Humulin is the brand name for a group of biosynthetic human insulin products, originally developed by Genentech in 1978 Generic names regular insulin, insulin isophane and the Lente series consisting of Lente known generically as insulin zinc suspension is actually a mixture of Ultralente and Semilente and later acquired by Eli Lilly and Company , the company who arguably facilitated the product s approval with the U.S. Food and Drug Administration. The Lente series was discontinued by Lilly 2005. Humulin is synthesized in a laboratory strain of Escherichia coli bacteria which has been genetically altered with recombinant DNA to produce biosynthetic human insulin. Humulin R consists of zinc insulin crystals dissolved in a clear fluid. The synthesized insulin is then combined with other compounds or types of insulin which affect its shelf life and absorption. For example, Humulin N is combined with protamine to extend the time activity profile of Humulin R for an extended period of time. Humulin by itself is a short acting insulin. Humulin R, like many other form of injectable insulin ... types Humulin R REGULAR human insulin injection rDNA origin is a short acting insulin that has a relatively short duration of activity as compared with other insulins. Humulin R Regular U 500 Concentrated insulin human injection, USP rDNA Origin is a stronger concentration 500 units mL of Humulin R. Humulin N human NPH insulin injection rDNA origin is an intermediate acting insulin with a slower onset of action and a longer duration of activity than Humulin R. Humulin 70 30 70 human insulin isophane ... acting insulin combined with the onset of action of HumulinHumulin 50 50 50 human insulin isophane ... insulin combined with the onset of action of Humulin R. Based on the company s web site, Humulin is identical ... content humulin brand of insulins.jsp title Humulin Brand of Insulins accessdate 16 November 2008 ... www.lillydiabetes.com content humulin brand of insulins.jsp Bot retrieved archive archivedate 12 ... more details
longer to work and lasts longer than normal insulin. An example of NPH insulin is Humulin ..., such as Humulin is synthesized in a special non disease producing laboratory strain of Escherichia ... more details
Following is a list of notable proteins that are generated from recombinant DNA . Since human recombinants have replaced the animal version in human therapeutics, the prefix of rh for human recombinant appears less and less in the literature Human recombinants that largely replaced animal or harvested from human types Growth hormone Human growth hormone rHGH Humatrope from Eli Lilly and Company Lilly and Serostim from Serono replaced cadaver harvested human growth hormone Biosynthetic Insulin human insulin BHI Humulin from Eli Lilly and Company Lilly and Novolin from Novo Nordisk among others largely replaced bovine and porcine insulin for human therapy. Some prefer to continue using the animal sourced preparations, as there is some evidence that synthetic insulin varieties are more likely to induce Diabetic hypoglycemia Hypoglycemic unawareness hypoglycemia unawareness . Remaining manufacturers of highly purified animal sourced insulin include the U.K. s Wockhardt Ltd. headquartered in India , Poland s Polfa Tarchomin S.A., Argentina s Laboratorios Beta S.A., and China s Wanbang Biopharma Co. Follicle stimulating hormone FSH as a recombinant gonadotropin preparation replaced Serono s Pergonal which was previously isolated from post menopausal female urine Factor VIII Kogenate from Bayer replaced blood harvested factor VIII Human recombinants with recombination as only source Erythropoietin EPO Epogen from Amgen Granulocyte colony stimulating factor G CSF filgrastim sold as Neupogen from Amgen pegfilgrastim sold as Neulasta alpha glactosidase A Fabrazyme by Genzyme alpha L iduronidase rhIDU laronidase Aldurazyme by BioMarin Pharmaceutical and Genzyme N acetylgalactosamine 4 sulfatase rhASB galsulfase Naglazyme TM by BioMarin Pharmaceutical Dornase alfa , a DNase sold under the trade name Pulmozyme by Genentech Tissue plasminogen activator TPA Activase by Genentech Glucocerebrosidase Ceredase by Genzyme Interferon IF Interferon beta 1a as Avonex from Biogen Idec Rebi ... more details
List of drugs H Hf Hz hi hm Hi Cor Hibiclens Hibistat hilafilcon B United States Adopted Name USAN hioxifilcon D United States Adopted Name USAN Hippuran i 131 Hipputope Hiprex Hiserpia Hispril Histafed Histalog histapyrrodine International Nonproprietary Name INN histidine International Nonproprietary Name INN histrelin International Nonproprietary Name INN Hivid Hiwolfia HMS ho hu hofocon A United States Adopted Name USAN Homapin homarylamine International Nonproprietary Name INN homatropine methylbromide International Nonproprietary Name INN homidium bromide International Nonproprietary Name INN homochlorcyclizine International Nonproprietary Name INN homofenazine International Nonproprietary Name INN homopipramol International Nonproprietary Name INN homosalate International Nonproprietary Name INN homprenorphine International Nonproprietary Name INN hopantenic acid International Nonproprietary Name INN hoquizil International Nonproprietary Name INN Humalog Human Secretin Votumumab HumaSPECT Humatin Humatrope Zanolimumab HuMax CD4 Zalutumumab HuMax EGFR Humegon Humorsol Humulin hy Hy Pam 25 Hy Phen hya hyc Hyalgan Sanofi Aventis redirects to hyaluronan hyalosidase International Nonproprietary Name INN hyaluronidase International Nonproprietary Name INN hybufocon A United States Adopted Name USAN Hycamtin Hycamtin GlaxoSmithKline hycanthone International Nonproprietary Name INN Hycodan Hycomine hyd hyde Hydeltra TBA Hydeltrasol Hydergine hydr hydra hydre Hydra Zide hydracarbazine International Nonproprietary Name INN hydralazine International Nonproprietary Name INN Hydramine Hydrap ES hydrargaphen International Nonproprietary Name INN Hydrea Hydrea Bristol Myers Squibb hydro Hydro D Hydro Reserp Hydro Ride Hydro Serp hydrob hydrot hydrobentizide International Nonproprietary Name INN Hydrocet hydrochlorothiazide International Nonproprietary Name INN hydrocodone International Nonproprietary Name INN hydrocortamate International Nonproprietary Name INN hydrocortiso ... more details
Image Insulin pen.JPG thumb 400 px Two types of modern, pre filled insulin syringes. An insulin pen is used to inject insulin for the treatment of diabetes . It is composed of an insulin cartridge integrated or bought separately and a dial to measure the dose, and is used with disposable Pen needles to deliver the dose. Types of pens A number of companies make insulin pens including Novo Nordisk , Aventis and Eli Lilly and Company Eli Lilly . These companies produce pens for most of their insulins, including Insulin aspart NovoLog NovoRapid , Insulin lispro Humalog , Insulin detemir Levemir and Insulin glargine Lantus . There are two pen systems durable and prefilled. A durable pen uses a replaceable insulin cartridge. When the insulin cartridge is empty, the empty cartridge is disposed of and a new one is inserted in the pen. A prefilled pen is entirely disposable. The pen comes pre filled with insulin, and when the insulin cartridge or reservoir is empty, the entire unit is discarded. Most brands of insulin are now available for use in pens, these include NovoLog , NovoRapid and Levemir by Novo Nordisk Lantus and Apidra by Sanofi Aventis Humulin and Humalog by Eli Lilly and Company Use Insulin pens are used by 90 to 95 of insulin treated patients in Europe, Asia, and Scandinavia with excellent results. ref Taking Control of Your Diabetes Education, Motivation, Self Advocacy by http www.tcoyd.org 05 homepage.shtml Steven V. Edelman, MD and Friends ref They are currently underutilized but growing in use in the United States. Insulin pens offer several significant advantages over insulin syringes ease of handling, accuracy, and more discreet to use. To use a pen Screw or click on a new pen needle If necessary, prime the pen to remove any air from the needle Turn the knob on the end of the pen or dial to the number of units needed Insert the needle into the skin Press the button on the end of the pen to deliver the dose Count to five Remove Advantages Insulin pens hav ... more details
insulin also known as Humulin N, Novolin N,Novolin NPH, NPH Lletin II, and isophane insulin, marketed by Eli Lilly and Company under the name Humulin N, is an intermediate acting insulin given to help ... FDA approval process 1983 Lilly produces synthetic, recombinant human insulin, branded Humulin 1985 ... more details
human synthetic insulins, Humulin N Novolin N NPH, is reasonable for dogs, but is usually ... peak action like Caninsulin Vetsulin or Humulin N. In other cases where the pet free feeds and normally ... veterinarians still use the outdated recommendation of using Humulin N or NPH insulin for cats ... and the often effective slower acting Lente and Ultralente Humulin L and Humulin U insulins are being ... more details
biosynthetic Humulin human insulin in the lab. ref name urlGenentech cite web url http www.gene.com ... to be approved by the FDA and commercially available under the brand name Humulin . ref http www.sciencemag.org ... more details
The term biopharmacology describes a field of research closely related to pharmacokinetics , sometimes called biopharmacy. Biopharmaceuticals are medical drugs see pharmacology produced using biotechnology . They are proteins including antibody antibodies , nucleic acids DNA , RNA or antisense oligonucleotide s used for therapeutic or in vivo diagnostic purposes, and are produced by means other than direct extraction from a native non engineered organism biological source. ref cite book last Walsh first Gary authorlink coauthors year title Biopharmaceuticals Biochemistry and Biotechnology, Second Edition publisher John Wiley & Sons Ltd location isbn 0 470 84326 8 ppc , ISBN 0 470 84327 6 pbk ref The first such substance approved for therapeutic use was biosynthetic human insulin made via recombinant DNA technology. Sometimes referred to as rHI, under the trade name Humulin, was developed by Genentech , but licensed to Eli Lilly and Company , who manufactured and marketed the product starting in 1982. Image Nrc bri bioprocess lr.jpg thumb Bioreactors for producing proteins, NRC Biotechnology Research Institute, Montr al, Canada The large majority of biopharmaceutical products are pharmaceuticals that are derived from life forms. Small molecule drugs are not typically regarded as biopharmaceutical in nature by the industry. However members of the press and the business and financial community often extend the definition to include pharmaceuticals not created through biotechnology. That is, the term has become an oft used buzzword for a variety of different companies producing new, apparently high tech pharmaceutical products. Research and development investment in new medicines by the biopharmaceutical industry stood at 65.2bn in 2008. ref cite web author BriskFox Financial title Biopharmaceutical sector sees rising R&D despite credit crunch, finds analysis url http www.briskfox.com open years 2009 q1 do v c44751.php accessdate 2009 03 11 ref When a biopharmaceutical ... more details
such insulin, Humulin, in 1982. Humulin was the first medication produced using modern genetic engineering ... the technique Lilly used to produce Humulin, although the company never commercially marketed ... biosynthetic human insulin with recombinant DNA technology, Humulin 1985 Axel Ullrich sequences a human ... more details
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