Supremacy can refer to:

• Supremacism, a philosophy that one is superior to others, so dominate, control or rule those who do not
• A 1940 military-themed variant of Monopoly
• Supremacy: The Game of the Superpowers, a 1984 strategic board game
• Supremacy: Your Will Be Done (called Overlord in USA), a computer game by Probe for the Amiga and C64 computer
• Air supremacy, aerial control of a battlefield by one side's air force.
• The Bourne Supremacy (film), the second installment of the Bourne film trilogy, loosely based on the novels by Robert Ludlum.
• Supremacy (album), an album by metalcore band Hatebreed.
• Supremacy (band), a Norwegian power metal band.
• The name given in the UK to the computer game Star Wars: Rebellion.