induced apoptosis. ref name entrez Interactions Apoptosisantagonizingtranscriptionfactor has been shown to Protein protein interaction interact with Sp1 transcriptionfactor , ref name pmid12847090 ... with apoptosisantagonizingtranscriptionfactor and enhances androgen receptor mediated transcription ... Page G, L dige I, K gel D, Scheidtmann KH title AATF, a novel transcriptionfactor that interacts with Dlk ZIP kinase and interferes with apoptosis. journal FEBS Lett. volume 462 issue 1 2 pages 187 ... in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation ... in cerebellar granule neurons. Modulation during neuronal apoptosis. journal Mol. Cell. Neurosci ..., human NLM content Transcription factors g1 The PBB Controls template provides controls for Protein ... inspection no update protein box yes update summary yes update citations yes Category Transcription ... more details
In molecular biology and genetics , a transcriptionfactor sometimes called a sequence specific DNA binding factor is a protein that binds to specific DNA sequence s, thereby controlling the flow or transcription ... 295 issue 5556 pages 813 8 year 2002 pmid 11823631 doi 10.1126 science.1066355 ref Transcriptionfactor ... factor, the transcription of the adjacent gene is either up or down regulated. Transcription factors ... of histone proteins. The transcriptionfactor can either do this directly or recruit other proteins ... corepressor proteins to the transcriptionfactor DNA complex ref name pmid10322133 cite journal ... factors called general transcriptionfactor s GTFs are necessary for transcription to occur ... and cellular differentiation . The Hox transcriptionfactor family, for example, is important ... example is the transcriptionfactor encoded by the SRY Sex determining Region Y SRY gene, which plays ... of a fairly short signaling cascade that involves the estrogen receptor transcriptionfactor ... of transcriptionfactor activity during cellular aging journal Biochem. Cell Biol. volume 74 issue 4 ... of these steps can be regulated to affect the production and thus activity of a transcriptionfactor ..., in a negative feedback loop, the transcriptionfactor acts as its own repressor If the transcription .... This is one mechanism to maintain low levels of a transcriptionfactor in a cell. Nuclear localization ... biochemistry ligand binding Not only is ligand binding able to influence where a transcriptionfactor is located within a cell but ligand binding can also affect whether the transcriptionfactor is in an active ... ref name pmid2149275 cite journal author Bohmann D title Transcriptionfactor phosphorylation ... access to the transcriptionfactor binding site. In many cases a transcriptionfactor needs to Competitive ... . Thus, for a single transcriptionfactor to initiate transcription, all of these other proteins must also be present, and the transcriptionfactor must be in a state where it can bind to them if necessary ... more details
protein Name AIFM1 apoptosis inducing factor, mitochondrion associated, 1 caption Crystallographic structure of the human apoptosis inducing factor rainbow color cartoon diagram, N terminus blue, C terminus ... action of apoptosis inducing factor journal Nat. Struct. Biol. volume 9 issue 9 pages 680 4 year 2002 month September pmid 12198487 doi 10.1038 nsb836 url issn ref image apoptosis inducing ... ref Function Apoptosis Inducing Factor AIF is a protein that triggers chromatin condensation and DNA ... apoptosis inducing factor isozymes include AIFM1 AIFM2 AIFM3 See also Apoptosis References Reflist External links MeshName Apoptosis inducing factor Flavoproteins Apoptosis signaling pathway Cell signaling DEFAULTSORT Apoptosis Inducing Factor Category Programmed cell death Category Cell signaling ... 004208 UniProt O95831 PDB ECnumber Chromosome X Arm q Band 25 LocusSupplementaryData q26 Apoptosis inducing factor is a flavoprotein . ref name pmid19723031 cite journal author Joza N, Pospisilik JA, Hangen E, Hanada T, Modjtahedi N, Penninger JM, Kroemer G title AIF not just an apoptosis inducing factor journal Ann. N. Y. Acad. Sci. volume 1171 issue pages 2 11 year 2009 month August pmid 19723031 doi 10.1111 j.1749 6632.2009.04681.x url issn ref Apoptosis inducing factor is involved in initiating a caspase independent pathway of apoptosis positive intrinsic regulator of apoptosis by causing ... is to regulate the permeability of the mitochondrial membrane upon apoptosis. Normally it is found ... that it is involved in apoptosis. ref name pmid19723031 ref name pmid12022952 cite journal author Cand C, Cohen I, Daugas E, Ravagnan L, Larochette N, Zamzami N, Kroemer G title Apoptosis inducing factor AIF a novel caspase independent death effector released from mitochondria journal Biochimie ... changes. The process triggering apoptosis starts when the mitochondria releases AIF, which exits ..., AIF folds into its functional configuration by the help of the co factor, flavin adenine dinucleotide ... more details
laysummary laysource laydate quote ref Apoptosisantagonizingtranscriptionfactor , ref name ...PBB geneid 6667 See also SP1 . Sp1 , also known as Specificity Protein 1, is a human transcriptionfactor ..., Vol. 23, No. 6. DOI 10.1128 MCB.23.6.1843 1855.2003 ref Interactions Sp1 transcriptionfactor has .... title Interaction of Sp1 with the growth and cell cycle regulated transcriptionfactor E2F journal ... month Jul. title A set of proteins interacting with transcriptionfactor Sp1 identified in a two hybrid ... doi cite journal author Szpirer J, Szpirer C, Riviere M, et al. title The Sp1 transcriptionfactor ... rich domains of human transcriptionfactor Sp1. journal Cell volume 59 issue 5 pages 827 36 year 1990 ... Kadonaga JT, Carner KR, Masiarz FR, Tjian R title Isolation of cDNA encoding transcriptionfactor ... al. title Functional analyses of the transcriptionfactor Sp4 reveal properties distinct from Sp1 ... Vpr of human immunodeficiency virus type 1 with cellular transcriptionfactor Sp1 and trans activation ... MP, Khachigian LM. title Angiotensin II inducible platelet derived growth factor D transcription requires ... geneid 6667 External links MeshName Sp1 TranscriptionFactorTranscription factors g2 The PBB Controls ... of transcription factors. The protein is 785 amino acids long, with a molecular mass molecular weight of 81 kDA. ref See http www.expasy.org uniprot P08047 UniProtKB entry ref The SP1 transcriptionfactor contains a zinc finger zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription. Its zinc fingers are of the Cys sub 2 sub His sub 2 sub type and bind the consensus ... promoter by myocyte enhancer factor 2C and Sp1 journal J. Biol. Chem. volume 273 issue 40 pages 26218 ... E year 1999 month Nov. title Transcription factors of the Sp1 family interaction with E2F and regulation ... coauthors Forsberg M, Lillhager P, Westin G year 1996 month Jun. title The transcription factors ... laydate quote doi 10.1023 A 1007177623283 ref Host cell factor C1 , ref name pmid10976766 ref ... more details
In molecular biology , activating transcriptionfactor , ATF , is a class of AP 1 transcriptionfactor AP 1 transcriptionfactor dimers. ref name van Dam cite journal author van Dam H, Castellazzi M title Distinct roles of Jun Fos and Jun ATF dimers in oncogenesis journal Oncogene volume 20 issue 19 pages 2453 64 year 2001 pmid 11402340 doi 10.1038 sj.onc.1204239 ref Genes include ATF1 , Activating transcriptionfactor 2 ATF2 , ATF3 , ATF4 , ATF5 , ATF6 , and ATF7 . References references External links MeshName Activating Transcription Factors protein stub Oncogenes Transcription factors g1 Category Transcription factors es Factor de transcripci n activador ... more details
GATA transcriptionfactor s are a family of transcriptionfactor s characterized by their ability to bind to the DNA sequence GATA . ref name pmid8321208 cite journal author Ko LJ, Engel JD title DNA binding specificities of the GATA transcriptionfactor family journal Mol. Cell. Biol. volume 13 issue 7 pages 4011 22 year 1993 pmid 8321208 doi pmc 359950 ref Genes GATA1 see also Gene GATA1 GATA2 see also Gene GATA2 GATA3 see also Gene GATA3 GATA4 see also Gene GATA4 GATA5 see also Gene GATA5 GATA6 see also Gene GATA6 References Reflist External links MeshName GATA transcription factors biochem stub Transcription factors g2 Category Transcription factors es GATA ... more details
protein Name ets variant gene 5 ets related molecule caption image width HGNCid 3494 Symbol ETV5 AltSymbols ERM EntrezGene 2119 OMIM 601600 RefSeq NM 004454 UniProt P41161 PDB ECnumber Chromosome 3 Arm q Band 28 LocusSupplementaryData ERM transcription factor is a transcription factor generated in Sertoli cell s, which are found in the testes and play a crucial role in spermatogenesis . External links MeshName ERM protein, human MeshName ETV5 protein, human gene 3 stub Transcription factors g3 Category Transcription factors ... more details
An octamer transcriptionfactor is a transcriptionfactor which binds to the ATTTGCAT sequence. ref cite journal author Petryniak B, Staudt LM, Postema CE, McCormack WT, Thompson CB title Characterization of chicken octamer binding proteins demonstrates that POU domain containing homeobox transcription factors have been highly conserved during vertebrate evolution journal Proc. Natl. Acad. Sci. U.S.A. volume 87 issue 3 pages 1099 103 year 1990 pmid 1967834 doi 10.1073 pnas.87.3.1099 pmc 53418 ref Examples include Oct 1 Gene POU2F1 Oct 2 Gene POU2F2 Oct 4 Oct 3 4 Gene POU5F1 POU3F1 Oct 6 Gene POU3F1 POU3F2 Oct 7 Gene POU3F2 Oct 8 Gene POU3F3 POU3F2 Oct 9 Gene POU3F4 POU2F3 Oct 11 Gene POU3F4 References references External links MeshName Octamer transcription factors Transcription factors g3 Category Transcription factors biochem stub ... more details
General transcription factors GTF s or basal transcription factors are protein transcriptionfactor s that have been shown to be important in the Transcription genetics transcription of class II gene s to mRNA templates. ref name pmid11092823 cite journal author Lee TI, Young RA title Transcription of eukaryotic protein coding genes journal Annu. Rev. Genet. volume 34 issue 1 pages 77 137 year 2000 ... Cell signaling Transcription factors g2 DEFAULTSORT General TranscriptionFactor Category Transcription factors genetics stub fr Facteur g n ral de transcription ja nl Basale transcriptiefactoren ... The general transcription factors of RNA polymerase II journal Genes Dev. volume 10 issue 21 pages 2657 ... holoenzyme, the final event in transcription initiation. These proteins are ubiquitous and interact with the core promoter region of DNA, which contains the transcription start site s of all class II ... step in transcription, Transcription genetics Elongation elongation . For example, members of the FACT ... transcription factors that are required for transcription by RNA polymerase II in vitro are ref name pmid11092823 http tfiib.med.harvard.edu transcription tfiia.html TFIIA see TFIIA TFIIA is not a real basal transcriptionfactor. http tfiib.med.harvard.edu transcription tfiib.html TFIIB see TFIIB http tfiib.med.harvard.edu transcription tfiid.html TFIID see TFIID and TATA binding protein http tfiib.med.harvard.edu transcription tfiie.html TFIIE see TFIIE http tfiib.med.harvard.edu transcription tfiif.html TFIIF see TFIIF http tfiib.med.harvard.edu transcription tfiih.html TFIIH see TFIIH Note Basal transcription in test tubes has been achieved using only highly purified recombinant TFIIB and TFIIF. See also RNA polymerase II for simpler explanation on transcription factors Nuclear receptor , an important class of transcription factors References Reflist External links http www.yeastgenome.org ... and researchers alike MeshName General Transcription Factors Descriptive images of GTF assembly ... more details
II, B TFIID transcriptionfactor associated, 170kDa Mot1 homolog, S. cerevisiae url http www.ncbi.nlm.nih.gov ... HTM, Meyers RE, Sharp PA title Composition of transcriptionfactor B TFIID journal Proc Natl Acad ... tube, only TBP is necessary for transcription genetics transcription at promoter biology promoter s that contain a TATA box . ref name Lee cite journal author Lee TI, Young RA title Transcription ... polypeptides required for iniation of transcription by RNA polymerase II, binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription ... also Transcription genetics Eukaryotic transcription RNA polymerase II holoenzyme General transcriptionfactor Regulation of gene expression Preinitiation complex TATA Binding Protein References Reflist External links MeshName TranscriptionFactor TFIID Cell signaling Transcription factors g2 Category Gene expression Category Molecular genetics Category Proteins Category Transcription factors Genetics ... more details
PBB geneid 4286 Microphthalmia associated transcriptionfactor Mitf is a basic helix loop helix leucine zipper transcriptionfactor involved in melanocyte ref name pmid16899407 cite journal author Levy ... DE title Mitf and Tfe3 members of a b HLH ZIP transcriptionfactor family essential for osteoclast ... genes confirmed by at least two independent sources of this transcriptionfactor include, CENTER TABLE ... author Luchin A, Purdom G, Murphy K, et al. title The microphthalmia transcriptionfactor reulates ... factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas journal ... The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcriptionfactor ... author Yasumoto K, Takeda K, Saito H, et al. title Microphthalmia associated transcriptionfactor ..., Akasaka E, et al. title Epistatic connections between microphthalmia associated transcriptionfactor ... A, Du J, Angeletti B, et al. title The microphthalmia transcriptionfactor Mitf controls expression ... E, et al. title Microphthalmia associated transcriptionfactor regulates RAB27A gene expression and controls ... transcriptionfactor in melanocytes journal J. Biol. Chem. volume 275 issue 29 pages 21920 7 year ... by inhibition of the activity of melanocyte transcriptionfactor, MITF journal Nucleic Acids Res. volume ... factor MITF and myc associated zinc finger protein related factor MAZR for transcription of mouse mast ... A new role for the STAT3 inhibitor, PIAS3 a repressor of microphthalmia transcriptionfactor journal ... Michael, Ostrowski Michael C year 2002 month Feb. title The microphthalmia transcriptionfactor ... Mar. title Regulation of microphthalmia associated transcriptionfactor MITF protein levels by association ... 2002 month Jun. title Microphthalmia associated transcriptionfactor interacts with LEF 1, a mediator ... links MeshName Microphthalmia associated transcriptionfactorTranscription factors g1 The PBB Controls ... citations no DEFAULTSORT Microphthalmia Associated TranscriptionFactor Category Transcription ... more details
, the ERG ETS transcriptionfactor is fused to the EWS gene, resulting in a condition called ... , or both. ref cite journal author Sharrocks AD title The ETS domain transcriptionfactor family ... refend DEFAULTSORT Ets TranscriptionFactor Family Category Gene expression Category Transcription ... , the ETS E twenty six family is one of the largest families of transcription factors and is unique ... AP title ETS transcription factors in endocrine systems journal Trends Endocrinol Metab volume 18 issue ... ERG ERG gene ERG , FLI1 , FEV ETS oncogene family FEV ERF Ets2 repressor factor ERF PE2 , ets variant ... PDEF PSE PEA3 ETV4 PEA3 E1AF , ETV5 ERM , ETV1 ER81 ER71 ETV2 ER71 SPI SPI1 PU.1 , SPIB , Spi C transcriptionfactor SPIC TCF ELK1 , ELK4 SAP1 , ELK3 NET SAP2 LIN TEL ETV6 TEL , ETV7 TEL2 YAN Structure ... control, cell migration , cell proliferation , apoptosis programmed cell death and angiogenesis . Multiple ... is achieved. ref cite journal author Verger A, Duterque Coquillaud M title When Ets transcription ... doi 10.1038 sj.onc.1204035 cite journal author Mimeault M title Structure function studies of ETS transcription ... cite journal author Oikawa T, Yamada T title Molecular biology of the Ets family of transcription factors ... journal author Verger A, Duterque Coquillaud M title When Ets transcription factors meet their partners ... more details
protein Name GTF2F1 general transcriptionfactor IIF, polypeptide 1, 74kDa caption image width HGNCid 4652 Symbol GTF2F1 AltSymbols TFIIF, BTF4, RAP74 EntrezGene 2962 OMIM 189968 RefSeq NM 002096 UniProt P35269 PDB ECnumber Chromosome 19 Arm p Band 13.3 LocusSupplementaryData protein Name GTF2F2 general transcriptionfactor IIF, polypeptide 2, 30kDa caption image width HGNCid 4653 Symbol GTF2F2 AltSymbols TFIIF, BTF4, RAP30 EntrezGene 2963 OMIM 189969 RefSeq NM 004128 UniProt P13984 PDB ECnumber Chromosome 13 Arm q Band 14 LocusSupplementaryData protein Name general transcriptionfactor IIF, polypeptide 2 like caption image width HGNCid 4654 Symbol GTF2F2L AltSymbols TFIIF EntrezGene 2964 OMIM RefSeq NG 003013 UniProt PDB ECnumber Chromosome 4 Arm q Band 31.22 LocusSupplementaryData Transcriptionfactor II F TF sub II sub F is one of several general transcriptionfactor s that make up the RNA polymerase II preinitiation complex . ref name isbn0 13 144946 X cite book author Lewin, Benjamin title Genes VIII publisher Pearson Prentice Hall location Upper Saddle River, NJ year 2004 pages p636 637 isbn 0 13 144946 X oclc doi ref TranscriptionFactor II F is encoded by the gene GTF2F1 , gene ... initiation factor for transcription by RNA polymerase II journal Nature volume 355 issue 6359 pages ... on the DNA may aid in DNA melting at the promoter biology promoter , forming the transcription bubble . Of all the general transcription factors, TFIIF is the most similar to bacterial sigma factor ... TranscriptionFactor TFIIF Cell signaling Transcription factors g2 DEFAULTSORT TranscriptionFactor Ii F Category Molecular genetics Category Proteins Category Gene expression Category Transcription ... polymerase II transcription are dispersed in the human genome journal Hum. Mol. Genet. volume 3 issue ... characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens journal ... Transcription of eukaryotic protein coding genes journal Annu. Rev. Genet. volume 34 issue pages ... more details
protein Name GTF2H1 general transcriptionfactor IIH, polypeptide 1, 62kDa caption image width HGNCid 4655 Symbol GTF2H1 AltSymbols BTF2 EntrezGene 2965 OMIM 189972 RefSeq NM 005316 UniProt P32780 PDB ECnumber Chromosome 11 Arm p Band 15.1 LocusSupplementaryData p14 protein Name GTF2H2 general transcriptionfactor IIH, polypeptide 2, 44kDa caption image width HGNCid 4656 Symbol GTF2H2 AltSymbols BTF2, TFIIH, BTF2P44, T BTF2P44 EntrezGene 2966 OMIM 601748 RefSeq NM 001515 UniProt Q13888 PDB ECnumber Chromosome 5 Arm q Band 12.2 LocusSupplementaryData 13.3 protein Name general transcriptionfactor IIH, polypeptide 3, 34kDa caption image width HGNCid 4657 Symbol GTF2H3 AltSymbols BTF2, TFIIH EntrezGene 2967 OMIM 601750 RefSeq NM 001516 UniProt Q13889 PDB ECnumber Chromosome 12 Arm q Band 24.31 LocusSupplementaryData Transcriptionfactor II H TFIIH is one of several general transcriptionfactor s that make up the RNA polymerase II preinitiation complex . TFIIH consists of ten subunits, 7 of which XPD, XPB, p62, p52, p44, p34 and TTDA form the core complex. The cyclin activating kinase subcomplex CDK7, MAT1, and cyclin H is linked to the core via the XPD protein ref name pmid11092823 cite journal author Lee TI, Young RA title Transcription of eukaryotic protein coding genes journal Annu. Rev. Genet. volume 34 issue pages 77 137 year 2000 pmid 11092823 doi 10.1146 annurev.genet.34.1.77 ref Two of the subunits, ERCC2 XPD and ERCC3 XPB , have helicase and ATPase activities and help create the transcription bubble . In a test tube these subunits are only required for transcription if the DNA template is not already DNA melting denatured or if it is DNA supercoil supercoiled . Two other ... . Next to a vital function in transcription initiation, TFIIH is also involved in nucleotide excision repair . References Reflist External links MeshName TranscriptionFactor TFIIH biochem stub Transcription factors g2 Category Gene expression Category Transcription factors de Transkriptionsfaktor IIH ... more details
PBB geneid 7291 Twist transcriptionfactor is a basic helix loop helix transcriptionfactor associated with Saethre Chotzen syndrome . The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text Basic helix loop helix bHLH transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcriptionfactor and shares similarity with another bHLH transcriptionfactor, Dermo1. The strongest expression of this mRNA is in placental tissue in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre Chotzen syndrome. ref name entrez cite web title Entrez Gene TWIST1 twist homolog 1 acrocephalosyndactyly 3 Saethre Chotzen syndrome Drosophila url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 7291 accessdate ref Interactions Twist transcriptionfactor has been shown to Protein protein interaction interact with EP300 , ref name pmid10025406 cite journal doi 10.1016 S0092 8674 00 80553 X last Hamamori first Y authorlink coauthors Sartorelli V, Ogryzko V, Puri P L, Wu H Y, Wang J Y, Nakatani Y, Kedes L year 1999 month Feb. title Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A journal Cell volume 96 issue 3 pages 405 13 publisher location UNITED STATES issn 0092 8674 pmid 10025406 bibcode oclc id url language format accessdate laysummary laysource laydate ... helix transcriptionfactor, in Saethre Chotzen syndrome. journal Nat. Genet. volume 15 issue 1 pages ... Chotzen Syndrome MeshName Twist transcriptionfactor NLM content Transcription factors g1 The PBB Controls ... update citations yes DEFAULTSORT Twist TranscriptionFactor Category Transcription factors gene 7 stub ... Twist is a potential oncogene that inhibits apoptosis. journal Genes Dev. volume 13 issue 17 pages ... more details
An artificial transcriptionfactor is an example of a Chimera protein chimeral protein , designed to target and modulate gene transcription. ref cite journal author Gommans W, Haisma H, Rots M title Engineering zinc finger protein transcription factors the therapeutic relevance of switching endogenous gene expression on or off at command journal J. Mol. Biol. volume 354 issue 3 pages 507 19 year 2005 pmid 16253273 url http www.rug.nl farmacie onderzoek basiseenheden therapeuticgenemodulation publicaties publicaties2004 2005 6.pdf doi 10.1016 j.jmb.2005.06.082 ref They are generally composed of a DNA binding domain specific to a certain sequence coupled to a modulatory domain which acts upon other transcription factors in order to alter the expression of a particular gene. It is also possible to downregulate expression of a gene by targeting the 5 untranslated region with a DNA binding domain that lacks a regulatory domain this will reduce transcription simply by blocking RNA polymerase progression along the DNA template. See also Therapeutic gene modulation Zinc finger Zinc finger protein transcriptionfactor Chimera protein Protein engineering References reflist Category Engineered proteins ... more details
protein Name general transcriptionfactor IIE, polypeptide 1, alpha 56kDa caption image width HGNCid 4650 Symbol GTF2E1 AltSymbols TF2E1 EntrezGene 2960 OMIM 189962 RefSeq NM 005513 UniProt P29083 PDB ECnumber Chromosome 3 Arm q Band 21 LocusSupplementaryData q24 protein Name general transcriptionfactor IIE, polypeptide 2, beta 34kDa caption image width HGNCid 4651 Symbol GTF2E2 AltSymbols TF2E2 EntrezGene 2961 OMIM 189964 RefSeq NM 002095 UniProt P29084 PDB ECnumber Chromosome 8 Arm p Band 12 LocusSupplementaryData Transcriptionfactor II E TF sub II sub E is one of several general transcriptionfactor s that make up the RNA polymerase II preinitiation complex . ref name isbn0 13 144946 X cite book author Lewin, Benjamin title Genes VIII publisher Pearson Prentice Hall location Upper Saddle River, NJ year 2004 pages p636 637 isbn 0 13 144946 X oclc doi ref TranscriptionFactor II E is encoded by the GTF2E1 and GTF2E2 genes. ref name pmid1454543 cite journal author Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M title Identification of two large subdomains in TFIIE alpha on the basis of homology between Xenopus and human sequences journal Nucleic Acids Res. volume 20 issue 21 pages 5838 year 1992 pmid 1454543 pmc 334425 doi 10.1093 nar 20.21.5838 issn ref ref name pmid8162052 cite journal author Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC title Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome journal Hum. Mol. Genet ... RG title Conserved sequence motifs in the small subunit of human general transcriptionfactor TFIIE ... transcriptionfactor TFIIE journal Nature volume 354 issue 6352 pages 398 401 year 1991 month ... TranscriptionFactor TFIIE Cell signaling Transcription factors g2 DEFAULTSORT TranscriptionFactor Ii E Category Molecular genetics Category Proteins Category Gene expression Category Transcription .... ref name pmid11092823 cite journal author Lee TI, Young RA title Transcription of eukaryotic protein ... more details
COUP transcriptionfactor can refer to COUP TFI COUP TFII disambig Short pages monitor This long comment was added to the page to prevent it being listed on Special Shortpages. It and the accompanying monitoring template were generated via Template Longcomment. Please do not remove the monitor template without removing the comment as well. ... more details
protein Name GTF2A1 general transcriptionfactor IIA, 1, 19 37kDa caption image width HGNCid 4646 Symbol GTF2A1 AltSymbols EntrezGene 2957 OMIM 600520 RefSeq NM 201595 UniProt P52655 PDB ECnumber Chromosome 14 Arm q Band 31 LocusSupplementaryData protein Name general transcriptionfactor IIA, 2, 12kDa caption image width HGNCid 4647 Symbol GTF2A2 AltSymbols EntrezGene 2958 OMIM 600519 RefSeq NM 004492 UniProt P52657 PDB ECnumber Chromosome 15 Arm q Band 21.3 LocusSupplementaryData Transcriptionfactor TFIIA is a cell nucleus nuclear protein involved in the RNA polymerase II dependent transcription genetics transcription of DNA . ref name pmid17560669 cite journal author H iby T, Zhou H, Mitsiou DJ, Stunnenberg HG title A facelift for the general transcriptionfactor TFIIA journal Biochim. Biophys. Acta volume 1769 issue 7 8 pages 429 36 year 2007 pmid 17560669 doi 10.1016 j.bbaexp.2007.04.008 ref TFIIA is one of several general basal transcriptionfactor s General transcriptionfactor GTF s that are required for all transcription events that use RNA polymerase II. Other GTFs include TFIID , a complex composed of the TATA binding protein TBP and TBP associated factors TAFs , as well as the factors TFIIB , TFIIE , TFIIF , and TFIIH . Together, these factors are responsible for promoter biology promoter recognition and the formation of a transcription preinitiation complex PIC capable of initiating RNA synthesis from a DNA template. Functions TFIIA interacts with the TBP subunit ... s. References Reflist External links MeshName TranscriptionFactor TFIIA Transcription factors g2 Category Gene expression Category Transcription factors de Transkriptionsfaktor IIA ... that might otherwise bind to TBP and interfere with PIC formation. TFIIA also acts as a transcription ... to increase, or activate, transcription. The requirement for TFIIA in vitro transcription ... transcription journal Genes Dev. volume 8 issue 19 pages 2324 35 year 1994 pmid 7958899 doi 10.1101 ... more details
PBB geneid 6670 Sp3 transcriptionfactor , also known as SP3 , refers to both a protein and the gene it is encoded by. This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC and GT box regulatory elements in target genes. This protein contains a zinc finger DNA binding domain and several transactivation domains, and has been reported to function as a bifunctional transcriptionfactor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoform s have been described for this gene, and one has been reported to initiate translation from a non AUG AUA start codon . Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. ref cite web title Entrez Gene SP3 Sp3 transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6670 accessdate ref Interactions Sp3 transcriptionfactor has been shown to Protein protein interaction interact with Histone deacetylase 2 , ref name pmid12151407 cite journal last Won first Jaejoon authorlink coauthors Yim Jeongbin, Kim Tae Kook date October 2002 title Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase hTERT promoter in normal human somatic cells journal J. Biol. Chem. volume 277 issue 41 pages 38230 8 publisher location United States issn 0021 9258 ... Frauke, Suske Guntram date October 2002 title Transcriptionfactor Sp3 is silenced through SUMO ... update summary no update citations yes DEFAULTSORT Sp3 TranscriptionFactor Category Transcription ... first H authorlink coauthors Geymayer S, Haidweger E date November 1999 title Transcription ... of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone ... year 2003 pmid 12943729 doi 10.1016 S0960 0760 03 00230 9 refend PDB Gallery geneid 6670 Transcription ... more details
, the activator protein 1 AP 1 is a transcriptionfactor which is a protein dimer heterodimeric protein composed of proteins belonging to the c Fos , c Jun , Activating TranscriptionFactor ATF and JDP ... bZIP transcriptionfactor c Fos c Jun bound to DNA journal Nature volume 373 issue 6511 pages ... cite journal author Lee W, Mitchell P, Tjian R title Purified transcriptionfactor AP 1 interacts ... cite journal author Ahn JD, Morishita R, Kaneda Y, et al. title Transcriptionfactor decoy for activator ... 2 External links http www.nlm.nih.gov cgi mesh 2008 MB cgi?mode &term TranscriptionFactor AP 1 NLM ... Atlas of Genetics Oncogenes Transcription factors g1 Category Transcription factors es Factor ... , growth factor s, stress, and bacterial and viral infections. ref name pmid15564374 AP 1 in turn ... Cell reproduction proliferation , and apoptosis . ref name pmid14585541 cite journal author Ameyar M, Wisniewska M, Weitzman JB title A role for AP 1 in apoptosis the case for and against journal ... upregulates transcription of genes containing the 12 O Tetradecanoylphorbol 13 acetate TPA DNA response ... specific and inducible transcription of the murine MIP 1 beta cytokine gene journal Gene volume 152 ... 1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer ... AP 1 activates BMP 4 transcription in Xenopus embryos journal Mech. Dev. volume 98 issue 1 2 pages ... author Wu J, Bresnick EH title Glucocorticoid and growth factor synergism requirement for Notch4 chromatin ... 17003107 doi 10.1242 jcs.03188 url ref tissue factor , ref name pmid16131569 cite journal author Nolasco ... endothelial cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor ... author Chang CJ, Chao JC title Effect of human milk and epidermal growth factor on growth of human ... the transcription of IL 13 in mast cells journal J. Immunol. volume 173 issue 9 pages 5564 73 year ... apoptosis in hematological malignancies journal Clin. Cancer Res. volume 8 issue 6 pages 1681 ... more details
PBB geneid 6671 Transcriptionfactor Sp4 is a protein that in humans is encoded by the SP4 gene . ref name pmid1454515 cite journal author Hagen G, Muller S, Beato M, Suske G title Cloning by recognition site screening of two novel GT box binding proteins a family of Sp1 related genes journal Nucleic Acids Res volume 20 issue 21 pages 5519 25 year 1993 month Jan pmid 1454515 pmc 334381 doi ref ref name entrez cite web title Entrez Gene SP4 Sp4 transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 6671 accessdate ref The PBB Summary template is automatically ... title summary text Interactions Sp4 transcriptionfactor has been shown to Protein protein interaction ... J, Preiss A, et al. title Functional analyses of the transcriptionfactor Sp4 reveal properties distinct ... title Human Sp4 transcriptionfactor gene SP4 maps to chromosome 7p15. journal Genomics volume 26 issue ... 10.1074 jbc.M201407200 cite journal author Lee DK, Suh D, Edenberg HJ, Hur MW title POZ domain transcriptionfactor, FBI 1, represses transcription of ADH5 FDH by interacting with the zinc finger and interfering ... variant of the SP4 transcriptionfactor and an intronic variant in the beta subunit of transducin ... doi refend PDB Gallery geneid 6671 External links MeshName Sp4 TranscriptionFactorTranscription ... authorlink coauthors Geymayer S, Haidweger E year 1999 month Nov. title Transcription factors of the Sp1 ... author Suske G title The Sp family of transcription factors. journal Gene volume 238 issue 2 pages ... Rotheneder H, Geymayer S, Haidweger E title Transcription factors of the Sp1 family interaction ... author Lerner LE, Gribanova YE, Ji M, et al. title Nrl and Sp nuclear proteins mediate transcription ... 1 EGR 1 and Sp family transcription factors. journal Nucleic Acids Res. volume 31 issue 3 pages ... author Higgins KJ, Liu S, Abdelrahim M, et al. title Vascular endothelial growth factor receptor ... yes update summary yes update citations yes Category Transcription factors gene 7 stub ... more details
PBB geneid 2959 Transcriptionfactor II B TF sub II sub B is one of several general transcriptionfactor ... the general transcription initiation factor IIB journal Nature volume 352 issue 6337 pages 689 ... Gene GTF2B general transcriptionfactor IIB url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 2959 accessdate ref It is involved in the selection of the transcription start site mutations in TFIIB cause a shift in the transcription start site. ref name pmid11092823 cite journal author Lee TI, Young RA title Transcription of eukaryotic protein coding genes journal ... ref Interactions TranscriptionFactor II B has been shown to Protein protein interaction interact .... title Sequence of general transcriptionfactor TFIIB and relationships to other initiation factors ... of human autoantibodies to transcriptionfactor IIB. journal Nucleic Acids Res. volume 23 ... domain of p65 NF kappa B with TATA binding protein, transcriptionfactor IIB, and coactivators ... and the general transcriptionfactor TFIIB with the cellular protein TAP. journal J. Virol ... 2959 External links MeshName TranscriptionFactor TFIIB Cell signaling Transcription factors g2 ... citations no DEFAULTSORT TranscriptionFactor Ii B Category Molecular genetics Category Proteins ... polymerase II transcription are dispersed in the human genome journal Hum. Mol. Genet. volume 3 issue 1 pages 61 4 year 1994 pmid 8162052 doi 10.1093 hmg 3.1.61 issn ref Transcriptionfactor IIB localizes to the nucleus where it forms a complex the DAB complex with transcription factors TranscriptionFactor II D IID and TFIIA IIA . The protein serves as a bridge between IID, the factor that initially ... glycosylase links DNA repair and transcription journal Mol. Cell volume 9 issue 2 pages 265 77 publisher ... of transcription an RNA polymerase II TFIIB cocrystal at 4.5 Angstroms journal Science journal ... Z F year 1996 month May. title RNA polymerase II associated protein RAP 74 binds transcription ... more details
gene . ref name entrez cite web title Entrez Gene REST RE1 silencing transcriptionfactor url http www.ncbi.nlm.nih.gov ... of the Kruppel like factors Kruppel type zinc finger transcriptionfactor family. It represses transcription ... off . Interactions RE1 silencing transcriptionfactor has been shown to Protein protein interaction ... and modular structure of RE 1 silencing transcriptionfactor REST , a repressor of neuronal genes ... G title RE 1 silencing transcriptionfactor REST regulates human synaptophysin gene transcription through ... M title Regulation of cholinergic gene expression by the neuron restrictive silencer factor repressor element 1 silencing transcriptionfactor. journal Life Sci. volume 72 issue 18 19 pages 2021 ...PBB geneid 5978 u RE u 1 u S u ilencing u T u ranscription factor REST , also known as u N u euron u ... pmid7871435 cite journal author Schoenherr CJ, Anderson DJ title The neuron restrictive silencer factor ... has not been determined. ref name entrez cite web title Entrez Gene REST RE1 silencing transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 5978 accessdate ... silencer factor NRSF a coordinate repressor of multiple neuron specific genes. journal Science ... author Scholl T, Stevens MB, Mahanta S, Strominger JL title A zinc finger protein that represses transcription ... cite journal author Palm K, Metsis M, Timmusk T title Neuron specific splicing of zinc finger transcriptionfactor REST NRSF XBR is frequent in neuroblastomas and conserved in human, mouse and rat ... silencer factor recruits mSin3 and histone deacetylase complex to repress neuron specific target ... restrictive silencer factor repressor is expressed in small cell lung cancer a potential role ... al. title Cell type non selective transcription of mouse and human genes encoding neural restrictive silencer factor. journal Brain Res. Mol. Brain Res. volume 90 issue 2 pages 174 86 year 2001 pmid ... JF title Regulation of Pax4 paired homeodomain gene by neuron restrictive silencer factor. journal ... more details
PBB geneid 121340 Transcriptionfactor Sp7 is a protein that in humans is encoded by the SP7 gene . ref name pmid11792318 cite journal author Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B title The novel zinc finger containing transcriptionfactor osterix is required for osteoblast differentiation and bone formation journal Cell volume 108 issue 1 pages 17 29 year 2002 month Jan pmid 11792318 pmc doi 10.1016 S0092 8674 01 00622 5 ref ref name entrez The PBB Summary template is automatically maintained by Protein Box Bot. See Template PBB Controls to Stop updates. PBB Summary section title summary text SP7 is a C2H2 type zinc finger transcriptionfactor of the SP gene family and a putative master regulator of bone cell differentiation Gao et al., 2004 . supplied by OMIM ref name entrez cite web title Entrez Gene SP7 Sp7 transcriptionfactor url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 121340 accessdate ref References reflist Further reading refbegin 2 PBB Further reading citations cite journal author Strausberg RL, Feingold EA, Grouse LH, et al. title Generation and initial analysis of more than 15,000 full length human and mouse cDNA sequences. journal Proc. Natl. Acad. Sci. U.S.A. volume 99 issue 26 pages 16899 903 year 2003 pmid 12477932 doi 10.1073 pnas.242603899 pmc 139241 cite journal author Gronthos S, Chen S, Wang CY, et al. title Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. journal J. Bone Miner. Res. volume 18 issue 4 pages ... year 2007 pmid 17352693 doi 10.1042 BJ20070104 refend External links MeshName Sp12 TranscriptionFactorTranscription factors g2 The PBB Controls template provides controls for Protein Box Bot, please ... 9 cite journal author Amorim BR, Okamura H, Yoshida K, et al. title The transcriptional factor Osterix ... protein box yes update summary yes update citations yes Category Transcription factors gene 12 ... more details
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