.209 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxythymidine monophosphate , also known as 5 thymidylic acid and abbreviated dTMP , is a nucleotide that is found in DNA . It is an ester of phosphoric acid with the nucleoside thymidine . dTMP consists of the phosphate Functional group group , the pentose sugar ribose , and the nucleobase deoxythymine . See also Nucleoside Nucleotide DNA RNA Oligonucleotide External links Nucleic acids Category Nucleotides biochem stub fr Thymidine monophosphate ja ... more details
chembox ImageFile DUMP chemical structure.png ImageSize IUPACName OtherNames dUMP Section1 Chembox Identifiers CASNo 964 26 1 PubChem 688 SMILES MeSHName 2 deoxyuridine 5 monophosphate Section2 Chembox Properties Formula C sub 9 sub H sub 13 sub N sub 2 sub O sub 8 sub P MolarMass 308.182 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxyuridine monophosphate is a deoxynucleotide . It is an intermediate in the metabolism of deoxyribonucleotide s. See also uridine monophosphate DCMP deaminase Nucleobases, nucleosides, and nucleotides biochem stub Category Nucleotides ca Monofosfat de desoxiuridina nl Deoxyuridinemonofosfaat ja sr Dezoksiuridin monofosfat ... more details
Unreferenced date October 2006 Chembox verifiedrevid 284182973 ImageFile Desoxyguanosinmonophosphat protoniert.svg ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo Ref cascite correct CAS CASNo 902 04 5 PubChem 161075 SMILES C1C C OC1N2C NC3 C2NC NC3 O N COP O O O O.N Section2 Chembox Properties Formula C sub 10 sub H sub 14 sub N sub 5 sub O sub 7 sub P MolarMass 347.2243 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxyguanosine monophosphate , also known as deoxyguanylate , or dGMP , is a derivative of the common nucleic acid guanosine triphosphate GTP , in which the OH hydroxyl group on the 2 carbon on the nucleotide s pentose has been reduced to just a hydrogen atom hence the deoxy part of the name . The monophosphate portion of the name indicates that two of the phosphate phosphoryl groups of GTP have been removed, most likely by hydrolysis . See also Nucleic acid DNA metabolism Cofactor biochemistry Cofactor Guanosine Nucleobases, nucleosides, and nucleotides DEFAULTSORT Deoxyguanosine Monophosphate Category Nucleotides ca Monofosfat de desoxiguanosina fr D soxyguanosine monophosphate nl Deoxyguanosinemonofosfaat sr Dezoksiguanozin monofosfat zh ... more details
soy protein , autolyzed yeast or soy sauce . As inhibitor of guanosine monophosphate synthesis in experimentell ... monophosphate Umami References references Nucleobases, nucleosides, and nucleotides DEFAULTSORT Guanosine Monophosphate Category Nucleotides Category Flavour enhancers Category Purines ca Monofosfat de guanosina da Guanosinmonofosfat de Guanosinmonophosphat es cido guan lico fr Guanosine monophosphate ... more details
chembox ImageFile DTMP chemical structure.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers CASNo 365 07 1 PubChem 1139 SMILES MeSHName Thymidine monophosphate Section2 Chembox Properties Formula C sub 10 sub H sub 15 sub N sub 2 sub O sub 8 sub P MolarMass 322.209 Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxythymidine monophosphate , also known as 5 thymidylic acid , thymidylate , TMP , or less commonly, dTMP , is a nucleotide that is found in DNA . It is an ester of phosphoric acid with the nucleoside thymidine . TMP consists of a phosphate Functional group group , the pentose sugar deoxyribose , and the nucleobase thymine . As a substituent , it takes the form of the prefix thymidylyl . See also Nucleoside Nucleotide DNA RNA Oligonucleotide External links Nucleobases, nucleosides, and nucleotides Category Nucleotides biochem stub ca Timidilat es Timidilato fr Thymidine monophosphate nl Thymidinemonofosfaat ja sr Timidin monofosfat zh ... more details
chembox verifiedrevid 396326056 ImageFile DCMP chemical structure.png ImageSize IUPACName OtherNames Section1 Chembox Identifiers ChemSpiderID Ref chemspidercite correct chemspider ChemSpiderID 13343 InChI 1 C9H14N3O7P c10 7 1 2 12 9 14 11 7 8 3 5 13 6 19 8 4 18 20 15,16 17 h1 2,5 6,8,13H,3 4H2, H2,10,11,14 H2,15,16,17 t5 ,6 ,8 m0 s1 InChIKey NCMVOABPESMRCP SHYZEUOFBL StdInChI Ref stdinchicite correct chemspider StdInChI 1S C9H14N3O7P c10 7 1 2 12 9 14 11 7 8 3 5 13 6 19 8 4 18 20 15,16 17 h1 2,5 6,8,13H,3 4H2, H2,10,11,14 H2,15,16,17 t5 ,6 ,8 m0 s1 StdInChIKey Ref stdinchicite correct chemspider StdInChIKey NCMVOABPESMRCP SHYZEUOFSA N CASNo Ref cascite correct CAS CASNo 1032 65 1 PubChem 624 SMILES c1cn c O nc1N C H 2C C H C H O2 COP O O O O MeSHName Deoxycytidine monophosphate Section2 Chembox Properties Formula C sub 9 sub H sub 14 sub N sub 3 sub O sub 7 sub P MolarMass 307.197 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Deoxycytidine monophosphate , also known as deoxycytidylate , or dCMP , is a deoxynucleotide , and one of the four monomer s that make up DNA . In a DNA double helix, it will base pair with deoxyguanosine monophosphate . Nucleobases, nucleosides, and nucleotides Category Nucleotides biochem stub ca Monofosfat de desoxicitidina fr D soxycytidine monophosphate nl Deoxycytidinemonofosfaat sr Dezoksicitidin monofosfat zh ... more details
cytosine hence, a ribonucleoside monophosphate . As a substituent it takes the form of the prefix ... in metabolism. See also Nucleoside Nucleotide DNA RNA Oligonucleotide Ribonucleoside monophosphate References reflist 2 Nucleobases, nucleosides, and nucleotides DEFAULTSORT Cytidine Monophosphate ... da Cytidinmonofosfat fr Cytidine monophosphate it Citosina monofosfato nl Cytidinemonofosfaat ja ... more details
Unreferenced date August 2007 In biochemistry , a synthase is an enzyme that catalyse s a Biosynthesis synthesis process. Following the EC number classification, they belong to the group of ligase s, with lyase s catalysing the reverse reaction. Note that, originally, biochemical nomenclature distinguished synthetases and synthases. Under the original definition, synthases do not use energy from nucleoside triphosphates such as ATP, GTP, CTP, TTP, and UTP , whereas synthetases do use nucleoside triphosphates. However, the Joint Commission on Biochemical Nomenclature JCBN dictates that synthase can be used with any enzyme that catalyzes synthesis whether or not it uses nucleoside triphosphates , whereas synthetase is to be used synonymously with ligase . ref http www.chem.qmul.ac.uk iubmb newsletter misc synthase.html ref Examples ATP synthase Citrate synthase Tryptophan synthase Pseudouridine synthase Fatty acid synthase Cellulose synthase UDP forming Cellulose synthase GDP forming References references Enzymes Category Lyases Enzyme stub de Synthasen fr Synthase lt Sintaz pl Syntazy sv Syntas zh ... more details
protein Name adenylosuccinate synthase caption image width HGNCid 292 Symbol ADSS AltSymbols EntrezGene 159 OMIM 103060 RefSeq NM 001126 UniProt P30520 PDB ECnumber 6.3.4.4 Chromosome 1 Arm q Band 44 LocusSupplementaryData Adenylosuccinate synthase or adenylosuccinate synthetase is an enzyme that converts Inosinemonophosphate IMP to adenylosuccinate as part of the purine nucleotide cycle . External links MeshName Adenylosuccinate synthase ligase stub Ligases Nucleotide metabolism ... more details
chembox ImageFile Orotidine monophosphate.svg ImageSize IUPACName 3 2R,3R,4S,5R 3,4 dihydroxy 5 & 8203 phosphonooxymethyl oxolan 2 yl & 8203 2,6 dioxo pyrimidine 4 carboxylic acid OtherNames Section1 Chembox Identifiers CASNo 2149 82 8 PubChem 968 SMILES C1 C N C O NC1 O C2C C C O2 COP O O O O O C O O MeSHName Orotidine 5 monophosphate Section2 Chembox Properties Formula C sub 10 sub H sub 13 sub N sub 2 sub O sub 11 sub P MolarMass 368.191 g mol Appearance Density MeltingPt BoilingPt Solubility Section3 Chembox Hazards MainHazards FlashPt Autoignition Orotidine 5 monophosphate OMP , also known as orotidylic acid, is a pyrimidine nucleotide which is the last intermediate in the biosynthesis of uridine monophosphate . In humans, the enzyme UMP synthase converts OMP into uridine 5 monophosphate . If UMP synthase is defective, orotic aciduria can result. Nucleotide metabolism intermediates Category Nucleotides Category Pyrimidinediones biochem stub ja 5 sr Orotidin 5 monofosfat ... more details
monophosphatesynthase journal J. Dairy Sci. volume 72 issue 11 pages 3035 9 year 1989 month ... monophosphatesynthase to human chromosome region 3q13 by in situ hybridization journal Genomics ... 5 monophosphatesynthase journal Biochemistry volume 19 issue 20 pages 4699 706 year 1981 pmid 6893554 ... of uridine monophosphatesynthase UMPS gene to river buffalo chromosomes by FISH journal Chromosome ...PBB geneid 7372 Uridine monophosphate synthetase UMPS orotate phosphoribosyl transferase and orotidine 5 decarboxylase is the enzyme EC number 4.1.1.23 that catalyses the formation of uridine monophosphate UMP , an energy carrying molecule in many important biosynthetic pathways. ref name entrez cite web title Entrez Gene UMPS uridine monophosphate synthetase orotate phosphoribosyl transferase and orotidine 5 decarboxylase url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 7372 accessdate ref In humans, the gene that codes for this enzyme is located on the long arm of chromosome 3 3q13 . ref name pmid2767686 cite journal author Qumsiyeh MB, Valentine MB, Suttle DP title Localization of the gene for uridine monophosphatesynthase to human chromosome region 3q13 by in situ hybridization journal Genomics volume 5 issue 1 pages 160 2 year 1989 month July pmid 2767686 ... cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic ... WP1601 highlight Uridine monophosphate synthetase See also orotidine 5 phosphate decarboxylase ... of human UMP synthase journal Adv. Exp. Med. Biol. volume 253A issue pages 511 8 year 1990 pmid 2624233 ... for the complete coding region of human UMP synthase journal Proc. Natl. Acad. Sci. U.S.A. volume 85 ... and initial characterization of the single polypeptide that synthesizes uridine 5 monophosphate ... author Suchi M, Mizuno H, Kawai Y, et al. title Molecular cloning of the human UMP synthase gene and characterization ... H, et al. title Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase ... more details
Inosine 5 monophosphate dehydrogenase IMPDH is an enzyme which salvages purine s to make guanine in the human pathogen Cryptosporidium parvum . The C. parvum enzyme IMPDH differs enough from human IMPDH to serve as a drug target. Chem. Biol. 15, 70 2008 Category Enzymes enzyme stub ... more details
Molybdopterin synthase is an enzyme required to sythesize molybdenum cofactor MoCo from precursor Z now known as cyclic pyranopterin monophosphate . It is heterodimeric and coded for by the MOCS2 gene. ref cite journal last1 Sloan first1 J last2 Kinghorn first2 JR last3 Unkles first3 SE title The two subunits of human molybdopterin synthase evidence for a bicistronic messenger RNA with overlapping reading frames journal Nucleic acids research volume 27 issue 3 pages 854 8 year 1999 pmc 148257 pmid 9889283 doi 10.1093 nar 27.3.854 ref References reflist Category Enzymes biochem stub ... more details
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