Refimprove date February 2008 The HumanGenomeDiversityProject HGDP was started by Stanford University ... American Regional Committee, HumanGenomeDiversityProject, published in the Houston Law Review .... Some members of the HumanGenomeProjectHumanGenomeProject HGP argued in favor of engaging in diversity research on data gleaned from the HumanGenomeDiversityProject , although most agreed that diversity ... to the HumanGenomeProject , and has attempted to maintain a completely distinct identity. Studied ... Marks http www.wired.com wired archive 5.07 updata.html The HumanGenome Controversy Not to be confused ... Category Population genetics Category Humangenome projects ... disease research. The project has noted the need to record the genetic profiles of endogenous populations ... TABLE Potential benefits According to the Morrison Institute, diversity research may yield new data ... . HGDP scientists have argued that in order to gain a full assessment of Human development biology human development scientists must engage in diversity research. They state that that is why research ... America become extinct. Another benefit of genomic diversity mapping would be in Medical research disease research . Diversity research could help explain why certain ethnic populations are vulnerable ... in biomedicine . Potential problems Denouncing the project since its outset, some indigenous communities , NGO s, and human rights organizations have objected to the HGDP s goals based on perceived issues ... could occur should the HGDP be completed. One major concern with the research project that they have ... might deny human rights based on this genetic data. For example, countries could define races ... race s genetic model. The rhetoric used by the HGDP and its participants to describe the project ... intentions of the project, infused in the discourse of the HGDP are both historical and problematic ... be obtained? Would individuals or groups fully understand the project s intentions, particularly ... more details
The HumanGenomeProject and a parallel project by Celera Genomics each produced and published a haploid ... genomes had not been sequenced in the HumanGenomeProject to protect the identity of volunteers who ... population. ref Cite web url http www.genome.gov 11006943 title HumanGenomeProject Completion Frequently ... in the humangenome is being undertaken by the International HapMap Project . The genomic loci and length ... physician trained in clinical medical genetics. The results of the HumanGenomeProject .... With the advent of the HumanGenome and International HapMap Project , it has become feasible ... Human genetic engineering HumanGenome Sequencing Center Noncoding DNA The Genographic Project Mitochondrial ... Genome Browser . http www.ornl.gov sci techresources HumanGenomeproject info.shtml HumanGenomeProject ... humangenome http diversity.inmegen.gob.mx gbrowse cgi bin gbrowse inmegen diversity INMEGEN Complete ... . The haploid humangenome occupies a total of just over 3 billion DNA base pair s. The HumanGenomeProject HGP produced a reference genome reference sequence of the euchromatin euchromatic humangenome, which is used worldwide in biomedical science s. The haploid humangenome contains ca. 23,000 ... Pathogenesis, 2 September 2009 ref ref name IHSGC2004 Cite journal author International HumanGenome Sequencing Consortium title Finishing the euchromatic sequence of the humangenome. journal Nature ... Genome Sequencing Consortium title Initial sequencing and analysis of the humangenome. journal Nature ... understood. Citation needed date September 2009 In addition to protein coding genes, the humangenome ... from Humangenome The humangenome has many different Regulatory regions regulatory sequences which ... exon s comprise less than 1.5 of the humangenome. ref name IHSGC2001 Aside from genes and known regulatory sequences, the humangenome contains vast regions of DNA the function of which, if any, remains ... The investigation of the vast quantity of sequence information in the humangenome whose function remains ... more details
of HumanGenomeDiversityProjecthuman genetic diversity . Example genome projects main List of sequenced .... The HumanGenomeProject was a landmark genomeproject that is already having a major impact on research .... ref cite web url http www.ornl.gov sci techresources HumanGenomeproject benefits.shtml title Potential Benefits of HumanGenomeProject Research publisher United States Department of Energy Department of Energy , HumanGenomeProject Information date 2009 10 09 accessdate 2010 06 18 ref Genome ... and share genome annotations. Genome annotation is the next major challenge for the HumanGenomeProject , now that the genome sequences of human and several model organisms are largely complete ... Human microbiome project International Grape Genome Program International HapMap Project See also ... in an organism to be determined. For bacteria , which usually have just one chromosome, a genomeproject ... De novo assembly of human genomes with massively parallel short read sequencing. journal Genome ... Metspalu first7 M. last8 Metspalu first8 E. last9 Kivisild first9 T. title Ancient humangenome sequence ... GeneRIF RefSeq Uniprot Vertebrate and Genome Annotation Project Vertebrate and Genome Annotation Project Vega At Wikipedia, genome annotation has started to become automated under the auspices of the Portal ... F last8 Su first8 AI issue 7 pmc 2443188 ref When is a genomeproject finished? When Genome sequencing ... also be argued that a complete genomeproject should include the sequences of mitochondria and for plants ... GenomeProject Many organisms have genome projects that have either been completed or will be completed shortly, including Human s, Homo sapiens see Humangenomeproject Palaeo Eskimo , ref name ReferenceA an ancient human Neanderthal , Homo neanderthalensis partial see Neanderthal GenomeProject Common Chimpanzee Pan troglodytes see Chimpanzee GenomeProject Domestic Cow ref http www.eurekalert.org ... Database http www.ncbi.nlm.nih.gov entrez query.fcgi?DB genomeprj GenomeProject Database http ... more details
Unreferenced date November 2008 COI date November 2008 The GDB HumanGenome Database was a community curated collection of human genomic data. What set GDB apart from other biological databases was its use of world class leaders in human genetics to act as curators for the data. In order to ensure a high degree of quality, records within GDB were subjected to a process of peer review , not unlike a traditional publication. Due to the International collaboration which made up the humangenomeproject, GDB received funding from numerous sources in both Europe and Asia. History In 1989 the Howard Hughes Medical Institute provided funding to establish a central repository for human genetic map ping data. This project ultimately resulted in the creation of the GDB HumanGenome DataBase in 1990. It was a key database in the HumanGenomeProject . Established under the leadership of Dr. s Peter L. Pearson Peter Pearson and Dick Lucier, GDB received significant financial support from the US Department of Energy and the National Institutes of Health . Located at the Johns Hopkins University School of Medicine , GDB became a source of high quality mapping data which were made available both on line as well as through numerous printed publications. In 1998, the change of focus in the humangenomeproject redirected funds which were previously available for GDB. However that same year, Dr. A. Jamie Cuticchia obtained funding from Canadian public and private sources to continue the operations of GDB. While the data curation continued to be performed at Johns Hopkins, GDB central operations were moved to The Hospital for Sick Children in Toronto, Ontario, Canada. In 2003 RTI International became the new host for GDB where it continued to be maintained as a public resource for high quality genetic and genomic information. On June 1, 2008 RTI International shut down GDB operations. External links DEFAULTSORT Gdb HumanGenome Database Category Biological databases Biological database ... more details
Primarysources date October 2007 The Baylor College of Medicine HumanGenome Sequencing Center BCM HGSC was established by Richard Gibbs biologist Richard A. Gibbs in 1996 when BCM was chosen as one of six worldwide sites to complete the final phase of the International HumanGenomeProject . Gibbs is the current director of the BCM HGSC. It occupies more than convert 36000 sqft m2 , employs over 200 staff, including eighteen faculty, and is one of three National Institutes of Health funded genome centers that were involved in the completion of the first HumanGenome Sequence in 2004. The BCM HGSC contributed approximately 10 percent of the total project by sequencing Chromosomes 3, 12 and X. The BCM HGSC collaborated with researchers at the U.S. Department of Energy s Lawrence Berkeley Laboratory and Celera Genomics to sequence the first species of Drosophilidae fruit fly , Drosophila melanogaster . The BCM HGSC also completed the second species of fruit fly Drosophila pseudoobscura , the honeybee Apis mellifera , and led an international consortium to sequence the Brown Norway rat. The HumanGenome Sequencing Center subsequently sequenced and annotated the genome of the cow Bos taurus , the sea urchin , Rhesus macaque, Tammar wallaby , Dictyostelium discoideum , and a number of bacteria that cause serious infection s Rickettsia typhi, Enterococcus faecium, Mannheimia Haemolytica , and Fusobacterium nucleatum . The BCM HGSC was a major contributor to the Mammalian Gene Collection program, to sequence all human cDNAs, as well as the International Haplotype Mapping Project HapMap . Other research within the BCM HGSC includes new molecular technologies for mapping and sequencing, exploration of novel chemistries for DNA tagging, development of instrumentation for DNA manipulation ..., and analyzing genome data. References http imgen.bcm.tmc.edu molgen facultyaz gibbs.html http www.hgsc.bcm.tmc.edu Category Humangenome projects ... more details
Infobox Company company name HumanGenome Sciences company logo Image Optimized image a711cef6.png company type Public company Public nasdaq HGSI slogan foundation 1992 location Rockville, Maryland key people H. Thomas Watkins, CEO & Pres num employees 770 industry Healthcare products Diagnostic Substances owner revenue homepage http www.hgsi.com www.hgsi.com HumanGenome Sciences nasdaq HGSI is a biopharmaceutical corporation founded in 1992. It uses the human DNA sequence to develop protein and antibody drugs. As of 2008, it has drugs under development to treat such diseases as hepatitis C , systemic lupus erythmatosis , anthrax disease, cancer, rheumatoid arthritis and HIV AIDS. It collaborates with other biotechnology and pharmaceutical companies, for development partnerships and licensing. ref HUMANGENOME SCIENCES ANNOUNCES 2008 GOALS AND REPORTS SUBSTANTIAL PROGRESS TOWARD COMMERCIALIZATION AT JPMORGAN HEALTHCARE CONFERENCE ref Benlysta belimumab received U.S. Food and Regulatory Administration approval for use in lupus in March 2011. Belimumab is being developed with Glaxo SmithKline, ref HGS Press Release, 2005 ref Abthrax raxibacumab for anthrax disease is the subject of a contract with the US Government under Project BioShield. ref HGS Press Release, June 20, 2006 ref Development of Albuferon albinterferon for Hepatitis C has been discontinued after fatalities during ...?type 2&cat 0&date 20030926&news 230228&isin US4449031081&mode 8 HumanGenome s drug falls short ... latest humangenome sciences announces 2008 goals and reports substantial progress toward ... deal http www.hgsi.com latest humangenome sciences announces collaboration with novartis for development ... humangenome sciences to sponsor conference call to discuss u.s. government agreement to purchase ... Reflist External links http www.hgsi.com HumanGenome Sciences Official Web Site . Category Companies ... elderly patients, using a protein spray called repifermin, made by a human gene called keratinocyte ... more details
The Cancer GenomeProject , based at the Wellcome Trust Sanger Institute , aims to identify genetic variation sequence variant s mutation s critical in the development of human cancer s. Like The Cancer Genome Atlas project within the United States, the Cancer GenomeProject represents an effort in the War on Cancer to improve cancer diagnosis, treatment, and prevention through a better understanding of the molecular basis of this disease. The Cancer GenomeProject, led by Michael Stratton and Andy Futreal, combines knowledge of the humangenome sequence with high throughput screening high throughput mutation detection techniques. See also Cancer genome sequencing The Cancer Genome Atlas and http cgap.nci.nih.gov The Cancer Genome Anatomy Project ref http www.cancer.gov cancertopics understandingcancer CGAP ref ref http www.ncbi.nlm.nih.gov ncicgap ref at the National Cancer Institute. International Cancer Genome Consortium COSMIC cancer database External links http www.sanger.ac.uk genetics CGP Cancer GenomeProject Official website http www.sciam.com article.cfm?id mapping the cancer genome Francis S. Collins and Anna D. Barker. Mapping the Cancer Genome . Scientific American, February 2007 References references genetics stub oncology stub sci org stub UK med org stub Category Humangenome projects Category Wellcome Trust pt Projeto Genoma do C ncer ... more details
evolution in the humangenome gives insights into our own evolutionary history and helps to resolve this neutralist selectionist debate . Identifying specific regions of the humangenome that show ... of any adaptive evolution in the humangenome, but simply shows that positive selection is not frequent ... regions within the humangenome which have been evolving adaptively e.g. Bakewell et al. 2007 . More ... up approximately 98 of the DNA in the humangenome. For example, Ponting and Lunter 2006 detect ... in the humangenome has often assumed to be constant over time. For example, the 35 estimate ... of positive selection acting on the humangenome is by inferring the distribution of fitness effects DFE of new advantageous mutations in the humangenome, but this DFE is difficult to infer because ... the estimates of the amount of adaptive evolution occurring in the humangenome Boyko et al. 2008 ... some of the types of gene which show strong evidence of adaptive evolution in the humangenome. Disease ..., this second explanation seems unlikely, because the mutation rate in the humangenome is fairly ... has occurred frequently in the humangenome Pollard et al. 2006, Galtier and Duret 2007 . Initially ... evolution in the humangenome format of table and some data displayed as in Table 1 of Eyre Walker ... the evolutionary impact of amino acid mutations in the humangenome, PLoS Genetics, Vol. 4 pp. ..., A.G. 2005 , Natural selection on protein coding genes in the humangenome, Nature, Vol. 437 ... genome and comparison with the humangenome, Nature, Vol. 437 pp. 69 87 Crespi, B., Summers ... and negative selection on the humangenome, Genetics, Vol. 158 pp. 1227 1234 Galtier, N., and Duret ...., Ponting, C., Hein, J. 2006 , Genome wide identification of human functional DNA using a neutral indel ..., A.G. 2007 , Recent and ongoing selection in the humangenome, Nature Review Genetics, Vol. 8 pp. ... shaping the fastest evolving regions of the humangenome, PLoS Genetics, Vol. 2 pp. 1599 1611 ... more details
Apes DEFAULTSORT Neanderthal GenomeProject Category Genome projects Category Human evolution Category Neanderthals Genome Category Ancient DNA human Category Ancient human genetic history es Genoma del Neandertal fr Neanderthal genomeproject ka pt Genoma do Neandertal ru simple Neanderthal genomeproject sv Neanderthal genomeproject ..., Germany The Neanderthal genomeproject is a collaboration of scientists coordinated by the Max Planck ... sequencing sequence the Neanderthal genome . Founded in July 2006, the project published their results ... genome is about the size of the modern humangenome . According to preliminary sequences ... into the modern humangenome. ref name Timmer The speech related gene FOXP2 with the same ... genome sequence share a most recent common ancestor 706,000 years ago, and that the human and Neanderthal ... be interpreted within the context of humandiversity. On the other hand, Noonan et al. found no evidence of Neanderthal admixture to the modern humangenome, but they did not preclude admixture of up ... Neanderthal genome An early analysis of the data suggested in the genome of Neanderthals, a human species ... maps Neanderthal genome In May 2010, the project released a draft of their report on the sequenced ... External links http www.eva.mpg.de neandertal The Neandertal GenomeProject Website National Public ... www.msnbc.msn.com id 13955661 MSNBC Neanderthal genomeproject launches 22 November 2006. http news.bbc.co.uk ... genome based on the analysis of four billion base pairs of Neanderthal DNA. The study determined that some ... evidence that elements of their genome remain in that of non African modern humans. ref cite journal author Green RE, Krause J, Briggs AW, et al. title A draft sequence of the Neandertal genome journal ... in Us ref Findings At roughly 3.2 billion base pair s, ref name Team in Germany maps Neanderthal genome cite news first Patrick last McGroarty title Team in Germany maps Neanderthal genome url http readingeagle.com ... more details
. http www.technologyreview.com Biotech 19824 Your Personal Genome , Technology Review , 6 December 2007 ref It s 2011. What s been done since 2007? See also HumanGenomeProject References Reflist ... medtech stemcells magazine 16 08 ff church Wired How the Personal GenomeProject Could Unlock the Mysteries of Life Category Humangenome projects de Personal GenomeProject es Personal GenomeProject ...The Personal GenomeProject PGP aims to publish the complete genomes and medical records of several volunteers, in order to enable research into personalized medicine . It was initiated by Harvard University s George Church and announced in January 2006. ref Emily Singer. http www.technologyreview.com BioTech Therapeutics wtr 16169,259,p1.html The Personal GenomeProject , Technology Review , 20 January 2006 ref ref cite news url http www.nytimes.com 2010 06 08 science 08church.html? r 1 title Scientist at Work George M. Church On a Mission to Sequence the Genomes of 100,000 People publisher The New York Times date 2010 06 07 accessdate 2010 08 18 first David last Duncan ref Volunteers are currently accepted only if they are US citizens and able to attend for screening in the US. The project will publish the genotype the full DNA sequence of all 46 chromosome s of the volunteers, along with extensive information about their phenotype medical records, various measurements, Magnetic resonance imaging MRI images, etc. All data will be freely available over the Internet , so that researchers ... of genes and environment environment and phenotype . An important part of the project will be the exploration ... and employers if the genome shows a predisposition for certain diseases. The Harvard Medical School ... for Genome Sciences and Policy ref Misha Angrist, Robert M. Cook Deegan http www.thenewatlantis.com archive 11 angristcook deegan.htm Who Owns the Genome? The New Atlantis, Number 11, Winter 2006, pp ... to redact their trait data before publication. He also announced that the project was about to expand ... more details
12552136 ref Starting the chimpanzee genomeprojectHuman and chimpanzee chromosome s are very ... 18 . After the completion of the Humangenomeproject , a Common Chimpanzee genomeproject was initiated ... genomeproject suggest that when ancestral chromosomes 2A and 2B fused to produce human chromosome ... Search Chimpanzee GenomeProject 1 Chimpanzee GenomeProject div div div Common Chimpanzee Human evolutionary genetics Chromosome 2 humanHuman chromosome 2 HumanGenomeProject Apes Category Primatology ...The Chimpanzee GenomeProject is an effort to determine the DNA sequence of the Chimpanzee genome . It is expected ... in part by the National HumanGenome Research Institute , one of the National Institutes of Health ... pii S0378 1119 04 00715 2 ref Results from the human and chimp genome analyses should help in understanding ... Consortium , show that 24 of the chimpanzee genome does not align with the humangenome. There are 3 ... linked copies of the PGML FOXD CBWD genes exist elsewhere in the humangenome, particularly near the p ... s are scattered through the humangenome. References references note fusion cite journal author ... genome and comparison with the humangenome author Chimpanzee Sequencing and Analysis Consortium journal ... 16136131 issue 7055 br cite journal title A genome wide comparison of recent chimpanzee and human ... Finds Chimps, Humans Very Similar at the DNA Level http www.genome.gov 15515096 National HumanGenome ... fusion site in human chromosome 2q13 2q14.1 and paralogous regions journal Genome Res. volume 12 ... human chromosome differences . The major structural difference is that human chromosome http www.ncbi.nlm.nih.gov ... author McConkey EH title Orthologous numbering of great ape and human chromosomes is essential for comparative genomics journal Cytogenet. Genome Res. volume 105 issue 1 pages 157 8 year 2004 pmid ...&typ pdf ref . Parts of human chromosome 2 are scattered among parts of several cat and rat chromosomes ... about 85 million years since the human rodent common ancestor ref cite journal author Springer MS, Murphy ... more details
The Vertebrate and Genome Annotation Vega project provides manual curation of vertebrate genomes for the scientific community. ref cite journal author Ashurst JL, Chen CK, Gilbert JG, et al. title The Vertebrate Genome Annotation Vega database journal Nucleic Acids Research volume 33 issue Database issue pages D459 65 year 2005 month January pmid 15608237 pmc 540089 doi 10.1093 nar gki135 ref The Vega data repository is publicly available, regularly updated and includes GenomeprojectGenome annotation annotations of several finished vertebrate genome sequences human, mouse, zebrafish, pig and dog. ref cite journal author Loveland J title VEGA, the genome browser with a difference journal Briefings in Bioinformatics volume 6 issue 2 pages 189 93 year 2005 month June pmid 15975227 doi 10.1093 bib 6.2.189 ref The Vega website is built upon the Ensembl codebase. ref cite journal author Searle SM, Gilbert J, Iyer V, Clamp M title The otter annotation system journal Genome Research volume 14 issue 5 pages 963 70 year 2004 month May pmid 15123593 pmc 479127 doi 10.1101 gr.1864804 ref The Vega database is run and developed by the Wellcome Trust Sanger Institute . References reflist External links http vega.sanger.ac.uk Vega homepage Category Bioinformatics Category Biological databases bioinformatics stub ... more details
Refimprove date November 2007 Flu The Influenza Genome Sequencing Project IGSP is an American based genomeproject aimed at improving the availability of genomic sequence data from influenza virus es and related information. The project is funded by the National Institute of Allergy and Infectious Diseases ... in humanhuman flu avian bird flu and swine swine flu populations, including many strains of H3N2 human , H1N1 human , and H5N1 avian E. Ghedin et al., Nature 2005 , 1162 1166. . Affiliations The project ... Genome Sequencing Project home page at NIAID http www.ncbi.nlm.nih.gov genomes FLU FLU.html ... subtype H5N1 Category Genome projects Category Influenza Genome Sequencing Project ... generated by the project has been placed into public domain through GenBank . Origins In early 2004 ... TIGR . Prior to this project, only a handful of flu genomes were publicly available. Citation needed ... ref http www.nature.com nature journal v437 n7062 full nature04239.html Large scale sequencing of human influenza reveals the dynamic nature of viral genome evolution. E. Ghedin, N.A. Sengamalay, M. Shumway ... Salzberg. Nature 2005 , 1162 1166. ref Research goals The project is making all sequence data publicly ... influenza viruses . The project began prospective studies of the 2007 influenza season with collaborators ... The project completed its first genomes in March 2005 and has rapidly accelerated since. As of mid ... of the NIH, which is an agency of the United States Department of Health and Human Services . The IGSP ... University and Rob Webster of St. Jude s Children s Hospital in Memphis, Tennessee. In 2006 the project ..., Aly MM, et al. Genome analysis linking recent European and African influenza H5N1 viruses. Emerg ... College of Medicine also joined the project in 2006, contributing over 150 influenza B isolates ... the initial results of this project http cbcb.umd.edu salzberg docs NatureFluGenomeProjectReprint.pdf ... in Nature on the initial results of this project. References references http www.tigr.org flu Influenza ... more details
Infobox Organization name Floral GenomeProject image image border size caption map msize mcaption motto formation 2001 type Academic Research headquarters Penn State University br University of Florida br Cornell University location flagicon USA United States membership language leader title leader name key people num staff budget website http fgp.bio.psu.edu Official website The Floral GenomeProject is a collaborative research cooperation primarily between Penn State University , University of Florida , and Cornell University . The initial funding came from a grant of 7.4 million from the National Science Foundation . The Floral GenomeProject was initiated to bridge the genomic gap between the most broadly studied plant model systems. According to the http www.floralgenome.org website , the following are the aims of the project blockquote The Floral GenomeProject will investigate the origin, conservation, and diversification of the genetic architecture of the flower, and develop conceptual and real tools for evolutionary functional genomics in plants. blockquote External links http fgp.bio.psu.edu Official Website University of Florida Cornell University Category Genome projects Category Botany Category University of Florida Category Cornell University botany stub pl Floral GenomeProject ... more details
The Music GenomeProject was first conceived by Will Glaser and Tim Westergren in late 1999. In January 2000 they joined forces with Jon Kraft to found Pandora Radio Pandora Media to bring their idea to market. ref http venturevoice.com shows venturevoice54 tim westergren pandora.mp3 ref The Music GenomeProject was an effort to capture the essence of music at the fundamental level using list of Music GenomeProject attributes almost 400 attributes to describe songs and a complex mathematical algorithm to organize them. Under the direction of Nolan Gasser , the musical structure and implementation of the Music GenomeProject, made up of 5 Genomes Pop Rock Hip Hop Electronica Jazz World Music and Classical , was advanced and codified. A given song is represented by a coordinate vector vector a list of attributes containing approximately 400 genes analogy analogous to trait determining gene ... GenomeProject is a registered trademark in the United States. The mark is owned by Pandora Media, Inc. ref http tess2.uspto.gov bin showfield?f doc&state e3mah4.2.1 Music GenomeProject US Trademark No. 2731047 United States Patent Office ref The Music GenomeProject is covered by United States ... GenomeProject US Patent No. 7,003,515 ref This patent shows William T. Glaser, Timothy B. Westergren ... owned by Pandora Media, Inc. See also List of Music GenomeProject attributes Moodbar MusicBrainz ... GenomeProject &mdash short historical statement by Tim Westergren div reflist Further reading refbegin Citation last Castelluccio first Michael title The Music GenomeProject journal Strategic ... first Joyce title Pandora and the Music GenomeProject journal Scientific Computing volume 23 issue ... GenomeProject and Pandora video https sites.google.com site thefirstmusicofgenes home The first ... it Music GenomeProject he lt Muzikos genomo projektas pl Music GenomeProject ... genome project.aspx?terms music 20genome issn 1930 5753 accessdate 2008 08 03 http www.nytimes.com ... more details
The Fiocruz Genome Comparison Project is a collaborative effort involving Brazil s Oswaldo Cruz Institute and IBM s World Community Grid , designed to produce a database comparing the gene s from many genome s with each other using SSEARCH http helix.nih.gov docs gcg ssearch.html . The program SSEARCH performs a rigorous Smith Waterman algorithm Smith Waterman alignment between a protein sequence and another protein sequence, a protein database, a DNA or a DNA library. The nature of the computation in the project allows it to easily take advantage of distributed computing . This, along with the likely humanitarian benefits of the research, has led the World Community Grid a distributed computing grid that uses idle computer clock time to run the Fiocruz project. All products are in the public domain by contract with WCG. Description The problem is that a very large information body structural, functional, cross references, etc. is attached to protein database entries. Once entered the information is rarely updated or corrected. This annotation of predicted protein function is often incomplete, uses non standard nomenclature or can be incorrect when cross referenced from previous sometimes incorrectly annotated sequences. Additionally, many proteins composed of several structural and or functional domains are overlooked by automated systems. The comparative information today is huge when compared to the early days of genomics. A single error is compounded and then made complex. The Genome Comparison Project performs a complete pairwise comparison between all predicted protein ... as a reference repository for the annotator community. The project provides invaluable data sources for biologists. The sequence similarity comparison program used in the Genome Comparison Project is called ... bioinfoteam templates archives GenomeComparison progress.html Genome Comparison Project http www.worldcommunitygrid.org projects showcase fgc viewFgcMain.do World Community Grid Project Category Genomics ... more details
orphan date August 2009 The Immunological GenomeProject ImmGen is a collaborative scientific research project that is currently building a gene expression microarray database for all characterized immune cells in the mouse. The overarching goal of the project is to computationally reconstruct the genetic regulatory network in immune cells. All data generated as part of ImmGen are made freely and publicly available. The ImmGen project began in 2008 as a collaboration between several immunology and computational biology laboratories across the United States. The project has several phases, and is expected to take about three years to complete. Currently, raw data from the first phase is being released as it is generated on www.ImmGen.org. Project Background A true understanding of cell differentiation in the immune system will require a general perspective on the transcripts that are present in each cell type of the adaptive and innate immune systems, and how these profiles evolve through cell differentiation or activation by immunogenic or tolerogenic ligands. This project aims to establish the roadmap of these transcriptional states. Gene expression microarray compendium The first aim of ImmGen is to generate a compendium of whole genome microarray datasets for nearly all characterized cell populations of the adaptive and innate immune systems in the mouse, at major stages of differentiation and activation. This effort is being carried out by a group of collaborating immunology research laboratories across the U.S. Each of the laboratories brings a unique expertise in a parrticular cell lineage, and all are all employing standardized procedures for cell sorting. The compendium of microarray data will include as many immunologically relevant cell types as possible, from ... representation of data Project participants from Brown University s Computer Sciences Department ... has profiled approximately 180 cell populations in the mouse. Data access The project s status and detailed ... more details
The Epilepsy Phenome GenomeProject EPGP is a government funded study to identify gene s that influence the development of epilepsy and genes that affect the response to treatment. The study involves 13 major epilepsy centers and more than 150 scientists and clinical staff around the United States. The goal is to create a repository of clinical and genetic information on a select group of patients with epilepsy. The hope is that this information will reveal new insights and improve diagnosis and treatment. EPGP is funded by the National Institutes of Health via http www.ninds.nih.gov The National Institute for Neurological Disorders and Stroke NINDS . The long term goal of EPGP is to identify potential molecular targets that could be the basis of much more specific and effective treatments for patients who have epilepsy, and the prevention of epilepsy in those at risk. Background on Genes and Epilepsy Although heredity has been known since antiquity to cause epilepsy, the progress to date in identifying the genetic basis of epilepsy has been limited primarily to the discovery of single gene mutations that cause epilepsy in relatively rare families. For the more common types of epilepsy, heredity plays a subtler role, and it is thought that a combination of mutations in multiple genes likely determine an individual s susceptibility to seizures, as well as the responsiveness to antiepileptic medications. EPGP Phenotyping The approach to teasing apart the more complicated genetic factors in epilepsy requires a very large number of patients whose epilepsy has been extremely well characterized. EPGP investigators will be enrolling 3,750 patients and 3,000 controls over the course of the study. Details about seizure types, EEGs, imaging studies, and effects of treatment will be collected and archived in a central data repository, and all participants will be asked to submit ..., Sabatti C. The human phenome project. Nat Genet. 2003 May 34 1 15 21 External links http www.epgp.org ... more details
The Universal Declaration on the HumanGenome and Human Rights is a document that was issued by the United Nations Educational, Scientific and Cultural Organization UNESCO at its 29th session in 1997. It was unanimously passed by the seventy seven national delegations in attendance. ref Mike Pezzella, International officials adopt rules covering cloning, gene research, Biotechnology Newswatch , 17 November 1997, p. 1. ref The declaration is perhaps best known for its statement against human cloning. Its eleventh article begins with the statement, Practices which are contrary to human dignity, such as reproductive cloning of human beings, shall not be permitted. References references See also Common heritage of mankind UNESCO Universal Declaration on the HumanGenome and Human Rights External links http unesdoc.unesco.org images 0012 001229 122990eo.pdf Universal Declaration on the HumanGenome and Human Rights 2000 publication UN stub Category UNESCO ... more details
the HumanGenomeProject http www.genome.gov DNADay National DNA Day http www.genome.gov HGP All About The HumanGenomeProject http www.genome.gov PolicyEthics LegDatabase pubsearch.cfm NHGRI Policy ...Image US NIH NHGRI Logo.svg 240px right The National HumanGenome Research Institute NHGRI is a division ... Center for HumanGenome Research NCHGR , which was established in 1989 to carry out the role of the NIH in the International HumanGenomeProject HGP . The HGP was developed in collaboration with the United States Department of Energy DOE and began in 1990 to map the humangenome . In 1993, NCHGR ... History main Important events in NHGRI history October 1, 1988 The Office for HumanGenome Research ... activities related to the humangenome. April 11, 1996 Human DNA sequencing begins with pilot studies at six universities in the United States. March 1999 Large scale sequencing of the humangenome begins. April 2003 The National HumanGenome Research Institute NHGRI celebrates the completion of the humangenome sequence, the 50th anniversary of the description of the DNA double helix and the publication ... as Director of National HumanGenome Research Institute Bot generated title ref Alan Edward Guttmacher ... Appoints Eric D. Green , M.D., Ph.D. to be Director of The National HumanGenome Research Institute ... Category National Institutes of Health HumanGenome Research Institute fa fr National HumanGenome Research Institute ... genome technologies to the study of specific diseases. In 1996, the Center for Inherited Disease Research ... components of complex disorders. In 1997 the United States Department of Health and Human Services DHHS renamed NCHGR the National HumanGenome Research Institute NHGRI , officially elevating it to the status of research institute one of 27 institutes and centers that make up the NIH. Now, with the humangenome sequence complete since April 2003, scientists around the world have access to a database ... more details
distinguish Chinese National HumanGenome Center, Shanghai Chinese National HumanGenome Center , Beijing CHGB , was established as one of the national level genome research center approved by the Ministry of Science & Technology . CHGB coordinates scientific activities in humangenome research with the Chinese Academy of Medical Sciences CAMS , Peking University , Academy of Military Medical Sciences , Chinese Academy of Science CAS , http www.chgc.sh.cn Chinese National HumanGenome Center at Shanghai , Microbial Genome Center at Ministry of Health, Tsinghua University , Institute of Biophysics Academia Sinica , Peking Union Hospital , Beijing Fuwai Hospital , Cancer Hospital at CAMS , Beijing Cancer Hospital , Peking University First Hospital , People s Hospital of Peking University , PLA General Hospital , Tianjin Medical University , Roche Co. etc. CHGB takes on Chinese important scientific and technological projects and impels genomics and proteomics in the world. In next several years, CHGB continues to serve for and support China important scientific and technological projects, set up and develop functional genomics research platform, train an excellent group, aiming at promoting competitive power and CHGB s value. CHGB promotes the commercialization of research products and initiate genome industry in China. As a national research institution, CHGB integrates all high level activities in basic research , clinical investigation , population genetics and bioinformatics projects in Beijing and North China . Prof. Boqin Qiang, academician of CAS, is Director and Chief Scientist of CHGB. Prof. Wu Min, academician of CAS, is the honorary Chairman of the academic committee. Prof. Yan Shen, academician of CAS, Prof. Fuchu He, academician of CAS, Prof. Dalong Ma, and Prof. Biao Chen are deputy directors of CHGB. See also Beijing Genomics Institute ... Humangenome projects Category Genetics or genomics research institutions Category Research institutes ... more details
Source http www.hgsi.com graphics hgs.gif Non free logo It is asserted that the use of this image in articles pertaining to or in reference to Human Genome Sciences and its associated properties qualifies as fair use for the following reasons It is a low resolution copy of the logo It does not affect the market for the original work this is a logo created to promote a company, not a commercial work sold to the public for profit By the nature of the image, no free alternative is possible The logo is widely identified with Human Genome Sciences via products, publications, advertisements etc. and so the inclusion of the logo adds significantly to the articles in which it is used History of File Hgs.gif 2008 01 12T20 21 07Z User CmdrObot CmdrObot User talk CmdrObot Talk Special Contributions CmdrObot contribs 708 bytes nowiki sp an company a company nowiki 2007 12 03T23 31 52Z User Boothy443 Boothy443 User talk Boothy443 Talk Special Contributions Boothy443 contribs 709 bytes nowiki Source http www.hgsi.com graphics hgs.gif Non free logo It is asserted that the use of this image in articles pertaining to or in reference to Human Genome Sciences and its associated properties qualifies as fair use for the following reasons I nowiki 2007 12 03T23 31 52Z User Boothy443 Boothy443 User talk Boothy443 Talk Special Contributions Boothy443 contribs 151x75 3048 bytes ... more details
A list of attributes used by the Music GenomeProject for classifying music, sorted by categories. Dynamic list Structures Musical composition Composition Basic Rock Song Structures Buildup Breakdown Chromaticism Chromatic Harmonic Structure Epic Buildup Breakdown Groove music Groove Based Composition Interesting Song Structure Melodic Songwriting Minimalist Arrangements Orchestral Arranging Repetitive Song Structure Subtle Buildup Breakdown Big Band Arrangements Lead Big Band Rhythm Meter music Meter Danceable Groove music Grooves Four Four Time Signature Hard Swingin Rhythm Heavy Syncopation Intricate Rhythm Rhythms Meter music Meter Complexity Mild Rhythmic Syncopation Triple metre Triple Meter Style Tuplet Triple Note Feel Twelve Eight Time Signature Syncopation Unsyncopated Musical ensemble Ensemble Rhythms Use of Groove music Groove Varying Tempo and Time signature Time Signatures Rhythm Rhythmic Intro Ostinato Acoustic music Acoustic Sonority Acousti Synthesizer synthetic Sonority Chord Progression Chordal Patterning Dominant Use of Riffs Electro Synthetic Sonority Extensive Vamping Highly Synthetic Sonority Intricate Melodic Phrasing Knack for Hook music Catchy Hooks Melodic Songwriting Modal Harmony Overall Meditative Sound Repetitive Verse chorus form Chorus Repetitive Melodic Phrasing Repetitive Verse chorus form Verse Synth acoustic Sonority Synth electric Sonority Tonality Tonal Harmony Roots Acid Jazz Roots Afro Latin Roots Basic Rap Roots Blues Roots Caribbean Roots Classic Jazz Roots Club Rap Roots Cool Jazz Roots Country Roots Disco Roots East Coast Rap Roots Electronica Roots Folk Roots Funk Roots Hard Bop Roots Hard Rock Roots Hawaiian Roots House music ... Swing elements References http www.pandora.com mgp.shtml The Music GenomeProject short historical statement by Tim Westergren Category Dynamic lists Music GenomeProject attributes Category Music related lists Music GenomeProject attributes it Lista degli attributi del Music GenomeProject ... more details
Human Epigenome Project HEP is a multinational science project, with the stated aim to identify, catalog, and interpret genome wide DNA methylation patterns of all human genes in all major tissues . ref cite web title Description Page publisher Human Epigenome Project url http www.epigenome.org index.php?page project accessdate 2009 01 30 ref It is financed by government funds as well as private investment, via a consortium of genetic research organisations. The call for such a project was widely suggested and supported by cancer research scientists from all over the world. ref name Esteller2006 cite journal author Esteller M title The necessity of a human epigenome project journal Carcinogenesis year 2006 volume 27 issue 6 page 1121 1125 pmid 16699174 doi 10.1093 carcin bgl033 ref ref name Jones2005 cite journal author Jones PA, Martienssen R title A blueprint for a Human Epigenome Project the AACR Human Epigenome Workshop journal Cancer Res year 2005 volume 65 issue 24 page 11241 11246 pmid 16357125 doi 10.1158 0008 5472.CAN 05 3865 ref ref name Rauscher2005 cite journal author Rauscher FJ 3rd title It is time for a Human Epigenome Project journal Cancer Res year 2005 volume 65 issue 24 page 11229 pmid 1635712 ref ref name Bradbury2003 cite journal author Bradbury J title Human epigenome project up and running journal PLoS Biol year 2003 volume 1 issue 3 page E82 pmid 14691553 doi 10.1371 journal.pbio.0000082 pmc 300691 ref Consortium The HEP consortium is made up of the following organizations The Wellcome Trust Sanger Institute &mdash UK Epigenomics AG &mdash Germany USA The Centre National de G notypage &mdash France References reflist External links http www.epigenome.org Human Epigenome Project Category Epigenetics Category Humangenome projects pt Projecto Epigenoma Humano ru Human Epigenome Project ... more details
of the HumanGenome Variation Society . The authority of those initiating this project is evidenced ... of work involved. See also Variome HumanGenomeProjectHuman genetic variation Population groups in biomedicine http www.hgmd.org Human Gene Mutation Database HGMD External links http www.humanvariomeproject.org Official Project website Category Humangenome projects ...Image Hvplogo.png right thumb The Human Variome Project FAIR USE of Hvplogo.png see image description page at http en.wikipedia.org wiki Image Hvplogo.png for rationale The Human Variome Project HVP is the global initiative to collect and curate all human genetic variation affecting human health. Its mission is to improve health outcomes by facilitating the unification of data on human genetic variation and its impact on human health. Inception The HVP concept was conceived by Richard Cotton Professor Richard Cotton , a leader in the field of human genetic variation . His group, the Genomic Disorders ... are of varying completeness and individualistic, so the Human Variome Project was born to establish a central project to encourage the collection and sourcing of this data, verifying it and ultimately ... scientists came together in June 2006 at the Human Variome Project Meeting, organized by Professor ... of Australia Federal Governments . This major international project, a natural partner to the HumanGenomeProject , will require substantial funding to get it to a sustainable position. A five year secure budget period of approximately US 12m per year has been proposed to initiate the project. This will enable the project to be organized and find operational funds for the tasks of system ... as collection systems that are open and accessible to all. The Human Variome Project seeks to provide ... Genomic Studies CAGS has initiated efforts to proceed with the Arab Human Variome Project under the Human Variome Project. CAGS was one of the participants of the HVP meeting in Melbourne. Since ... more details
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