Crystal structure of human CDK4 in complex with a D type cyclin journal Proc. Natl. Acad. Sci. U.S.A. ... ECnumber Chromosome 6 Arm p Band 21 LocusSupplementaryData CyclinD is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclinD is initiated during G1 and drives the G1 S phase transition. CyclinD protein is anywhere from 155 in zebra mussel ... through an APC c dependent pathway. CyclinD is one of the major cyclins produced in terms of its ... D Cdk4 6 complex accumulation is of great importance for cell cycle progression. Namely, cyclin ... have one cyclinD protein. In humans, in addition to the mouse homologue, two more cyclinD proteins ... name curie Homologues The most studied homologues of cyclinD are found in yeast and virus es. The yeast homologue of cyclinD, referred to as CLN3 Cln3 , interacts with Cdc28 cell division control ... 8 Kaposi s sarcoma associated herpesvirus HHV 8 Kaposi s sarcoma associated herpesvirus cyclinD ... benefit. ref name Hardwick Viral cyclinD binds human Cyclin dependent kinase 6 Cdk6 and inhibits .... Other than Rb, viral cyclinD Cdk6 complex also targets CDKN1B p27 sup Kip sup , a Cdk inhibitor of cyclin E and A. In addition, viral cyclinD Cdk6 is resistant to Cdk inhibitors, such as p21 sup ... forming an active complex with cyclinD. ref name Hardwick ref name Kufe Function Cyclins in humans ... cyclinD production. One of the members of the pathways, MAPK activates a transcription factor Myc, which alters transcription of genes important in cell cycle, among which is cyclinD. In this way, cyclinD is synthesized as long as the growth factor is present. Even though cyclinD levels ... S transition is active cyclinD Cdk4 6 complexes. Despite this, cyclinD has no effect on G1 S transition unless it forms a complex with Cdk 4 or 6. One of the best known substrates of cyclinD Cdk4 ... cells from progressing through G1. Active cyclinD Cdk4 and 6 inhibit Rb by partial phosphorylation ... more details
sub 1 sub S transition , Cyclin A Cyclin dependent kinase 2 CDK2 active in S sub sub phase. CyclinDCyclin dependent kinase 4 CDK4 , CyclinDCyclin dependent kinase 6 CDK6 , and Cyclin E CDK2 regulates ... Puc1, Cig1? Cdk1 Cig2, Cig1? Cdk1 Cdc13 Cdk1 align center D. melanogaster cyclinD Cdk4 cyclin E ... cyclin E Cdk2 cyclin E, A Cdk2,1 cyclin A, B, B3 Cdk1 align center H. sapiens cyclinD 1,2,3 Cdk4,6 ... , Cyclin B3 CCNB3 align center C Cyclin C CCNC align center CyclinDDCyclin D1 CCND1 , Cyclin D2 CCND2 ... cycle by activating cyclin dependent kinase Cdk enzyme s. ref name pmid12910258 cite journal title ... FP author3 Giordano A author separator , ref Function Image Cyclin Expression.svg thumb left 400px ... according to their conserved cyclin box structure, and not all these cyclins alter in level through ... ref . The oscillations of the cyclins, namely fluctuations in cyclin gene expression and destruction by proteolysis, induce oscillations in Cdk activity to drive the cell cycle. A cyclin forms a complex ... Cdk1 cdc2 or Cyclin dependent kinase 1 cdk1 proteins, form the maturation promoting factor . MPFs ... in late G1 and fall in early S phase. The Cdk G1 S cyclin complex begins to induce the initial processes ... early events in mitosis. M cyclin concentrations rise as the cell begins to enter mitosis and the concentrations ... spindles and alignment of sister chromatids along the spindles are induced by M cyclin Cdk complexes ..., or amino acid sequence. The similarity between members of the cyclin family are similar in the 100 amino acids that make up the cyclin box. Cyclins contain two protein domain domains of similar all .... The first of which is the conserved cyclin box, outside of which cyclins are divergent. For example ... for proteolysis in mitosis. valign top Pfam box Symbol Cyclin N Name Cyclin, N terminal domain image PDB 1vin EBI.jpg width caption Structure of bovine cyclin A. ref name pmid8591034 cite journal author Brown NR, Noble ME, Endicott JA, et al. title The crystal structure of cyclin A journal ... more details
protein Name CCNA1 cyclin A1 caption image width HGNCid 1577 Symbol CCNA1 AltSymbols EntrezGene 8900 OMIM 604036 RefSeq NM 003914 UniProt P78396 PDB ECnumber Chromosome 13 Arm q Band 12.3 LocusSupplementaryData q13 protein Name cyclin A2 caption image width HGNCid 1578 Symbol CCNA2 AltSymbols CCNA, CCN1 EntrezGene 890 OMIM 123835 RefSeq NM 001237 UniProt P20248 PDB ECnumber Chromosome 4 Arm q Band 27 LocusSupplementaryData Cyclin A is a member of the cyclin family. Cyclin A binds to S phase Cdk2 and is required for the cell to progress through the S phase . Cyclin A Cdk2 is inhibited by the complex p21CIP. Image Cyclinexpression waehrend Zellzyklus.png center 422px Expression of cyclins through the cell cycle . External links http www.sdbonline.org fly newgene cyclina1.htm Drosophila Cyclin A The Interactive Fly MeshName Cyclin A Cell biology stub Cell cycle proteins Category Cell cycle Category Proteins es Ciclina A ... more details
protein Name CCNE1 cyclin E1 caption image width HGNCid 1589 Symbol CCNE1 AltSymbols CCNE EntrezGene 898 OMIM 123837 RefSeq NM 001238 UniProt P24864 PDB ECnumber Chromosome 19 Arm q Band 12 LocusSupplementaryData protein Name CCNE2 cyclin E2 caption image width HGNCid 1590 Symbol CCNE2 AltSymbols EntrezGene 9134 OMIM 603775 RefSeq NM 057749 UniProt O96020 PDB ECnumber Chromosome 8 Arm q Band 22.1 LocusSupplementaryData Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase G sub 1 sub phase Cdk2 , which is required for the transition from G sub 1 sub to S phase . The Cyclin E CDK2 complex phosphorylation phosphorylates p27 sup Kip1 sup an Enzyme inhibitor inhibitor of CyclinD , tagging it for degradation, thus promoting expression of Cyclin A , allowing progression to S phase. Image Cyclinexpression waehrend Zellzyklus.png center 422px Expression of cyclins through the cell cycle . External links MeshName Cyclin E Cell biology stub Cell cycle proteins Category Cell cycle Category Proteins es Ciclina E ... more details
The CyclinD Cdk4 complex is a compound structure of CyclinD and Cdk4 , regulated by the GATA1 GATA 1 transcription factor . ref cite journal author Muntean A, Pang L, Poncz M, Dowdy S, Blobel G, Crispino J title CyclinD Cdk4 is regulated by GATA 1 and required for megakaryocyte growth and polyploidization journal Blood volume 109 issue 12 pages 5199 207 year 2007 pmid 17317855 doi 10.1182 blood 2006 11 059378 pmc 1890844 ref See also Human papillomavirus References references biochemistry stub Category Cell cycle Category Human proteins Category Papillomavirus Category Protein complexes Category Transcription factors es Ciclina D Cdk4 ... more details
kinase activity for cdk6, a novel cyclinD partner. journal Mol. Cell. Biol. volume 14 issue 3 ... AR, Shiffman D, Chan CS, et al. title Functional analysis of the human cyclin D2 and cyclin D3 promoters ... journal author G mez Lahoz E, Liegeois NJ, Zhang P, et al. title CyclinD and E dependent kinases ... cite journal author Choi D, Lee EY, Yoon S, et al. title Clinical correlation of cyclin ...PBB geneid 894 G1 S specific cyclin D2 is a protein that in humans is encoded by the CCND2 gene . ref ... AT title Genomic organization, chromosomal localization, and independent expression of human cyclinD genes journal Genomics volume 13 issue 3 pages 565 74 year 1992 month Aug pmid 1386335 pmc doi 10.1016 0888 7543 92 90126 D ref The PBB Summary template is automatically maintained by Protein Box Bot ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... of cyclin dependent kinases. Different cyclins exhibit distinct Gene expression expression and degradation patterns which contribute to the temporal coordination of each mitosis mitotic event. This cyclin ... web title Entrez Gene CCND2 cyclin D2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... citations cite journal author Xiong Y, Menninger J, Beach D, Ward DC title Molecular cloning and chromosomal mapping of CCND genes encoding human D type cyclins. journal Genomics volume 13 issue ..., Roussel MF, Kato JY, et al. title Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclinD dependent kinases CDK4 and CDK6. journal Mol. Cell. Biol. volume 15 issue 5 pages 2672 81 year ... protein with mammalian D type cyclins. journal Cell volume 73 issue 3 pages 487 97 year ... cite journal author Hirai H, Sherr CJ title Interaction of D type cyclins with a novel ... Cyclin D2 is an FSH responsive gene involved in gonadal cell proliferation and oncogenesis. journal ... Kitagawa M, Higashi H, Jung HK, et al. title The consensus motif for phosphorylation by cyclin ... more details
PBB geneid 8900 Cyclin A1 is a protein that in humans is encoded by the CCNA1 gene . ref name pmid9041194 cite journal author Yang R, Morosetti R, Koeffler HP title Characterization of a second human cyclin ... section title summary text The protein encoded by this gene belongs to the highly conserved cyclin ... complex together with cyclin dependent kinases cyclin dependent kinases CDKs . Different cyclins ... of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of meiosis . This cyclin ..., the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind ... Cip family of CDK inhibitor proteins. ref name entrez Cite web title Entrez Gene CCNA1 cyclin ... ref Interactions Cyclin A1 Protein protein interaction interacts with E2F1 , ref name pmid10022926 ... H P year 1999 month Mar. title Functions of cyclin A1 in the cell cycle and its interactions ... S, Hatakeyama M year 2000 month Feb. title Human p55 CDC Cdc20 associates with cyclin A and is phosphorylated by the cyclin A Cdk2 complex journal Biochem. Biophys. Res. Commun. volume 268 issue ... protein , ref name pmid10022926 Cyclin dependent kinase 2 , ref name pmid9041194 cite journal quotes ... Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic ... Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M year 1996 month Jan. title A distinct cyclin A is expressed in germ cells in the mouse journal Development volume 122 issue 1 ... W E, Serve H, Saville M, Watson R, Koeffler H P year 2001 month Apr. title Cyclin A1 directly interacts with B myb and cyclin A1 cdk2 phosphorylate B myb at functionally important serine and threonine ... peptides for cyclin dependent kinases journal Nat. Cell Biol. volume 1 issue 7 pages 438 43 publisher ... month Aug. title Identification of interaction partners and substrates of the cyclin A1 CDK2 complex ... more details
Seghezzi W, Parry D, Mahony D, Lees E year 1999 month Feb. title Cyclin E associates with BAF155 ... D title Subunit rearrangement of the cyclin dependent kinases is associated with cellular transformation ...PBB geneid 891 G2 mitotic specific cyclin B1 is a protein that in humans is encoded by the CCNB1 gene ... 92 90190 4 ref Function Cyclin B1 is a regulatory protein involved in mitosis . The gene product complexes ... web title Entrez Gene CCNB1 cyclin B1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 891 accessdate ref Cyclin B1 contributes to the switch like all or none behavior ... loops ensure that once the cyclin B1 Cdk1 complex is activated it is not deactivated. Cyclin B1 ... breakdown, and spindle pole assembly. Once activated, cyclin B1 Cdk1 promotes several of the events .... Another important function of the cyclin B1 Cdk1 complex is to break down the nuclear envelope ... of Lamin nuclear lamins . Phosphorylation of the lamins by cyclin B1 Cdk1 causes them to dissociate ... Image Nsp cellcycle 5 3 5 8.jpg thumb 300px left Cyclin B1 accumulates throughout the cell ... cell cycle. Like all cyclins, levels of cyclin B1 oscillate over the course of the cell cycle. Just prior to mitosis, a large amount of cyclin B1 is present in the cell, but it is inactive due to phosphorylation .... A possible trigger for activation is phosphorylation by cyclin A Cdk, which functions before cyclin B1 Cdk in the cell cycle. Active Cdk1 is also capable of phosphorylating and activating Cdc25 and thus promote its own activation, resulting in a positive feedback loop. Once cyclin B1 Cdk1 is activated, it remains stably active for the rest of mitosis. Another mechanism by which cyclin B1 Cdk1 activity is regulated is through subcellular localization. Before mitosis almost all cyclin ... by the phosphorylation of cyclin B1, in contrast to phosphorylation of Cdk1 regulating the activity of the complex. Phosphorylation of cyclin B1 causes it to be imported to the nucleus ... more details
CCND3 cyclin D3 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 896 accessdate ref See also CyclinCyclinD Interactions Cyclin D3 has been shown to Protein protein ... X, Wolgemuth D J year 1999 month Jun. title Developmentally regulated expression of cyclin D3 and its ... of G1 kinase activity for cdk6, a novel cyclinD partner journal Mol. Cell. Biol. volume 14 issue 3 ... of G1 kinase activity for cdk6, a novel cyclinD partner. journal Mol. Cell. Biol. volume ... cite journal author Brooks AR, Shiffman D, Chan CS, et al. title Functional analysis of the human cyclin ... author G mez Lahoz E, Liegeois NJ, Zhang P, et al. title CyclinD and E dependent kinases and the p57 ... J, et al. title A cyclinD Cdk4 activity required for G2 phase cell cycle progression is inhibited ...PBB geneid 896 G1 S specific cyclin D3 is a protein that in humans is encoded by the CCND3 gene . ref ... AT title Genomic organization, chromosomal localization, and independent expression of human cyclinD genes journal Genomics volume 13 issue 3 pages 565 74 year 1992 month Aug pmid 1386335 pmc doi 10.1016 0888 7543 92 90126 D ref The PBB Summary template is automatically maintained by Protein Box Bot ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions ... protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell ... Alexandra, Rochette Egly C cile, Chomienne Christine, Delva Laurent year 2003 month Feb. title Cyclin ... Pierre P, Pirson Isabelle year 2004 month Mar. title A novel partner for D type cyclins protein ... kinase, with cyclin D3 journal J. Biol. Chem. volume 277 issue 38 pages 35314 22 publisher location ... format accessdate laysummary laysource laydate quote ref CRABP2 , ref name pmid12482873 Cyclin ..., Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi Guedehoussou Nono, Klitgord Niels ... more details
J D, Dutta A date May 1998 title Human CDC6 Cdc18 Associates with Orc1 and Cyclin cdk and Is Selectively ...PBB geneid 890 Cyclin A2 is a protein that in humans is encoded by the CCNA2 gene . ref name pmid1675006 ... in the human cyclin A gene journal Nucleic Acids Res volume 19 issue 9 pages 2516 date July 1991 ... summary text The protein encoded by this gene belongs to the highly conserved cyclin family, whose members ... patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin .... ref name entrez cite web title Entrez Gene CCNA2 cyclin A2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 890 accessdate ref See also Cyclin A Interactions Cyclin A2 has been shown to Protein protein interaction interact with ITGB3BP , ref name pmid10673397 ... M date January 2000 title beta3 endonexin as a novel inhibitor of cyclin A associated kinase ... K A, Peng C Y, Yee A S, Piwnica Worms H date December 1994 title Cyclin A CDK2 binds directly ... C S, Bartek J, Helin K date January 1999 title Phosphorylation of mammalian CDC6 by cyclin A CDK2 ... Koundrioukoff St phane, H bscher Ulrich date July 2003 title Phosphorylation of human Fen1 by cyclin ... F, et al. title Cyclin A is required at two points in the human cell cycle journal EMBO J. volume 11 ... T, Bornens M title Cytoplasmic accumulation of cyclin B1 in human cells association with a detergent ... between human cyclin A and adenovirus E1A associated p107 protein journal Science volume 255 ... LR, Adamczewski JP, Hunt T, La Thangue NB title Cyclin A and the retinoblastoma gene product complex ... Assignment of a human cyclin A gene to 4q26 q27 journal Genomics volume 8 issue 3 pages 595 7 year ... B, Br chot C title Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma ... 7630397 doi 10.1038 376313a0 cite journal author Xu M, Sheppard KA, Peng CY, et al. title Cyclin ... more details
see also CyclinD PBB geneid 595 G1 S specific cyclin D1 is a protein that in humans is encoded by the CCND1 ... and cyclinD interacting protein, regulates E2F mediated transcriptional activity journal J. Biol ... authorlink coauthors Rushton J J, Sellers W R, Kaelin W G, Robbins P D year 2000 month Nov. title Cyclin ... Dec. title A new regulatory motif in cell cycle control causing specific inhibition of cyclinD CDK4 ... P D year 1999 month Jan. title Cyclin D1 associates with the TBP associated factor TAF II 250 ... expression of human cyclinD genes journal Genomics volume 13 issue 3 pages 565 74 year 1992 ... B, Beach D title Human D type cyclin journal Cell volume 65 issue 4 pages 691 9 year 1991 pmid ... JV, Kronenberg HM, Arnold A title A novel cyclin encoded by a bcl1 linked candidate oncogene journal ... novel human cyclins by rescue of G1 cyclin Cln function in yeast journal Cell volume 66 issue 6 pages ... cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout ... event. This cyclin forms a complex with and functions as a regulatory subunit of Cyclin dependent kinase 4 CDK4 or Cyclin dependent kinase 6 CDK6 , whose activity is required for cell cycle G1 S transition ... title Entrez Gene CCND1 cyclin D1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 595 accessdate ref Image Mantle cell lymphoma intermed mag cyclin D1.jpg thumb right 125px Micrograph of cyclin D1 staining in a mantle cell lymphoma . Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma . Interactions Cyclin D1 has been shown ... Aug. title Cyclin D1 Is a Ligand independent Co repressor for Thyroid Hormone Receptors journal J ... protein with human D cyclins journal Cell volume 73 issue 3 pages 499 511 publisher location ... Jan. title A central domain of cyclin D1 mediates nuclear receptor corepressor activity journal Oncogene ... K C year 1999 month May. title D type cyclins complex with the androgen receptor and inhibit its ... more details
Image 2B9R.png thumb alt Structure of PDB 2B9R human cyclin B rendered with PyMol DeLano Scientific Freeware . Structure of human cyclin B. ref name pmid17495533 cite journal author Petri, E.T., Errico, A., Escobedo, L., Hunt, T., and Basavappa, R. title The crystal structure of human cyclin B journal Cell Cycle volume 11 issue 11 pages 1342 9 year 2007 pmid 17495533 ref protein Name cyclin B1 caption image width HGNCid 1579 Symbol cyclin B1 CCNB1 AltSymbols CCNB EntrezGene 891 OMIM 123836 RefSeq NM 031966 UniProt P14635 PDB ECnumber Chromosome 5 Arm q Band 12 LocusSupplementaryData protein Name cyclin B2 caption image width HGNCid 1580 Symbol cyclin B2 CCNB2 AltSymbols EntrezGene 9133 OMIM 602755 RefSeq NM 004701 UniProt O95067 PDB ECnumber Chromosome 15 Arm q Band 21.3 LocusSupplementaryData protein Name cyclin B3 caption image width HGNCid 18709 Symbol CCNB3 AltSymbols EntrezGene 85417 OMIM 300456 RefSeq NM 033670 UniProt Q8WWL7 PDB ECnumber Chromosome X Arm p Band 11 LocusSupplementaryData Cyclin B is a member of the cyclin family. Cyclin B is a mitosis mitotic cyclin. The amount of cyclin B which binds to Cdk1 and the activity of the cyclin B Cdk complex rise through the cell cycle ref name pmid11089869 cite journal author Ito M title Factors controlling cyclin B expression journal Plant Mol. Biol. volume 43 issue 5 6 pages 677 90 year 2000 month August pmid 11089869 doi 10.1023 A 1006336005587 url http www.kluweronline.com art.pdf?issn 0167 4412&volume 43&page 677 issn ref until mitosis, where they fall abruptly due to degradation of cyclin B Cdk1 is constitutively present ... of cyclin B journal Philos. Trans. R. Soc. Lond., B, Biol. Sci. volume 354 issue 1389 pages ... url issn ref The complex of Cdk and cyclin B is called maturation promoting factor or mitosis ... through the cell cycle . See also Cyclin B1 Cyclin B2 References Reflist External links MeshName Cyclin B http www.sdbonline.org fly newgene cyclinb1.htm Drosophila Cyclin B The Interactive Fly Cell ... more details
J, Lee G, Price D H, Flores O year 1999 month Dec. title Cyclin K functions as a CDK9 regulatory subunit ...PBB geneid 8812 Cyclin K is a protein that in humans is encoded by the CCNK gene . ref name pmid9632813 cite journal author Edwards MC, Wong C, Elledge SJ title Human Cyclin K, a Novel RNA Polymerase II Associated Cyclin Possessing Both Carboxy Terminal Domain Kinase and Cdk Activating Kinase Activity journal Mol Cell Biol volume 18 issue 7 pages 4291 300 year 1998 month Jul pmid 9632813 pmc 109013 doi ref ref name pmid10574912 cite journal author Fu TJ, Peng J, Lee G, Price DH, Flores O title Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription journal J Biol Chem volume 274 issue 49 pages 34527 30 year 2000 month Feb pmid 10574912 pmc doi 10.1074 jbc.274.49.34527 ref ref name entrez cite web title Entrez Gene CCNK cyclin K url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 8812 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB ... cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin dependent kinases CDK that phosphorylate the C terminal domain CTD of the large subunit ... II activities. ref name entrez Interactions Cyclin K has been shown to Protein protein interaction ... R, Fujinaga K, Peterlin BM title P TEFb containing cyclin K and Cdk9 can activate transcription via ... jbc.M200117200 cite journal author Mori T title Cyclin K as a Direct Transcriptional Target of the p53 ... separator , author2 Jedrychowski M author3 Schwartz D display authors 3 last4 Elias first4 JE ... first5 Am lie last6 Li first6 Ning last7 Berriz first7 Gabriel F. last8 Gibbons first8 Francis D. last9 ... author Baek K, Brown RS, Birrane G, Ladias JA title Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin dependent Kinase 9 journal J. Mol. Biol. volume 366 issue 2 pages 563 73 year ... more details
D H year 1998 month Mar. title Identification of multiple cyclin subunits of human P TEFb journal ...PBB geneid 905 Cyclin T2 is a protein that in humans is encoded by the CCNT2 gene . ref name pmid9499409 cite journal author Peng J, Zhu Y, Milton JT, Price DH title Identification of multiple cyclin subunits ... Gene CCNT2 cyclin T2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch ... by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic ... to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p TEFb. The p TEFb complex containing this cyclin ..., have been described. ref name entrez cite web title Entrez Gene CCNT2 cyclin T2 url http www.ncbi.nlm.nih.gov ... Cyclin T2 has been shown to Protein protein interaction interact with CDK9 ref name pmid9499409 ... and human immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins ... cite journal author Kwak YT, Ivanov D, Guo J, et al. title Role of the human and murine cyclin T proteins in regulating HIV 1 tat activation. journal J. Mol. Biol. volume 288 issue 1 pages ... TA, Bogerd HP, Cullen BR title Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat cyclin T complexes. journal J. Virol. volume ... MA title The Cdk9 and cyclin T subunits of TAK P TEFb localize to splicing factor rich nuclear ... to and inhibits the activity of CDK9 cyclin T complexes. journal Nature volume 414 issue 6861 pages ... author Michels AA, Nguyen VT, Fraldi A, et al. title MAQ1 and 7SK RNA interact with CDK9 cyclin T complexes ... SA, Jedrychowski M, Schwartz D, et al. title Large scale characterization of HeLa cell nuclear ... BM title Transcriptional activity and substrate recognition of cyclin T2 from P TEFb. journal Gene ... is a novel partner of cyclin T2a in muscle differentiation. journal J. Cell. Physiol. volume 207 issue ... more details
Seghezzi W, Parry D, Mahony D, Lees E year 1999 month Feb. title Cyclin E associates with BAF155 and BRG1 ... D, et al. title Formation and activation of a cyclin E cdk2 complex during the G1 phase of the human ... pmc 19547 Cite journal author Mumberg D, Wick M, B rger C, et al. title Cyclin ET, a new splice variant ...Cleanup date November 2007 PBB geneid 898 G1 S specific cyclin E1 is a protein that in humans is encoded ... of three novel human cyclins by rescue of G1 cyclin Cln function in yeast journal Cell volume ... conserved cyclin family, whose members are characterized by a dramatic periodicity in protein ... of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2 ... is not yet available. ref name entrez Cite web title Entrez Gene CCNE1 cyclin E1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 898 accessdate ref See also cyclin E Interactions Cyclin E1 has been shown to Protein protein interaction interact with Retinoblastoma ... science.1388288 last Koff first A authorlink coauthors Giordano A, Desai D, Yamashita K, Harper J W, Elledge S, Nishimoto T, Morgan D O, Franza B R, Roberts J M year 1992 month Sep. title Formation and activation of a cyclin E cdk2 complex during the G1 phase of the human cell cycle journal Science ... oclc id url language format accessdate laysummary laysource laydate quote ref Cyclin dependent ... P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland A M, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian S V, Teng D H, Lees E year 2000 month Nov. title BRG1, a component of the SWI ... first J D authorlink coauthors Gurian West M, Clurman B, Roberts J M year 1999 month Sep. title Cullin 3 targets cyclin E for ubiquitination and controls S phase in mammalian cells journal Genes Dev. volume ... doi Cite journal author Mazumder S, DuPree EL, Almasan A title A dual role of cyclin E in cell ... science.1388288 Cite journal author Koff A, Cross F, Fisher A, et al. title Human cyclin E, a new ... more details
PBB geneid 902 Cyclin H is a protein that in humans is encoded by the CCNH gene . ref name pmid9465303 ... title Mapping of the human genes encoding cyclin H CCNH and the CDK activating kinase CAK assembly factor ... cite web title Entrez Gene CCNH cyclin H url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ... The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized ... which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex ... kinases, thus functions as a CDK activating kinase CAK . This cyclin and its kinase partner are components ... and the cell cycle machinery. ref name entrez Interactions Cyclin H has been shown to Protein ... laydate quote ref Cyclin dependent kinase 7 ref name pmid8078587 cite journal last M kel first ... Sep. title A cyclin associated with the CDK activating kinase MO15 journal Nature journal Nature ... R, Xiong Y year 1995 month Dec. title Molecular cloning of CDK7 associated human MAT1, a cyclin ... Mark D, O Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang ... interacts with MAT1, a cyclin dependent kinase activating kinase complex ring finger factor, and regulates ... 1998 pmid 9570510 doi 10.1007 BF02253352 cite journal author Yankulov K, Bentley D title Transcriptional ... 3 last4 Fesquet first4 D last5 Martinez first5 AM last6 Galas first6 S last7 Cavadore first7 ... X cite journal author Fisher RP, Morgan DO title A novel cyclin associates with MO15 CDK7 to form ... 0092 8674 94 90535 5 cite journal author M kel TP title A cyclin associated with the CDK activating ... TW cite journal author Tassan JP title In vitro assembly of a functional human CDK7 cyclin H complex ... Adamczewski JP title MAT1, cdk7 and cyclin H form a kinase complex which is UV light sensitive upon ... authors 3 last4 O Hare first4 P last5 Greenblatt first5 J last6 Bentley first6 D cite journal ... cite journal author Drapkin R title Human cyclin dependent kinase activating kinase exists in three ... more details
PBB geneid 9133 G2 mitotic specific cyclin B2 is a protein that in humans is encoded by the CCNB2 gene . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Cyclin B2 is a member of the cyclin family, specifically the B type cyclins. The B type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2 cdc2 may play a key role in transforming growth factor beta mediated cell cycle control. ref name entrez cite web title Entrez Gene CCNB2 cyclin B2 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 9133 accessdate ref See also Cyclin B Interactions Cyclin B2 has been shown to Protein protein interaction interact with TGF beta receptor 2 . ref name pmid9926943 cite journal last Liu first J H authorlink coauthors Wei S, Burnette P K, Gamero A M, Hutton M, Djeu J Y year 1999 month Jan. title Functional association of TGF beta receptor II with cyclin B journal Oncogene volume 18 issue 1 pages 269 75 publisher location ENGLAND issn 0950 9232 pmid 9926943 doi 10.1038 sj.onc.1202263 bibcode oclc id url language format accessdate laysummary laysource laydate quote ref ... 11 pages 6705 11 year 1995 pmid 7474080 doi pmc 189580 cite journal author Re F, Braaten D, Franke ... the activation of p34cdc2 cyclin B. journal J. Virol. volume 69 issue 11 pages 6859 64 year 1995 ... localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. journal ... al. title Cyclin B2 null mice develop normally and are fertile whereas cyclin B1 null mice die in utero ... association of TGF beta receptor II with cyclin B. journal Oncogene volume 18 issue 1 pages ... more details
Peng J, Lee G, Price D H, Flores O year 1999 month Dec. title Cyclin K functions as a CDK9 regulatory ...PBB geneid 904 Cyclin T1 is a protein that in humans is encoded by the CCNT1 gene . ref name pmid9491887 ... C type cyclin interacts directly with HIV 1 Tat and mediates its high affinity, loop specific binding ..., Price DH title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev volume ... conserved cyclin family, whose members are characterized by a dramatic periodicity in protein ... mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p TEFb. The kinase complex containing this cyclin and the elongation ... transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation ... cite web title Entrez Gene CCNT1 cyclin T1 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 904 accessdate ref Interactions Cyclin T1 has been shown to Protein protein ..., Lania Luigi, Bensaude Olivier year 2003 month Jul. title MAQ1 and 7SK RNA interact with CDK9 cyclin ... interacts with cyclin T1 and modulates P TEFb dependent transcription journal Mol. Cell. Biol. volume ... cite journal last Peng first J authorlink coauthors Zhu Y, Milton J T, Price D H year 1998 month Mar. title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev. volume 12 issue ... Sep. title The human I mfa domain containing protein, HIC, interacts with cyclin T1 and modulates ... J C, Lorca T, Nakayama Ki K, Benkirane M year 2001 month Dec. title Interaction between cyclin ... of human cyclin T1 to nuclear bodies through direct interaction with the PML protein journal ... K, Bentley D title Transcriptional control Tat cofactors and transcriptional elongation. journal ... cite journal author Romano G, Kasten M, De Falco G, et al. title Regulatory functions of Cdk9 and of cyclin ... 1570162052772924 cite journal author Gibellini D, Vitone F, Schiavone P, Re MC title HIV 1 tat protein ... more details
PBB geneid 10309 Cyclin O is a protein that in humans is encoded by the CCNO gene . ref name entrez cite web title Entrez Gene CCNO cyclin O url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 10309 accessdate ref The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Interactions Cyclin O has been shown to Protein protein interaction interact with RPA2 ref name pmid10393198 cite journal last Otterlei first M authorlink coauthors Warbrick E, Nagelhus T A, Haug T, Slupphaug G, Akbari M, Aas P A, Steinsbekk K, Bakke O, Krokan H E year 1999 month Jul. title Post replicative base excision repair in replication foci journal EMBO J. volume 18 issue 13 pages 3834 44 publisher location ENGLAND issn 0261 4189 pmid 10393198 doi 10.1093 emboj 18.13.3834 bibcode oclc id url language format accessdate laysummary laysource laydate quote pmc 1171460 ref and PCNA . ref name pmid10393198 ref name pmid12171929 cite journal last Ohta first Satoshi authorlink coauthors Shiomi Yasushi, Sugimoto Katsunori, Obuse Chikashi, Tsurimoto Toshiki year 2002 month Oct. title A proteomics approach to identify proliferating cell nuclear antigen PCNA binding proteins in human cell lysates. Identification of the human CHL12 RFCs2 5 complex as a novel PCNA binding protein journal J. Biol. Chem. volume 277 issue 43 pages 40362 7 publisher location United States issn 0021 9258 pmid 12171929 ... title Cell cycle regulation of a human cyclin like gene encoding uracil DNA glycosylase journal J. Biol ... display authors 3 author1 Lu X author2 Bocangel D author3 Nannenga B author separator , last4 Yamaguchi ... S last7 Gordon first7 LA last8 Scott first8 D last9 Xie first9 G cite journal title The Status, Quality ... Rasooly first9 R pmc 528928 cite journal title The cyclin like uracil DNA glycosylase UDG of murine ... Miller D author separator , cite journal title Latency Associated Nuclear Antigen of Kaposi s Sarcoma ... more details
Unreferenced stub auto yes date December 2009 A cyclin dependent kinase complex abbreviated cdkc , also called cyclin CDK is a protein complex formed by the association of cyclin with cyclin dependent kinase . These complexes are able to phosphorylate other compounds under consumption of Adenosine triphosphate ATP , and are thereby involved in the regulation of the cell cycle . Depending on the type of cyclin attached to CDK, it has a different function. These serve as markers in each phase which are integral for the correct sequence of events, as well as facilitating the transition to the next phase. Classes Image Cyclinexpression waehrend Zellzyklus.png thumb 422px Expression of cyclins through the cell cycle . There are three classes of cdkc depending on the phase of the cell cycle. G1 phase G sub 1 sub phase cdkc, including mostly cyclinD and cyclin E DNA replication S phase cdkc mitosis M phase cdkc See also Cell cycle DEFAULTSORT Cyclin Dependent Kinase Complex Category Cell cycle Cell biology stub ... more details
class wikitable CDK Cyclin partner Function Deletion Phenotype in Mice Cdk1 Cyclin B M phase None. E2.5. Cdk2 Cyclin E G1 S transition Reduced size, imparted neural progenitor cell proliferation. Viable, but both males & females sterile. Cdk2 Cyclin A S phase, G2 phase Cdk3 Cyclin C G1 phase ? No defects. Viable, fertile. Cdk4 CyclinD G1 phase Reduced size, insulin deficient diabetes. Viable, but both ... after birth. Cdk6 CyclinD G1 phase Cdk7 Cyclin H CDK activating kinase, transcription Cdk8 Cyclin C Transcription Cdk11 Cyclin L ? Mitotic defects. E3.5. ? Cyclin F ? Defects in extraembryonic tissues. E10.5. ? Cyclin G ? CDKs and Cyclins in the Cell Cycle Most of the known cyclin CDK complexes ... Phase Cyclin CDK G0 C Cdk3 G1 D, E Cdk4, Cdk2, Cdk6 S A, E Cdk2 G2 A Cdk2, Cdk1 M B Cdk1 Table 3 Cyclin dependent kinases that control the cell cycle in model organisms. ref name Morgan2007 class wikitable ... or activating. Cip Kip proteins activate cyclinD and CDK4 or CDK6 complexes by enhancing complex ... of mitosis in relation to the other phases has been exaggerated in this diagram Cyclin dependent ... domain. ref name Morgan2007 By definition, a CDK binds a regulatory protein called a cyclin . Without cyclin , CDK has little kinase activity only the cyclin CDK complex is an active kinase ..., their cyclin partners, and their functions in the human ref name Morgan1997 and consequences of deletion ... cells, CDK1, with its partners cyclin A2 and B1, alone can drive the cell cycle. ref name Satyanarayana2009 ... Cyclin CDK complexes phosphorylate substrates appropriate for the particular cell cycle phase. ref name Morgan1997 Cyclin CDK complexes in earlier cell cycle phase help activate cyclin CDK complexes ... M Cdk4 301 G1 Cdk6 326 G1 A list of CDKs with their regulator protein, cyclin or other. CDK1 cyclin A , cyclin B Cyclin dependent kinase 2 CDK2 cyclin A , cyclin E Gene CDK3 cyclin C CDK4 cyclin D1 , cyclin D2 , cyclin D3 CDK5 CDK5R1 , CDK5R2 . See also CDKL5 . CDK6 cyclin D1 , cyclin D2 , cyclin ... more details
Entrez Gene CDK6 cyclin dependent kinase 6 url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 1021 accessdate ref It is regulated by CyclinD . The PBB Summary template ... O, Jeffrey P D, Pavletich N P year 1998 month Sep. title Structural basis for inhibition of the cyclin ... cyclinD partner journal Mol. Cell. Biol. volume 14 issue 3 pages 2077 86 publisher location UNITED ... of the PLSTIRE protein cyclin dependent kinase 6 cdk6 , a major cyclinD associated cdk4 homologue ... for cdk6, a novel cyclinD partner journal Mol. Cell. Biol. volume 14 issue 3 pages 2077 86 year 1994 ... of the retinoblastoma protein pRb by cyclinD Cdk4 6 complexes results in active pRb journal Proc ... of mouse liver cells results in altered cyclinD CDK protein complexes journal Carcinogenesis .... title Crystal structure of the complex of the cyclinD dependent kinase Cdk6 bound to the cell cycle ... section title summary text The protein encoded by this gene is a member of the cyclin dependent kinase cyclin dependent protein kinase CDK family. CDK family members are highly similar to the gene ... D type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has ... entrez Interactions Cyclin dependent kinase 6 has been shown to Protein protein interaction interact ... D, O Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang ... cite journal last Jeffrey first P D authorlink coauthors Tong L, Pavletich N P year 2000 month Dec. title Structural basis of inhibition of CDK cyclin complexes by INK4 inhibitors journal Genes Dev. volume ... Paramio J M, Ball K L, La n S, Lane D P year 1996 month Jan. title Inhibition of pRb phosphorylation ... J year 2001 month Dec. title CAK independent activation of CDK6 by a viral cyclin journal Mol. Biol ... J year 2000 month Nov. title Dephosphorylation of human cyclin dependent kinases by protein phosphatase ... url language format accessdate laysummary laysource laydate quote ref Cyclin D3 , ref name pmid11360184 ... more details
PBB geneid 1025 Cyclin dependent kinase 9 or CDK9 is a cyclin dependent kinase associated with P TEFb ... of the cyclin dependent protein kinase CDK family. CDK family members are highly similar to the gene ... by its regulatory subunit cyclin T or cyclin K. HIV 1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. ref cite web title Entrez Gene CDK9 cyclin dependent kinase 9 CDC2 related kinase url http www.ncbi.nlm.nih.gov ... been shown to Protein protein interaction interact with Cyclin K , ref name pmid10574912 cite journal last Fu first T J authorlink coauthors Peng J, Lee G, Price D H, Flores O year 1999 month Dec. title Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription ... doi 10.1074 jbc.274.49.34527 ref Cyclin T2 , ref name pmid9499409 cite journal last Peng first J authorlink coauthors Zhu Y, Milton J T, Price D H year 1998 month Mar. title Identification of multiple cyclin subunits of human P TEFb journal Genes Dev. volume 12 issue 5 pages 755 62 publisher location ... bibcode oclc id url language format accessdate laysummary laysource laydate quote ref Cyclin ... I mfa domain containing protein, HIC, interacts with cyclin T1 and modulates P TEFb dependent ... RNA interact with CDK9 cyclin T complexes in a transcription dependent manner journal Mol. Cell ... 2003 month Mar. title The growth factor granulin interacts with cyclin T1 and modulates P TEFb dependent ... T, Nakayama Ki K, Benkirane M year 2001 month Dec. title Interaction between cyclin T1 and SCF SKP2 ... pmid11266437 cite journal last Lee first D K authorlink coauthors Duan H O, Chang C year 2001 month ... 24 7 year 1998 pmid 9570510 doi 10.1007 BF02253352 cite journal author Yankulov K, Bentley D title Transcriptional ... G, Kasten M, De Falco G, et al. title Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation ... cite journal author Gibellini D, Vitone F, Schiavone P, Re MC title HIV 1 tat protein and cell proliferation ... more details
gene . ref name pmid8069918 cite journal author Fisher RP, Morgan DO title A novel cyclin associates ... is a member of the Cyclin dependent kinase cyclin dependent protein kinase CDK family. CDK family ... forms a trimeric complex with cyclin H and MAT1 , which functions as a Cdk activating kinase CAK ... of transcription and the cell cycle. ref name entrez cite web title Entrez Gene CDK7 cyclin dependent ... entrez?Db gene&Cmd ShowDetailView&TermToSearch 1022 accessdate ref Interactions Cyclin dependent kinase ... MAT1, a cyclin dependent kinase activating kinase CAK assembly factor journal Cancer Res. volume ... id url language format accessdate laysummary laysource laydate quote ref Cyclin H , ref name pmid8078587 ... G J, Weinberg R A year 1994 month Sep. title A cyclin associated with the CDK activating kinase MO15 ... cyclin H in a p36MAT1 dependent manner journal Mol. Cell. Biol. volume 17 issue 12 pages 7220 9 ... Lee first D K authorlink coauthors Duan H O, Chang C year 2000 month Mar. title From androgen receptor ... F, Fisher R P, Drapkin R, Dynlacht B, Wessling H C, Morgan D O, Reinberg D year 1995 month ..., a cyclin dependent kinase activating kinase complex ring finger factor, and regulates estrogen ... . ref name pmid10958691 See also Cyclin dependent kinase CDK7 pathway References reflist Further reading ... doi 10.1007 BF02253352 cite journal author Yankulov K, Bentley D title Transcriptional control Tat ... cite journal author Aprelikova O, Xiong Y, Liu ET title Both p16 and p21 families of cyclin dependent kinase CDK inhibitors block the phosphorylation of cyclin dependent kinases by the CDK activating ... abbi.1994.1416 cite journal author M kel TP, Tassan JP, Nigg EA, et al. title A cyclin associated ... cloning of the human CAK1 gene encoding a cyclin dependent kinase activating kinase journal ... MA, Wu L, et al. title Molecular cloning of CDK7 associated human MAT1, a cyclin dependent kinase ... H, et al. title Human cyclin dependent kinase activating kinase exists in three distinct complexes journal ... more details
ref Cyclin B1 CCNB1 , ref name pmid9891079 cite journal author Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E title Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI SNF complex ... author Hannon GJ, Casso D, Beach D title KAP a dual specificity phosphatase that interacts with cyclin ... factor Cyclin dependent kinase CDK cyclin A cyclin B cyclinDcyclin E Wee cell cycle Cell cycle proteins ...PBB geneid 983 Cyclin dependent kinase 1 also known as CDK1 or cell division control protein 2 homolog ... 6117 pages 31 35 year 1987 month Jun pmid 3553962 pmc doi 10.1038 327031a0 ref With its cyclin ... HD, Morgan DO, Kim SH title Crystal structure of cyclin dependent kinase 2 journal Nature volume ..., like other cyclin dependent kinase s, contains a T loop, which, in the absence of an interacting cyclin, prevents substrate binding to the Cdk1 active site. Cdk1 also contains a PSTAIRE helix, which, upon cyclin binding, moves and rearranges the actives site, facilitating Cdk1 kinase activities ... activity. ref name isbn0 19 920610 4 br When bound to its cyclin partners, Cdk1 phosphorylation leads ... sub 1 sub S cyclin Cdk1 activity leads to preparation for S phase entry e.g., duplication of centromeres ... by its binding with its cyclin partners. Cyclin binding alters access to the active site of Cdk1 ... The structural basis for specificity of substrate and recruitment peptides for cyclin dependent ... . Cdk1 cyclin complexes are also governed by direct binding of Cdk inhibitor proteins CKIs . One such protein ... cite journal author Pines J, Hunter T title Isolation of a human cyclin cDNA evidence for cyclin ... Cyclin F regulates the nuclear localization of cyclin B1 through a cyclincyclin interaction journal ... emboj 19.6.1378 url issn ref Cyclin E1 CCNE1 , ref name pmid9891079 ref name pmid1388288 cite journal author Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM title Formation and activation of a cyclin E cdk2 complex during the G1 phase ... more details
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