protein Name deoxyribonucleaseII alpha caption image width HGNCid 2960 Symbol DNASE2 AltSymbols DNASE2A, DRN2, DNL, DNL2 EntrezGene 1777 OMIM 126350 RefSeq NM 001375 UniProt O00115 PDB ECnumber 3.1.22.1 Chromosome 19 Arm p Band 13.2 LocusSupplementaryData protein Name deoxyribonucleaseII beta caption image width HGNCid 28875 Symbol DNASE2B AltSymbols EntrezGene 58511 OMIM 608057 RefSeq NM 021233 UniProt Q8WZ79 PDB ECnumber 3.1.22.1 Chromosome 1 Arm p Band 22.3 LocusSupplementaryData DeoxyribonucleaseII , or Acid DNase, hydrolyzes deoxyribonucleotide linkages in native and denatured DNA, yielding products with 3 phosphates. As the name implies, it is more effective at acid pH. There are several known DNases II, including DNase II alpha usually just called DNase II DNase II beta also called DLAD, or DNase II Like Acid DNase External links MeshName deoxyribonucleaseII hydrolase stub Nucleases Category EC 3.1.21 ... more details
Image DNase1.jpg thumb right Crystals of DNase protein. A deoxyribonuclease DNase , for short is any enzyme that catalyzes the hydrolysis hydrolytic cleavage of phosphodiester bonds phosphodiester linkages in the DNA backbone. Thus, deoxyribonucleases are one type of nuclease . A wide variety of deoxyribonucleases are known, which differ in their substrate biochemistry substrate specificities, chemical mechanisms, and biological functions. Modes of action Some DNases cleave only residues at the ends of DNA molecules exodeoxyribonuclease s, a type of exonuclease . Others cleave anywhere along the chain endodeoxyribonuclease s, a subset of endonuclease s . Some are fairly indiscriminate about the DNA sequence at which they cut, while others, including restriction enzyme s, are very sequence specific. Some cleave only double stranded DNA others are specific for single stranded molecules and still others are active toward both. DNase enzymes can be inhaled using a nebuliser by cystic fibrosis sufferers. DNase enzymes help because white blood cells accumulate in the mucus, and, when they break down, they release DNA, which adds to the stickiness of the mucus. DNase enzymes break down the DNA, and the mucus is much easier to clear from the lungs. Types of deoxyribonucleases The two main types of DNase found in metazoans are known as deoxyribonuclease I and deoxyribonucleaseII . Other types of DNase include Micrococcal nuclease . Assay of deoxyribonucleases DNA absorbs UV light with a wavelength of maximal absorbance near 260 nm. This absorption is due to the pi electrons in the aromatic bases of the DNA. In dsDNA, or even regions of RNA where double stranded structure occurs, the bases are stacked parallel to each other, and the overlap of the base molecular orbitals leads to a decrease in absorbance of UV light. This phenomenon is called the hyperchromic effect. When DNAse liberates nucleotides from dsDNA, the bases are no longer stacked as they are in dsDNA, so that orbital ... more details
Deoxyribonuclease IV is a type of deoxyribonuclease that functions at AP sites. See also phage T4 External links MeshName Deoxyriboendonuclease IV EC number 3.1.21.2 cite journal author Lindahl T, Gally JA, Edelman GM title Deoxyribonuclease IV a new exonuclease from mammalian tissues journal Proc. Natl. Acad. Sci. U.S.A. volume 62 issue 2 pages 597 603 year 1969 pmid 5256235 doi 10.1073 pnas.62.2.597 pmc 277851 Nucleases hydrolase stub biochem stub Category EC 3.1.21 ... more details
PBB geneid 1773 Deoxyribonuclease I usually called DNase I , is an endonuclease coded by the human gene DNASE1 . ref name entrez cite web title Entrez Gene DNASE1 deoxyribonuclease I url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1773 accessdate ref DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide , yielding 5 phosphate terminated polynucleotides with a free hydroxyl group on position 3 , on average producing tetranucleotides. It acts on single stranded DNA, double stranded DNA, and chromatin . It has been suggested to be one of the deoxyribonuclease s responsible for DNA fragmentation during ... polymorphic deoxyribonuclease purification, characterization, and multiplicity of urine deoxyribonuclease ... journal author Kishi K, Yasuda T, Ikehara Y, et al. title Human serum deoxyribonuclease I DNase I polymorphism ... journal author Kishi K, Yasuda T, Awazu S, Mizuta K title Genetic polymorphism of human urine deoxyribonuclease ... interleukin 1 inhibitor. Homology with deoxyribonuclease I. journal J. Exp. Med. volume 168 issue ... T, Nadano D, Takeshita H, et al. title Molecular analysis of the third allele of human deoxyribonuclease ... A title Structure of the human deoxyribonuclease I DNase I gene identification of the nucleotide ... author Yasuda T, Nadano D, Iida R, et al. title Chromosomal assignment of the human deoxyribonuclease ... deoxyribonuclease I identification of the nucleotide substitution that generates the fourth allele ... 95 00037 A cite journal author Yasuda T, Nadano D, Tenjo E, et al. title Genotyping of human deoxyribonuclease ... polymorphic site in human deoxyribonuclease I DNase I . journal Hum. Genet. volume 98 issue ... M, et al. title The fifth allele of the human deoxyribonuclease I DNase I polymorphism. journal ... deoxyribonuclease I polymorphism encodes an Arg to Cys substitution responsible for its instability ... year 2002 pmid 12005024 doi 10.1023 A 1014999624430 refend External links MeshName deoxyribonuclease ... more details
Ii or ii can refer to ii digraph , a digraph in certain romanized alphabets Ii, Finland , a municipality of Finland Ii is a Japanese surname , daimyo of Hikone Ii clan , Japanese clan Sengoku period Ii Naomasa , one of four Guardians of the Tokugawa clan iiNet , a major Australian Internet service provider trading as simply iiIi irc client an IRC client with a filesystem interface. 2 number , in lowercase Roman numerals Illegal immigrant especially in Hong Kong vernacular Invariant chain ref http www.cryst.bbk.ac.uk pps97 assignments projects coadwell 007.htm School of Crystallography The Invariant chain ref John Papa , Hawaiian noble Yi language ISO 639 alpha 2, ii Supertonic , in music References reflist See also II disambiguation disambig Category Surnames eo Ii no Ii pt II fi Ii t smennyssivu ... more details
Refimprove date July 2009 Infobox rocket stage name S II image ap6 MSFC 6758331.jpg caption The Apollo 6 S II stage during stacking operations in the Vehicle Assembly Building VAB manufacturer North American ... LH2 The S II pronounced ess two was the second stage of the Saturn V rocket. It was built by North ... building in Seal Beach, CA The beginning of the S II came in December 1959 when a committee recommended ... time the S II stage design began to take shape. Initially it was to have four J 2 engines and be 22.5 ... second stage.jpg left thumb Cutaway illustration of the S II second stage When fully loaded with propellant, the S II had a mass of about 481 tonne s. The hardware was only 7.6 of this 92.4 was liquid ... like the S IC , the S II used a common bulkhead that included both the top of the LOX tank and bottom .... The final method was to spray insulation on by hand and trim the excess. The S II was constructed ... efefef Current location style background efefef Notes S II F Used as Dynamic Test Stage replacement after destruction of S II S D and S II T At the U.S. Space & Rocket Center , Huntsville, Alabama Huntsville , Alabama br coord 34.710544 86.657185 format dms type landmark region US AL name S II F S II T Destroyed in explosion May 28, 1966 S II D Construction canceled S II S D Structural and Dynamic Test Vehicle Destroyed in test stand September 29, 1965 S II 1 Apollo 4 November 9, 1967 coord 32 12 N 39 40 W name S II 1 Carried Camera Targets spaced around the forward skirt and carried cameras to record first stage separation S II 2 Apollo 6 April 4, 1968 carried cameras to record first stage separation S II 3 Apollo 8 December 21, 1968 coord 31 50 N 38 0 W name S II 3 S II 4 Apollo 9 March 3, 1969 coord 31 28 N 34 2 W name S II 4 1800 kg lighter allowing 600 kg more payload, more powerful engines and carried more LOX S II 5 Apollo 10 May 18, 1969 coord 31 31 N 34 31 W name S II 5 S II 6 Apollo 11 July 16, 1969 coord 31 32 N 34 51 W name S II 6 S II 7 Apollo 12 November 14 ... more details
Infobox film name Troll II Part II image director Claudio Fragasso story Rossella Drudi and br Claudio Fragasso Troll II Part II Troll 2 Part 2 will be a horror film and sequel of the film Troll II , The film is being planned by Claudio Fragasso . After the phenomena of Troll 2 gaining and becoming a cult classic as the Worst Movie of All Time and recent success over the past years, Fragasso and writer Rossella Drudi announced plans for a sequel to Troll II, there was a poll taken from a Troll II screening audience that they took on what the movie should be named, The title ended up being dubbed Troll II Part II, a fitting title since Troll II had nothing to do with Troll 1. Fragasso asked Stephenson to be apart of the sequel. There has not been any further details about Troll II Part II. References External links Troll II Part II at http en.wikipedia.org wiki Troll 2 Troll II Part II at http www.f13community.com board showthread.php?t 3305 Troll II Part II at http www.horrorforum.com showthread.php?t 13944 Troll II Part II at http www.timewinds.com clive forum viewtopic.php?t 350&sid 7a490455732f3a7969bf67322bf46aae Troll II Part II at http www.bloodsprayer.com news troll 2 part 2 a new interview with george hardy unearths the dirt Categories Uncategorized date March 2011 Category Articles created via the Article Wizard ... more details
Anastasius II or Anastasios II could refer to Anastasios II emperor Pope Anastasius II disambig bg II fr Anastase II gl Anastasio II hr Anastazije II. it Anastasio II he la Anastasius II fi Anastasius II ... more details
Ramiro II may refer to Ramiro II of Le n died 951 Ramiro II of Aragon died 1157 hndis an Remiro II ca Ramir II es Ramiro II fr Ramiro II gl Ramiro II pt Ramiro II ru II ... more details
Boleslaus II Boleslav II, Boleslaw II, Boles aw II may refer to Boleslaus II of Bohemia died 999 Boleslaus II of Poland ca. 1041 or 1042 1081 or 1082 Boles aw II of Cieszyn ca. 1425 28 1452 Boles aw II the Bald Boleslaus II of Masovia See also Boleslaus disambiguation , other kings of this name hndis bs Boleslav II vor cs Boleslav II. rozcestn k lv Bo eslavs II nl Boleslav II pl Boles aw II sv Boleslav II ... more details
Class II may refer to Class II appliance Class II bacteriocin Class II cabinet Class II gene Class II PI 3 kinases Class II railroad Class II star MHC class II dab Long comment to avoid being listed on short pages ... more details
Alexius II may refer to Alexius II Comnenus 1167 1183 , Byzantine Emperor Alexius II of Trebizond 1297 1330 , Emperor of Trebizond Patriarch Alexius II 1990 2008 , Patriarch of Moscow and All Russia hndis Alexius II de Alexios II. fr Alexis II it Alessio II la Alexius II nl Alexius II pl Aleksy II pt Alexis II ru II ... more details
Eric II may refer to Eric II of Denmark c. 1090 1137 Eric II of Norway 1268 1299 Eric II, Duke of Schleswig c. 1290 1325 Eric II of Pomerania between 1418 and 1425 1474 Eric II, Duke of Calenberg 1528 1584 hndis Eric II fr ric II ... more details
Isabel II can refer to Queen Isabella II of Spain Spanish cruiser Isabel II Isabel II , a Spanish cruiser that fought in the Spanish American War. Queen Elizabeth II of the United Kingdom disambig an Isabel II ast Sabela II ca Isabel II ceb Isabel II es Isabel II eu Isabel II.a gl Isabel II pt Isabel II ... more details
George II may refer to George II of Abkhazia 916 960 George II of Georgia 1072 1089 Yuri II of Vladimir or George II 1212 1216, 1218 1237 George II of Bulgaria 1321 1322 George II of Kakheti 1511 1513 George II of Imereti 1565 1585 George II, Landgrave of Hesse Darmstadt 1605 1661 George II of Great Britain 1683 1760 George Tupou II of Tonga 1874 1918 He s really Tupou II, not George II, but it does no harm having him here. George II of Greece 1890 1947 See also ura II , of Zeta died 1403 hndis George II de Liste der Herrscher namens Georg Georg II. es Jorge II fr Georges II it Giorgio II he ka II hu II. Gy rgy egy rtelm s t lap nl George II ja 2 pl Jerzy II ru II sk Juraj II. fi Yrj II sv Georg II tr II. George uk II zh ... more details
Maximilian II may refer to Maximilian II of Burgundy 1514 1558 Maximilian II, Holy Roman Emperor 1527 1576 Maximilian II Emanuel, Elector of Bavaria 1662 1726 Maximilian II of Bavaria 1811 1864 hndis Maximilian II bg II cs Maxmili n II. de Maximilian II. et Maximilian II ko 2 it Massimiliano II lv Maksimili ns II nl Maximiliaan II ja 2 pt Maximiliano II sv Maximilian II zh ... more details
Baldwin II may refer to Baldwin II of Flanders c. 865 918 Baldwin II, Count of Hainaut 1056 1098 Baldwin II of Jerusalem , King of Jerusalem died 1131 Baldwin II of Constantinople , Latin Emperor of Constantinople 1217 1273 hndis Baldwin II cs Balduin II. de Liste der Herrscher namens Balduin Balduin II. es Balduino II fr Baudouin II ko 2 it Baldovino II he hu II. Balduin egy rtelm s t lap nl Boudewijn II ja 2 pl Baldwin II ru II ... more details
Manuel II may refer to Manuel II Palaiologos , Byzantine Emperor Manuel II of Trebizond , Emperor of Trebizond Manuel II of Portugal , King of Portugal Patriarch Manuel II of Constantinople Manuel II , Patriarch of Constantinople hndis es Manuel II fa fr Manuel II ko 2 it Manuele II hu II. M nuel egy rtelm s t lap nl Manuel II ja 2 pl Manuel II pt Manuel II scn Manuel II fi Manuel II zh ... more details
Odo II may refer to Odo II, Count of Troyes 9th century Odo II, Count of Blois 983 1037 Odo II, Margrave of the Saxon Ostmark d. 1046 hndis it Oddone II ... more details
Sancho II may refer to Sancho II of Castile 1040 1072 , King of Castile 1065 1072 and Leon 1072 Sancho II of Pamplona b. aft. 935 994 , King of Pamplona and Count of Aragon 970 994 Sancho II of Portugal 1207 1248 , King of Portugal 1223 1247 hndis de Sancho II. es Sancho II fr Sanche II gl Sancho II ko 2 la Sanctius II ja 2 pl Sancho II pt Sancho II ... more details
Letter NumberCombination IH IJ HI JI wiktionarypar IIII is the Roman numeral for 2 number two II may also refer to Music II The Presidents of the United States of America album II The Presidents of the United States of America album II Boyz II Men album II Boyz II Men album II 2 Unlimited album II 2 Unlimited album II Espers album II Espers album II Krux album II Krux album II Hardline album II Hardline album Viva Koenji , Koenji Hyakkei album, also known as IIII Maylene and the Sons of Disaster Kingston Wall II album II Kingston Wall album II Darna album II Darna album II The Kinleys album II The Kinleys album II Charade album , an album by Charade Led Zeppelin II Two Cursed album II Cursed album Miscellanea II, the IBC Airways IATA airline designator Immortality Institute Infiltration and Inflow , an alternate name for Sanitary sewer overflow Institutional Investor Magazine , an American magazine Image intensifier , medical imaging equipment Index Islamicus Internet Infidels , discussion forum Internationalization Index , used by the UN to rank nations and companies in evaluating their degree of integration with the world economy. See also Ii disambiguation disambig de II es II eo Ii fr II ko II it II sw II lt II ja II no Ii pl II pt II ru II fi Ii t smennyssivu ... more details
Conrad II may refer to Conrad II, Holy Roman Emperor c. 990 1039 Conrad II, Duke of Transjurane Burgundy fl. 858 864 Conrad II of Znojmo Conrad II of Bohemia died 1191 Conrad II of Dachau died 1159 Conrad II of Italy 1074 1101 Conrad II of Jerusalem 1228 1254 Conrad II of Teck 1235 1292 Conrad II, Duke of Carinthia probably 1003 1039 hndis cs Konr d II. rozcestn k et Konrad II fr Conrad II pl Konrad II ... more details
Robert II may refer to Robert II, Count of Worms 770 807 Robert II of France 972 1031 Robert Curthose , Duke of Normandy c. 1051 1134 also known as Robert II Robert II de Brus fl. 1138, died ca. 1189 or 1194 Robert II of Dreux 1154 1218 Robert II of Scotland 1316 1390 , known as The Steward Robert II of Flanders 1065 1111 , known as Robert of Jerusalem Robert II, Count of Artois 1250 1302 Robert II, Duke of Burgundy 1248 1306 hndis Robert II et Robert II fr Robert II ko 2 hu II. R bert egy rtelm s t lap nl Robert II ja 2 pl Robert II ru II fi Robert II sv Robert II zh ... more details
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