Transplants between genetically non-identical humans induce the creation of antibodies in the recipient. These non-identical cell-surface antigens in the donor and produce antiserum in the recipient. Under certain conditions one or two isoform specificities are obtained from the recipient. This results in a serotype that is capable of identifying other individuals who have the same differential isoform in the donor. Serotyping along with new-PCR based techniques are how tissues for organ-donor programs are characterized. (for more detailed information see Human leukocyte antigens and HLA Serotype tutorial.)
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