3 which acts as a deoxyribozyme that uses light to repair a thymine dimer , using ... 14691255?dopt Abstract title A deoxyribozyme that harnesses light to repair thymine dimers in DNA. author ... ref ref cite web url http intl.pnas.org content 101 1 65.full title A deoxyribozyme that harnesses light ... j.molcatb.2004.01.016 ref . See also Ribozyme References references External links MeshName Deoxyribozyme ... more details
Dz13 is an experimental treatment developed by Australia n scientists which aims to combat a range of illnesses from diabetes to Heart Disease heart disease and cancer . How it works Dz13 is a Deoxyribozyme DNAzyme that targets c Jun , a transcription factor found in diseased blood vessels, eyes, lungs and joints. The treatment works by destroying RNA , essentially inhibiting c Jun expression in cells. ref name Dass2008 The potential of Dz13 as a therapeutic derives from the fact that deactivation of c Jun can have an effect on Upstream and downstream transduction downstream gene genes such as MMP 2 , MMP 9 , VEGF and FGF 2 . ref name Fahmy2006 Dz13 in cancer Dz13 has been shown to inhibit tumour growth and angiogenesis in Squamous cell carcinoma . ref name Fahmy2006 Anti cancer effects have also been demonstrated in models of prostate cancer , breast cancer and osteosarcoma . ref name Tan2010 Clinical trials of Dz13 in patients with skin cancer basal cell carcinoma commenced in 2010. ref name ACT2010 References Reflist refs ref name Dass2008 Dass, C.R. et al 2008 . DNAzyme technology and cancer therapy cleave and let die. Mol Cancer Ther. 7 2 243 51. ref ref name Fahmy2006 Fahmy, R. et al 2006 . Suppression of vascular permeability and inflammation by targeting of the transcription factor c Jun. Nat Biotechnol. 24 7 856 863. ref ref name Tan2010 Tan, M.L. et al 2010 . Direct anti metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP 2, MMP 9 and MT1 MMP in tumours. Cancer Cell Int. 10 9. ref ref name ACT2010 Australian Cancer Trials 2010 . A phase I study of the Dz13 drug targeting the c Jun gene in subjects with skin cance nodular Basal Cell Carcinoma . http www.australiancancertrials.gov.au search clinical trials search results clinical trials details.aspx?TrialID 335133&ds 1 . ref External links http www.smh.com.au news National New super drug may combat cancer 2006 07 03 1151778858991.html New super drug may combat cancer Category Experimental medica ... more details
, enzymes, DNA tiling, and polymerase chain reaction . DNAzymes Catalytic DNA deoxyribozyme ... I ref cite journal author Milan Stojanovic, Darko Stefanovic date 2003 title A Deoxyribozyme ... title Deoxyribozyme Based Logic Gates journal Journal of the American Chemical Society volume 124 ... Versatility of 8 17 Deoxyribozyme journal Chemistry & Biology volume 11 issue 1 pages 57 67 pmid ... more details
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