Infobox Disease Name Endometrioidtumor Image Caption DiseasesDB ICD10 ICD9 ICDO 8380 8381 OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D018269 Endometrioid tumors are a class of tumor characterized by a resemblance to endometrium ref name urlDorlands Medical Dictionary endometrioidtumor cite web url http www.mercksource.com pp us cns cns hl dorlands split.jsp?pg ppdocs us common dorlands dorland nine 13959057.htm title Dorlands Medical Dictionary endometrioidtumor work accessdate ref endometrial carcinoma, and over a third of cases have focal squamous differentiation. Ovary They are part of the surface epithelial stromal tumor surface epithelial tumor group of Ovarian cancer ovarian neoplasm s 10 20 of which are the endometrioid type . Benign and borderline variants are rare, as the majority are malignant . There is an association with endometriosis and concurrent primary endometrial carcinoma endometrial cancer . On gross pathology pathological examination, the tumor is cystic and may be solid and some arise in cystic endometriosis. In 40 of cases, endometrioid tumors are found bilaterally. ref Robbins and Cotran. Pathologic Basis of Disease. Saunders, 7th ed. ref Endometrium Endometrioid carcinoma can also arise in the endometrium. ref name pmid18156975 cite journal author Mulvany NJ, Allen DG title Combined large cell neuroendocrine and endometrioid carcinoma of the endometrium journal Int. J. Gynecol. Pathol. volume 27 issue 1 pages 49 57 year 2008 month January pmid 18156975 doi 10.1097 pgp.0b013e31806219c5 url http meta.wkhealth.com pt pt core template journal lwwgateway media landingpage.htm?issn 0277 1691&volume 27&issue 1&spage 49 ref ref MeshName Carcinoma, Endometrioid ref Grades 1 and 2 are considered type 1 endometrial cancer , while grade 3 is considered ... work accessdate 2010 03 24 ref References reflist Tumor histology Breast cancer urogenital neoplasia DEFAULTSORT EndometrioidTumor Category Gynecological cancer oncology stub ... more details
Image Hidradenoma.jpg thumb 200px Neoplasm Neoplastic tumor of the cheek skin, here a benign neoplasm of the sweat glands called Hidradenoma. A tumor or tumour is the name for a neoplasm or a solid lesion formed by an abnormal growth of cells termed Neoplasm neoplastic which looks like a swelling. ref DorlandsDict eight 000112106 Tumor ref Tumor is not synonymous with cancer . A tumor can be Benign neoplasm benign , pre malignant or malignant , whereas cancer is by definition malignant. Etymology The term tumour tumor is derived from the Latin word for swelling tumor and has come to the English language via the Old French tumour contemporary French tumeur . In the Commonwealth the spelling tumour is commonly used, whereas in the U.S. it is usually spelled tumor . In its medical sense it originally meant an abnormal swelling of the flesh. Celsus ca 30 BC 38 AD described four cardinal signs of acute inflammation as tumor , dolor , calor and rubor swelling, pain, increased heat and redness . But in contemporary English, tumor is synonymous with solid neoplasm , ref Tumor in http www.nlm.nih.gov ... by genetic mutation s. Most neoplasms cause a tumor, with a few exceptions like leukemia or carcinoma in situ . The nature of the tumor is determined by a Anatomical pathology pathologist after examination of the tumor tissues from a biopsy or a Surgery surgical excision specimen. References references ... tumor tumour http www.skintumor.info skintumor.info Gallery Tumors Inflammation Category Anatomical pathology Category Medical signs Category Oncology ar bs Tumor bg ca Tumor ceb Tumor cs Tumor da Tumor de Tumor es Tumor eo Tumoro eu Tumore fa fr Tumeur gl Tumor ko hi hr Novotvorina io Tumoro id Tumor it Tumore he ku T mor la Tumor lt Auglys hu Daganat ms Tumor nl Tumor ja no Svulst ps pl Guz medycyna pt Tumor ro Tumoare qu Q umpuyasqa ru sco Clyre scn Tumuri simple Tumour sk N dor sl Tumor sh Tumor fi Kasvain sv Tum r th tr T m r uk ... more details
A primary tumor is a tumor growing at the anatomical site where tumor progression began and proceeded to yield a cancerous mass. References Weinberg, Robert. The Biology of Cancer, 2007. Category Diseases and disorders disease stub de Prim rtumor ... more details
Vascular tumor may mean tumor of vascular origin , a growth Benign tumor benign or malignant formed from blood vessel s for example, hemangioma , hemangioendothelioma , Kaposi sarcoma , angiosarcoma , etc. a highly vascularized tumor or poorly vascularized tumor , referring to the degree of adequate or inadequate ischemic blood supply to a tumor formed from any biological tissue disambig ... more details
Tumor initiation is a process in which normal cells are changed so that they are able to form tumor s. Substances that cause cancer can be tumor initiators. See also Tumor promotion External links http www.cancer.gov Templates db alpha.aspx?CdrID 390314 Tumor initiation entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Oncology Oncology stub ... more details
A stromal tumor is a tumor that arises in the supporting connective tissue of an organ. External links http www.cancer.gov Templates db alpha.aspx?CdrID 44929 Stromal tumor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Types of cancer Oncology stub ... more details
A papillary tumor is a tumor shaped like a small mushroom , with its stem attached to the epithelial layer inner lining of an organ. External links http www.cancer.gov Templates db alpha.aspx?CdrID 46240 Papillary tumor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Oncology oncology stub ... more details
Infobox disease Name Warthin s tumor ICD10 ICD10 D 11 d 10 ICD9 ICD9 210.2 ICDO 8561 0 Image Warthin s tumor.jpg Caption This Warthin s tumor presented as a parotid mass in a middle aged male, who underwent superficial parotidectomy. The tumor, at the right of the image, is well demarcated from the adjacent ... Warthin s tumor or Warthin tumour , also known as wiktionary Papillary papillary cystadenoma lymphomatosum or adenolymphoma, is a type of benign tumor of the salivary glands . Etiology Its etiology ... times greater risk of developing Warthin s tumor than the general population. ref name robbins ... than pleomorphic adenoma , Warthin s tumor is the second most common benign parotid tumor. Characteristic ... tumor arising from the parotid gland. Warthin s tumor primarily affects older individuals age 60&ndash ... been associated with a strong male predilection. This change is possibly due to the tumor s association with cigarette smoking and the growing use of cigarettes by women. The tumor is slow growing ... mandible . In 5&ndash 14 of cases, Warthin s tumor is bilateral, but the two masses usually are at different times. Warthin s tumor is highly unlikely to become malignant . Histology The appearance of this tumor under the microscope is unique. There are cystic spaces surrounded by two uniform rows ... images gallery Image Warthin tumor 1 .jpg Histopathology of Warthin tumor in the parotid gland. H&E stain. Image Warthin tumor 2 .jpg Histopathology of Warthin tumor in the parotid gland. Another view of a file Warthin tumor 1 .jpg . H&E stain. Image Warthin tumor 3 .jpg Histopathology of Warthin tumor in the parotid gland. Higher magnification of a file Warthin tumor 1 .jpg . H&E stain. Image Papillary cystadenoma lymphomatosum2.jpg Intermediate magnification micrograph of a Warthin tumor . Image Papillary cystadenoma lymphomatosum3.jpg High magnification micrograph of a Warthin tumor showing ... nci Warthin s Tumor Overview Tumor histology Tumors of lip, oral cavity and pharynx ... more details
Tumor antigen is an antigen ic substance produced in tumor Cell biology cells , i.e., it triggers an immune response in the Host biology host . Tumor antigens are useful in identifying tumor cells and are potential candidates for use in cancer therapy . Mechanism of tumor antigenesis Normal protein s in the body ... of tumor antigens Initially they were broadly classified into two categories based on their pattern of expression Tumor Specific Antigens TSA , which are present only on tumor cells and not on any other cell and Tumor Associated Antigens TAA , which are present on some tumor cells and also some normal cells. This classification, however,is imperfect because many antigens thought to be tumor specific turned out to be expressed on some normal cells as well. The modern classification of tumor ... needed date June 2010 Products of Mutated Oncogenes and Tumor Suppressor Genes Products of Other Mutated Genes Overexpressed or Aberrantly Expressed Cellular Proteins Tumor Antigens Produced ... Specific Differentiation Antigens Types Any protein produced in a tumor cell that has an abnormal structure due to mutation can act as a tumor antigen. Such abnormal proteins are produced due to mutation of the concerned gene . Mutation of protooncogene s and tumor suppressor s which lead to abnormal protein production are the cause of the tumor and thus such abnormal proteins are called tumor specific antigens . Examples of tumor specific antigens include the abnormal products of ras and p53 genes. In contrast, mutation of other genes unrelated to the tumor formation may lead to synthesis of abnormal proteins which are called tumor associated antigens . Proteins that are normally produced in very low quantities but whose production is dramatically increased in tumor cells, trigger an immune ... in melanoma cells. Oncofetal antigen s are another important class of tumor antigens. Examples are alphafetoprotein ... s may also have an abnormal structure in tumor cells and could thus be targets of the immune system ... more details
Glial tumor is a general term for numerous tumors of the central nervous system , including astrocytomas , ependymal tumor s, glioblastoma multiforme , and primitive neuroectodermal tumor s. External links http www.cancer.gov Templates db alpha.aspx?CdrID 45697 Glial tumor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict oncology stub Category Types of cancer Category Neurology ... more details
Tumor promotion is a process in which existing tumors are stimulated to grow. Tumor promoters are not able to cause tumors to form. See also Tumor initiation External links http www.cancer.gov Templates db alpha.aspx?CdrID 390316 Tumor promotion entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Oncology Oncology stub ... more details
Infobox Disease Name Neuroectodermal tumor Image Caption DiseasesDB ICD10 ICD9 ICDO OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D018358 A neuroectodermal tumor is a tumor of the central nervous system central or peripheral nervous system . See also Neuroendocrine tumors Neuroectoderm Primitive neuroectodermal tumor PNET Medulloblastoma External links http www.cancer.gov Templates db alpha.aspx?CdrID 45952 Neuroectodermal tumor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Central nervous system tumors Category Anatomical pathology Category Medical signs Category Oncology Category Oncology stubs oncology stub ... more details
An ependymal tumor is a type of brain tumor that begins in cells lining the spinal cord central canal fluid filled space down the center or the Ventricular system ventricles fluid filled spaces of the brain . Ependymal tumors may also form in the choroid plexus tissue in the ventricles that makes cerebrospinal fluid . Also called ependymoma . External links http www.cancer.gov Templates db alpha.aspx?CdrID 45679 Ependymal tumor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Central nervous system tumors Category Brain tumor oncology stub ... more details
A Mixed tumor is a tumor that derives from multiple tissue types. ref http medical dictionary.thefreedictionary.com mixed tumor ref For example, a Chondroid syringoma is a cutaneous condition characterized histology histologically by nests of cuboidal or polygonal epithelial cells in the dermis . ref name Andrews cite book author James, William D. Berger, Timothy G. et al. title Andrews Diseases of the Skin clinical Dermatology publisher Saunders Elsevier location year 2006 pages isbn 0 7216 2921 0 oclc doi accessdate ref rp 667 See also Malignant mixed tumor Cylindroma List of cutaneous conditions References reflist Epidermal growth stub Category Epidermal nevi, neoplasms, cysts ... more details
Orphan date February 2009 A functioning tumor is a tumor that is found in endocrine tissue and makes hormones chemicals that travel in the bloodstream and control the actions of other cells or organs . External links http www.cancer.gov Templates db alpha.aspx?CdrID 458094 Functioning tumor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Category Oncology oncology stub ... more details
A Tumor Bank , as used in this article, is a term commonly used to describe a service that collects, stores and distributes fresh human tumor tissue for the purposes of biomedical research, primarily cancer research. A Tumor Bank is sometimes also referred to as a Tissue Bank , since normal tissues for research are also often collected. However, this function is distinct from a Tissue bank Tissue Bank which collects and harvests human cadaver tissue for medical research and education, and banks which store Biomedical tissue for organ transplantation. Cancer Samples Most tumor banks collect their tumor samples from discarded tissues not needed for pathologic diagnosis, after patients undergo surgery to remove the tumor. The tissue is often snap frozen in liquid nitrogen but may also be preserved in special fixative such as RNAlater which preserves RNA , or formalin which preserved tissue architecture. Many NCI designated Cancer Center Cancer Centers in the U.S. have a Tumor Bank to supply biomedical scientists with actual patient samples of cancer and associated adjacent normal tissue. This process is currently a high priority to support more Translational Research . See also Cooperative Human Tissue Network CHTN References cite journal author Hidalgo DO, Entrena NR title Tumor Banks for genomic and proteomic research journal Clinical and Translational Oncology volume 6 pages 381 390 year 2004 url http www.springerlink.com content x764rw76q2268446 cite journal author Isabelle M, Teodorovic I, Morente MM, et al. title TuBaFrost 5 multifunctional central database application for a European tumor bank journal Eur. J. Cancer volume 42 issue 18 pages 3103 9 year 2006 month December pmid 17029787 doi 10.1016 j.ejca.2006.04.032 External links http www.umassmed.edu cancercenter tissuebank index.aspx UMass Cancer Center Tumor Bank http www.cancerdiagnosis.nci.nih.gov specimens National Cancer Institute Human specimens for research Category Medical research ... more details
Infobox Disease Name PAGENAME Image Adenomatoid tumour b very high mag.jpg Caption High magnification micrograph of an adenomatoid tumor. H&E stain . DiseasesDB ICD10 ICD9 ICDO 9054 0 OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D018254 Adenomatoid tumor is a benign mesothelial tumor . It generally presents in the genital tract, in regions such as the testis ref cite journal author Williams SB, Han M, Jones R, Andrawis R title Adenomatoid tumor of the testes journal Urology volume 63 issue 4 pages 779 81 year 2004 pmid 15072910 doi 10.1016 j.urology.2003.11.035 ref and epididymis . ref name titleAdenomatoid tumor of the epididymis cite web url http www.gfmer.ch selected images v2 detail list.php?cat1 6&cat3 139&stype d title Adenomatoid tumor of the epididymis accessdate 2007 12 15 format work ref However, it also has been found in the pancreas . ref name titleModern Pathology Adenomatoid Tumor of the Pancreas A Case Report with Comparison of Histology and Aspiration Cytology cite journal author Overstreet K, Wixom C, Shabaik A, Bouvet M, Herndier B title Adenomatoid tumor of the pancreas a case report with comparison of histology and aspiration cytology journal Mod Pathol. volume 16 issue 6 pages 613 7 year 2003 month Jun pmid 12808068 doi 10.1097 01.MP.0000072803.37527.C8 url http www.nature.com modpathol journal v16 n6 full 3880812a.html ref In the female, it has been found in the body of the uterus and the fallopian tube . ref cite journal author Huang CC, Chang DY, Chen CK, Chou YY, Huang SC title Adenomatoid tumor of the female genital tract journal Int J Gynaecol Obstet volume 50 issue 3 pages 275 80 year 1995 month Sep pmid 8543111 doi 10.1016 0020 7292 95 02453 J url http linkinghub.elsevier.com retrieve pii 002072929502453J ref References reflist neoplasm stub Soft tissue tumors and sarcomas Category Benign neoplasms ... more details
Infobox Disease Name Wilms& 39 tumor Image Wilms tumor.jpg Caption Cut section showing two halves of a nephroblastoma ... of tumor into the renal pelvis, resembling botryoid rhabdomyosarcoma. DiseasesDB 8896 ICD10 ICD10 ... med eMedicineTopic 3093 eMedicine mult eMedicine2 ped 2440 MeshID D009396 Image Wilms Tumor CTScan.OGG thumb right thumbtime 3 Computed tomography CT Scan of 11 cm Wilms tumor of right kidney in 13 month old patient. Wilms tumor or nephroblastoma is cancer of the kidney s that typically occurs ... , referring to Dr. Max Wilms , the German surgeon 1867&ndash 1918 who first described this kind of tumor ... specimen of adult Wilms tumor. Image Adult Wilms tumour 2.JPEG thumb Tubular pattern resembling .... In cases of metastasis it is usually to the lung. A rupture of Wilms tumor puts the patient at risk of hemorrhage and peritoneal dissemination of the tumor. In such cases, surgical intervention by a surgeon who is experienced in the removal of such a fragile tumor is imperative. Pathologically, a triphasic nephroblastoma comprises three elements blastema mesenchyme epithelium Wilms tumor is a malignant tumor containing metanephric blastema , stromal and epithelial derivatives. Characteristic ... may include striated muscle , cartilage , bone , fat tissue, fibrous tissue. The tumor is compressing ... poorly developed cells Prognosis Tumor specific loss of heterozygosity LOH for chromosomes 1p and 16q identifies a subset of Wilms tumor patients who have a significantly increased risk of relapse ... R, Tomlinson G, Huff V, Green DM National Wilms Tumor Study Group. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable histology Wilms tumor a report from the National Wilms Tumor Study Group. J Clin Oncol. 2005 Oct 10 23 29 7312 21. ref Genome wide copy number and LOH status can be assessed with Virtual Karyotype virtual karyotyping of tumor cells fresh ... of a zinc finger polypeptide gene at the human chromosome 11 Wilms tumor locus journal Cell volume 60 ... more details
Infobox Disease Name Pancoast tumor Image Pancoast Tumor 1.jpg Caption Chest radiograph showing a Pancoast tumor labeled as P, non small cell lung carcinoma, right lung , from a 47 year old female smoker. DiseasesDB 31266 ICD10 ICD10 C 34 1 c 30 ICD9 ICD9 162.3 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 3418 MeshID D010178 A Pancoast tumor , also called a pulmonary sulcus tumor or superior sulcus tumor , is a lung cancer tumor of the lung pulmonary apex. It is a type of lung cancer defined primarily by its location situated at the top end of either the right or left lung . It typically ... cancers. The growing tumor can cause compression of a brachiocephalic vein , subclavian artery , phrenic ..., fever, weight loss and fatigue, Pancoast tumor can include a complete Horner s syndrome in severe ... pain and weakness in the muscles of the arm and hand . The tumor can also compress the right recurrent ... syndrome , obstruction of the superior vena cava by a tumor mass effect causes facial swelling, cyanosis and dilatation of the veins of the head and neck. A Pancoast tumor is an apical tumor that is typically ..., rapid onset of clinical signs and symptoms, and pleuritic pain can suggest an apical tumor. A Pancoast tumor can give rise to both Pancoast syndrome and Horner s syndrome. When the brachial plexus ... watch?v x67dV8n7asI gallery Image Pancoast Tumor 2.jpg CT scan showing a Pancoast tumor labeled ... references External links eMedicine radio 515 Pancoast Tumor http meded.ucsd.edu isp 1994 im quiz pancoast.htm Pancoast Tumor UCSD Xray http www.cancer.gov Templates db alpha.aspx?CdrID 44446 Pulmonary sulcus tumor entry in the public domain NCI Dictionary of Cancer Terms NCI cancer dict Respiratory tract neoplasia Category Lung cancer Category Pulmonology Category Types of cancer ca Tumor de Pancoast de Pancoast Tumor es S ndrome de Pancoast Tobias fr Syndrome de Pancoast Tobias it Sindrome di Pancoast nl Pancoasttumor pl Guz Pancoasta pt Tumor de Pancoast ru ... more details
no footnotes date July 2009 Tumor M2 PK is a synonym for the Dimer chemistry dimeric form of the pyruvate kinase isoenzyme type M2 PKM2 . Tumor M2 PK is a key enzyme within tumor metabolome tumor metabolism ... bowel cancer and in EDTA blood plasma plasma samples for the follow up of various cancer s. Tumor M2 PK is not an organ specific tumor marker , such as prostate specific antigen PSA . As a biomarker the amount of Tumor M2 PK in stool and EDTA plasma reflects the specific metabolic status of the tumors. Sandwich ELISA ELISA s based on two monoclonal antibodies which specifically recognize Tumor M2 PK the dimeric form of M2 PK are available for the quantification of Tumor M2 PK in stool and EDTA plasma samples respectively. Tumor M2 PK screening for the early detection of colorectal tumors and polyps ... Tumor M2 PK as a biomarker for the early detection of colorectal tumors bowel cancer , have revealed ... tumor patients. For polyps with a diameter larger than 1 cm the sensitivity was 60 for polyps ... of Tumor M2 PK in stool samples, with follow up by colonoscopy to clarify the Tumor M2 ... research is needed before the test can be recommended as a screening procedure. Tumor M2 PK measurements ... increased amount of Tumor M2 PK in EDTA plasma samples of patients with renal, lung, breast ... skin cancer , which correlated with the cancer staging tumor stage . The combination of Tumor M2 PK with the appropriate classical tumor marker, such as carcinoembryonic antigen CEA for bowel cancer ... to detect various cancers. An important application of the Tumor M2 PK test in EDTA plasma is for follow up during tumor therapy, to monitor the success or failure of the chosen treatment, as well as predicting the chances of a cure and survival. If Tumor M2 PK levels decrease during therapy and then remain low after therapy it points towards successful treatment. An increase in the Tumor M2 PK values during or after therapy points towards relapse and or metastasis. Increased Tumor M2 PK ... more details
The term tumor metabolome describes the characteristic metabolic phenotype of tumor cells. Comparison of the metabolic characteristics of different tumor cell lines and tumors revealed that during tumorigenesis, the same alterations always occur in distinct metabolic parameters regardless of the basic metabolism of the tissues from which the tumor developed, such as brain or liver and regardless of the molecular mechanism by which tumorigenesis was induced. The characteristic attributes of the tumor metabolome are high glycolysis glycolytic enzyme activities the expression of the pyruvate kinase isoenzyme type M2, which is mainly in its dimeric form Tumor M2 PK increased channeling of glucose carbons into synthetic processes, such as nucleic acid , amino acid and phospholipid synthesis a high rate of pyrimidine and purine de novo synthesis a low ATP GTP CTP UTP ratio low AMP levels high glutaminolysis glutaminolytic capacities release of immunosuppressive substances dependency on methionine References cite journal last Mazurek first S. coauthors Grimm H. Boschek CB Vaupel P Eigenbrodt E title Pyruvate kinase type M2 a crossroad in the tumor metabolome journal The British Journal of Nutrition month January year 2002 volume 87 issue S1 pages S23 S29 pmid 11895152 doi 10.1079 BJN2001455 cite journal last Mazurek first S. coauthors Eigenbrodt E. title The tumor metabolome journal Anticancer Research month March April year 2003 volume 23 pages 1149 1154 pmid 12820363 issue 2A External links http www.metabolic database.com metabolic database Category Metabolism Category Oncology oncology stub ... more details
Infobox Disease Name Odontogenic tumor Image Caption DiseasesDB ICD10 ICD9 ICDO 9270 9349 OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D009808 A odontogenic tumor is a neoplasm of the cells or tissues that initiate Odontogenic processes. An example is ameloblastoma . Odontogenic tumors Category Anatomical pathology Category Oncology Category Types of cancer Category Oral pathology disease stub ja ... more details
Tumor hypoxia is the situation where tumor cell biology cells have been deprived of oxygen . As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. Hypoxic tumor cells are usually resistant to radiotherapy and chemotherapy , ref W. A. Denny, Prodrug strategies in cancer therapy, Eur. J. Med. Chem., 2001, 36, 577 595 ref but they can be made more susceptible to treatment by increasing the amount of oxygen in them. Bioreductive prodrugs also play a significant part in dealing with these kinds of cells they can kill the oxygen deficient tumor cells selectively as hypoxic cytotoxins . The study of tumors in such conditions was pioneered by Louis Harold Gray Dr L. H. Gray . It can also be a result of the high degree of cell proliferation undergone in tumor tissue, causing a higher cell density, and thus taxing the local oxygen supply. There are several companies working to address tumor hypoxia Novacea, Inc., Proacta Inc. and Threshold Pharmaceuticals, Inc. These companies are developing the following drug candidates AQ4N Novacea , PR 104 Proacta and TH 302 Threshold Pharmaceuticals . These drug candidates target levels of hypoxia that are common in tumors but are rare in normal tissues. The hypoxic zones of tumors generally evade traditional chemotherapeutic agents and ultimately contribute to relapse. In the literature, hypoxia has been demonstrated to be associated .... ref Association between tumor hypoxia and malignant progression in advanced cancer of the uterine ... tumor hypoxia in cancer treatment J.M. Brown and W.R. Wilson Nat.Rev.Canc.4,437, 2004. ref ref Hypoxia targeting the tumor R.G. Boyle and S. Travess Anticancer Agents Med. Chem. 64 281, 2006. ref ... and radio sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. Niacinamide ... Richard Sullivan, Charles H. Graham Cancer Metastatis Review 2007 26 319 331 DEFAULTSORT Tumor ... more details
Infobox Disease Name Krukenberg tumor Image Krukenberg Tumor.jpg Caption Krukenberg Tumor DiseasesDB 30081 ICD10 ICD10 C 56 c 51 ICD9 ICD9 183 ICDO 8490 6 OMIM MedlinePlus eMedicineSubj eMedicineTopic MeshID D007725 A Krukenberg tumor , also Krukenberg tumour , classically refers to a metastatic ovarian malignancy whose primary site arose in the gastrointestinal tract or breast. Diffuse gastric carcinoma ... secreting signet ring cell s in the tissue of the ovary when the primary tumor is discovered, the same signet ring cells are typically found. Historical The Krukenberg tumor is named after Friedrich Ernst ... females, around or following menopause . Symptoms Patients with Krukenberg tumor often come to the attention ... of the tumor cells from the stomach, appendix or colon to the ovaries classically it was thought that direct seeding across the abdominal cavity accounted for the spread of this tumor, but recently ... apron which envelops the organs of the abdomen and lies between the stomach and ovaries , and that the tumor ... tumors. Citation needed date January 2010 Although a Krukenberg tumor is most commonly a metastasis ... have appeared in the medical literature. A metastatic tumor originating in the breast may also fit the category of Krukenberg tumor if it expresses intracellular mucin and displays positive .... Vol 2, p1708, 2004 ref Treatment and Prognosis Since the Krukenberg tumor is a secondary metastatic tumor, management of the tumor must involve finding and treating the primary cancer. In general, most cases of Krukenberg tumor have a poor prognosis and radical operation such as removal of the ovaries ... and radiotherapy before surgery may be used to shrink the tumor and facilitate its removal ... urogenital neoplasia Digestive system neoplasia DEFAULTSORT Krukenberg Tumor Category Gastrointestinal cancer Category Gynecological cancer de Krukenberg Tumor fr Tumeur de Krukenberg pl Guz Krukenberga pt Tumor de Krukenberg fi Krukenbergin tuumori ... more details
mucinous tumor, however this is a rare cause of this condition, which is a rare condition. A more common cause of pseudomyxoma peritonei is a mucin producing tumor of the appendix. Since mucinous ... ovaries with a mucinous tumor suggests that the tumor may have arisen in another location, and further ... mucinous cystadenocarcinomas, the survival is approximately 66 . DEFAULTSORT Mucinous Tumor ... more details
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