Purine nucleoside phosphorylase (also known as PNPase) is an enzyme () involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. Confusingly, the same abbreviation (PNPase), is also used for another, otherwise unrelated, enzyme, namely Polynucleotide Phosphorylase.

Diseases linked to PNP: PNP deficient patients will have an immunodeficiency problem. Curiously, it affects only T-cells, B-cells are unaffected by the deficiency.

See also

• Purine nucleoside phosphorylase deficiency

References

Further reading

External links

• Human PNP at Cornell University
• E. Coli PNP at Cornell University

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