Search: in
Epidermal growth factor receptor
Epidermal growth factor receptor in Encyclopedia Encyclopedia
  Tutorials     Encyclopedia     Videos     Books     Software     DVDs  
       
Encyclopedia results for Epidermal growth factor receptor

Epidermal growth factor receptor





Encyclopedia results for Epidermal growth factor receptor

  1. Epidermal growth factor receptor

    geneid 1956 The epidermal growth factor receptor EGFR ErbB 1 HER1 in humans is the Cell membrane cell surface receptor biochemistry receptor for members of the epidermal growth factor family EGF family ... Herbst RS title Review of epidermal growth factor receptor biology journal Int. J. Radiat. Oncol. Biol ... url ref The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily ... or Medicine in 1986. Function EGFR epidermal growth factor receptor exists on the cell surface ..., Funahashi A, Kitano H title A comprehensive pathway map of epidermal growth factor receptor signaling ... DA title Activating mutations in the epidermal growth factor receptor underlying responsiveness of non ... LV, Johnson BE title Impact of epidermal growth factor receptor and KRAS mutations on clinical ... factor 4 small GTPase mediates epidermal growth factor receptor dependent phospholipase D2 activation ... J H, Lipkowitz S year 1999 month Mar. title cbl b inhibits epidermal growth factor receptor signaling ... Brian I year 2002 month May. title Identification of epidermal growth factor receptor as a target ... Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor journal ... for the epidermal growth factor receptor journal J. Biol. Chem. volume 274 issue 8 pages 4489 92 ... in lipid rafts and interacts with the epidermal growth factor receptor journal Biochemistry ... with the epidermal growth factor receptor in human tumor cells. Phosphatidic acid activates receptor ... of the protein tyrosine phosphatase SHP 1 to the epidermal growth factor receptor and attenuation ... stimulated transactivation of epidermal growth factor receptor and mitogen activated protein kinase ... the epidermal growth factor receptor COOH terminal region for signal transducer and activator of transcription ... is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living ... BIES3 3.0.CO 2 1 cite journal author Filardo EJ title Epidermal growth factor receptor EGFR transactivation ...   more details



  1. Epidermal growth factor

    affinity to epidermal growth factor receptor EGFR on the plasma membrane cell surface and stimulating ... are potential substances for this purpose. Interactions Epidermal growth factor has been shown to Protein protein interaction interact with Epidermal growth factor receptor ref name pmid12093292 cite ... of the epidermal growth factor EGF receptor in amphiregulin and EGF mitogenic signaling journal J. Biol ...PBB geneid 1950 Epidermal growth factor or EGF is a growth factor that plays an important role in the regulation of cell growth , cell growth proliferation , and Cellular differentiation differentiation by binding to its receptor Epidermal growth factor receptor EGFR . Human EGF is a 6045 dalton unit ... pmid2186024 cite journal author Carpenter G, Cohen S title Epidermal growth factor journal The Journal ..., and survival. ref name Herbst cite journal author Herbst RS title Review of epidermal growth factor receptor biology journal International Journal of Radiation Oncology, Biology, Physics ... ref Biological Sources Epidermal growth factor can be found in human platelets, macrophages, urine, saliva ... RA, Knaver DJ, Cunningham DD title Epidermal growth factor immunoreactive material in the central ... citations cite journal author Boonstra J, Rijken P, Humbel B, et al. title The epidermal growth factor ... cite journal author Dvorak B title Epidermal growth factor and necrotizing enterocolitis journal ... cite journal author Howell WM title Epidermal growth factor gene polymorphism and development ... ref name dreux cite journal author Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA title The epidermal growth ... url issn ref Heparin binding EGF like growth factor HB EGF TGF alpha transforming growth factor TGF Amphiregulin AR Epiregulin EPR Epigen Betacellulin BTC neuregulin 1 NRG1 neuregulin ... growth factor in ErbB 2 ErbB 3 binding studied by phage display journal Biochemistry volume ... growth factor http www.ebi.ac.uk biomodels main static pages.do?page ModelMonth 252FAugust2006 ...   more details



  1. Growth factor receptor

    A growth factor receptor is a Receptor biochemistry receptor which binds to growth factor . ref MeshName Growth Factor Receptors ref These receptors may use the JAK STAT signaling pathway JAK STAT , MAP kinase , and Phosphoinositide 3 kinase PI3 kinase pathways. ref name HoffbrandMoss2006 cite book author1 A. V. Hoffbrand author2 P. A. H. Moss author3 J. E. Pettit title Essential haematology url http books.google.com books?id IFFL 1YNy oC&pg PA6 accessdate 28 November 2010 year 2006 publisher Wiley Blackwell isbn 9781405136495 pages 6 ref References reflist Growth factor receptors Category Receptors biochem stub ...   more details



  1. Fibroblast growth factor receptor

    The fibroblast growth factor receptors are, as their name implies, Receptor biochemistry receptors that bind to members of the fibroblast growth factor family of proteins. Structure The fibroblast growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. These receptors bind fibroblast growth factor s, members of the largest family of growth factor ligands, comprising 22 members. ref name ornitz cite journal author Ornitz DM. and Itoh, N. title Fibroblast growth factors journal Genome Biol. year 2001 volume 2 issue 3 pages REVIEWS 3005 pmid 11276432 doi 10.1186 gb 2001 2 3 reviews3005 pmc 138918 ref The natural gene splicing alternate splicing of four fibroblast growth factor receptor FGFR genes results in the production of over 48 different ... of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co receptor binding ... al. title Identification of a new fibroblast growth factor receptor, FGFR5 journal Gene year 2001 ... superfamily FGFR1 to FGFR4 . Gene FGFR1 see also Fibroblast growth factor receptor 1 CD331 Gene FGFR2 see also Fibroblast growth factor receptor 2 CD332 Gene FGFR3 see also Fibroblast growth factor receptor 3 CD333 Gene FGFR4 see also Fibroblast growth factor receptor 4 CD334 Gene FGFR6 References ... Growth factor receptors Tyrosine kinases DEFAULTSORT Fibroblast Growth Factor Receptor Category ... like domains D2 and D3 are sufficient for FGF binding. Each receptor can be activated by several FGFs. In many cases, the FGFs themselves can also activate more than one receptor i.e., FGF 1, which binds all seven principal FGFRs ref name ornitz2 cite journal author Ornitz DM, et al. title Receptor Specificity of the Fibroblast Growth Factor Family. journal JBC volume 271 issue 25 pages 15292 15297 ..., and Gallagher JT. title Receptors for fibroblast growth factors journal Immunol. Cell. Biol. year ...   more details



  1. Nerve growth factor receptor

    Nerve growth factor receptors are a group of growth factor receptor s which specifically bind to neurotrophin s. There are two classes of receptors, p75 and the Trk family of Tyrosine kinase s receptors. p75 is a low affinity neurotrophin receptor , to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase x only applies to this receptor. ref MeshName Nerve Growth Factor Receptor p75 ref The Trk receptor Trk family include TrkA , TrkB , and TrkC , and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins. NGF binds to TrkA, BDNF and NT 4 bind to TrkB and NT 3 binds to TrkC . In addition NT 3 also binds to and activates TrkA and TrkB but it does so less efficiently. Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis . TrkA, B, and C receptors TrkA is a receptor tyrosine kinase meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling . There are other related Trk receptors TrkB and TrkC , and there are other neurotrophic factors structurally related to NGF BDNF , NT 3 , and NT 4 TrkA mediates the effects of NGF TrkB binds and is activated by BDNF , NT 4 , and NT 3 TrkC binds and is activated only by NT 3 LNGFR receptor The other NGF receptor, the LNGFR , for Low affinity nerve growth factor receptor , commonly known as p75 , plays a less clear role. LNGFR binds and serves as a sink for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity since they have a higher microconcentration of the neurotrophin. However ... basalis of postmortem Alzheimer s brains. References reflist External links MeshName Nerve Growth Factor Receptors Growth factor receptors Category Receptors biochem stub ...   more details



  1. Fibroblast growth factor receptor 4

    protein tyrosine kinases and the epidermal growth factor receptor journal J. Biol. Chem. volume 270 ...PBB geneid 2264 Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 ... growth factor receptor family, where amino acid sequence is highly conserved between members and throughout ... fibroblast growth factor receptor 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2264 accessdate ref Interactions Fibroblast growth factor receptor 4 has been shown ... domain of recombinant human fibroblast growth factor receptor 4 journal Int. J. Biochem ... al. title A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter ... J, Bellosta P, et al. title Fibroblast growth factor receptor 4 shows novel features in genomic ... FGFR 4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern journal ... kinases expressed in human lung fourth member of the fibroblast growth factor receptor family and an intracellular ... Signal transduction by fibroblast growth factor receptor 4 FGFR 4 . Comparison with FGFR 1 journal ... D, Reich R, Chedid M, et al. title Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor journal J. Biol ... P, Alitalo K title Association of a 85 kDa serine kinase with activated fibroblast growth factor receptor ... DM, Xu J, Colvin JS, et al. title Receptor specificity of the fibroblast growth factor family journal ... factor receptor 4 gene to chromosome region 5q33 qter journal Genes Chromosomes Cancer volume 4 issue ... molecules between keratinocyte growth factor and basic fibroblast growth factor define domains ... tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth ... for members 1 3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor ...   more details



  1. Fibroblast growth factor receptor 3

    Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder ...PBB geneid 2261 Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene . ref name pmid1847508 cite journal author Keegan K, Johnson DE, Williams LT, Hayman MJ title Isolation of an additional member of the fibroblast growth factor receptor family, FGFR 3 journal Proc Natl Acad Sci U S A volume 88 issue 4 pages 1095 9 year 1991 month Mar pmid 1847508 pmc 50963 doi 10.1073 pnas.88.4.1095 ref FGFR3 has also been designated as CD333 cluster of differentiation 333 . Structure and function The PBB Summary template is automatically maintained by Protein Box Bot. See ... by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence ... FGFR3 fibroblast growth factor receptor 3 achondroplasia, thanatophoric dwarfism url http www.ncbi.nlm.nih.gov ... 17085196 doi 10.1016 j.juro.2006.07.132 ref Interactions Fibroblast growth factor receptor 3 has been ... Fibroblast growth factor receptor References Reflist Further reading refbegin 2 PBB Further ... Horton WA, Lunstrum GP title Fibroblast growth factor receptor 3 mutations in achondroplasia and related ... growth factor receptor autoinhibition and ligand binding promiscuity. journal Pnas USA ... Expression and biological activity of mouse fibroblast growth factor 9 journal J. Biol. Chem. volume ... M, Ornitz D M year 1999 month Dec. title Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity journal J. Biol ... NLM content Tyrosine kinases Growth factor receptors Clusters of differentiation The PBB Controls ... of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals ... acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations ... Hafner C, Hartmann A, Vogt T title FGFR3 mutations in epidermal nevi and seborrheic keratoses lessons ...   more details



  1. Insulin-like growth factor 1 receptor

    or radiotherapy. In breast cancer, where Epidermal growth factor receptor EGFR inhibitors such as erlotinib ... growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 SH2 domain ... factor receptor interplay with the epidermal growth factor receptor. journal Growth Factors volume ...PBB geneid 3480 The Insulin like Growth Factor 1 IGF 1 Receptor is a transmembrane receptor transmembrane receptor proteomics receptor that is activated by IGF 1 and by the related growth factor IGF 2 ... like growth factor 2 receptor IGF 2R and their respective ligands IGF 1 and IGF 2 , along with several ... C, Hofmann F, Krystal GW title The insulin like growth factor I receptor kinase inhibitor, NVP ADW742 ... D, Knowlden JM, Williams S, Wakeling AE, Nicholson RI title Insulin like growth factor I receptor ... R, Brewster SF, Macaulay VM title Expression of the type 1 insulin like growth factor receptor is up ..., Bell RH, Hurtado Coll A, Fazli L, Gleave ME, Cox ME title Increased insulin like growth factor I receptor ... AM, Voelker MA, Sternberg H, Timiras PS title Insulin like growth factor 1 receptor immunoreactive ... growth factor 1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically ... . Interactions Insulin like growth factor 1 receptor has been shown to Protein protein interaction ... with the insulin like growth factor I receptor journal Biochem. Biophys. Res. Commun. volume ... month Aug. title Localization of the insulin like growth factor I receptor binding sites for the SH2 ... like growth factor I receptor journal J. Biol. Chem. volume 273 issue 37 pages 24095 ... ligand induced ubiquitination and stability of the insulin like growth factor I receptor journal ... interaction of the insulin like growth factor I receptor with IRS 1, Shc, and Grb10 journal ... like growth factor I receptor journal Cancer Res. volume 56 issue 14 pages 3165 7 publisher ... kinase associates with ligand stimulated insulin like growth factor I receptor journal J. Biol. Chem ...   more details



  1. Platelet-derived growth factor receptor

    Refimprove date September 2010 protein Name PDGFRA platelet derived growth factor receptor, alpha polypeptide ... PDGFRB platelet derived growth factor receptor, beta polypeptide caption Ribbon image of two molecules of human PDGF receptor beta yellow and magenta in complex with dimeric PDGFB PDGF B cyan and green ... Platelet derived growth factor receptors PDGF R are cell surface receptor tyrosine kinase tyrosine kinase receptor s for members of the platelet derived growth factor PDGF family. PDGF subunits PDGFA ... growth , Morphogenesis development and many diseases including cancer . ref name pmid2538922 Cite journal author Williams LT title Signal transduction by the platelet derived growth factor receptor ... derived growth factor three isoforms and two receptor types journal Trends Genet. volume 5 issue ... derived growth factor isoform specific signalling via heterodimeric or homodimeric receptor complexes ... MeshName Platelet Derived Growth Factor Receptors Tyrosine kinases Growth factor receptors http angiogenesis.amgen.com DEFAULTSORT Platelet Derived Growth Factor Receptor Category Growth factors Category ... X. title Structures of a platelet derived growth factor propeptide complex and a platelet derived growth factor receptor complex journal PNAS volume 107 issue 25 no 25 pages 11307 12 year 2010 pmid 20534510 ... Depending on which growth factor is bound, PDGF R homo or heterodimerizes. ref name pmid1315403 Cite ... with signal transduction molecules Tyrosine phosphorylation sites in growth factor receptors serve ... in their monomer ic forms. The PDGFs bind to the protein Receptor tyrosine kinase tyrosine kinase receptor s PDGF receptor and . These two receptor isoform s protein dimer dimer ize upon binding the PDGF dimer, leading to three possible receptor combinations, namely , and . The extracellular region of the Receptor biochemistry receptor consists of five immunoglobulin like domains ... AA binds only to PDGFR , while PDGF BB is the only PDGF that can bind all three receptor combinations ...   more details



  1. Fibroblast growth factor receptor 2

    PBB geneid 2263 Fibroblast growth factor receptor 2 FGFR2 also known as CD332 cluster of differentiation ... A, Courtois Y, Breathnach R title Related fibroblast growth factor receptor genes exist in the human ... and basic fibroblast growth factors journal EMBO J. volume 9 issue 9 pages 2685 92 year 1990 month September pmid 1697263 pmc 551973 doi url issn ref FGFR2 is a receptor for fibroblast growth factor . The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where ... Entrez Gene FGFR2 fibroblast growth factor receptor 2 bacteria expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson Weiss syndrome ... alternatives of fibroblast growth factor receptor 2 FGFR2 journal Dev. Biol. volume 158 ... growth factor receptor with its ligands journal Proc. Natl. Acad. Sci. U.S.A. volume 97 issue ... TL title Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin ... Receptor specificity of the fibroblast growth factor family journal J. Biol. Chem. volume 271 issue ... growth factor receptor family, these receptors signal by binding to their ligand and dimerisation ... localized derivative of the fibroblast growth factor receptor 3 kinase domain journal Mol ... 2 cite journal author McKeehan WL, Kan M title Heparan sulfate fibroblast growth factor receptor ... 2005 pmid 15622262 doi refend External links MeshName Fibroblast Growth Factor Receptor 2 PDB Gallery ... and or keratinocyte growth factor, depending on the isoform. Isoforms FGFR2 has two naturally occurring ... of this gene and isoform are associated with craniosynostosis . Interactions Fibroblast growth factor ... A, Ornitz DM title Expression and biological activity of mouse fibroblast growth factor 9 journal ... fibroblast growth factor 2 , FGF4 4 , FGF6 6 , FGF8 8 , FGF9 9 , FGF17 17 and FGF18 18 These differences ... domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting ...   more details



  1. Insulin-like growth factor 2 receptor

    . Interactions Insulin like growth factor 2 receptor has been shown to Protein protein interaction ... JC, Standring DN, et al. title Insulin like growth factor II receptor as a multifunctional binding protein ... of heterozygosity on 6q at the mannose 6 phosphate insulin like growth factor II receptor locus in human ... like growth factor II binding site to amino acids 1508 1566 in repeat 11 of the mannose 6 phosphate insulin like growth factor II receptor. journal J. Biol. Chem. volume 270 issue 25 pages 14975 82 ... of insulin like growth factor II receptor in human pancreatic cancer. journal Pancreas volume ... EI, Vorum H, et al. title Mannose 6 phosphate insulin like growth factor II receptor targets ... refend External links MeshName Insulin Like Growth Factor II Receptor PDB Gallery geneid 3482 Clusters of differentiation Growth factor receptors Category Receptors Category Clusters of differentiation ... A, Francke U title Chromosomal mapping of the gene for the type II insulin like growth factor ... ref IGF2R is a multifunctional protein receptor biochemistry receptor that binds insulin like growth ... cite journal author O Dell SD, Day IN title Insulin like growth factor II IGF II . journal ... 2725 98 00048 X cite journal author Hawkes C, Kar S title The insulin like growth factor II mannose ... T, Neville Golden J, Maxwell M title Expression of insulin like growth factors I and II and their receptor ... 1370435 doi 10.1002 ijc.2910500210 cite journal author Zhou J, Bondy C title Insulin like growth factor ..., Voutilainen R title Insulin like growth factor binding proteins in the human adrenal gland. journal ...PBB geneid 3482 about the cation independent mannose 6 phosphate receptor the cation dependent receptor cation dependent mannose 6 phosphate receptor In the fields of biochemistry and cell biology , the insulin like growth factor 2 receptor IGF2R , also called the cation independent mannose 6 phosphate receptor CI MPR is a protein that in humans is encoded by the IGF2R gene . ref name pmid2963003 cite ...   more details



  1. Fibroblast growth factor receptor 1

    PBB geneid 2260 Fibroblast growth factor receptor 1 FGFR1 , also known as basic fibroblast growth factor receptor 1 , fms related tyrosine kinase 2 Pfeiffer syndrome , and cluster of differentiation CD 331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome . ref name pmid2162671 cite ... form of human basic fibroblast growth factor receptor deduced from its cDNA journal Biochem. Biophys ... growth factor receptor FGFR family, where amino acid sequence is highly conserved between members and throughout ... Entrez Gene FGFR1 fibroblast growth factor receptor 1 fms related tyrosine kinase 2, Pfeiffer syndrome ... ref Interactions Fibroblast growth factor receptor 1 has been shown to Protein protein interaction ... Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner journal J. Biol. Chem. volume 275 issue 11 pages 7771 8 year 2000 ... Xu H, Lee KW, Goldfarb M title Novel recognition motif on fibroblast growth factor receptor mediates ... M title The structure and function of vertebrate fibroblast growth factor receptor 1. journal ... pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors ... fibroblast growth factor 9 journal J. Biol. Chem. volume 271 issue 3 pages 1726 31 year 1996 month ... Wilkie AO title Bad bones, absent smell, selfish testes the pleiotropic consequences of human FGF receptor mutations. journal Cytokine Growth Factor Rev. volume 16 issue 2 pages 187 203 year 2005 pmid ... tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factor s, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors ..., Williams LT title Structural and functional diversity in the FGF receptor multigene family. journal ...   more details



  1. Growth factor

    factor BDNF Epidermal growth factor EGF Erythropoietin EPO Fibroblast growth factor FGF Glial ... of involved growth factors Signal transduction Receptor biochemistry Cytokine Angiogenesis Human Genome Organisation Growth factor receptor Mitogen References reflist External links MeshName Growth ...A growth factor is a naturally occurring substance capable of stimulating cellular growth , ref DorlandsDict three 000038554 growth factor ref proliferation and cellular differentiation . Usually it is a protein or a steroid hormone . Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling molecules between cells. Examples are cytokine ... differentiation, while fibroblast growth factor s and vascular endothelial growth factor s stimulate blood vessel differentiation angiogenesis . Growth factors versus cytokines Growth factor is sometimes ... development and in the mature organism. While growth factor implies a positive effect on cell division ... growth factor proteins tend to occur as members of larger families of structurally and evolution arily ... colony stimulating factor GM CSF Growth differentiation factor 9 GDF9 Hepatocyte growth factor HGF Hepatoma derived growth factor HDGF Insulin like growth factor IGF Migration stimulating factor Myostatin GDF 8 Nerve growth factor NGF and other neurotrophins Platelet derived growth factor PDGF Thrombopoietin TPO Transforming growth factor alpha TGF Transforming growth factor beta TGF Tumour necrosis factor alpha TNF Vascular endothelial growth factor VEGF Wnt Signaling Pathway placental growth factor PlGF Foetal Bovine Somatotrophin FBS IL 1 Cofactor for IL 3 and IL 6. Activates T cells. IL 2 T cell growth factor. Stimulates IL 1 synthesis. Activates B cells and NK cells. IL 3 Stimulates production of all non lymphoid cells. IL 4 Growth factor for activated B cells, resting ... Ig synthesis. Growth factor for plasma cells. IL 7 Growth factor for pre B cells. Stimulates ...   more details



  1. Growth factor-like domain

    Pfam box Symbol APP CU bd Name Amyloid precursor N terminal image 1mwp gfld.png width 200 caption The GFLD region of amyloid precursor protein Pfam PF02177 InterPro IPR008154 SMART SM00006 PROSITE SCOP 1mwp TCDB PDB PDB2 1mwp , PDB2 1owt , PDB2 2fjz , PDB2 2fk1 , PDB2 2fk2 , PDB2 2fk3 , PDB2 2fkl , PDB2 2fma A growth factor like domain GFLD is a protein domain structurally related to epidermal growth factor , which has a high binding affinity for the epidermal growth factor receptor . As structural domains within larger proteins, GFLD regions commonly bind calcium ion s. A subtype present in the N terminus N terminal region of the amyloid precursor protein is a member of the heparin binding class of GFLDs and may itself have growth factor function, particularly in promoting neuron al development. References Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. 1999 . Crystal structure of the N terminal, growth factor like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6 4 327 31. protein stub Category Protein domains ...   more details



  1. Growth hormone secretagogue receptor

    PBB geneid 2693 Growth hormone secretagogue receptor is a G protein coupled receptor that binds ghrelin ... S title Loss of constitutive activity of the growth hormone secretagogue receptor in familial short ... name entrez cite web title Entrez Gene GHSR growth hormone secretagogue receptor url http www.ncbi.nlm.nih.gov ... and regulation of the growth hormone secretagogue receptor. journal Minerva Endocrinol. volume 27 ... of the 5 flanking region of the human growth hormone secretagogue receptor gene. journal ... hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. journal ... and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic ... of transgenic mice overexpressing growth hormone GH secretagogue receptor 1A in GH releasing hormone ... archiveurl archivedate quote MeshName growth hormone secretagogue receptor http www.vivo.colostate.edu ..., Pin JP, Spedding M, Kojima M, Kangawa K title International Union of Pharmacology. LVI. Ghrelin receptor ... 17983854 doi 10.1016 S0083 6729 06 77005 4 ref Function Ghrelin is an appetite regulating factor secreted from peripheral organs that is involved in regulation of energy homoeostasis via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. ref cite journal author ... intake and growth hormone secretion journal Endocrinology volume 141 issue 11 pages 4325 8 year 2000 ...?view long&pmid 11089570 ref The pathway activated by binding of Ghrelin to the Growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen activated protein kinase ... One of the important features of GHSR1a displays Receptor biochemistry Binding and activation ... of receptor internalization as well as of signaling activity. ref name pazos2007 Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity. ref cite ... signaling of the ghrelin receptor identification of a potent inverse agonist journal Mol. Endocrinol ...   more details



  1. Transforming growth factor

    Transforming growth factor sometimes referred to as Tumor growth factor , or TGF is used to describe two classes of polypeptide growth factor s, TGF&alpha and TGF beta TGF&beta . The name Transforming Growth Factor is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor biochemistry receptor mechanism biology mechanisms . Furthermore, they do not always induce cellular transformation , and are not the only growth factors that induce cellular transformation. Types TGF&alpha is upregulated in some human cancer s. It is produced in macrophage s, brain cells, and keratinocyte s, and induces epithelium epithelial development. TGF beta TGF exists in three known subtypes in humans, TGF&beta 1, TGF&beta 2, and TGF&beta 3. These are upregulated in Marfan s syndrome ref name dysregmarfan Circulating transforming growth factor beta in Marfan syndrome. Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De Backer J, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC GenTAC Consortium. Circulation. 2009 Aug 11 120 6 526 32. Epub 2009 Jul 27. PMID 19635970 ref ref name popmarfan http sciencenow.sciencemag.org cgi content full 2008 625 3?etoc Inhibiting TGF to help Marfan ref and some human cancers, and play crucial roles in tissue regeneration , cell differentiation ... growth factor beta TGF 1 are also thought to be involved in the pathogenesis of pre eclampsia . TGF&beta receptors are single pass serine threonine kinase receptor s. Function These proteins were originally ...?search TGF Tumor growth factor TGF citations http www.ihop net.org UniPub iHOP gs 125537.html ... MeshName Transforming Growth Factors Signaling proteins Category Growth factors Category Signal transduction cs Transformuj c r stov faktor de Transforming growth factor fr Transforming growth factor ... in a specific cell culture system, rat kidney fibroblasts. Application of the transforming growth factors ...   more details



  1. Growth hormone receptor

    PBB geneid 2690 Growth hormone receptor is a protein that in humans is encoded by the GHR gene . ref name entrez cite web title Entrez Gene GHR growth hormone receptor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2690 accessdate ref GHR orthologs ref name OrthoMaM cite web title OrthoMaM phylogenetic marker GHR coding sequence url http www.orthomam.univ montp2.fr orthomam data cds detailMarkers ENSG00000112964 GHR.xml ref have been identified in most mammals . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls ... receptor for growth hormone . Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra and intercellular signal transduction pathway leading to growth ... interacts with the ubiquitin dependent endocytosis UbE motif of the growth hormone receptor journal ... Mutation of the SHP 2 binding site in growth hormone GH receptor prolongs GH promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B journal Mol. Endocrinol. volume 14 issue 9 pages 1338 ... required for coupling to the growth hormone receptor journal J. Biol. Chem. volume 270 issue 24 ..., Norstedt G, Carter Su C year 1994 month Aug. title Domains of the growth hormone receptor required ... The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver journal Growth Horm .... Mutations in this gene have been associated with Laron syndrome , also known as the growth ... of the weight of normal siblings , and also show a 40 increase in lifespan. Interactions Growth hormone receptor has been shown to Protein protein interaction interact with SGTA , ref name pmid12735788 ... J year 1998 month Jun. title Grb10 identified as a potential regulator of growth hormone GH signaling by cloning of GH receptor target proteins journal J. Biol. Chem. volume 273 issue 26 pages 15906 ... inhibition of growth hormone stimulated STAT5 signaling by multiple mechanisms journal J. Biol ...   more details



  1. Keratinocyte growth factor

    The Keratinocyte Growth Factor KGF , also known as FGF7 , is a growth factor present in the epithelialization phase of wound healing . In this phase, keratinocytes are covering the wound, forming the epithelium . KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b FGFR2b . ref name pmid18575591 cite journal author Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A title Silencing of keratinocyte growth factor receptor restores 5 fluorouracil and tamoxifen efficacy on responsive cancer cells journal PLoS ONE volume 3 issue 6 pages e2528 year 2008 pmid 18575591 pmc 2424182 doi 10.1371 journal.pone.0002528 url http www.plosone.org article info doi 10.1371 journal.pone.0002528 ref For signalling to occur, a dimer is required between two FGF FGFR complexes that is linked together by a molecule of heparin. There are 23 known FGFs, and 4 FGF receptor s. FGF FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner. FGF10 is also known as Keratinocyte growth factor 2 . ref name urliHOP Information Hyperlinked over Proteins FGF10 cite web url http www.ihop net.org UniPub iHOP gs 88201.html title iHOP Information Hyperlinked over Proteins FGF10 format work accessdate ref See also Palifermin References reflist External links http www personal.umich.edu lpt fgf 1fq9 files side.jpg http www personal.umich.edu lpt fgf 1fq9.htm Category Growth factors medicine stub Growth factors ...   more details



  1. Platelet-derived growth factor

    derived growth factor PDGF receptor activation by PDGF AB journal J. Biol. Chem. volume 266 issue ... terminal domain of alpha platelet derived growth factor alpha PDGF receptor for PDGF focus forming ... growth factor, VEGF C, is a ligand for the Flt4 VEGFR 3 and KDR VEGFR 2 receptor tyrosine kinases ... title An antibody reactive with domain 4 of the platelet derived growth factor beta receptor allows ... Family members Human genes encoding proteins that belong to the platelet derived growth factor family include C fos induced growth factor FIGF PDGFA PDGFB PDGFC PDGFD Placental growth factor PGF Vascular endothelial growth factor VEGF VEGF41 Vascular endothelial growth factor B VEGFB Vascular endothelial growth factor C VEGFC See also Platelet activating factor Platelet derived growth factor receptor ...Pfam box Symbol PDGF Name Platelet derived growth factor PDGF image width caption Pfam PF00341 InterPro ... In molecular biology , platelet derived growth factor PDGF is one of the numerous growth factor s, or protein .... In chemical terms, platelet derived growth factor is protein dimer dimeric glycoprotein composed ... journal author Hannink M, Donoghue DJ title Structure and function of platelet derived growth factor ... on platelet derived growth factor journal EMBO J. volume 11 issue 12 pages 4251 4259 year 1992 ... Aaronson SA title Chimeric alpha and beta platelet derived growth factor PDGF receptors define three ... U title Vascular endothelial growth factor B, a novel growth factor for endothelial cells journal ... in angiogenesis and endothelial cell growth, and placenta growth factor PlGF which is also ... mRNAs coding for the angiogenic factor, placenta growth factor PlGF , are transcribed from a single ... of the first growth factor s characterized, ref cite journal author Paul D, Lipton A, Klinger I ... pmc 389008 ref and has led to an understanding of the mechanism of many growth factor biochemical ... MeshName platelet derived growth factor eMedicineDictionary platelet derived growth factor Signaling ...   more details



  1. Insulin-like growth factor

    Image 3GF1 Insulin Like Growth Factor Nmr 10 01.png thumb ILGF The insulin like growth factors IGFs are protein ... often referred to as the IGF axis consists of two cell surface receptor s IGF1R and IGF2R , two ligand s IGF 1 and IGF 2 , a family of six high affinity Insulin like growth factor binding protein IGF binding proteins IGFBP 1 6 , as well as associated Insulin like growth factor binding protein IGFBP ... referred to as the Growth Hormone IGF1 Axis. Insulin like growth factor 1 IGF 1 is mainly secreted by the liver as a result of stimulation by growth hormone GH . IGF 1 is important for both the regulation ... death apoptosis . Insulin like growth factor 2 IGF 2 is thought to be a primary growth factor required for early development while IGF 1 expression is required for achieving maximal growth. Gene ... like Growth Factor I and Insulin like Growth Factor Binding Protein 3 with Intelligence Quotient ... 2 are regulated by a family of proteins known as the Insulin like growth factor binding protein ... title Insulin like growth factor I receptors are overexpressed and predict a low risk in human breast ... title Deafferentation induced increases in hippocampal insulin like growth factor 1 messenger RNA expression ... like growth factor 1 Insulin like growth factor 2 Growth hormone treatment HGH controversies Insulin ... D last2 Dawes first2 PJ. year 2007 title Childhood hearing is associated with growth rates in infancy ... PDR.0b013e3181425869 ref IGF Receptors The IGF s are known to bind the IGF 1 receptor , the insulin receptor , the IGF 2 receptor, the insulin related receptor and possibly other receptors. The IGF 1 receptor is the physiologic receptor IGF 1 binds to it at significantly higher affinity than it binds the insulin receptor. Like the insulin receptor, the IGF 1 receptor is a receptor tyrosine kinase meaning the receptor signals by causing the addition of a phosphate molecule on particular tyrosines. The IGF 2 receptor only binds IGF 2 and acts as a clearance receptor it activates no intracellular ...   more details



  1. Placental growth factor

    growth factor placenta growth factor receptor Flt 1 required for binding and structural stability ... Neuropilin 2 is a receptor for the vascular endothelial growth factor VEGF forms VEGF 145 and VEGF 165 ...PBB geneid 5228 Placental growth factor is a protein that in humans is encoded by the PGF gene . ref name entrez cite web title Entrez Gene PGF placental growth factor, vascular endothelial growth factor ... mRNAs coding for the angiogenic factor, placenta growth factor PlGF , are transcribed from a single ... doi url issn ref Placental growth factor PGF is a member of the VEGF vascular endothelial growth ... url issn ref Clinical significance Placental growth factor expression within human atherosclerosis ... A, Collen D, Martin JF, Carmeliet P, Zachary IC title Placental growth factor promotes atherosclerotic ... cite journal author Shibuya M title Vascular endothelial growth factor dependent and independent ... A, Collen D, Martin JF, Carmeliet P, Zachary IC title Placental growth factor promotes atherosclerotic ... name pmid18452647 cite journal author Shibuya M title Vascular endothelial growth factor dependent ... reading refbegin 2 cite journal author Luttun A, Tjwa M, Carmeliet P title Placental growth factor PlGF ..., placenta growth factor PlGF , are transcribed from a single gene of chromosome 14. journal Oncogene ... J, et al. title Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity ... S, Weich HA title A heparin binding form of placenta growth factor PlGF 2 is expressed in human umbilical ... O, et al. title Assignment of vascular endothelial growth factor VEGF and placenta growth factor PLGF ... D, Ribatti D, et al. title Placenta growth factor 1 is chemotactic, mitogenic, and angiogenic ... Vuorela P, Hatva E, Lymboussaki A, et al. title Expression of vascular endothelial growth factor and placenta growth factor in human placenta. journal Biol. Reprod. volume 56 issue 2 pages 489 94 year ... Placenta growth factor identification and characterization of a novel isoform generated by RNA ...   more details



  1. Hepatocyte growth factor

    Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor journal ... refend PDB Gallery geneid 3082 See also growth factor hepatocyte growth factor receptor HGFR External links MeshName Hepatocyte growth factor Category Growth factors Category Developmental genes ...PBB geneid 3082 Hepatocyte growth factor scatter factor HGF SF is a paracrine cellular growth, motility and morphogen morphogenic factor . It is secreted by mesenchymal cell s and targets and acts primarily upon epithelial cell s and endothelial cell s, but also acts on haematopoiesis haemopoietic progenitor cells . It has been shown to have a major role in embryonic organ development, in adult organ ... growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto oncogenic c Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi functional cytokine on cells of mainly .... ref cite web title Entrez Gene HGF hepatocyte growth factor hepapoietin A scatter factor url ... Interactions Hepatocyte growth factor has been shown to Protein protein interaction interact with C ... T title Structure and function of hepatocyte growth factor. journal Prog. Growth Factor Res. volume ... H, Nakamura T title Hepatocyte growth factor from diagnosis to clinical applications. journal Clin ... 9 cite journal author Skibinski G title The role of hepatocyte growth factor c met interactions in the immune ... al. title Hepatocyte growth factor scatter factor and prostate cancer a review. journal Histol. Histopathol ... with growth factors and morphogens editor Iozzo, M, V. year 2000 publisher Marcel Dekker ..., biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells journal ... Ware LB, Matthay MA title Keratinocyte and hepatocyte growth factors in the lung roles in lung development ... yes update citations yes es Factor de crecimiento de hepatocitos id Faktor pertumbuhan hepatosit it HGF ...   more details



  1. Fibroblast growth factor

    Members FGF1 through FGF10 all bind fibroblast growth factor receptor s FGFRs . FGF1 is also known as acidic , and FGF2 is also known as basic fibroblast growth factor . Members FGF11 , FGF12 , FGF13 ... growth factor receptor family has 4 members, FGFR1 , FGFR2 , FGFR3 , and FGFR4 . The FGFRs consist ... of growth factor s involved in angiogenesis , wound healing , and embryonic development ... fibroblast growth factor journal Biochemistry volume 35 issue 7 pages 2086 94 year 1996 month February .... ref cite journal author Olsen SK, Garbi M. et al. title Fibroblast growth factor FGF homologous ... growth factor, KGF binds only to FGFR2b KGFR . The signaling complex at the cell surface is believed ... and either one or two heparan sulfate chains. History Fibroblast growth factor was found in pituitary ... in 1974 . ref cite journal author Gospodarowicz D title Localisation of a fibroblast growth factor ... named acidic fibroblast growth factor FGF1 and basic fibroblast growth factor FGF2 . These proteins ... M, Chen Y., et al. title Nuclear activities of basic fibroblast growth factor potentiation of low ... title Promiscuity of fibroblast growth factor receptors ref Promiscuous refers to the biochemistry ... development , ref cite journal author B ttcher RT, Niehrs C. title Fibroblast growth factor signaling ... author Borland C.Z., Schutzman J.L. and Stern M.J. title Fibroblast growth factor signaling in Caenorhabditis ... endothelial growth factor VEGF or platelet derived growth factor PDGF . ref cite journal author ... also known as Keratinocyte Growth Factor s KGF and KGF2, respectively stimulate the repair of injured ... stimulating factor G CSF granulocyte macrophage colony stimulating factor GM CSF nerve growth factor NGF neurotrophins erythropoietin EPO thrombopoietin TPO myostatin GDF 8 Growth Differentiation factor ... technology.php FGF1 in Cosmetic Products Signaling proteins DEFAULTSORT Fibroblast Growth Factor Category Growth factors Category Morphogens de Fibroblast Growth Factor es Factor de crecimiento ...   more details



  1. Nerve Growth factor IB

    PBB geneid 3164 The nerve Growth factor IB NGFIB also known as Nur77 or NR4A1 nuclear receptor subfamily ... name pmid2626032 Nerve Growth factor IB is a member of the Nur biology Nur nuclear receptor family ... factor s. ref name pmid3272167 cite journal author Milbrandt J title Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene journal Neuron volume 1 issue 3 pages 183 ... expression and posttranslational modification. ref name pmid16339277 Biochemistry Nerve Growth factor ... Hiromura M, Suizu F, Narita M, Kinowaki K, Noguchi M title Identification of nerve growth factor ... Nerve Growth factor IB has the systematic Human Genome Organisation HUGO gene symbol NR4A1 ... nuclear receptor transcription factor, NURR1 journal Gene date 1997 03 10 accessdate 2007 12 20 pmid ... growth factor induced clone B in rat s, Nur77 in mice and TR3 in human s. ref name pmid17407572 ... pmid 17407572 pmc 1852551 ref Pathology Along with 16 other genes, Nerve Growth factor IB is a signature ... 2003 pmid 12469122 doi 10.1038 ng1060 issn ref Interactions Nerve Growth factor IB has been shown ... hormone receptor gene related to the NUR 77 NGFI B genes. journal Cell Growth Differ. volume 2 issue ... Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear ... author Chang C, Kokontis J, Liao SS, Chang Y title Isolation and characterization of human TR3 receptor a member of steroid receptor superfamily journal J. Steroid Biochem. volume 34 issue 1 6 pages ... by the orphan nuclear receptor Nur77 journal Mol. Endocrinol. volume 20 issue 4 pages 786 94 year 2006 ... Entrez Gene NR4A1 nuclear receptor subfamily 4, group A, member 1 url http www.ncbi.nlm.nih.gov ... factor kappa B complex, a ubiquitous transcription factor involved in cellular response to stress ... physiological stimuli such as fatty acids, stress, prostaglandins, growth factors, calcium, inflammatory ... ising with COUP TF an orphan nuclear receptor and retinoid X receptor RXR in mediating transcription ...   more details



  1. Nerve growth factor

    structure of nerve growth factor in complex with the ligand binding domain of the TrkA receptor journal ... laydate quote ref and Low affinity nerve growth factor receptor . ref name pmid14985763 ref name ... neurotrophin 3 neurotrophin 4 nerve growth factor receptor Hericium erinaceus an edible mushroom that has ...PBB geneid 4803 Nerve growth factor NGF , is a small secreted protein that is important for the growth ... ref It is perhaps the prototypical growth factor , in that it is one of the first to be described. While nerve growth factor refers to a single factor, ref MeshName Nerve Growth Factor ref nerve ... pages 111 26 year 2004 pmid 14699960 doi 10.1016 S0079 6123 03 46008 1 url issn ref Nerve growth factor ... NGF binds with at least two classes of receptors the p75 LNGFR for low affinity nerve growth factor ... homeostasis . ref name pmid14699984 cite journal author Levi Montalcini R title The nerve growth factor ... TL title New protein fold revealed by a 2.3 A resolution crystal structure of nerve growth factor ... before. Hence NGF is the founding member of the neurotrophin nerve growth factor family of structurally ... M., Blesch A. 2004 . Nerve growth factor from animal models of cholinergic neuronal degeneration ... N title Expression of nerve growth factor in the airways and its possible role in asthma journal Prog ... cite journal author Villoslada P, Genain CP title Role of nerve growth factor and other trophic ... Nerve growth factor and wound healing journal Prog. Brain Res. volume 146 issue pages 369 84 year ... s disease . ref cite journal author Counts S, Mufson E title The role of nerve growth factor receptors ... growth factor NGF has high levels when people first fall in love , but these levels return ... Raised plasma nerve growth factor levels associated with early stage romantic love journal Psychoneuroendocrinology ... Calissano has suggested that nerve growth factor may contribute to increased longevity and mental capacity ... of eternal life? date April 25, 2009 ref Interactions Nerve growth factor has been shown to Protein ...   more details




Articles 1 - 25 of 120518          Next


Search   in  
Search for Epidermal growth factor receptor in Tutorials
Search for Epidermal growth factor receptor in Encyclopedia
Search for Epidermal growth factor receptor in Videos
Search for Epidermal growth factor receptor in Books
Search for Epidermal growth factor receptor in Software
Search for Epidermal growth factor receptor in DVDs
Search for Epidermal growth factor receptor in Store


Advertisement




Epidermal growth factor receptor in Encyclopedia
Epidermal growth factor receptor top Epidermal growth factor receptor
Home - Add TutorGig to Your Site - Disclaimer

©2011-2013 TutorGig.com. All Rights Reserved. Privacy Statement