SignSymptom infobox Name Cachexia ICD10 ICD10 R 64 r 50 ICD9 ICD9 799.4 MeshID D002100 Cachexia IPAc ... webster.com dictionary Cachexia ref or wasting syndrome is weight loss loss of weight , muscle atrophy ... trying to lose weight. The formal definition of cachexia is the loss of body mass that cannot ..., indicating there is a fundamental pathology in place Citation needed date March 2011 . Cachexia ... has cachexia, the chance of death from the underlying condition is increased dramatically. It can be a sign medicine sign of various underlying disorders when a patient presents with cachexia, a doctor ... . Cachexia physically weakens patients to a state of immobility stemming from loss of appetite ... cite journal author Lainscak M, Podbregar M, Anker SD title How does cachexia influence survival in cancer ... for cancer cachexia journal Expert Opin Investig Drugs volume 16 issue 8 pages 1241 53 year 2007 month ... 13543784.16.8.1241 ref Disease settings Cachexia is often seen in end stage cancer , and in that context is called cancer cachexia. It was also prevalent in HIV patients before the advent of highly active ... syndrome. Also, a cachexia co morbidity is seen in patients that have any of the range of illnesses ... vesanic cachexia Citation needed date January 2009 from vesania , a Latin term for insanity ..., resulting in muscle atrophy and great muscle loss. In most cases cachexia can be reversed with just ... August pmid 1927227 ref Mechanism The exact mechanism in which these diseases cause cachexia is poorly ... of ghrelin . Ghrelin levels are also high in patients who have cancer induced cachexia. ref name ... induced cachexia journal J. Clin. Endocrinol. Metab. volume 90 issue 5 pages 2920 6 year 2005 ... long&pmid 15713718 ref Treatment Currently, there are no widely accepted drugs to treat cachexia and there are no FDA approved drugs to treat cancer cachexia. Cachexia may be treated by steroid s such as corticosteroid ... for the treatment of cachexia in some states such as Michigan, Washington, Oregon, California, Colorado ... more details
Anticachexia is a drug or effect that works against cachexia loss of body weight and muscle mass . See also Cachexia Treatment External links http www.cancer.gov dictionary ?searchTxt anticachexia National Cancer Institute Dictionary Definition of Anticachexia http www.cancersource.com LibraryAndResources Dictionary 36,CDR0000044104 CancerSource Cancer Dictionary Anticachexia Category Drugs pharma stub ... more details
Expert subject Medicine date March 2009 FACES syndrome is a syndrome of unique facial features, Anorexia symptom anorexia , cachexia , Human eye eye and Human skin skin anomalies. ref name pmid6438152 cite journal author Friedman E, Goodman RM title The FACES syndrome a new syndrome with unique facies, anorexia, cachexia, and eye and skin lesions journal J. Craniofac. Genet. Dev. Biol. volume 4 issue 3 pages 227 31 year 1984 pmid 6438152 ref References reflist disease stub Category Syndromes Category Musculoskeletal disorders Category Rare diseases ... more details
In the pre modern medical practice of humorism , cacochymy , or cacochymia , referred to a depraved habit of body, replete with ill humors, from various causes. When the repletion was merely with blood, it was called plethora . Joannis Gorraeus gave the name cacochymia to the abundance and excess of any ill humor, provided it is only one in excess plethora he called the abundance or excess of all the humors together. 1728 See also cachexia Category Humorism ... more details
unsourced date August 2008 Malnutrition inflammation complex syndrome , abbreviated as MICS and also known as malnutrition inflammation cachexia syndrome , is a common condition in chronic disease states such as chronic kidney disease where it is also known as uremic malnutrition or protein energy wasting and chronic heart failure . The MICS is believed to be a cause of survival paradoxes seen in these distinct patient populations, also known as reverse epidemiology populations. References http www.ncbi.nlm.nih.gov sites entrez?cmd search&db pubmed&term malnutrition inflammation complex syndrome PubMed articles on MICS Category Diseases and disorders Category Nutrition ... more details
Serostim recombinant DNA somatropin is Serono s brand name prescription drug form of recombinant DNA synthetic growth hormone , marketed for AIDS cachexia wasting . ref http www.serostim.com ref In December 2007, the U.S. District Court of Massachusetts settled a class action lawsuit that involved Merck Serono and the drug Serostim. The lawsuit claims that Merck Serono encouraged doctors to prescribe Serostim off label for criteria that were not approved by the FDA. Merck Serono denies these claims and any liability. However, Merck Serono has entered into a settlement solely to avoid the further expense, inconvenience, burden, and uncertainty of these lawsuits. The settlement will pay consumers of Serostim who paid the full cash amount or a co payment as part of their medical treatment. References references External links http www.serostimsettlement.com Category Growth hormones Category Hormonal agents pharma stub ... more details
Orphan date February 2009 Anatomy This system is defined anatomically as a collection of central nervous system circuits which include Neurons that express hypothalamic neuropeptide Y and agouti gene related protein or pro opiomelanocortin and that originate in the arcuate nucleus. Brainstem pro opiomelanocortic neurons originating in the commissural nucleus of the solitary tract. Downstream targets of these pro opiomelanocortic and agouiti related protein neurons expressing the Melanocortin 3 and Melanocortin 4 receptors Mechanism of Action This system is involved in body weight regulation through its role in appetite and energy expenditure via Leptin , Grhelin and Agouti Related Protein. It receives inputs from hormones , nutrients and afferent neural inputs, and is unique in its composition of fibers which express both agonists and antagonists of melanocortin receptors. Due to the prominence of obesity as a health concern, much funding and research has been invested in this area with respect to the Central Melanocortin System. However, it is important to note that this system also elicits effects on cardiovascular and sexual function. Therapeutic Implications This system is a target for drugs which treat obesity, diabetes and cachexia. Stimulation of the Melanocortin 4 receptor causes a decrease in appetite and an increase in metabolism of fat and lean body mass, even in a relatively starved state. Conversely, damage to this receptor has been shown to result in morbid obesity. References Cone 2005 Anatomy and Regulation of the Central Melanocortin System Nature Neuroscience 7 1048 54 Daniel L. Marks, Nicholas Ling and Roger D. Cone 2001 Role of the Central Melanocortin System in Cachexia Cancer Research 61, 1432 1438 Joyce J. Hwa, Lorraine Ghibaudi, Jun Gao, and Eric M. Parker 2001 Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats AJP Regulatory, Integrative and Comparative Physiology Vol. 281, Issue 2, R444 R451 Ca ... more details
The Hippocratic face facies Hippocratica in Latin is the change produced in the face by impending death , ref name urlDorlands Medical Dictionary hippocratic facies cite web url http www.mercksource.com pp us cns cns hl dorlands split.jsp?pg ppdocs us common dorlands dorland nine 18770921.htm title Dorlands Medical Dictionary hippocratic facies format work accessdate ref or long illness , excessive defecation evacuation s, excessive hunger , and the like. blockquote If the patient s facial appearance may be described thus the nose sharp, the eyes sunken, the temples fallen in, the ears cold and drawn in and their lobes distorted, the skin of the face hard, stretched and dry, and the colour of the face pale or dusky. and if there is no improvement within a prescribed period of time , it must be realized that this sign portends death. ref name Chadwick 1978 cite book author Chadwick, J. & Mann, W.N. trans. title Hippocratic writings publisher Penguin location Harmondsworth, UK year 1978 pages 170&ndash 171 isbn 0 14 044451 3 oclc doi ref blockquote The Hippocratic face is so called because it was first described by Hippocrates . A related term is cachexia . References reflist Category Medical signs med sign stub de Facies hippocratica it Faccia ippocratica ru tl Hipokratikong mukha ... more details
Interventions infobox Name PAGENAME Image ICD10 ICD9 07.6 MeshID D007016 OtherCodes Hypophysectomy is the surgical removal of the pituitary gland hypophysis pituitary gland . It is most commonly performed to treat tumors, especially craniopharyngioma tumors. Sometimes it is used to treat Cushing s syndrome due to pituitary adenoma . It is also applied in neuroscience s in experiments with lab animals to understand the functioning of hypophysis. Medications that are given as hormone replacement therapy following a complete hypophysectomy removal of the pituitary gland are Glucocorticoids and Thyroid Medications. Complications Hypophysectomy performed at any age causes atrophy of the thyroid and adrenal glands as well as asthenia and cachexia . When the procedure is performed before sexual maturity, the reproductive tract remains undeveloped and non functional. There is also a general lack of growth. If performed after sexual maturity, there is loss of reproductive function along with atrophy of gonads and accessory reproductive structures. External links http www.surgeryencyclopedia.com Fi La Hypophysectomy.html Encyclopedia of Surgery Neuro procedures Endocrine system intervention oncology stub surgery stub Category Surgical oncology Category Surgical removal procedures nl Hypofysectomie ... more details
Lois Austin April 3, 1901, Minneapolis, Minnesota April 26, 1957, Hollywood, California was an United States American actress, who had a number of film and television roles to her credit, including The Amos n Andy Show as Harriett Harrington . She was also documented in the series You Are There series You Are There in 1955. Death She died from cachexia , aged 56. External links imdb name id 0042453 name Lois Austin http www.findagrave.com cgi bin fg.cgi?page gr&GRid 12712 Lois Austin at Find A Grave Persondata Metadata see Wikipedia Persondata . NAME Austin, Lois ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH PLACE OF BIRTH DATE OF DEATH PLACE OF DEATH DEFAULTSORT Austin, Lois Category 1901 births Category 1957 deaths Category Actors from Minnesota Category American film actors Category American television actors Category People from Minneapolis, Minnesota Category People from the Greater Los Angeles Area US film actor 1900s stub ... more details
The burnt out diabetes or burnt out diabetes mellitus is a term for a medical hypothesis which holds that hyperglycemia high blood sugar of diabetes mellitus may disappear in a proportion of diabetic patients with end stage renal disease including dialysis patients , even if these individuals have already suffered from some terminal consequences of diabetes mellitus including diabetic nephropathy that led to their kidney failure . The terminology was first discussed by India Indian nephrologists in The Hindu reference and then systematically discussed by Csaba P Kovesdy and his colleagues in an aricle that appeared early 2010 in the Seminars in Dialysis ref cite journal author Kovesdy CP, Park JC, Kalantar Zadeh K. title Glycemic Control and Burnt Out Diabetes in ESRDGlycemic Control and Burnt Out Diabetes in ESRD journal Semin Dial. volume 1 issue 1 pages 793 808 year 2010 month March pmid 20374552 doi .x ref References reflist External links refbegin http www.hindu.com thehindu mag 2003 11 09 stories 2003110900330700.htm The Hindu journal describing burnt out diabetes http www.ncbi.nlm.nih.gov pubmed 20374552 burnt out diabetes paper in Seminars in Dialysis http www.cachexia.com Cachexia Society refend Category Medical conditions related to obesity Category Epidemiology med stub ... more details
Infobox Disease Name PAGENAME Image Caption DiseasesDB ICD10 ICD10 E 40 e 40 ICD10 E 44 e 40 ICD9 ICD9 260 ICD9 263 ICDO OMIM MedlinePlus eMedicineSubj derm eMedicineTopic 797 MeshID Protein energy malnutrition or protein calorie malnutrition refers to a form of malnutrition where there is inadequate protein intake. Types include ref name pmid10341499 cite journal author Franco VH, Hotta JK, Jorge SM, dos Santos JE title Plasma fatty acids in children with grade III protein energy malnutrition in its different clinical forms marasmus, marasmic kwashiorkor, and kwashiorkor journal J. Trop. Pediatr. volume 45 issue 2 pages 71 5 year 1999 month April pmid 10341499 doi 10.1093 tropej 45.2.71 url http tropej.oxfordjournals.org cgi pmidlookup?view long&pmid 10341499 ref Kwashiorkor protein malnutrition predominant Marasmus deficiency in both calorie and protein nutrition Marasmic Kwashiorkor marked protein deficiency and marked calorie insufficiency signs present, sometimes referred to as the most severe form of malnutrition Note that this may also be secondary to other conditions such as chronic renal disease ref cite journal last Muscaritoli first M coauthors Molfino A, Bollea MR, Rossi Fanelli F. date 2009 Jul title Malnutrition and wasting in renal disease journal Curr Opin Clin Nutr Metab Care volume 12 issue 4 pages 378 83 pmid 19474712 url http www.ncbi.nlm.nih.gov pubmed 19474712 doi 10.1097 MCO.0b013e32832c7ae1 ref or cancer cachexia ref Bosaeus I. http www.ncbi.nlm.nih.gov pubmed 18196284 Nutritional support in multimodal therapy for cancer cachexia. Support Care Cancer. 2008 May 16 5 447 51. ref in which protein energy wasting may occur. Protein energy malnutrition affects children the most because they have less protein intake. The few rare cases found in the developed world are almost entirely found in small children as a result of fad diets, or ignorance of the nutritional needs of children, particularly in cases of milk allergy. ref Liu, Howard et al. Kwash ... more details
Wasting could also mean Economic efficiency inefficient and or Effectiveness ineffective Consumption economics consumption . See waste . In medicine, wasting refers to the process by which a debilitating disease causes muscle and fat biological tissue tissue to waste away. Wasting is sometimes referred to as acute malnutrition because it is believed that episodes of wasting have a short duration, in contrast to stunted growth stunting , which is regarded as chronic malnutrition. Causes Wasting can be caused by an extremely low energy intake e.g., caused by famine , nutrient losses due to infection, or a combination of low intake and high loss. Infections and conditions associated with wasting include tuberculosis , chronic diarrhea , AIDS , and Superior mesenteric artery syndrome . The mechanism may involve cachectin also called tumor necrosis factor, a macrophage secreted cytokine . Caretakers and health providers can sometimes contribute to wasting if the patient is placed on an improper diet. Voluntary weight loss and eating disorder s are excluded as causes of wasting. Classification Children Weight for height WFH . In infants under 24 months, recumbent supine length is used. WFH as of median reference value is calculated this way math mathrm WFH frac mbox weight of a given child mbox median weight for a given child of that height times 100 math Cutoff points may vary, but 80 close to 2 Z score is often used. Adults Body Mass Index BMI is the quotient between weight and height squared kg m sup 2 sup . An individual with a BMI 18.5 is regarded as a case of wasting. Percent of body weight lost At Tufts, an unintentional loss of 6 or more in 6 months is regarded as wasting See also Atrophy Cachexia Weight loss Anorexia symptom Anorexia Superior mesenteric artery syndrome External links http www.cdc.gov ncidod EID vol10no6 03 1082.htm http www.tufts.edu med nutrition infection hiv health weight loss.html http www.annalsnyas.org cgi content abstract 587 1 325 http ww ... more details
Incomplete date August 2008 Unreferenced date August 2008 SignSymptom infobox Name Emaciation Image Starved child.jpg Caption This photo taken in 1972 shows an emaciated child in India suffering from marasmus ICD10 ICD9 MeshID D004614 Emaciation IPAc en icon m e i e n or IPAc en m e s i e n occurs when an organism loses substantial amounts of much needed fat and often muscle tissue, making that organism look extremely thin. The cause of emaciation is a lack of nutrients, starvation , or disease. Many women and some men have targeted the emaciation look, and such is the result of eating disorder s such as anorexia nervosa and bulimia . The shape of the bones in a severely emaciated person is distinguishable, the shoulder blades are prominently sharp, and the ribs and spine can be clearly seen, while the arms and legs are not significantly wider than the bones that support them. Death may occur. Although this condition can be acquired by humans deliberately, it is often also the case of many starving animals and peoples across the planet due to lack of food or unsanitary living conditions. See also Starvation Cachexia Marasmus Kwashiorkor Category Malnutrition med sign stub Nutritional pathology Symptoms concerning nutrition, metabolism and development de Inanition ja no underern ring ... more details
Unreferenced date December 2009 The 1994 expanded World Health Organization AIDS case definition came around through the developments in the understanding of the spectrum of severe HIV related illness both in developed and developing countries, and the increased availability of laboratory diagnostic methods, a meeting was convened in Geneva , Switzerland by the World Health Organization Global Programme on AIDS to review the 1985 World Health Organization AIDS surveillance case definition Bangui definition and to modify and expand them for use in adults and adolescents. Both the 1985 World Health Organization AIDS surveillance case definition and the 1994 expanded World Health Organization AIDS case definition are case definitions for AIDS surveillance and not for clinically staging HIV infection. The main change from the Bangui definition is the addition of an HIV HIV test test for HIV antibody . If this test gives a positive result and one or more of the following conditions, the individual is considered to have AIDS. 10 body weight loss or cachexia, with diarrhoea or fever , or both, intermittent or constant for at least 1 month, not known to be due to a condition unrelated to HIV infection. cryptococcal meningitis pulmonary or extra pulmonary tuberculosis Kaposi s sarcoma neurological impairment that is sufficient to prevent independent daily activities, not known to be due to a condition unrelated to HIV infection for example, trauma, or cerebrovascular accident . candiasis of the oesophagus which may be presumptively diagnosed based on the presence of oral candiasis accompanied by dysphagia. clinically diagnosed life threatening or recurrent episodes of pneumonia, with or without etiological confirmation invasive cervical cancer AIDS DEFAULTSORT 1994 Expanded World Health Organization Aids Case Definition Category World Health Organization Category History of HIV AIDS id Definisi World Health Organization tentang AIDS tahun 1994 ... more details
File Etienne Lancereaux.gif right thumb Etienne Lancereaux 1829 1910 tienne Lancereaux November 27, 1829 &ndash October 26, 1910 was a French physician born in Br cy Bri res . He is remembered for pioneer contributions made in the understanding of diabetes . He studied medicine in Reims and Paris , receiving his doctorate in 1862. From 1869 he was M decin des h pitaux and worked in various hospitals in Paris. In 1872 he earned his agr gation , and later in his career was appointed president of the Acad mie Nationale de M decine . His best known student was Nicolae Paulescu 1869 1931 , the discoverer of insulin . Through clinical pathological research, Lancereaux believed that the cause of diabetes mellitus was located in the pancreas , and in an 1877 paper coined the term diab te pancr atique pancreatic diabetes . His ideas in regards to diabetes were later confirmed through experimentation by Oskar Minkowski 1858 1931 and Josef von Mering 1849 1908 . Lancereaux also provided distinctions on the two primary forms of diabetes, which he referred to as diabetes maigre lean diabetes and diabetes gras fat diabetes . In addition to diabetes, he also made contributions in his research of alcoholism , syphilis , infectious forms of jaundice and the transmission of typhus by water. Associated eponym Lancereaux s diabetes Diabetes mellitus with marked emaciation cachexia . Selected publications Trait historique et pratique de la syphilis , Paris 1866 Atlas d anatomie pathologique , 3 volumes Paris 1875 1889 Trait de l herp tisme , Paris 1883 Trait des maladies du foie et du pancr as , Paris 1899 Alcoolisme , Paris 1907 Trait de la goutte , Paris 1910 References This article is based on translation of articles from the French and German Wikipedia. Persondata Metadata see Wikipedia Persondata . NAME Lancereaux, Etienne ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH November 27, 1829 PLACE OF BIRTH DATE OF DEATH October 26, 1910 PLACE OF DEATH DEFAULTSORT Lancereaux, Eti ... more details
Infobox Scientist name Bernard Peyrilhe box width image Replace this image male.svg image size 150px caption Bernard Peyrilhe birth date 1737 birth place death date 1804 death place residence citizenship nationality France ethnicity field Cancer work institutions alma mater doctoral advisor doctoral students known for transmission of the Cancer author abbrev bot author abbrev zoo influences influenced prizes religion footnotes signature Bernard Peyrilhe 1737 1804 was a French people French surgeon known as one of the founders of experimental cancer research. He injected some extracts of breast cancer to study the transmission of the disease. A notable event in the history of cancer research was the essay of Peyrilhe 1735 to 1804 submitted to the Academy of Lyons in answer to the question, Qu est ce que le cancer? This was the first systematic investigation of the whole subject and dealt with the cancer toxin, the nature of the disease, the manner of growth, and the treatment. He spoke of the local origin, the production of a specific virus from degeneration of the tumor, and the development of cachexia from this source. He endeavored to demonstrate the virus by injecting tumor emulsion beneath the skin of a dog, but an abscess resulted and his servant drowned the animal. He treated ulceration effectively with the newly discovered carbonic acid. His imagination was satisfied by the Cartesian lymph theory of the times. ref http books.google.com books?id zFM11IvIbxcC&printsec frontcover&dq James Ewing&ei m2X1S6 vA5WizQTN tCUCg&cd 1 v onepage&q&f false Neoplastic diseases by James Ewing ref Notes Wilmanns JC. Surgical treatment of breast carcinoma since Hippocrates of Cos .Gynakol Geburtshilfliche Rundsch. 1995 35 2 103 11. PMID 7620376 References Reflist Persondata Metadata see Wikipedia Persondata . NAME Peyrilhe, Bernard ALTERNATIVE NAMES SHORT DESCRIPTION DATE OF BIRTH 1737 PLACE OF BIRTH DATE OF DEATH 1804 PLACE OF DEATH DEFAULTSORT Peyrilhe, Bernard Category Frenc ... more details
under the trade name Megace. ref name urlMalnutrition and Cachexia Treatment Megace ES megestrol acetate cite web url http www.megacees.com title Malnutrition and Cachexia Treatment & 124 Megace ... more details
Orphan date February 2009 CNTO 328 sometimes called Anti IL 6 chimeric monoclonal antibody or cCLB8 is a chimeric made from human and mouse proteins monoclonal antibody being studied in the treatment of advanced kidney cancer and other types of cancer . ref name Zaki2004 cite journal url http www.ncbi.nlm.nih.gov pubmed 15239138 title CNTO 328, a monoclonal antibody to IL 6, inhibits human tumor induced cachexia in nude mice. author Zaki et al year 2004 ref Anti IL 6 chimeric monoclonal antibody works by inhibiting interleukin 6 IL 6 to reduce inflammation and tumor growth. It binds to IL 6 preventing IL 6 activating IL 6 receptors. It has undergone a phase I clinical trial in Patients With B Cell Non Hodgkin s Lymphoma, Multiple Myeloma, or Castleman s Disease. ref cite web url http clinicaltrials.gov ct2 show NCT00412321 title A Safety and Efficacy Study of CNTO 328 in Patients With B Cell Non Hodgkin s Lymphoma, Multiple Myeloma, or Castleman s Disease ref It gave encouraging results in a small trial for advanced ovarian cancer . ref cite web url http healthinfoispower.wordpress.com 2009 04 07 cnto 328 shows promise for ovarian cancer in small clinical trial say uk scientists title CNTO 328 Shows Promise For Ovarian Cancer In Small Clinical Trial, Say U.K. Scientists. year 2009 ref Encouraging results have been reported from a phase II trial for relapsed or refractory multiple myeloma . ref cite news url http www.asco.org ascov2 Meetings Abstracts?&vmview abst detail view&confID 65&abstractID 33250 title A phase II multicenter study of CNTO 328, an anti IL 6 monoclonal antibody, in patients pts with relapsed or refractory multiple myeloma MM year 2009 ref See also Anti IL 6 agents. Further reading http www.ingentaconnect.com content bsc bjh 2009 00000145 00000004 art00006 Targeted inhibition of interleukin 6 with CNTO 328 sensitizes pre clinical models of multiple myeloma to dexamethasone mediated cell death. 2009 References reflist External links http www.cancer ... more details
Orphan date February 2009 RosePharma is a private company that was founded in 2003 as Gastrotech Pharma. Its headquarters are located in Copenhagen, Denmark, in the Medicon Valley region. Hans T. Schambye, Chairman, Enda Kenny, CEO, Michael Forer, Prof. Dr. Olle Isaksson, Florian Sch nharting, Christian Karsten Hansen , Leif Helth Jensen, Charles Woler are some important people within the company. Rose Pharma formerly Gastrotech Pharma is a clinical stage biotechnology company focused on the development of novel treatments for IBS and anorexia cachexia associated with cancer and other major pathologies. Rose Pharma is a virtual company. History Rose Pharma was formerly known as Gastrotech Pharma. Gastrotech was founded in 2003 and had a broad interest in gastroenterology. It was initially established to exploit intellectual property from the Sahlgrenska Institute in Stockholm but was later relocated to the Medicon Valley region of Copenhagen due to the large presence of its main venture backers. RosePharma works with other third party companies in the research and development of its main drug, Rose 010. This shift in focus towards this product is reflected in the change of company name. Products ROSE 010 is a pharmaceutical therapy intended to treat the symptoms of irritable bowel syndrome . The pharmaceutical, Rose 010, treats IBS by delaying gastric contractions in releasing tension of the gastric musculature which prohibits the cycle of contractions and spasms. Rose 010 also modulates smooth muscle contraction. More specifically, this drug mimics the hormone GLP 1 which also modulates smooth muscle contractions, thus reducing contractions associated with IBS. ROSE 010 must be administered subcutaneously or intravenously. As of December 2005 Rose 010 was in the phase II double blinded placebo controlled stage of testing. Partnerships Dor BioPharma joined with RosePharma in 2005 to further fund the research. Companies such as CAT Invest, Nordic Biotech, BML Healthc ... more details
Nelson K. Sewankambo , sometimes spelled as Nelson Sewankambo is a Uganda n physician , academician , medical researcher and medical administrator. Currently he is Professor of Medicine and Principal, Makerere University College of Health Sciences , a semi autonomous constituent college of Makerere University , the oldest university in Uganda. Background He was born in Wakiso District . Education Professor Sewankambo was educated at Namilyango College , a prestigious all boys residential middle and high school Grades 8 13 , located in Mukono District , from 1965 until 1970. In 1971, he entered Makerere University School of Medicine , where he obtained the degree of Bachelor of Medicine and Bachelor of Surgery MBChB , graduating in 1976. He went on to obtain the Master of Medicine MMed degree, specializing in Internal Medicine , also from Makerere in the early 1980s. He later obtained a Master of Science MSc degree in Clinical Epidemiology, from McMaster University in Hamilton, Ontario , Canada . He is a Fellow of the Royal College of Physicians Fellow of the Royal College of Physicians FRCP . He was later awarded an honorary degree of Doctor of Laws Legum Doctor LLD by McMaster University. ref http med.mak.ac.ug downloads Staff Principal.pdf Academic Qualifications of Nelson Sewankambo ref Work experience In the early 1980s, Dr. Sewankambo was one of the earliest physicians in Uganda to recognize the new disease that caused patients to lose weight and slim down to abnormal cachexia chachectic sizes. The new disease, at first called Slim Disease , became known as HIV AIDS . He has been at the forefront on the research about the disease, specializing in HIV clinical drug trials. ref http www.pgaf.org newsletter issue02 sewankambo.html Dr. Sewankambo at Forefront of AIDS Research in Africa ref He has extensively published the finding of his research in medical journals and other peer publications. ref http med.mak.ac.ug downloads Staff Principal.pdf The Published Liter ... more details
Clinical nutrition is nutrition of patients in health care . wiktionary clinical Clinical in this sense refers to the manage of patients, not only outpatients at clinic s, but also, and actually mainly, inpatients in hospitals. It incorporates mainly the scientific fields of nutrition and diet nutrition dietetics . It aims to keep a healthy Energy balance biology energy balance in patients, as well as providing sufficient amounts other nutrients such as protein, vitamins, minerals. Methods of nutrition Among the routes of administration , the preferred means of nutrition is, if possible, oral administration . Alternatives include enteral administration in nasogastric feeding , and intravenous in parenteral nutrition . Clinical malnutrition In the field of clinical nutrition, malnutrition has distinct causes, epidemiology and management than malnutrition that is mainly associated with poverty. The main causes of clinical malnutrition are Cachexia caused by diseases, injuries and or aging Difficulties with ingestion, such as stroke , paresis , dementia , Depression mood depression , dysphagia Also clinical malnutrition may also be aggravated by iatrogenic factors, that is, inability of the health care entity to appropriately compensate for causes of malnutrition. There are various definitions of clinical malnutrition. According to one of them, patients are defined as severely undernourished when meeting at least one of the following criteria body mass index BMI less than or 20 kg m sup 2 sup and or more than or 5 unintentional weight loss in the past month and or or 10 unintentional weight loss in the past 6 months. By the same system, the patient is moderately undernourished if they met at least one of the following criteria BMI 20.1 22 kg m sup 2 sup and or 5 10 unintentional weight loss in the past six months. ref cite journal author Kruizenga HM, de Vet HC, Van Marissing CM, et al. title The SNAQ RC , an easy traffic light system as a first step in the recognition ... more details
Cachexia Syndrome See Cachexia In many people suffering from solid malignancy , especially gastric ... is the lead drug of this class for the management of cachexia. Adverse effects Adverse effects ... more details
Encyclopedia
top
