Spiro(s) or Spyro(s) may refer to:

• ARA Spiro (P-43), the corvette of the Argentine Navy named after Samuel Spiro
• Spiro Agnew, thirty-ninth Vice President of the United States
• Spiro compound, a class of organic compound featuring two rings joined at one atom
• Spiro (device), 1970s telephone hacking device
• Spiro (name) including the spelling "Spyro(s)", origin of the name and people with this name
• Spiro, Oklahoma
  • Spiro Mounds, an archaeological site near Spiro, Oklahoma
• Spiros Louis Stadium, the Athens Olympic Stadium named after Spiros Louis
• SPYRO Suite, a steam cracking simulation programme suite
• Spyro the Dragon (series), a series of video games
  • Spyro the Dragon, the first game in the series, usually referred to as Spyro
  • Spyro the Dragon (character), the fictional titular character of the video games
  • Spyro the Dragon (film).
• Spyros, a Greek tanker involved in Spyros disaster

See also

• Dum Spiro Spero, Latin motto meaning "While I breathe, I hope"
• Spira (disambiguation)
• Spyro Gyra, an American jazz fusion band
• Spirogyra, a type of green alga
• Spirogyra (band), a British folk band
• Spironolactone, commonly used as a diuretic or as an antiandrogen

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