In genetics rs6311 is a gene variation?a single nucleotide polymorphism (SNP)?in the human HTR2A gene that codes for the 5-HT_2A receptor. 5-HT_2A is neuroreceptor and a number of brain-related investigations have been reported, e.g., about personality traits measured with the Temperament and Character Inventory^[1][2][3][4] or a psychological task measuring impulsive behavior.^[5] But the SNP has also been investigated in rheumatology studies.^[6][7]

Some research studies may refer to this gene variation as a C/T SNP,^[2] while others refer to it as a G/A polymorphism in the promotor region, thus writing it as, e.g., ?1438 G/A or 1438G>A.^[8][9][10]

As of 2008 meta-analysis of research studies indicates that people with the A-allele may have slightly elevated risk of schizophrenia.^[11]

rs6313, rs6314 and rs7997012 are other investigated SNPs in the HTR2A gene.

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