Punchinello may refer to:

• Pulcinella, the Commedia character, and its English descendant, Punch
• The American spinoff of Punch magazine.
• A magazine published in New York City, USA, from April through December of 1870. All 39 issues of this magazine can be found online at page images from Cornell University's Making of America and in transcribed form at Project Gutenberg
• The third main boss in the Super Nintendo video game Super Mario RPG: Legend of the Seven Stars
• The main character in Max Lucado's 1997 book, You Are Special and subsequent books about Lucado's fictional society of wooden people called the "Wemmicks"
• The Punchinello Crime Family and its leader, Don Angelo Punchinello, the main antagonists for the first couple of chapters of the video game Max Payne