other uses refimprove date March 2009 Infobox protein family Symbol Serum albumin Name Serum albumin family image PDB 1ao6 EBI.jpg width caption Structure of human serum albumin. ref cite journal author Sugio S, Kashima A, Mochizuki S, Noda M, Kobayashi K title Crystal structure of human serum albumin ... , PDB2 2vue , PDB2 2vuf , PDB2 3b9l , PDB2 3b9m Albumin Latin albus, white refers generally to any ... containing albumin, such as egg white , are called albuminoids . A number of serum transport proteins are known to be evolutionarily related, including serum albumin , alpha fetoprotein , vitamin ..., Schoenberg DR, Wahli W title Amphibian albumins as members of the albumin, alpha fetoprotein, vitamin ... as in serum albumin and alpha fetoprotein journal Biochim. Biophys. Acta volume 871 issue 2 pages ... JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM title Afamin is a new member of the albumin, alpha ... 27 pages 18149 54 year 1994 month July pmid 7517938 doi url issn ref Function Albumin is the main protein ... as to fatty acids. The biological role of afamin alpha albumin has not yet been characterised. citation needed date January 2011 Structure The 3D structure of human serum albumin has been determined ... DC title Atomic structure and chemistry of human serum albumin journal Nature volume 358 issue 6383 pages 209 15 year 1992 month July pmid 1630489 doi 10.1038 358209a0 url issn ref Albumin comprises ... The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities ..., x any amino acid source Types Serum albumin main Serum albumin Serum albumin is the most abundant .... The human version is human serum albumin , and it normally constitutes about 60 of human plasma protein ... referred as a molecular taxi . Competition between drugs for albumin binding sites may cause ... types include human serum albumin bovine serum albumin cattle serum albumin or BSA, often used in medical and molecular biology labs. Low albumin hypoalbuminemia may be caused by liver disease ... more details
About the family of mammalian albumin proteins the human variant human serum albumin the cow variant bovine serum albumin PBB geneid 213 Serum albumin , often referred to simply as albumin is a protein ... A title The human serum albumin gene structure of a unique locus journal Gene volume 19 issue ... ME, Dugaiczyk A title Linkage of the evolutionarily related serum albumin and alpha fetoprotein genes ... Gene albumin url http www.ncbi.nlm.nih.gov sites entrez?Db gene&Cmd ShowDetailView&TermToSearch 213 accessdate ref Serum albumin is the most abundant plasma protein in mammal s. Albumin is essential for maintaining ... albumin in the body can be harmful. Function Major contributors to oncotic pressure known also as colloid osmotic pressure of plasma carriers for various substances. Albumin is a soluble, monomeric protein which comprises about one half of the blood serum protein. Albumin functions primarily as a carrier ... extracellular fluid volume. Albumin is a globular un glycosylation glycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N terminus ... the secreted albumin. ref name entrez Types Serum albumin is widely distributed in mammals. Examples include The human version is human serum albumin . Bovine serum albumin , or BSA, is commonly ... properties . Physical properties Albumin when ionized in water at pH 7.4, as found in the body is negatively ... suggest that this prevents the filtration of albumin in the urine. According to this theory, that charge plays a major role in the selective exclusion of albumin from the glomerular filtrate. A defect in this property results in nephrotic syndrome leading to albumin loss in the urine. Nephrotic syndrome patients are sometimes given albumin to replace the lost albumin. Because smaller animals ... need less albumin to maintain proper fluid distribution. Structure main albumin The general structure of Albumin is characterized by several long alpha helices, this allows it to maintain ... more details
div style float right border solid 10px white Test sample values div CSF albumin is a measurement used to determine the levels of albumin in cerebrospinal fluid . ref name pmid10585175 cite journal author Murakami K, Nakagawa T, Shozu M, Uchide K, Koike K, Inoue M title Changes with aging of steroidal levels in the cerebrospinal fluid of women journal Maturitas volume 33 issue 1 pages 71 80 year 1999 month September pmid 10585175 doi 10.1016 S0378 5122 99 00040 7 url http linkinghub.elsevier.com retrieve pii S0378 5122 99 00040 7 ref A closely related test, CSF total protein is a measurement used to determine the levels of protein in cerebrospinal fluid . ref name urlMedlinePlus Medical Encyclopedia CSF total protein cite web url http www.nlm.nih.gov medlineplus ency article 003628.htm title MedlinePlus Medical Encyclopedia CSF total protein work accessdate ref ref name pmid14524396 cite journal author Seehusen DA, Reeves MM, Fomin DA title Cerebrospinal fluid analysis journal Am Fam Physician volume 68 issue 6 pages 1103 8 year 2003 month September pmid 14524396 doi url http www.aafp.org afp 20030915 1103.html ref It combines the albumin, IgG , and other proteins. It can be useful in distinguishing among causes of Meningitis . It is more likely to be elevated in bacterial meningitis than in viral meningitis . The upper normal range is 150 mg dl in neonates, and 50 mg dl in adults. ref name isbn0 07 140816 9 cite book author Karen Roos title Principles of neurologic infectious diseases publisher McGraw Hill, Medical Pub. Division location New York year 2005 pages 4 isbn 0 07 140816 9 oclc doi accessdate ref References Reflist CSF tests Category Body fluids Category CSF tests medicine stub ... more details
Drugbox IUPAC name image CAS number 9006 52 4 ATC prefix A07 ATC suffix XA01 PubChem DrugBank chemical formula molecular weight bioavailability protein bound metabolism elimination half life excretion pregnancy AU A B1 B2 B3 C D X pregnancy US A B C D X pregnancy category legal AU Unscheduled S2 S3 S4 S5 S6 S7 S8 S9 legal CA Schedule I, II, III, IV, V, VI, VII, VIII legal UK GSL P POM CD Class A, B, C legal US OTC Rx only Schedule I, II, III, IV, V legal status routes of administration Albumin tannate also known as Tannin albuminate is an antidiarrheal . Antidiarrheals, intestinal anti inflammatory anti infective agents Category Antidiarrhoeals gastrointestinal drug stub ja ... more details
orphan date November 2007 Radioiodinated serum albumin , abbreviated RISA, is a marker used in identifying blood plasma via the dilution method in renal physiology . Category Renal physiology Category Iodine medicine stub ... more details
About albumin specific to humans the cow variant bovine serum albumin the family of mammalian albumins serum albumin protein name albumin caption Protein Data Bank PDB rendering based on 1e7h. image ALB ... P02768 PDB 1E7H ECnumber Chromosome 4 Arm q Band 13.3 LocusSupplementaryData Human serum albumin is the most abundant protein in human blood plasma . It is produced in the liver . Albumin comprises about half of the blood serum protein. It is soluble and monomeric. The gene for albumin is located ... albumin gene is 16,961 nucleotides long from the putative cap site to the first poly A addition site ... by triplication of a single primordial domain. Albumin is synthesized in the liver as preproalbumin ... the secreted albumin. The reference range for albumin concentrations in blood is 3.4 to 5.4 g dL. ref cite web url http www.nlm.nih.gov medlineplus ency article 003480.htm title Albumin serum ... many medication drugs serum albumin levels can affect the half life of drugs Competitively binds calcium ions Ca sup 2 sup Buffers pH Serum albumin, as a negative acute phase protein, is down ... in inflammatory states Prevents photodegradation of folic acid Measurement Plasma albumin is a component of liver function tests LFTs , but may be ordered separately. Albumin can be measured ... ranges for blood tests , comparing blood content of albumin shown in purple at right with other constituents. Pathology Hypoalbuminemia Low blood albumin levels hypoalbuminemia can be caused by Liver ... zinc to prevent this. Zinc also regulates transport of the cellular osmolyte taurine , and albumin ... A production from beta carotene, and in lab experiments retinol reduced human albumin production. ref ... T, Suzuki T title All trans retinoic acid down regulates human albumin gene expression through ... A deficiency alone could cause albumin levels to become raised. Patients recovering from chronic ... ref and serum albumin ref name nonenzymatically595 cite journal author Day JF, Thorpe SR, Baynes JW ... more details
About albumin specific to cows the human variant human serum albumin the family of mammalian albumins serum albumin Infobox nonhuman protein Name albumin image width caption Organism Bos taurus domestic cow TaxID 9913 Symbol ALB AltSymbols CAS number CAS supplemental EntrezGene 280717 PDB RefSeqmRNA NM 180992 RefSeqProtein NP 851335 UniProt P02769 ECnumber Chromosome 6 EntrezChromosome NC 007304 GenLoc start 91543999 GenLoc end 91567876 Bovine serum albumin also known as BSA or Fraction V is a serum albumin protein that has numerous biochemical applications including ELISA s Enzyme Linked Immunosorbent Assay , immunoblots, and immunohistochemistry . It is also used as a nutrient in cell and microbial culture. In restriction digest s, BSA is used to stabilize some enzymes during digestion of DNA and to prevent adhesion of the enzyme to reaction tubes and other blood vessel vessels . This protein does not affect other enzyme s that do not need it for stabilization. BSA is also commonly used to determine the quantity of other proteins, by comparing an unknown quantity of protein to known amounts of BSA. BSA is used because of its stability, its lack of effect in many biochemical reactions, and its low cost, since large quantities of it can be readily purified from bovine blood, a byproduct of the cattle industry. The nickname Fraction V refers to albumin being the fifth fraction of the original ... commercialized with human albumin for medical use and later adopted for production of BSA. Nomenclature ... author Wright AK, Thompson MR title Hydrodynamic structure of bovine serum albumin determined by transient ... daily intake Protein allergy Human serum albumin Serum albumin References Reflist Further reading ... serum albumin by ESIMS and Frit FAB LC MS journal Biochem. Biophys. Res. Commun. volume 173 issue ... MeshName Serum Albumin, Bovine DEFAULTSORT Bovine Serum Albumin Category Proteins cs Hov z s rov albumin es Alb mina de suero bovino fr Albumine de s rum bovin nl Runderalbumine pl Surowicza albumina ... more details
Test sample values align right The serum ascites albumin gradient SAAG is a calculation used in medicine to help determine the cause of ascites . ref name pmid18334692 cite journal author Wong CL, Holroyd Leduc J, Thorpe KE, Straus SE title Does this patient have bacterial peritonitis or portal hypertension? How do I perform a paracentesis and analyze the results? journal JAMA volume 299 issue 10 pages 1166 78 year 2008 month March pmid 18334692 doi 10.1001 jama.299.10.1166 url http jama.ama assn.org cgi pmidlookup?view long&pmid 18334692 ref The SAAG may be a better discriminant than the older method of classifying ascites fluid as a transudate versus exudate . ref name pmid1616215 cite journal author Runyon BA, Montano AA, Akriviadis EA, Antillon MR, Irving MA, McHutchison JG title The serum ascites albumin gradient is superior to the exudate transudate concept in the differential diagnosis of ascites journal Annals of Internal Medicine volume 117 issue 3 pages 215 20 year 1992 month August pmid 1616215 doi url ref The formula is as follows SAAG albumin concentration of Blood serum serum albumin concentration of ascitic fluid . Ideally, the two values should be measured at the same time. Differential High gradient A high gradient 1.1 g dL indicates the ascites is due to portal hypertension with 97 accuracy. ref name pmid1616215 This is due to increased hydrostatic pressure within the blood vessels of the hepatic portal system , which in turn forces water out into the peritoneal cavity but leaves proteins such as albumin within the vasculature. Important causes of high SAAG ascites 1.1 g dL include high protein 2.5 heart failure , Budd Chiari syndrome low protein 2.5 cirrhosis of the liver ref Gines P, Cardenas A, Arroyo V, Rodes J. Management of cirrhosis and ascites. N Engl J Med. 2004 15 350 1646 54. PMID 15084697 ref Low gradient A low gradient 1.1 g dL indicates ascites not associated with increased portal pressure, including nephrotic syndrome , tuberculosis , and various ... more details
Technetium sup 99m sup Tc albumin aggregated sup 99m sup Tc MAA is an injectable radiopharmaceutical used in nuclear medicine . It consists of a sterile aqueous suspension of Technetium 99m sup 99m sup Tc labeled to human albumin aggregate particles in the pH range of 3.8 to 8.0. Preparation Kits for preparing sup 99m sup Tc MAA are available from a number of different manufacturers including Bracco, CIS US, Draximage and Mallinckrodt . These kits vary in the amount of human albumin aggregated, SnCl sub 2 sub , and preservatives. The kits are delivered to nuclear pharmacies as Freeze drying lyophilized powders of non radioactive ingredients sealed under nitrogen. A nuclear pharmacist adds anywhere from 50 100 mCi of Na sup 99m sup Tc to the reaction vial to make the final product. After being allowed to set at room temperature for 15 minutes to ensure maximum tagging of 99mTc to the human albumin, the kit can then be diluted with sterile normal saline as needed. Once prepared the product will have a turbid white appearance. Quality control Particle Size No less than 90 of MAA particles can be between 10 90 micrometres in size and no particles may exceed 150 micrometres. Radiochemical purity No less than 90 of the radioactivity present in the product must be tagged to albumin particles. Thus, no more than 10 soluble impurities may be present. Both of the above quality controls must be met before the product can be used in humans. Indications, Dosage & Imaging Perfusion lung imaging to assess the presence of pulmonary emboli Isotope venography to identify lower extremity venous thrombosis Assessment of peritoneovenous LeVeen shunt patency The typical adult dose for a lung imaging study is 3 4 mCi containing between 100,000 250,000 albumin particles . The particle burden should be lowered for most pediatric patients and lowered to 50,000 for infants. The use of more than 250,000 particles in a dose is controversial as little extra data is acquired from such scans while ... more details
orphan date March 2010 The surfactant albumin ratio is a test for assessing Fetus fetal lung maturity. ref name pmid10920328 cite journal author Liu KZ, Shaw RA, Dembinski TC, Reid GJ, Ying SL, Mantsch HH title Comparison of infrared spectroscopic and fluorescence depolarization assays for fetal lung maturity journal Am. J. Obstet. Gynecol. volume 183 issue 1 pages 181 7 year 2000 month July pmid 10920328 doi 10.1067 mob.2000.105345 url http linkinghub.elsevier.com retrieve pii S0002 9378 00 77338 8 ref References reflist Obstetrical procedures Category Embryology medicine stub ... more details
div style float right border solid 10px white Test sample values div CSF serum albumin ratio is a test performed to compare the levels of albumin in the cerebrospinal fluid and the Blood serum serum . It is useful as a measure of the integrity of the blood brain barrier . ref name pmid17531849 cite journal author Luque FA, Jaffe SL title Cerebrospinal fluid analysis in multiple sclerosis journal Int. Rev. Neurobiol. volume 79 issue pages 341 56 year 2007 pmid 17531849 doi 10.1016 S0074 7742 07 79015 3 url http linkinghub.elsevier.com retrieve pii S0074 7742 07 79015 3 ref ref name pmid15932356 cite journal author Anckars ter H, Forsman A, Blennow K title Increased CSF serum albumin ratio a recurrent finding in violent offenders journal Acta Neurol. Scand. volume 112 issue 1 pages 48 50 year 2005 month July pmid 15932356 doi 10.1111 j.1600 0404.2005.00433.x url http www3.interscience.wiley.com resolve openurl?genre article&sid nlm pubmed&issn 0001 6314&date 2005&volume 112&issue 1&spage 48 ref ref name pmid17511849 cite journal author Algotsson A, Winblad B title The integrity of the blood brain barrier in Alzheimer s disease journal Acta Neurol. Scand. volume 115 issue 6 pages 403 8 year 2007 month June pmid 17511849 doi 10.1111 j.1600 0404.2007.00823.x url http www3.interscience.wiley.com resolve openurl?genre article&sid nlm pubmed&issn 0001 6314&date 2007&volume 115&issue 6&spage 403 ref References Reflist Category Neurology Category CSF tests medicine stub CSF tests ... more details
Analbuminaemia is a genetically inherited metabolism metabolic defect characterised by an impaired synthesis of human serum albumin serum albumin . ref cite journal author Watkins S, Madison J, Galliano M, Minchiotti L, Putnam FW title Analbuminemia three cases resulting from different point mutations in the albumin gene journal Proc. Natl. Acad. Sci. U.S.A. volume 91 issue 20 pages 9417 21 year 1994 pmid 7937781 doi 10.1073 pnas.91.20.9417 pmc 44823 ref Despite the fact that albumin is the most common serum protein, analbuminemia is a benign condition. References references Category Inborn errors of metabolism Category Blood disorders pathology stub pl Analbuminemia ... more details
Albumen or Albumin may refer to Biochemistry Albumin with an i refers to a major class of several hundred proteins almost all non globulin s , especially blood , but also in animal connective tissues Serum albumin , a solubility water soluble protein Human serum albumin the human variant Bovine serum albumin the cow variant The egg white albumen of almost any animal, which consists of water 60 95 and any of a class of several dozen proteins called Albumin , predominantly ovalbumin . Archaic and some technical use of Albumen can refer to the non germ bulk of certain grains which serve the same structural and metabolic purposes. Miscellaneous Albumen print s, the first commercial photographic prints on paper. http www.albumen.org.uk Albumen Records is a UK based record label. Operation Albumen , a series of sabotages against airfields on occupied Crete in 1942 See also Endosperm , tissue produced in the seeds of most flowering plants Albumen print , method of producing a print on a paper base from a negative using egg white. Albumen Egg White disambiguation title Albumen ... more details
Redia or redia can be A synonym for the plant genus Cleidion of the family Euphorbiaceae A Trematode lifecycle stages stage in the development of a trematode A dipstick for urinalysis , determining levels of glucose , albumin and erythrocytes disambig ja ... more details
Infobox disease Name Hypoalbuminemia Image Caption DiseasesDB 31324 ICD10 ICD9 ICD9 273.8 ICDO OMIM MedlinePlus eMedicineSubj med eMedicineTopic 1116 MeshID D034141 Hypoalbuminemia is a medical condition where levels of human serum albumin albumin in blood serum are abnormally low. It is a specific form of hypoproteinemia . Albumin is a major protein in the human body, making up about 60 of total human Blood plasma plasma protein by mass. Many hormone s, drug s, and other molecules are mostly bound to albumin in the bloodstream and must be released before becoming biologically active. For example, calcium binds to albumin and hypoalbuminemia leads to an increase in free ionized calcium. Albumin is synthesized in the liver , and low serum albumin may be indicative of liver failure or diseases such as cirrhosis or chronic hepatitis . Hypoalbuminemia can also present as part of the nephrotic syndrome , in which protein is lost in the urine due to kidney damage. Low albumin levels can be an indicator of chronic malnutrition or protein losing enteropathy . Hypoalbuminemia may cause generalized edema swelling via a decrease in oncotic pressure . The serum albumin level is part of a standard panel of liver function tests . Levels below 3.5 grams per deciliter are generally considered low External links CrispThesaurus 00004012 http www.medscape.com viewarticle 484802 Treating Hypoalbuminemia In Critically Ill Patients Abnormal clinical and laboratory findings for blood Category Abnormal clinical and laboratory findings for blood disease stub de Hypalbumin mie es Hipoalbuminemia id Hipoalbuminemia ja pl Hipoalbuminemia pt Hipoalbuminemia ru ... more details
SAAG can mean South Asia Analysis Group , a non profit thinktank concerned with South Asian affairs. serum ascites albumin gradient See also Saag , an Indian foodstuff disambig ... more details
A tannate is the salt or ester of tannic acid ref http medical dictionary.thefreedictionary.com tannate Medical Dictionary definition ref . Albumin tannate also known as Tannin albuminate is an antidiarrheal. References reflist tannin category tannins polyphenol stub ... more details
Jeanatope is iodinated I 125 human serum albumin , typically injected to aid in the determination of total blood and blood plasma plasma volume . I 125 is a radioactive isotope of Iodine , it decays by electron capture with a physical half life of 60.14 days. The biologic half life in normal individuals for I 125 has been reported to be approximately 14 days. Iodinated I 131 albumin Volumex, Daxor is used for a similar purpose. External links http www.isotexdiagnostics.com jeanatope i 125.html Jeanatope at isotexdiagnostics.com Category Iodine pharma stub ... more details
orphan date April 2009 Bisalbuminemia is the, sometimes inherited, condition of having two types of serum albumin that differ in mobility during electrophoresis . It can be seen in densitometry as a bifid mountain where albumin has 2 heads. Inherited bisalbuminemia has no pathologic effects, but is of interest to researchers who study the evolution and functional changes in the protein. ref http www.clinchem.org cgi content full 48 11 2076 ref References Reflist Category Blood disorders ... more details
Refimprove date November 2008 Pediatric end stage liver disease PELD is a disease severity scoring system for children under 12 years of age. It is calculated from the patient s human serum albumin albumin , bilirubin , and international normalized ratio INR together with the patient s age and degree of growth failure . This score is also used by the United Network for Organ Sharing UNOS for prioritizing allocation of Liver transplantation liver transplants . Determination PELD uses the patient s values for serum bilirubin , serum albumin , the Prothrombin time international normalized ratio for prothrombin time INR , whether the patient is less than 1 year old, and whether the patient has growth failure 2 standard deviation to predict survival. It is calculated according to the following formula ref http www.unos.org SharedContentDocuments MELD PELD Calculator Documentation.pdf ref PELD 4.80 Ln serum bilirubin mg dL 18.57 Ln INR 6.87 Ln albumin g dL 4.36 1 year old 6.67 growth failure See also Liver transplantation Model for end stage liver disease MELD References Reflist http www.unos.org United Network for Organ Sharing External links http www.unos.org resources MeldPeldCalculator.asp?index 99 PELD Calculator Category Gastroenterology Category Hepatology Category Medical scoring system med stub ... more details
Thyroxine binding proteins is a protein which binds thyroid hormone . Examples include Thyroxine binding globulin Transthyretin Serum albumin External links MeshName Thyroxine binding proteins Glycoproteins Biochem stub Category Human proteins Category Blood proteins ... more details
Unreferenced stub auto yes date December 2009 Orphan date November 2006 Riboflavin carrier proteins RFCPs together with human serum albumin transport flavin mononucleotide FMN in the Circulatory system blood circuit . RFCPs are important in pregnancy . DEFAULTSORT Riboflavin Carrier Protein Category Hematology Biochem stub ... more details
Lactalbumin is the albumins albumin contained in milk and obtained from whey . Lactalbumin is found in the milk of many mammals. There are Alpha lactalbumin alpha and beta lactalbumins both contained in milk. External links MeshName Lactalbumin Albumins Category Milk protein stub de Lactalbumin ... more details
DBP may refer to Dewan Bahasa dan Pustaka , a government body responsible for coordinating the use of the Malay language in Malaysia and Brunei German Farmers Party Deutsche Bauernpartei , former German political party Deutsche Bundespost , former German federal post office Development Bank of the Philippines Dibutyl phthalate , a plasticizer Disinfection by product , a material occurring as a result of administering a disinfectant in medicine , Diastolic blood pressure A gene coding for the DBP gene D site of albumin promoter albumin D box binding protein Disambig de DBP es DBP it DBP pl DBP ... more details
media differ from serum free media in that bovine serum albumin or human serum albumin with either a chemically defined recombinant version which lacks the albumin associated lipids or synthetic chemical ... albumin Chen et al., 2008 using the above definitions this type of media is referred to as serum free media. Serum free media are commonly supplemented with bovine or human serum albumin, insulin ... free media include Animal protein free media, containing human serum albumin, human transferrin ... albumin, human transferrin, human insulin, and chemically defined or human lipids. Recombinant, xeno free media, containing Recombinant DNA recombinant human serum albumin or a synthetic replacement ... more details
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