The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates.

The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo we can distinguish eight rhombomeres, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere).

A rare disease of the rhomencephalon, "rhombencephalosynapsis" is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia.

The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure.^[1]

Myelencephalon

Rhombomeres Rh7-Rh4 form the myelencephalon.

The myelencephalon forms the medulla oblongata in the adult brain; it contains:

• a portion of the fourth ventricle,
• the glossopharyngeal nerve (CN IX),
• vagus nerve (CN X),
• accessory nerve (CN XI),
• hypoglossal nerve (CN XII),
• and a portion of the vestibulocochlear nerve (CN VIII).

Metencephalon

Rhombomeres Rh3-Rh1 form the metencephalon.

The metencephalon is composed of the pons and the cerebellum; it contains:

• a portion of the fourth ventricle,
• the trigeminal nerve (CN V),
• abducens nerve (CN VI),
• facial nerve (CN VII),
• and a portion of the vestibulocochlear nerve (CN VIII).

Additional images

<gallery> Image:Gray18.png|Chick embryo of thirty-three hours? incubation, viewed from the dorsal aspect. X 30. Image:Gray40.png|Embryo between eighteen and twenty-one days. </gallery>

References

1. ↑ SpringerLink - Journal Article