Fibrin also called Factor Ia is a fibrous protein involved in the clotting of blood, and is non globular. It is a fibrillar protein that is Polymerization polymerised to form a mesh that forms a hemostasis hemostatic plug or clot in conjunction with platelets over a wound site. Fibrin is involved in the following biological processes signal transduction, blood coagulation , platelet activation , and protein polymerization . Role in disease Excessive generation of fibrin due to activation of the coagulation cascade leads to thrombosis , more commonly known as a clot, while ineffective generation or premature lysis of fibrin predisposes to hemorrhage . Dysfunction or disease of the liver can lead to a decrease in fibrinogen production or the production of abnormal fibrinogen molecules with reduced activity dysfibrinogenaemia . Hereditary abnormalities of fibrinogen the gene is carried on chromosome 4 are of both quantitative and qualitative in nature and include afibrinogenaemia , hypofibrinogenaemia , dysfibrinogenaemia , and hypodysfibrinogenaemia . Consequences of reduced, absent, or dysfunctional fibrin is likely to render patients as hemophiliacs. Physiology Fibrin from different animal sources is generally glycosylate d with complex type diantennary asparagine linked glycan s. Variety ... MS and its application to fibrin N glycans journal Anal. Chem. volume 79 issue 13 pages 5051 7 year ... left thumb 240px Crystal structure of the double d fragment from human fibrin The image at the left is a crystal structure of the double d fragment from human fibrin with two bound ligands. The experimental ... sub NO sub 6 sub . See also Fibrinogen Fibrin glue Fibrin Scaffold References Reflist External links ... proteins bg cs Fibrin da Fibrin de Fibrin es Fibrina eu Fibrina fr Fibrine gl Fibrina io Fibrino it Fibrina he lt Fibrinas nl Fibrine ja om Fibrin nds Fibrin pl Fibryna pt Fibrina ru sl Fibrin fi Fibriini sv Fibrin uk zh ... more details
Fibrin glue also called fibrin sealant is a synthetic substance used to create a fibrin clot . ref name bmj http www.bmj.com cgi content extract 308 6934 933 ref ref http www.theannals.com cgi content abstract 22 12 946 ref ref http www.medhelp.org forums gastro archive 1054.html ref ref http content.karger.com ProdukteDB produkte.asp?Doi 8552 ref ref http www.healthsystem.virginia.edu internet stac research spfibgl.cfm ref ref name IJPS http www.ijps.org article.asp?issn 0970 0358 year 2003 volume 36 issue 1 spage 14 epage 17 aulast Saxena ref ref http www3.interscience.wiley.com journal 121466570 abstract ref It is made up of fibrinogen and thrombin ref name bmj that are injection medicine injected through one head into the site of a fibrin tear. ref name bmj Thrombin acts as an enzyme and converts the fibrogen into fibrin between 10 and 60 seconds and acts as a tissue adhesive . ref name IJPS ref cite pmid 19820991 ref It may also contain aprotinin , fibronectin and plasminogen . ref http www.fass.se LIF produktfakta artikel produkt.jsp?NplID 19950119000010&DocTypeID 5 Tisseel From the Swedish official drug catalog ref This glue can be used for repairing dura tears, bronchial fistula s and for achieving hemostasis after spleen and liver trauma. ref name IJPS It is also employed in no surgical suture sutures corneal transplantation . ref name pmid17379570 cite journal author Narendran N, Mohamed S, Shah S title No sutures corneal grafting a novel use of overlay sutures and fibrin glue in Deep Anterior Lamellar Keratoplasty journal Cont Lens Anterior Eye volume 30 issue 3 pages 207 9 year 2007 month July pmid 17379570 doi 10.1016 j.clae.2007.02.007 url http linkinghub.elsevier.com retrieve pii S1367 0484 07 00031 8 ref ref cite pmid 19668958 ref References reflist Category Blood Category Surgery Category Adhesives med stub de Fibrinkleber it Colla di fibrina Fibrin glue http www.intexmatrix.com baxter bio surgery.html ... more details
cleanup jargon date June 2009 cleanup date June 2009 POV check date June 2009 A fibrin scaffold is a network ... consists of naturally occurring biomaterial s composed of a cross linked fibrin network and has a broad use in biomedical applications. Fibrin consists of the blood proteins fibrinogen and thrombin which participate in blood clotting . Fibrin glue or fibrin sealant is also referred to as a fibrin ... like antibiotics to tissues exposed. ref http www.surgeryencyclopedia.com Ce Fi Fibrin Sealants.html Fibrin Sealants test, blood, complications, time, infection, risk, rate, Definition, Purpose, Description, Preparation, Normal results ref ref name Atrah cite journal author Atrah HI title Fibrin ... url http bmj.com cgi pmidlookup?view long&pmid 8173397 ref Fibrin scaffold use is helpful in repairing ... TA, Morey AF title Fibrin sealant for the management of genitourinary injuries, fistulas and surgical ..., Varela JE, Cohn SM, Compton RP, McKenney MG title Fibrin glue eliminates the need for packing after ... role of fibrin in acute lung injury journal American Journal of Physiology. Lung Cellular and Molecular ... ajplung.90633.2008 ref spleen, ref cite journal author Modi P, Rahamim J title Fibrin sealant treatment ... kidney, ref cite journal author Patel R, Caruso RP, Taneja S, Stifelman M title Use of fibrin glue ... using a fibrin glue sheet journal Interactive Cardiovascular and Thoracic Surgery volume 6 issue ... research, fibrin scaffolds have been used to fill bone cavities, repair neurons, heart valves, ref ..., interference of new cells and biological cues is provided by a scaffold material. Fibrin scaffold ... healing is helpful in surgical applications. Many factors can be bound to fibrin scaffold and those ... by combining fibrin with other suitable scaffolds. Each biomedical application has its own characteristic requirement for different kinds of tissues and recent studies with fibrin scaffold are promising towards faster recovery, less complications and long lasting solutions. Advantages of fibrin ... more details
A fibrin ring granuloma is a histopathology histopathological finding that is characteristic of Q fever . On H&E stain hematoxylin eosin stain ing, the fibrin ring granuloma consists of a central lipid vacuole usually washed out during fixing and staining, leaving only an empty hole surrounded by a dense red fibrin ring and epithelioid macrophage s. Fibrin ring granulomas may also be seen in Hodgkin s disease and infectious mononucleosis . ref name pmid11881318 cite journal author Tjwa M, De Hertogh G, Neuville B, Roskams T, Nevens F, Van Steenbergen W title Hepatic fibrin ring granulomas in granulomatous hepatitis report of four cases and review of the literature journal Acta Clin Belg volume 56 issue 6 pages 341 8 year 2001 pmid 11881318 doi url ref ref name pmid8514044 cite journal author de Bayser L, Roblot P, Ramassamy A, Silvain C, Levillain P, Becq Giraudon B title Hepatic fibrin ring granulomas in giant cell arteritis journal Gastroenterology volume 105 issue 1 pages 272 3 year 1993 month July pmid 8514044 doi url ref See also Granuloma References Reflist 2 DEFAULTSORT Fibrin Ring Granuloma Category Histopathology Pathology stub ... more details
Image D dimer.png thumb Principles of D dimer testing Fibrin degradation product FDPs , also known as fibrin split products, are components of the blood produced by clot degeneration. ref name pmid7786784 cite journal author Gaffney PJ, Edgell T, Creighton Kempsford LJ, Wheeler S, Tarelli E title Fibrin degradation product FnDP assays analysis of standardization issues and target antigens in plasma journal Br. J. Haematol. volume 90 issue 1 pages 187 94 year 1995 pmid 7786784 doi 10.1111 j.1365 2141.1995.tb03399.x ref These are produced by the action of plasmin on deposited fibrin. The most notable subtype of fibrin degradation products is D dimer . The levels of these FDPs rises after any thrombotic event. It can be used to test for disseminated intravascular coagulation . ref http peir.path.uab.edu coag article 77.shtml Fibrin Fibrinogen Degradation Products Bot generated title ref See also D dimer References references External links MedlinePlus 003655 medicine stub Category Coagulation system nl Fibrinedegradatieproduct sl Razgradni produkt fibrina ... more details
orphan date August 2010 Primary fibrinogenolysis is a Disease medical condition that appears with abnormal production of Fibrin degradation product fibrinogen fibrin degradation products FDP , degradation of coagulation factors V, VIII, IX, XI and or degradation of the fibrin present in any pre existing localized Thrombus thrombi and hemostatic clots. ref name marder cite journal author Marder VJ, Williams WJ, Beutler E, Erslev AJ, Lichtman MA, eds. title Consumptive thrombohemorrhagic disorders journal Hematology year 1990 ref ref name Potron cite journal author Potron G, Caen JP, Tobelem G, Soria C, eds. title Fisiopatologia delle iperfibrinolisi journal Milano Masson year 1988 ref References reflist 2 Category Coagulation system Category Diseases and disorders medicine stub ... more details
FGB can refer to The Fibrinogen beta chain , a protein subunit of fibrin First Guaranty Bank , headquartered in Hammond, Louisiana First Gulf Bank Functional Cargo Block FGB is the Russian acronym for see Zarya disambig de FGB ... more details
Staphylokinase SAK is a amino acid enzyme from Staphylococcus aureus . ref Bokarewa MI, Jin T, Tarkowski A. 2006 Staphylococcus aureus Staphylokinase Int J Biochem Cell Biol 38 4 504 9 ref It is positively regulated by the agr gene regulator. It activates plasminogen to form plasmin, which digest fibrin clots. This disrupts the fibrin meshwork which can often form to keep an infection localized. Staphylokinase also cleaves IgG and complement component C3b , inhibiting phagocytosis. It is classified under EC number 3.4.99.22 . References reflist Category Staphylococcaceae Category Enzymes enzyme stub Proteases de Staphylokinase ... more details
Multiple issues orphan February 2009 unreferenced November 2008 original research November 2008 COI November 2008 Vivostat Aktieselskab A S is privately owned Denmark Danish medical company located north of Copenhagen, Denmark . The company develops, manufactures, and markets a blood processing technology Vivostat system that utilizes the patient s own blood to derive either a surgical sealant to prevent and stop bleeding autologous fibrin sealant , or a gel with a high concentration of growth factor s Platelet Rich Fibrin also known as PRF that stimulates the healing of chronic wound s. Category Companies of Denmark med company stub ... more details
Cryofibrinogenemia is defined by the presence of circulating cold insoluble complexes of fibrin , fibrinogen , fibronectin, and fibrin split products with albumin, immunoglobulins and plasma proteins that precipitate from the patient s plasma in the cold. ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 822 See also Cryofibrinogenemic purpura References reflist Category Immune system disorders ... more details
Platelet Poor Plasma PPP is blood plasma with very low number of platelets 50000 uL . Traditionally, PPP was recommended for use in platelet aggregation studies to both adjust the Platelet rich plasma concentration, and to serve as a control ref Marco Cattaneo, Anna Lecchi, Maddalena Loredana Zighetti, Federico Lussana. Platelet aggregation studies autologous platelet poor plasma inhibits platelet aggregation when added to platelet rich plasma to normalize platelet count . Haematologica, 2007, 92 05 ref . PPP may have elevated levels of fibrinogen, which has the ability to be form a fibrin rich clot once activated. Wound healing requires cell migration and attachment, which is facilitated by this fibrin colt ref Richard A.F. Clark. Fibrin and Wound Healing . Annals New York Academy of Sciences, 2001, vol.936 pg.355 367. ref . Current Uses Fibrin sealants have found use in many clinical situations such as blood management ref R.K. Spence. Current concepts in Blood Management . Orthopaedics, 2004 27 S643 S641 ref , orthopaedic surgery ref R. Justin Thomas, Scott E. Marwin. The role of fibrin sealants in orthopaedic surgery . Journal of the American Academy of Orthopaedic Surgeons, 2009, Vol 17, No 12. ref , and cosmetic surgery ref Man, D., Plosker, H., Winland Brown, J.E. The use of autologous platelet rich plasma platelet gel and autologous platelet poor plasma fibrin glue in cosmetic surgery . Plastic and Reconstructive Surgery, Vol 107, Issue 1, Pages 229 239 ref . Future possibilites As a by product of PRP preparation, PPP may also find use in tissue engineering applications as autologous degradable scaffolds as this plasma portion is frequently discarded when used with PRP treatments. Notes Reflist ... more details
Infobox Disease Name PAGENAME Image Pericarditis fibrinosa.jpg Caption Pericarditis fibrinosa DiseasesDB ICD10 N18.8 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID Uremic pericarditis is a form of pericarditis . It causes fibrinous pericarditis. ref name urlCIN2003. Agarwal UREMIC PERICARDITIS cite web url http www.uninet.edu cin2003 conf agarwal agarwal.html title CIN 2003. Agarwal UREMIC PERICARDITIS format work accessdate 2009 03 14 ref Presentation Fibrinous pericarditis is an exudative inflammation . The pericardium is infiltrated by the fibrinous exudate. This consists of fibrin strands and leukocytes . Fibrin describes an amorphous, eosinophilic pink network. Leukocytes white blood cells mainly neutrophils are found within the fibrin deposits and intrapericardic. Vascular congestion is also present. The myocardium has no changes. Sometimes referred to as having Bread and Butter Appearance . Treatment It is sometimes treated with dialysis . ref name pmid11216584 cite journal author Rivera M, Teruel JL, Marc n R, Ortu o J title Intensive continuous peritoneal dialysis as treatment of uremic pericarditis journal Perit Dial Int volume 20 issue 6 pages 803 year 2000 pmid 11216584 doi url http www.pdiconnect.com cgi pmidlookup?view long&pmid 11216584 format dead link date May 2010 ref References reflist Circulatory system pathology Urologic disease Category Cardiology ... more details
The dysfibrinogenemias are a group of autosomal dominant disorders of qualitatively abnormal fibrinogen s http emedicine.medscape.com article 199723 overview . There are various different fibrinogen abnormalities, each named after the place where it was discovered. Each dysfibrinogenemia is associated with slightly different effects on the thrombin time and on normal clotting. Some dysfibrinogenemias cause abnormal bleeding or even thrombosis , while others have no effect on either bleeding or thrombosis. Some examples are Amsterdam is a major defect, characterized by aggregation of fibrin monomer s, prolonged thrombin time, and an inhibitory effect on normal clotting but it is asymptomatic. Detroit is a major defect, there is fibrinopeptide release, the thrombin time is prolonged, there is an inhibitory effect on normal clotting and there is abnormal bleeding. Wiesbaden is a major efect, there is aggregation of fibrin monomers, the thrombin time is prolonged, there is an inhibitory effect on normal clotting and there is both bleeding and thrombosis. Category Blood disorders ... more details
Fibrinolysis is the process wherein a fibrin thrombus clot , the product of coagulation , is broken down. ref name pmid15842654 cite journal author Cesarman Maus G, Hajjar KA title Molecular mechanisms of fibrinolysis journal British journal of haematology volume 129 issue 3 pages 307 21 year 2005 month May pmid 15842654 doi 10.1111 j.1365 2141.2005.05444.x ref Its main enzyme plasmin cuts the fibrin mesh at various places, leading to the production of circulating fragments that are cleared by other protease s or by the kidney and liver . Physiology Image Fibrinolysis.png right 360px thumb Fibrinolysis ... in an inactive form, plasminogen , in the liver. Although plasminogen cannot cleave fibrin, it still ... residues on fibrin ogen . When converted from plasminogen into plasmin, it functions as a serine protease , cutting C terminal to these lysine and arginine residues. Fibrin monomers, when polymerized ... covalently. Within a single strand, the fibrin monomers are covalently linked through the actions of coagulation factor XIII . Thus, plasmin action on a clot initially creates nicks in the fibrin further ... title The molecular weights, mass distribution, chain composition, and structure of soluble fibrin degradation products released from a fibrin clot perfused with plasmin journal The Journal of biological ... activated, it breaks down the fibrin mesh. t PA and urokinase are themselves inhibited by plasminogen ... by thrombin activatable fibrinolysis inhibitor TAFI , which modifies fibrin to make it more resistant to the tPA mediated plasminogen. Measurement When plasmin breaks down fibrin, a number of soluble parts are produced. These are called fibrin degradation product s FDPs . FDPs compete with thrombin, and thus slow down clot formation by preventing the conversion of fibrinogen to fibrin. This effect ... a role in disease states associated with inflammation. Plasmin , in addition to lysing fibrin clots, also cleaves the complement system component C3, and fibrin degradation products have some vascular ... more details
Coagulase is a protein produced by several microorganisms that enables the conversion of fibrinogen to fibrin . In the laboratory , it is used to distinguish between different types of Staphylococcus isolates. Coagulase negativity excludes S. aureus . That is to say, S. aureus is coagulase positive. It is also produced by Yersinia pestis . ref DorlandsDict two 000022192 coagulase ref Coagulase reacts with prothrombin in the blood. The resulting complex is called staphylothrombin , which enables the enzyme protease to convert fibrinogen to fibrin. This results in clotting of the blood. Coagulase is tightly bound to the surface of the bacteria S. aureus and can coat its surface with fibrin upon contact with blood. It has been proposed that fibrin coated staphylococci resist phagocytosis making the bacteria more virulent. Bound coagulase is part of the larger family of MSCRAMM Coagulase test The coagulase test is used to differentiate Staphylococcus aureus from Staphylococus coagulase negative staphylococci . The test uses rabbit Blood plasma plasma that has been inoculated with a staphylococcal colony. The tube is then incubated at 37 degrees Celsius for 1 hours. If negative then continue incubation up to 18 hours. If positive i.e., the suspect colony is S. aureus , the serum will coagulate, ref DorlandsDict eight 000106603 coagulase test ref resulting in a clot sometimes the clot is so pronounced that the liquid will completely solidify . If negative , the plasma remains liquid. The negative result may be S. epidermidis but only a more detailed identification test can confirm this, using biochemical tests as in API tests and BBL CRYSTAL methods. List of coagulase positive staphylococci Staphylococcus aureus subsp. anaerobius, Staphylococcus aureus subsp. aureus, Staphylococcus delphini, Staphylococcus hyicus, Staphylococcus intermedius, Staphylococcus lutrae, Staphylococcus schleiferi subsp. coagulan. References reflist External links Tube coagulase test rabbit plasma ... more details
protein Name fibrinogen alpha chain caption Crystallographic structure of a fragment of human fibrin . ref name pmid9628725 PDB 1FZC cite journal author Everse SJ, Spraggon G, Veerapandian L, Riley M, Doolittle RF title Crystal structure of fragment double D from human fibrin with two different bound ligands journal Biochemistry volume 37 issue 24 pages 8637 42 year 1998 month June pmid 9628725 doi ... by thrombin into fibrin during blood coagulation. This is achieved through processes in the coagulation ... for converting fibrinogen into fibrin. Fibrin is then cross linked by factor XIII to form a clot. FXIIIa stabilizes fibrin further by incorporation of the fibrinolysis inhibitors alpha 2 ... of Factor XIII by thrombin and plasminogen activator t PA are catalyzed by fibrin. ref name Muszbek Fibrin specifically binds the activated coagulation factors factor Xa and thrombin and entraps ... research has shown that fibrin plays a key role in the inflammatory response and development of rheumatoid ... or trauma. Besides low fibrinogen level, fibrin polymerization disorders which can be induced by several factors, including plasma expanders, can also lead to severe bleeding problems. ref name Lang Fibrin ... GpIIIa IIIa surface membrane protein s however its major function is as the precursor to fibrin. Fibrinogen ... of fibrinogen to fibrin occurs in several steps. First, thrombin cleaves the N terminus of the fibrinogen ... author Blomb ck B, Hessel B, Hogg D, Therkildsen L title A two step fibrinogen fibrin transition ... 692730 doi 10.1038 275501a0 url issn ref The resulting fibrin monomers polymerize end to end to from protofibrils which in turn associate laterally to form fibrin fibers. ref name pmid7036348 cite journal author Hermans J, McDonagh J title Fibrin structure and interactions journal Semin. Thromb. Hemost ... url issn ref In a final step, the fibrin fibers associate to form the fibrin gel. ref name isbn0 250 ... title Chemistry and Biology of Thrombin chapter hrombin and fibrin stabilization language publisher ... more details
List of drugs F Fi fi fiacitabine International Nonproprietary Name INN fialuridine International Nonproprietary Name INN fibracillin International Nonproprietary Name INN fibrin, bovine International Nonproprietary Name INN fibrin, human International Nonproprietary Name INN fibrinogen 125 I International Nonproprietary Name INN Biciromab FibriScint fibrinolysin human International Nonproprietary Name INN fidarestat International Nonproprietary Name INN fidaxomicin United States Adopted Name USAN , International Nonproprietary Name INN fidexaban United States Adopted Name USAN figitumumab United States Adopted Name USAN , International Nonproprietary Name INN filaminast International Nonproprietary Name INN filenadol International Nonproprietary Name INN filgrastim International Nonproprietary Name INN filibuvir United States Adopted Name USAN , International Nonproprietary Name INN filipin International Nonproprietary Name INN fimasartan International Nonproprietary Name INN Finacea finasteride International Nonproprietary Name INN fingolimod United States Adopted Name USAN Fioricet Fiorinal fipexide International Nonproprietary Name INN firategrast United States Adopted Name USAN , International Nonproprietary Name INN firocoxib United States Adopted Name USAN fispemifene United States Adopted Name USAN ... more details
FSP may stand for Hereditary spastic paraplegia Familial Spastic Paraparesis Fellow of The School of Pharmacy, University of London The School of Pharmacy Fibre saturation point Fibrin Split Products, a test of clotting dysfunction in human physiology . Also known as fibrin degradation products Florida State Prison Folha de S o Paulo Folsom State Prison Food Stamp Program Foro de S o Paulo Freedom Socialist Party Free State Project FSP Group , Taiwanese PSU manufacturer. Saint Pierre Airport , the IATA airport code. Florent Sinama Pongolle , a French footballer In Computing File Service Protocol , a UDP based protocol similar to File Transfer Protocol MS Windows file system drivers refer to File System Process as the asynchronous part of a file I O call executed in a system worker thread context http msdn.microsoft.com en us library aa488425.aspx . disambig de FSP fr FSP it FSP ko FSP ja FSP pt FSP ... more details
Expert subject Medicine Pathology task force date February 2009 Fibrinoid necrosis is a form of necrosis , or tissue death, in which there is accumulation of amorphous, basic, proteinaceous material in the tissue matrix with a staining pattern reminiscent of fibrin. It is associated with conditions such as immune vasculitis e.g. Henoch Schonlein purpura , malignant hypertension , or hyperacute transplant rejection. Fibrinoid material does usually contain fibrin and tends to be eosinophilic staining red with the acidic dye eosin . However, in systemic lupus erythematosus the fibrinoid deposits may contain significant amounts of nuclear debris, including acidic DNA, and may be haematoxyphilic staining purple or blue with the basic dye haematoxylin . Fibrinoid necrosis is distinguished from hyaline deposits, which are more homogeneous and glassy, and caseous necrosis, which is associated with the tuberculosis. Fibrinoid is now a somewhat historic term, based on traditional haematoxylin and eosin staining. Its significance is different in different contexts, such as malignant hypertension and rheumatoid nodules. However, in context it remains a diagnostically useful term. The idea that autoimmune diseases such as systemic lupus and rheumatoid arthritis were based on a common lesion of fibrinoid necrosis of collagen led to the popular term collagen vascular disease , which is now obsolete. It is cells that are dead, not collagen. The presence of fibrin indicates that nearby blood vessels have become highly permeable and often themselves destroyed but vasculitis is not necessarily present at sites of fibrinoid deposition. Fibrinoid necrosis can be associated with immune complex associated disease, as in the synovitis and nodules of rheumatoid arthritis and various forms of immune based vasculitis and glomerular disease. It may be associated with deposition of immune complexes and complement components in vessel walls. In small vessel vasculitis fibrin plugs frequently occ ... more details
Orphan date October 2006 Image Gematogen.jpg thumb 250px Hematogen bar. Hematogen in Russian language Russian , sometimes transliterated as Gematogen is a Russia n fudge candy bar , which is notable in that one of its main ingredients is processed fibrin defibrinated cow s blood . It is often considered to be a medicinal product, and is used to treat anemia as indicated by its name, which is Greek language Greek for blood maker . External links http www.gematogen.com Company s official website ru icon confectionery stub Category Candy bars ka ru ... more details
Orphan date December 2007 Automatically added by User SoxBot. If this is an error, please contact User Soxred93 Albert Dastre November 7, 1844 October 22, 1917 was a French physiologist . He studied and worked under Claude Bernard 1813 1878 and Paul Bert 1830 1886 in Paris , and in 1886 attained the chair of General Physiology at the Sorbonne . In 1904 Dastre became a member of the Acad mie des sciences . One of his better known assistants was Romanian physiologist Nicolae Paulescu 1869 1931 , who was the discoverer of insulin . Albert Dastre specialized in the field of physiological chemistry , and is remembered for his studies of glycosuria and diabetes , as well as his discovery involving the proteolytic properties of blood. In 1893, he noticed a reduction of fibrin during a Venipuncture phlebotomy in dogs, which he attributed to a destruction of fibrin. He called this phenomena, fibrinolysis to describe the dissolution of fibrin and the break up of blood clots. Dastre also observed fibrin dissolve when mixed with an antiseptic salt solution, and postulated that it was a form of digestion. Among his written works was a philosophic and scientific treatise on life and death titled La Vie et la Mort , and in 1878 79 he published and edited Le ons sur les Ph nom nes de la vie communs aux animaux et aux v g taux , a work composed by his former mentor, Claude Bernard. With his colleague Jean Pierre Morat 1846 1920 , the Dastre Morat Law is derived, which states that constriction of the body s surface blood vessel s is usually accompanied by Vasodilation dilation of vessels of the viscera, and vice versa . References cite book title Laws and Models author Carl W. Hall year 2000 publisher CRC Press isbn 0 8493 2018 6 url http books.google.com books?id EEhpsf6L09gC&pg PA109&lpg PA109&dq 22dastre morat 22 law&source web&ots SxS8SYxh1L&sig EVAXW0mRYUsHuJ4ITPu8gQ4NtfM PPA109,M1 Persondata Metadata see Wikipedia Persondata . NAME Dastre, Albert ALTERNATIVE NAMES SHORT DESCRIP ... more details
Reptilase time RT is a blood test used to detect deficiency or abnormalities in fibrinogen , ref name pmid12162688 cite journal author Van Cott EM, Smith EY, Galanakis DK title Elevated fibrinogen in an acute phase reaction prolongs the reptilase time but typically not the thrombin time journal Am. J. Clin. Pathol. volume 118 issue 2 pages 263 8 year 2002 month August pmid 12162688 doi 10.1309 WUB3 72JT E50M EU8J url http ajcp.metapress.com openurl.asp?genre article&issn 0002 9173&volume 118&issue 2&spage 263 ref ref name pmid200301 cite journal author Johnson PJ, White Y, Woolf IL, Williams R title Reptilase time in cirrhosis and hepatocellular carcinoma journal Br Med J volume 2 issue 6091 pages 869 70 year 1977 month October pmid 200301 pmc 1631704 doi 10.1136 bmj.2.6091.869 a url ref especially in cases of heparin contamination. Reptilase , an enzyme found in the venom of Bothrops Bothrops snakes , has activity similar to thrombin . Unlike thrombin, reptilase is resistant to inhibition by antithrombin III . Thus, the reptilase time is not prolonged in blood samples containing heparin, hirudin , or direct thrombin inhibitor s, whereas the thrombin time will be prolonged in these samples. Reptilase also differs from thrombin by releasing fibrinopeptide A, but not fibrinopeptide B, in its cleavage of fibrin . Other causes of prolonged reptilase time include the presence of fibrin degradation products , which interfere with fibrin polymerization. References reflist Myeloid blood tests Category Blood tests med stub fr temps de reptilase ... more details
Image Stabilisation de la fibrine par le factor XIII.png right thumb 260px Factor XIII crosslinks fibrin protein Name F13A1 coagulation factor XIII, br A1 polypeptide caption image width HGNCid 3531 Symbol F13A1 AltSymbols F13A EntrezGene 2162 OMIM 134570 RefSeq NM 000129 UniProt P00488 PDB ECnumber Chromosome 6 Arm p Band 24 LocusSupplementaryData .2 p23 protein Name F13B coagulation factor XIII, br B polypeptide caption image width HGNCid 3534 Symbol F13B AltSymbols EntrezGene 2165 OMIM 134580 RefSeq NM 001994 UniProt P05160 PDB ECnumber Chromosome 1 Arm q Band 31 LocusSupplementaryData q32.1 Factor XIII or fibrin stabilizing factor is an enzyme EC number 2.3.2.13 of the coagulation blood coagulation system that crosslinks fibrin . Function Factor XIII is a transglutaminase that circulates in the plasma as a heterotetramer of two catalytic A subunits and two carrier B subunits. When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E unit is crosslinked to only one D unit. Factor XIII is activated by thrombin into factor XIIIa its activation into Factor XIIIa requires calcium in biology calcium as a Cofactor biochemistry cofactor . A cleavage by thrombin between residue Arg37 and Gly38 on the N terminus of the A subunit, leads to the release of the activation peptide MW 4000 da . In the presence of calcium the carrier subunits dissociate from the catalytic subunits, leading to a 3D change in conformation of factor XIII and hence the exposure of catalytic cysteine residue. Upon activation by thrombin, factor XIIIa acts on fibrin to form glutamyl lysyl amide cross links between fibrin molecules to form an insoluble clot. Discovery FXIII is known also as Laki Lorand factor, after the scientists who first proposed its existence in 1948. ref name Laki cite journal author Laki K, L r nd L title On the Solubility of Fibrin Clots journal Science volume 108 issue 2802 pages 280 year 1948 month September pmid 17842715 doi ... more details
and plasminogen binding sites within fibrin ogen alpha C domains journal Biochemistry volume 40 issue ... Jul. title Localization of the binding site of tissue type plasminogen activator to fibrin journal ... refbegin 2 PBB Further reading citations cite journal author Doolittle RF title Fibrinogen and fibrin ... Everse SJ title New insights into fibrin ogen structure and function. journal Vox Sang. volume 83 ... PJ title Genetic and environmental determinants of fibrin structure and function relevance to clinical ... 15217804 doi 10.1161 01.ATV.0000136649.83297.bf cite journal author Lord ST title Fibrinogen and fibrin ... PA title Localization of the alpha chain cross link acceptor sites of human fibrin. journal J. Biol ... asparagine 139. Impaired fibrin gel formation but normal fibrin facilitated plasminogen activation ..., fibrinogen Caracas II, characterized by impaired fibrin gel formation. journal J. Biol. Chem. volume ... more details
Encyclopedia
top
