The term sudden cardiac death refers to natural death from cardiac causes, heralded by abrupt loss of consciousness within one hour of the onset of acute symptoms.^[1] Other forms of sudden death may be noncardiac in origin. Examples of this include respiratory arrest (such as due to airway obstruction, which may be seen in cases of choking or asphyxiation), toxicity or poisoning, anaphylaxis, or trauma.^[2]

It is important to make a distinction between this term and the related term cardiac arrest, which refers to cessation of cardiac pump function which may be reversible (i.e., may not be fatal). The phrase sudden cardiac death is a public health concept incorporating the features of natural, rapid, and unexpected. It does not specifically refer to the mechanism or cause of death.

Causes

Although the most frequent underlying cause of sudden cardiac death is coronary artery disease, other categories of causes include:

• Non-atherosclerotic coronary artery abnormalities
• Hypertrophy of ventricular myocardium
• Myocardial diseases and heart failure, including
  • Arrhythmogenic right ventricular cardiomyopathy
  • Hypertrophic cardiomyopathy
  • Dilated cardiomyopathy
  • Myocardial infarction
  • Noncompaction Cardiomyopathy
• Inflammatory, infiltrative, neoplastic, and degenerative processes
• Diseases of the cardiac valves
• Congenital heart disease
• Primary electrophysiological abnormalities, such as
  • Long QT syndrome, both congenital and acquired
  • Sick sinus syndrome
  • Brugada syndrome
  • Catecholaminergic polymorphic ventricular tachycardia
• Rhythm instability related to neurohumoral and central nervous system influences
• Commotio cordis
• Mechanical interference with venous return
• Aortic dissection
• Toxic/metabolic disturbances

References

1. ↑ Myerburg, Robert J. "Cardiac Arrest and Sudden Cardiac Death" in Heart Disease: A Textbook of Cardiovascular Medicine, 7th edition. Philadelphia: WB Saunders, 2005.
2. ↑ Sudden Unexpected Death: Causes and Contributing Factors on poptop.hypermart.net.

External links

• Information from the Stanford Hypertrophic Cardiomyopathy Center
• Sudden Cardiac Arrest Foundation
• Arrhythmia Alliance Sudden Cardiac Arrest Page

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