geneid 1956 The epidermalgrowthfactorreceptor EGFR ErbB 1 HER1 in humans is the Cell membrane cell surface receptor biochemistry receptor for members of the epidermalgrowthfactor family EGF family ... Herbst RS title Review of epidermalgrowthfactorreceptor biology journal Int. J. Radiat. Oncol. Biol ... url ref The epidermalgrowthfactorreceptor is a member of the ErbB family of receptors, a subfamily ... or Medicine in 1986. Function EGFR epidermalgrowthfactorreceptor exists on the cell surface ..., Funahashi A, Kitano H title A comprehensive pathway map of epidermalgrowthfactorreceptor signaling ... DA title Activating mutations in the epidermalgrowthfactorreceptor underlying responsiveness of non ... LV, Johnson BE title Impact of epidermalgrowthfactorreceptor and KRAS mutations on clinical ... factor 4 small GTPase mediates epidermalgrowthfactorreceptor dependent phospholipase D2 activation ... J H, Lipkowitz S year 1999 month Mar. title cbl b inhibits epidermalgrowthfactorreceptor signaling ... Brian I year 2002 month May. title Identification of epidermalgrowthfactorreceptor as a target ... Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermalgrowthfactorreceptor journal ... for the epidermalgrowthfactorreceptor journal J. Biol. Chem. volume 274 issue 8 pages 4489 92 ... in lipid rafts and interacts with the epidermalgrowthfactorreceptor journal Biochemistry ... with the epidermalgrowthfactorreceptor in human tumor cells. Phosphatidic acid activates receptor ... of the protein tyrosine phosphatase SHP 1 to the epidermalgrowthfactorreceptor and attenuation ... stimulated transactivation of epidermalgrowthfactorreceptor and mitogen activated protein kinase ... the epidermalgrowthfactorreceptor COOH terminal region for signal transducer and activator of transcription ... is associated with the adapter protein Grb2 and the epidermalgrowthfactorreceptor in living ... BIES3 3.0.CO 2 1 cite journal author Filardo EJ title Epidermalgrowthfactorreceptor EGFR transactivation ... more details
affinity to epidermalgrowthfactorreceptor EGFR on the plasma membrane cell surface and stimulating ... are potential substances for this purpose. Interactions Epidermalgrowthfactor has been shown to Protein protein interaction interact with Epidermalgrowthfactorreceptor ref name pmid12093292 cite ... of the epidermalgrowthfactor EGF receptor in amphiregulin and EGF mitogenic signaling journal J. Biol ...PBB geneid 1950 Epidermalgrowthfactor or EGF is a growthfactor that plays an important role in the regulation of cell growth , cell growth proliferation , and Cellular differentiation differentiation by binding to its receptorEpidermalgrowthfactorreceptor EGFR . Human EGF is a 6045 dalton unit ... pmid2186024 cite journal author Carpenter G, Cohen S title Epidermalgrowthfactor journal The Journal ..., and survival. ref name Herbst cite journal author Herbst RS title Review of epidermalgrowthfactorreceptor biology journal International Journal of Radiation Oncology, Biology, Physics ... ref Biological Sources Epidermalgrowthfactor can be found in human platelets, macrophages, urine, saliva ... RA, Knaver DJ, Cunningham DD title Epidermalgrowthfactor immunoreactive material in the central ... citations cite journal author Boonstra J, Rijken P, Humbel B, et al. title The epidermalgrowthfactor ... cite journal author Dvorak B title Epidermalgrowthfactor and necrotizing enterocolitis journal ... cite journal author Howell WM title Epidermalgrowthfactor gene polymorphism and development ... ref name dreux cite journal author Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA title The epidermalgrowth ... url issn ref Heparin binding EGF like growthfactor HB EGF TGF alpha transforming growthfactor TGF Amphiregulin AR Epiregulin EPR Epigen Betacellulin BTC neuregulin 1 NRG1 neuregulin ... growthfactor in ErbB 2 ErbB 3 binding studied by phage display journal Biochemistry volume ... growthfactor http www.ebi.ac.uk biomodels main static pages.do?page ModelMonth 252FAugust2006 ... more details
A growthfactorreceptor is a Receptor biochemistry receptor which binds to growthfactor . ref MeshName GrowthFactor Receptors ref These receptors may use the JAK STAT signaling pathway JAK STAT , MAP kinase , and Phosphoinositide 3 kinase PI3 kinase pathways. ref name HoffbrandMoss2006 cite book author1 A. V. Hoffbrand author2 P. A. H. Moss author3 J. E. Pettit title Essential haematology url http books.google.com books?id IFFL 1YNy oC&pg PA6 accessdate 28 November 2010 year 2006 publisher Wiley Blackwell isbn 9781405136495 pages 6 ref References reflist Growthfactor receptors Category Receptors biochem stub ... more details
The fibroblast growthfactor receptors are, as their name implies, Receptor biochemistry receptors that bind to members of the fibroblast growthfactor family of proteins. Structure The fibroblast growthfactor receptors consist of an extracellular ligand domain composed of three immunoglobulin like domains, a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity. These receptors bind fibroblast growthfactor s, members of the largest family of growthfactor ligands, comprising 22 members. ref name ornitz cite journal author Ornitz DM. and Itoh, N. title Fibroblast growth factors journal Genome Biol. year 2001 volume 2 issue 3 pages REVIEWS 3005 pmid 11276432 doi 10.1186 gb 2001 2 3 reviews3005 pmc 138918 ref The natural gene splicing alternate splicing of four fibroblast growthfactorreceptor FGFR genes results in the production of over 48 different ... of fibroblast growthfactorreceptor 1 regulates ligand and heparan sulfate co receptor binding ... al. title Identification of a new fibroblast growthfactorreceptor, FGFR5 journal Gene year 2001 ... superfamily FGFR1 to FGFR4 . Gene FGFR1 see also Fibroblast growthfactorreceptor 1 CD331 Gene FGFR2 see also Fibroblast growthfactorreceptor 2 CD332 Gene FGFR3 see also Fibroblast growthfactorreceptor 3 CD333 Gene FGFR4 see also Fibroblast growthfactorreceptor 4 CD334 Gene FGFR6 References ... Growthfactor receptors Tyrosine kinases DEFAULTSORT Fibroblast GrowthFactorReceptor Category ... like domains D2 and D3 are sufficient for FGF binding. Each receptor can be activated by several FGFs. In many cases, the FGFs themselves can also activate more than one receptor i.e., FGF 1, which binds all seven principal FGFRs ref name ornitz2 cite journal author Ornitz DM, et al. title Receptor Specificity of the Fibroblast GrowthFactor Family. journal JBC volume 271 issue 25 pages 15292 15297 ..., and Gallagher JT. title Receptors for fibroblast growth factors journal Immunol. Cell. Biol. year ... more details
Nerve growthfactor receptors are a group of growthfactorreceptor s which specifically bind to neurotrophin s. There are two classes of receptors, p75 and the Trk family of Tyrosine kinase s receptors. p75 is a low affinity neurotrophin receptor , to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase x only applies to this receptor. ref MeshName Nerve GrowthFactorReceptor p75 ref The Trk receptor Trk family include TrkA , TrkB , and TrkC , and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins. NGF binds to TrkA, BDNF and NT 4 bind to TrkB and NT 3 binds to TrkC . In addition NT 3 also binds to and activates TrkA and TrkB but it does so less efficiently. Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis . TrkA, B, and C receptors TrkA is a receptor tyrosine kinase meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling . There are other related Trk receptors TrkB and TrkC , and there are other neurotrophic factors structurally related to NGF BDNF , NT 3 , and NT 4 TrkA mediates the effects of NGF TrkB binds and is activated by BDNF , NT 4 , and NT 3 TrkC binds and is activated only by NT 3 LNGFR receptor The other NGF receptor, the LNGFR , for Low affinity nerve growthfactorreceptor , commonly known as p75 , plays a less clear role. LNGFR binds and serves as a sink for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity since they have a higher microconcentration of the neurotrophin. However ... basalis of postmortem Alzheimer s brains. References reflist External links MeshName Nerve GrowthFactor Receptors Growthfactor receptors Category Receptors biochem stub ... more details
protein tyrosine kinases and the epidermalgrowthfactorreceptor journal J. Biol. Chem. volume 270 ...PBB geneid 2264 Fibroblast growthfactorreceptor 4 is a protein that in humans is encoded by the FGFR4 ... growthfactorreceptor family, where amino acid sequence is highly conserved between members and throughout ... fibroblast growthfactorreceptor 4 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2264 accessdate ref Interactions Fibroblast growthfactorreceptor 4 has been shown ... domain of recombinant human fibroblast growthfactorreceptor 4 journal Int. J. Biochem ... al. title A radiation hybrid map of 18 growthfactor, growthfactorreceptor, hormone receptor, or neurotransmitter ... J, Bellosta P, et al. title Fibroblast growthfactorreceptor 4 shows novel features in genomic ... FGFR 4, a novel acidic fibroblast growthfactorreceptor with a distinct expression pattern journal ... kinases expressed in human lung fourth member of the fibroblast growthfactorreceptor family and an intracellular ... Signal transduction by fibroblast growthfactorreceptor 4 FGFR 4 . Comparison with FGFR 1 journal ... D, Reich R, Chedid M, et al. title Fibroblast growthfactorreceptor 4 is a high affinity receptor for both acidic and basic fibroblast growthfactor but not for keratinocyte growthfactor journal J. Biol ... P, Alitalo K title Association of a 85 kDa serine kinase with activated fibroblast growthfactorreceptor ... DM, Xu J, Colvin JS, et al. title Receptor specificity of the fibroblast growthfactor family journal ... factorreceptor 4 gene to chromosome region 5q33 qter journal Genes Chromosomes Cancer volume 4 issue ... molecules between keratinocyte growthfactor and basic fibroblast growthfactor define domains ... tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth ... for members 1 3. This particular family member preferentially binds acidic fibroblast growthfactor and, although its specific function is unknown, it is overexpressed in gynecological tumor ... more details
Fibroblast growthfactorreceptor 3 mutations in epidermal nevi and associated low grade bladder ...PBB geneid 2261 Fibroblast growthfactorreceptor 3 is a protein that in humans is encoded by the FGFR3 gene . ref name pmid1847508 cite journal author Keegan K, Johnson DE, Williams LT, Hayman MJ title Isolation of an additional member of the fibroblast growthfactorreceptor family, FGFR 3 journal Proc Natl Acad Sci U S A volume 88 issue 4 pages 1095 9 year 1991 month Mar pmid 1847508 pmc 50963 doi 10.1073 pnas.88.4.1095 ref FGFR3 has also been designated as CD333 cluster of differentiation 333 . Structure and function The PBB Summary template is automatically maintained by Protein Box Bot. See ... by this gene is a member of the fibroblast growthfactorreceptor family, where amino acid sequence ... FGFR3 fibroblast growthfactorreceptor 3 achondroplasia, thanatophoric dwarfism url http www.ncbi.nlm.nih.gov ... 17085196 doi 10.1016 j.juro.2006.07.132 ref Interactions Fibroblast growthfactorreceptor 3 has been ... Fibroblast growthfactorreceptor References Reflist Further reading refbegin 2 PBB Further ... Horton WA, Lunstrum GP title Fibroblast growthfactorreceptor 3 mutations in achondroplasia and related ... growthfactorreceptor autoinhibition and ligand binding promiscuity. journal Pnas USA ... Expression and biological activity of mouse fibroblast growthfactor 9 journal J. Biol. Chem. volume ... M, Ornitz D M year 1999 month Dec. title Mapping ligand binding domains in chimeric fibroblast growthfactorreceptor molecules. Multiple regions determine ligand binding specificity journal J. Biol ... NLM content Tyrosine kinases Growthfactor receptors Clusters of differentiation The PBB Controls ... of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals ... acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations ... Hafner C, Hartmann A, Vogt T title FGFR3 mutations in epidermal nevi and seborrheic keratoses lessons ... more details
or radiotherapy. In breast cancer, where Epidermalgrowthfactorreceptor EGFR inhibitors such as erlotinib ... growthfactor I receptor, and epidermalgrowthfactorreceptor via the Grb10 Src homology 2 SH2 domain ... factorreceptor interplay with the epidermalgrowthfactorreceptor. journal Growth Factors volume ...PBB geneid 3480 The Insulin like GrowthFactor 1 IGF 1 Receptor is a transmembrane receptor transmembrane receptor proteomics receptor that is activated by IGF 1 and by the related growthfactor IGF 2 ... like growthfactor 2 receptor IGF 2R and their respective ligands IGF 1 and IGF 2 , along with several ... C, Hofmann F, Krystal GW title The insulin like growthfactor I receptor kinase inhibitor, NVP ADW742 ... D, Knowlden JM, Williams S, Wakeling AE, Nicholson RI title Insulin like growthfactor I receptor ... R, Brewster SF, Macaulay VM title Expression of the type 1 insulin like growthfactorreceptor is up ..., Bell RH, Hurtado Coll A, Fazli L, Gleave ME, Cox ME title Increased insulin like growthfactor I receptor ... AM, Voelker MA, Sternberg H, Timiras PS title Insulin like growthfactor 1 receptor immunoreactive ... growthfactor 1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically ... . Interactions Insulin like growthfactor 1 receptor has been shown to Protein protein interaction ... with the insulin like growthfactor I receptor journal Biochem. Biophys. Res. Commun. volume ... month Aug. title Localization of the insulin like growthfactor I receptor binding sites for the SH2 ... like growthfactor I receptor journal J. Biol. Chem. volume 273 issue 37 pages 24095 ... ligand induced ubiquitination and stability of the insulin like growthfactor I receptor journal ... interaction of the insulin like growthfactor I receptor with IRS 1, Shc, and Grb10 journal ... like growthfactor I receptor journal Cancer Res. volume 56 issue 14 pages 3165 7 publisher ... kinase associates with ligand stimulated insulin like growthfactor I receptor journal J. Biol. Chem ... more details
Refimprove date September 2010 protein Name PDGFRA platelet derived growthfactorreceptor, alpha polypeptide ... PDGFRB platelet derived growthfactorreceptor, beta polypeptide caption Ribbon image of two molecules of human PDGF receptor beta yellow and magenta in complex with dimeric PDGFB PDGF B cyan and green ... Platelet derived growthfactor receptors PDGF R are cell surface receptor tyrosine kinase tyrosine kinase receptor s for members of the platelet derived growthfactor PDGF family. PDGF subunits PDGFA ... growth , Morphogenesis development and many diseases including cancer . ref name pmid2538922 Cite journal author Williams LT title Signal transduction by the platelet derived growthfactorreceptor ... derived growthfactor three isoforms and two receptor types journal Trends Genet. volume 5 issue ... derived growthfactor isoform specific signalling via heterodimeric or homodimeric receptor complexes ... MeshName Platelet Derived GrowthFactor Receptors Tyrosine kinases Growthfactor receptors http angiogenesis.amgen.com DEFAULTSORT Platelet Derived GrowthFactorReceptor Category Growth factors Category ... X. title Structures of a platelet derived growthfactor propeptide complex and a platelet derived growthfactorreceptor complex journal PNAS volume 107 issue 25 no 25 pages 11307 12 year 2010 pmid 20534510 ... Depending on which growthfactor is bound, PDGF R homo or heterodimerizes. ref name pmid1315403 Cite ... with signal transduction molecules Tyrosine phosphorylation sites in growthfactor receptors serve ... in their monomer ic forms. The PDGFs bind to the protein Receptor tyrosine kinase tyrosine kinase receptor s PDGF receptor and . These two receptor isoform s protein dimer dimer ize upon binding the PDGF dimer, leading to three possible receptor combinations, namely , and . The extracellular region of the Receptor biochemistry receptor consists of five immunoglobulin like domains ... AA binds only to PDGFR , while PDGF BB is the only PDGF that can bind all three receptor combinations ... more details
PBB geneid 2263 Fibroblast growthfactorreceptor 2 FGFR2 also known as CD332 cluster of differentiation ... A, Courtois Y, Breathnach R title Related fibroblast growthfactorreceptor genes exist in the human ... and basic fibroblast growth factors journal EMBO J. volume 9 issue 9 pages 2685 92 year 1990 month September pmid 1697263 pmc 551973 doi url issn ref FGFR2 is a receptor for fibroblast growthfactor . The protein encoded by this gene is a member of the fibroblast growthfactorreceptor family, where ... Entrez Gene FGFR2 fibroblast growthfactorreceptor 2 bacteria expressed kinase, keratinocyte growthfactorreceptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson Weiss syndrome ... alternatives of fibroblast growthfactorreceptor 2 FGFR2 journal Dev. Biol. volume 158 ... growthfactorreceptor with its ligands journal Proc. Natl. Acad. Sci. U.S.A. volume 97 issue ... TL title Crystal structure of fibroblast growthfactorreceptor ectodomain bound to ligand and heparin ... Receptor specificity of the fibroblast growthfactor family journal J. Biol. Chem. volume 271 issue ... growthfactorreceptor family, these receptors signal by binding to their ligand and dimerisation ... localized derivative of the fibroblast growthfactorreceptor 3 kinase domain journal Mol ... 2 cite journal author McKeehan WL, Kan M title Heparan sulfate fibroblast growthfactorreceptor ... 2005 pmid 15622262 doi refend External links MeshName Fibroblast GrowthFactorReceptor 2 PDB Gallery ... and or keratinocyte growthfactor, depending on the isoform. Isoforms FGFR2 has two naturally occurring ... of this gene and isoform are associated with craniosynostosis . Interactions Fibroblast growthfactor ... A, Ornitz DM title Expression and biological activity of mouse fibroblast growthfactor 9 journal ... fibroblast growthfactor 2 , FGF4 4 , FGF6 6 , FGF8 8 , FGF9 9 , FGF17 17 and FGF18 18 These differences ... domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting ... more details
. Interactions Insulin like growthfactor 2 receptor has been shown to Protein protein interaction ... JC, Standring DN, et al. title Insulin like growthfactor II receptor as a multifunctional binding protein ... of heterozygosity on 6q at the mannose 6 phosphate insulin like growthfactor II receptor locus in human ... like growthfactor II binding site to amino acids 1508 1566 in repeat 11 of the mannose 6 phosphate insulin like growthfactor II receptor. journal J. Biol. Chem. volume 270 issue 25 pages 14975 82 ... of insulin like growthfactor II receptor in human pancreatic cancer. journal Pancreas volume ... EI, Vorum H, et al. title Mannose 6 phosphate insulin like growthfactor II receptor targets ... refend External links MeshName Insulin Like GrowthFactor II Receptor PDB Gallery geneid 3482 Clusters of differentiation Growthfactor receptors Category Receptors Category Clusters of differentiation ... A, Francke U title Chromosomal mapping of the gene for the type II insulin like growthfactor ... ref IGF2R is a multifunctional protein receptor biochemistry receptor that binds insulin like growth ... cite journal author O Dell SD, Day IN title Insulin like growthfactor II IGF II . journal ... 2725 98 00048 X cite journal author Hawkes C, Kar S title The insulin like growthfactor II mannose ... T, Neville Golden J, Maxwell M title Expression of insulin like growth factors I and II and their receptor ... 1370435 doi 10.1002 ijc.2910500210 cite journal author Zhou J, Bondy C title Insulin like growthfactor ..., Voutilainen R title Insulin like growthfactor binding proteins in the human adrenal gland. journal ...PBB geneid 3482 about the cation independent mannose 6 phosphate receptor the cation dependent receptor cation dependent mannose 6 phosphate receptor In the fields of biochemistry and cell biology , the insulin like growthfactor 2 receptor IGF2R , also called the cation independent mannose 6 phosphate receptor CI MPR is a protein that in humans is encoded by the IGF2R gene . ref name pmid2963003 cite ... more details
PBB geneid 2260 Fibroblast growthfactorreceptor 1 FGFR1 , also known as basic fibroblast growthfactorreceptor 1 , fms related tyrosine kinase 2 Pfeiffer syndrome , and cluster of differentiation CD 331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growthfactor family. FGFR1 has been shown to be associated with Pfeiffer syndrome . ref name pmid2162671 cite ... form of human basic fibroblast growthfactorreceptor deduced from its cDNA journal Biochem. Biophys ... growthfactorreceptor FGFR family, where amino acid sequence is highly conserved between members and throughout ... Entrez Gene FGFR1 fibroblast growthfactorreceptor 1 fms related tyrosine kinase 2, Pfeiffer syndrome ... ref Interactions Fibroblast growthfactorreceptor 1 has been shown to Protein protein interaction ... Association of fibroblast growthfactorreceptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner journal J. Biol. Chem. volume 275 issue 11 pages 7771 8 year 2000 ... Xu H, Lee KW, Goldfarb M title Novel recognition motif on fibroblast growthfactorreceptor mediates ... M title The structure and function of vertebrate fibroblast growthfactorreceptor 1. journal ... pathways by binding to diverse targets on fibroblast growthfactor and nerve growthfactor receptors ... fibroblast growthfactor 9 journal J. Biol. Chem. volume 271 issue 3 pages 1726 31 year 1996 month ... Wilkie AO title Bad bones, absent smell, selfish testes the pleiotropic consequences of human FGF receptor mutations. journal Cytokine GrowthFactor Rev. volume 16 issue 2 pages 187 203 year 2005 pmid ... tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growthfactor s, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors ..., Williams LT title Structural and functional diversity in the FGF receptor multigene family. journal ... more details
factor BDNF Epidermalgrowthfactor EGF Erythropoietin EPO Fibroblast growthfactor FGF Glial ... of involved growth factors Signal transduction Receptor biochemistry Cytokine Angiogenesis Human Genome Organisation Growthfactorreceptor Mitogen References reflist External links MeshName Growth ...A growthfactor is a naturally occurring substance capable of stimulating cellular growth , ref DorlandsDict three 000038554 growthfactor ref proliferation and cellular differentiation . Usually it is a protein or a steroid hormone . Growth factors are important for regulating a variety of cellular processes. Growth factors typically act as signaling molecules between cells. Examples are cytokine ... differentiation, while fibroblast growthfactor s and vascular endothelial growthfactor s stimulate blood vessel differentiation angiogenesis . Growth factors versus cytokines Growthfactor is sometimes ... development and in the mature organism. While growthfactor implies a positive effect on cell division ... growthfactor proteins tend to occur as members of larger families of structurally and evolution arily ... colony stimulating factor GM CSF Growth differentiation factor 9 GDF9 Hepatocyte growthfactor HGF Hepatoma derived growthfactor HDGF Insulin like growthfactor IGF Migration stimulating factor Myostatin GDF 8 Nerve growthfactor NGF and other neurotrophins Platelet derived growthfactor PDGF Thrombopoietin TPO Transforming growthfactor alpha TGF Transforming growthfactor beta TGF Tumour necrosis factor alpha TNF Vascular endothelial growthfactor VEGF Wnt Signaling Pathway placental growthfactor PlGF Foetal Bovine Somatotrophin FBS IL 1 Cofactor for IL 3 and IL 6. Activates T cells. IL 2 T cell growthfactor. Stimulates IL 1 synthesis. Activates B cells and NK cells. IL 3 Stimulates production of all non lymphoid cells. IL 4 Growthfactor for activated B cells, resting ... Ig synthesis. Growthfactor for plasma cells. IL 7 Growthfactor for pre B cells. Stimulates ... more details
Pfam box Symbol APP CU bd Name Amyloid precursor N terminal image 1mwp gfld.png width 200 caption The GFLD region of amyloid precursor protein Pfam PF02177 InterPro IPR008154 SMART SM00006 PROSITE SCOP 1mwp TCDB PDB PDB2 1mwp , PDB2 1owt , PDB2 2fjz , PDB2 2fk1 , PDB2 2fk2 , PDB2 2fk3 , PDB2 2fkl , PDB2 2fma A growth factor like domain GFLD is a protein domain structurally related to epidermal growth factor , which has a high binding affinity for the epidermal growth factor receptor . As structural domains within larger proteins, GFLD regions commonly bind calcium ion s. A subtype present in the N terminus N terminal region of the amyloid precursor protein is a member of the heparin binding class of GFLDs and may itself have growth factor function, particularly in promoting neuron al development. References Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW. 1999 . Crystal structure of the N terminal, growth factor like domain of Alzheimer amyloid precursor protein. Nat Struct Biol 6 4 327 31. protein stub Category Protein domains ... more details
PBB geneid 2693 Growth hormone secretagogue receptor is a G protein coupled receptor that binds ghrelin ... S title Loss of constitutive activity of the growth hormone secretagogue receptor in familial short ... name entrez cite web title Entrez Gene GHSR growth hormone secretagogue receptor url http www.ncbi.nlm.nih.gov ... and regulation of the growth hormone secretagogue receptor. journal Minerva Endocrinol. volume 27 ... of the 5 flanking region of the human growth hormone secretagogue receptor gene. journal ... hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity. journal ... and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic ... of transgenic mice overexpressing growth hormone GH secretagogue receptor 1A in GH releasing hormone ... archiveurl archivedate quote MeshName growth hormone secretagogue receptor http www.vivo.colostate.edu ..., Pin JP, Spedding M, Kojima M, Kangawa K title International Union of Pharmacology. LVI. Ghrelin receptor ... 17983854 doi 10.1016 S0083 6729 06 77005 4 ref Function Ghrelin is an appetite regulating factor secreted from peripheral organs that is involved in regulation of energy homoeostasis via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. ref cite journal author ... intake and growth hormone secretion journal Endocrinology volume 141 issue 11 pages 4325 8 year 2000 ...?view long&pmid 11089570 ref The pathway activated by binding of Ghrelin to the Growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen activated protein kinase ... One of the important features of GHSR1a displays Receptor biochemistry Binding and activation ... of receptor internalization as well as of signaling activity. ref name pazos2007 Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity. ref cite ... signaling of the ghrelin receptor identification of a potent inverse agonist journal Mol. Endocrinol ... more details
Transforming growthfactor sometimes referred to as Tumor growthfactor , or TGF is used to describe two classes of polypeptide growthfactor s, TGF&alpha and TGF beta TGF&beta . The name Transforming GrowthFactor is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor biochemistry receptor mechanism biology mechanisms . Furthermore, they do not always induce cellular transformation , and are not the only growth factors that induce cellular transformation. Types TGF&alpha is upregulated in some human cancer s. It is produced in macrophage s, brain cells, and keratinocyte s, and induces epithelium epithelial development. TGF beta TGF exists in three known subtypes in humans, TGF&beta 1, TGF&beta 2, and TGF&beta 3. These are upregulated in Marfan s syndrome ref name dysregmarfan Circulating transforming growthfactor beta in Marfan syndrome. Matt P, Schoenhoff F, Habashi J, Holm T, Van Erp C, Loch D, Carlson OD, Griswold BF, Fu Q, De Backer J, Loeys B, Huso DL, McDonnell NB, Van Eyk JE, Dietz HC GenTAC Consortium. Circulation. 2009 Aug 11 120 6 526 32. Epub 2009 Jul 27. PMID 19635970 ref ref name popmarfan http sciencenow.sciencemag.org cgi content full 2008 625 3?etoc Inhibiting TGF to help Marfan ref and some human cancers, and play crucial roles in tissue regeneration , cell differentiation ... growthfactor beta TGF 1 are also thought to be involved in the pathogenesis of pre eclampsia . TGF&beta receptors are single pass serine threonine kinase receptor s. Function These proteins were originally ...?search TGF Tumor growthfactor TGF citations http www.ihop net.org UniPub iHOP gs 125537.html ... MeshName Transforming Growth Factors Signaling proteins Category Growth factors Category Signal transduction cs Transformuj c r stov faktor de Transforming growthfactor fr Transforming growthfactor ... in a specific cell culture system, rat kidney fibroblasts. Application of the transforming growth factors ... more details
PBB geneid 2690 Growth hormone receptor is a protein that in humans is encoded by the GHR gene . ref name entrez cite web title Entrez Gene GHR growth hormone receptor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2690 accessdate ref GHR orthologs ref name OrthoMaM cite web title OrthoMaM phylogenetic marker GHR coding sequence url http www.orthomam.univ montp2.fr orthomam data cds detailMarkers ENSG00000112964 GHR.xml ref have been identified in most mammals . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls ... receptor for growth hormone . Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra and intercellular signal transduction pathway leading to growth ... interacts with the ubiquitin dependent endocytosis UbE motif of the growth hormone receptor journal ... Mutation of the SHP 2 binding site in growth hormone GH receptor prolongs GH promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B journal Mol. Endocrinol. volume 14 issue 9 pages 1338 ... required for coupling to the growth hormone receptor journal J. Biol. Chem. volume 270 issue 24 ..., Norstedt G, Carter Su C year 1994 month Aug. title Domains of the growth hormone receptor required ... The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver journal Growth Horm .... Mutations in this gene have been associated with Laron syndrome , also known as the growth ... of the weight of normal siblings , and also show a 40 increase in lifespan. Interactions Growth hormone receptor has been shown to Protein protein interaction interact with SGTA , ref name pmid12735788 ... J year 1998 month Jun. title Grb10 identified as a potential regulator of growth hormone GH signaling by cloning of GH receptor target proteins journal J. Biol. Chem. volume 273 issue 26 pages 15906 ... inhibition of growth hormone stimulated STAT5 signaling by multiple mechanisms journal J. Biol ... more details
The Keratinocyte GrowthFactor KGF , also known as FGF7 , is a growthfactor present in the epithelialization phase of wound healing . In this phase, keratinocytes are covering the wound, forming the epithelium . KGF is a small signaling molecule that binds to fibroblast growthfactorreceptor 2b FGFR2b . ref name pmid18575591 cite journal author Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A title Silencing of keratinocyte growthfactorreceptor restores 5 fluorouracil and tamoxifen efficacy on responsive cancer cells journal PLoS ONE volume 3 issue 6 pages e2528 year 2008 pmid 18575591 pmc 2424182 doi 10.1371 journal.pone.0002528 url http www.plosone.org article info doi 10.1371 journal.pone.0002528 ref For signalling to occur, a dimer is required between two FGF FGFR complexes that is linked together by a molecule of heparin. There are 23 known FGFs, and 4 FGF receptor s. FGF FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner. FGF10 is also known as Keratinocyte growthfactor 2 . ref name urliHOP Information Hyperlinked over Proteins FGF10 cite web url http www.ihop net.org UniPub iHOP gs 88201.html title iHOP Information Hyperlinked over Proteins FGF10 format work accessdate ref See also Palifermin References reflist External links http www personal.umich.edu lpt fgf 1fq9 files side.jpg http www personal.umich.edu lpt fgf 1fq9.htm Category Growth factors medicine stub Growth factors ... more details
derived growthfactor PDGF receptor activation by PDGF AB journal J. Biol. Chem. volume 266 issue ... terminal domain of alpha platelet derived growthfactor alpha PDGF receptor for PDGF focus forming ... growthfactor, VEGF C, is a ligand for the Flt4 VEGFR 3 and KDR VEGFR 2 receptor tyrosine kinases ... title An antibody reactive with domain 4 of the platelet derived growthfactor beta receptor allows ... Family members Human genes encoding proteins that belong to the platelet derived growthfactor family include C fos induced growthfactor FIGF PDGFA PDGFB PDGFC PDGFD Placental growthfactor PGF Vascular endothelial growthfactor VEGF VEGF41 Vascular endothelial growthfactor B VEGFB Vascular endothelial growthfactor C VEGFC See also Platelet activating factor Platelet derived growthfactorreceptor ...Pfam box Symbol PDGF Name Platelet derived growthfactor PDGF image width caption Pfam PF00341 InterPro ... In molecular biology , platelet derived growthfactor PDGF is one of the numerous growthfactor s, or protein .... In chemical terms, platelet derived growthfactor is protein dimer dimeric glycoprotein composed ... journal author Hannink M, Donoghue DJ title Structure and function of platelet derived growthfactor ... on platelet derived growthfactor journal EMBO J. volume 11 issue 12 pages 4251 4259 year 1992 ... Aaronson SA title Chimeric alpha and beta platelet derived growthfactor PDGF receptors define three ... U title Vascular endothelial growthfactor B, a novel growthfactor for endothelial cells journal ... in angiogenesis and endothelial cell growth, and placenta growthfactor PlGF which is also ... mRNAs coding for the angiogenic factor, placenta growthfactor PlGF , are transcribed from a single ... of the first growthfactor s characterized, ref cite journal author Paul D, Lipton A, Klinger I ... pmc 389008 ref and has led to an understanding of the mechanism of many growthfactor biochemical ... MeshName platelet derived growthfactor eMedicineDictionary platelet derived growthfactor Signaling ... more details
Image 3GF1 Insulin Like GrowthFactor Nmr 10 01.png thumb ILGF The insulin like growth factors IGFs are protein ... often referred to as the IGF axis consists of two cell surface receptor s IGF1R and IGF2R , two ligand s IGF 1 and IGF 2 , a family of six high affinity Insulin like growthfactor binding protein IGF binding proteins IGFBP 1 6 , as well as associated Insulin like growthfactor binding protein IGFBP ... referred to as the Growth Hormone IGF1 Axis. Insulin like growthfactor 1 IGF 1 is mainly secreted by the liver as a result of stimulation by growth hormone GH . IGF 1 is important for both the regulation ... death apoptosis . Insulin like growthfactor 2 IGF 2 is thought to be a primary growthfactor required for early development while IGF 1 expression is required for achieving maximal growth. Gene ... like GrowthFactor I and Insulin like GrowthFactor Binding Protein 3 with Intelligence Quotient ... 2 are regulated by a family of proteins known as the Insulin like growthfactor binding protein ... title Insulin like growthfactor I receptors are overexpressed and predict a low risk in human breast ... title Deafferentation induced increases in hippocampal insulin like growthfactor 1 messenger RNA expression ... like growthfactor 1 Insulin like growthfactor 2 Growth hormone treatment HGH controversies Insulin ... D last2 Dawes first2 PJ. year 2007 title Childhood hearing is associated with growth rates in infancy ... PDR.0b013e3181425869 ref IGF Receptors The IGF s are known to bind the IGF 1 receptor , the insulin receptor , the IGF 2 receptor, the insulin related receptor and possibly other receptors. The IGF 1 receptor is the physiologic receptor IGF 1 binds to it at significantly higher affinity than it binds the insulin receptor. Like the insulin receptor, the IGF 1 receptor is a receptor tyrosine kinase meaning the receptor signals by causing the addition of a phosphate molecule on particular tyrosines. The IGF 2 receptor only binds IGF 2 and acts as a clearance receptor it activates no intracellular ... more details
growthfactor placenta growthfactorreceptor Flt 1 required for binding and structural stability ... Neuropilin 2 is a receptor for the vascular endothelial growthfactor VEGF forms VEGF 145 and VEGF 165 ...PBB geneid 5228 Placental growthfactor is a protein that in humans is encoded by the PGF gene . ref name entrez cite web title Entrez Gene PGF placental growthfactor, vascular endothelial growthfactor ... mRNAs coding for the angiogenic factor, placenta growthfactor PlGF , are transcribed from a single ... doi url issn ref Placental growthfactor PGF is a member of the VEGF vascular endothelial growth ... url issn ref Clinical significance Placental growthfactor expression within human atherosclerosis ... A, Collen D, Martin JF, Carmeliet P, Zachary IC title Placental growthfactor promotes atherosclerotic ... cite journal author Shibuya M title Vascular endothelial growthfactor dependent and independent ... A, Collen D, Martin JF, Carmeliet P, Zachary IC title Placental growthfactor promotes atherosclerotic ... name pmid18452647 cite journal author Shibuya M title Vascular endothelial growthfactor dependent ... reading refbegin 2 cite journal author Luttun A, Tjwa M, Carmeliet P title Placental growthfactor PlGF ..., placenta growthfactor PlGF , are transcribed from a single gene of chromosome 14. journal Oncogene ... J, et al. title Placenta growthfactor. Potentiation of vascular endothelial growthfactor bioactivity ... S, Weich HA title A heparin binding form of placenta growthfactor PlGF 2 is expressed in human umbilical ... O, et al. title Assignment of vascular endothelial growthfactor VEGF and placenta growthfactor PLGF ... D, Ribatti D, et al. title Placenta growthfactor 1 is chemotactic, mitogenic, and angiogenic ... Vuorela P, Hatva E, Lymboussaki A, et al. title Expression of vascular endothelial growthfactor and placenta growthfactor in human placenta. journal Biol. Reprod. volume 56 issue 2 pages 489 94 year ... Placenta growthfactor identification and characterization of a novel isoform generated by RNA ... more details
Scatter factor and hepatocyte growthfactor are indistinguishable ligands for the MET receptor journal ... refend PDB Gallery geneid 3082 See also growthfactor hepatocyte growthfactorreceptor HGFR External links MeshName Hepatocyte growthfactor Category Growth factors Category Developmental genes ...PBB geneid 3082 Hepatocyte growthfactor scatter factor HGF SF is a paracrine cellular growth, motility and morphogen morphogenic factor . It is secreted by mesenchymal cell s and targets and acts primarily upon epithelial cell s and endothelial cell s, but also acts on haematopoiesis haemopoietic progenitor cells . It has been shown to have a major role in embryonic organ development, in adult organ ... growthfactor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto oncogenic c Met receptor. Hepatocyte growthfactor is secreted by mesenchymal cells and acts as a multi functional cytokine on cells of mainly .... ref cite web title Entrez Gene HGF hepatocyte growthfactor hepapoietin A scatter factor url ... Interactions Hepatocyte growthfactor has been shown to Protein protein interaction interact with C ... T title Structure and function of hepatocyte growthfactor. journal Prog. GrowthFactor Res. volume ... H, Nakamura T title Hepatocyte growthfactor from diagnosis to clinical applications. journal Clin ... 9 cite journal author Skibinski G title The role of hepatocyte growthfactor c met interactions in the immune ... al. title Hepatocyte growthfactor scatter factor and prostate cancer a review. journal Histol. Histopathol ... with growth factors and morphogens editor Iozzo, M, V. year 2000 publisher Marcel Dekker ..., biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells journal ... Ware LB, Matthay MA title Keratinocyte and hepatocyte growth factors in the lung roles in lung development ... yes update citations yes es Factor de crecimiento de hepatocitos id Faktor pertumbuhan hepatosit it HGF ... more details
Members FGF1 through FGF10 all bind fibroblast growthfactorreceptor s FGFRs . FGF1 is also known as acidic , and FGF2 is also known as basic fibroblast growthfactor . Members FGF11 , FGF12 , FGF13 ... growthfactorreceptor family has 4 members, FGFR1 , FGFR2 , FGFR3 , and FGFR4 . The FGFRs consist ... of growthfactor s involved in angiogenesis , wound healing , and embryonic development ... fibroblast growthfactor journal Biochemistry volume 35 issue 7 pages 2086 94 year 1996 month February .... ref cite journal author Olsen SK, Garbi M. et al. title Fibroblast growthfactor FGF homologous ... growthfactor, KGF binds only to FGFR2b KGFR . The signaling complex at the cell surface is believed ... and either one or two heparan sulfate chains. History Fibroblast growthfactor was found in pituitary ... in 1974 . ref cite journal author Gospodarowicz D title Localisation of a fibroblast growthfactor ... named acidic fibroblast growthfactor FGF1 and basic fibroblast growthfactor FGF2 . These proteins ... M, Chen Y., et al. title Nuclear activities of basic fibroblast growthfactor potentiation of low ... title Promiscuity of fibroblast growthfactor receptors ref Promiscuous refers to the biochemistry ... development , ref cite journal author B ttcher RT, Niehrs C. title Fibroblast growthfactor signaling ... author Borland C.Z., Schutzman J.L. and Stern M.J. title Fibroblast growthfactor signaling in Caenorhabditis ... endothelial growthfactor VEGF or platelet derived growthfactor PDGF . ref cite journal author ... also known as Keratinocyte GrowthFactor s KGF and KGF2, respectively stimulate the repair of injured ... stimulating factor G CSF granulocyte macrophage colony stimulating factor GM CSF nerve growthfactor NGF neurotrophins erythropoietin EPO thrombopoietin TPO myostatin GDF 8 Growth Differentiation factor ... technology.php FGF1 in Cosmetic Products Signaling proteins DEFAULTSORT Fibroblast GrowthFactor Category Growth factors Category Morphogens de Fibroblast GrowthFactor es Factor de crecimiento ... more details
PBB geneid 3164 The nerve Growthfactor IB NGFIB also known as Nur77 or NR4A1 nuclear receptor subfamily ... name pmid2626032 Nerve Growthfactor IB is a member of the Nur biology Nur nuclear receptor family ... factor s. ref name pmid3272167 cite journal author Milbrandt J title Nerve growthfactor induces a gene homologous to the glucocorticoid receptor gene journal Neuron volume 1 issue 3 pages 183 ... expression and posttranslational modification. ref name pmid16339277 Biochemistry Nerve Growthfactor ... Hiromura M, Suizu F, Narita M, Kinowaki K, Noguchi M title Identification of nerve growthfactor ... Nerve Growthfactor IB has the systematic Human Genome Organisation HUGO gene symbol NR4A1 ... nuclear receptor transcription factor, NURR1 journal Gene date 1997 03 10 accessdate 2007 12 20 pmid ... growthfactor induced clone B in rat s, Nur77 in mice and TR3 in human s. ref name pmid17407572 ... pmid 17407572 pmc 1852551 ref Pathology Along with 16 other genes, Nerve Growthfactor IB is a signature ... 2003 pmid 12469122 doi 10.1038 ng1060 issn ref Interactions Nerve Growthfactor IB has been shown ... hormone receptor gene related to the NUR 77 NGFI B genes. journal Cell Growth Differ. volume 2 issue ... Structure, mapping and expression of a growthfactor inducible gene encoding a putative nuclear ... author Chang C, Kokontis J, Liao SS, Chang Y title Isolation and characterization of human TR3 receptor a member of steroid receptor superfamily journal J. Steroid Biochem. volume 34 issue 1 6 pages ... by the orphan nuclear receptor Nur77 journal Mol. Endocrinol. volume 20 issue 4 pages 786 94 year 2006 ... Entrez Gene NR4A1 nuclear receptor subfamily 4, group A, member 1 url http www.ncbi.nlm.nih.gov ... factor kappa B complex, a ubiquitous transcription factor involved in cellular response to stress ... physiological stimuli such as fatty acids, stress, prostaglandins, growth factors, calcium, inflammatory ... ising with COUP TF an orphan nuclear receptor and retinoid X receptor RXR in mediating transcription ... more details
structure of nerve growthfactor in complex with the ligand binding domain of the TrkA receptor journal ... laydate quote ref and Low affinity nerve growthfactorreceptor . ref name pmid14985763 ref name ... neurotrophin 3 neurotrophin 4 nerve growthfactorreceptor Hericium erinaceus an edible mushroom that has ...PBB geneid 4803 Nerve growthfactor NGF , is a small secreted protein that is important for the growth ... ref It is perhaps the prototypical growthfactor , in that it is one of the first to be described. While nerve growthfactor refers to a single factor, ref MeshName Nerve GrowthFactor ref nerve ... pages 111 26 year 2004 pmid 14699960 doi 10.1016 S0079 6123 03 46008 1 url issn ref Nerve growthfactor ... NGF binds with at least two classes of receptors the p75 LNGFR for low affinity nerve growthfactor ... homeostasis . ref name pmid14699984 cite journal author Levi Montalcini R title The nerve growthfactor ... TL title New protein fold revealed by a 2.3 A resolution crystal structure of nerve growthfactor ... before. Hence NGF is the founding member of the neurotrophin nerve growthfactor family of structurally ... M., Blesch A. 2004 . Nerve growthfactor from animal models of cholinergic neuronal degeneration ... N title Expression of nerve growthfactor in the airways and its possible role in asthma journal Prog ... cite journal author Villoslada P, Genain CP title Role of nerve growthfactor and other trophic ... Nerve growthfactor and wound healing journal Prog. Brain Res. volume 146 issue pages 369 84 year ... s disease . ref cite journal author Counts S, Mufson E title The role of nerve growthfactor receptors ... growthfactor NGF has high levels when people first fall in love , but these levels return ... Raised plasma nerve growthfactor levels associated with early stage romantic love journal Psychoneuroendocrinology ... Calissano has suggested that nerve growthfactor may contribute to increased longevity and mental capacity ... of eternal life? date April 25, 2009 ref Interactions Nerve growthfactor has been shown to Protein ... more details