Phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P₂) is a minor phospholipid component of cell membranes. PtdIns(4,5)P₂ is enriched at the plasma membrane where it is an important substrate for a number of important signaling proteins.^[1]

Phospholipase C hydrolyzes the phosphodiester link in PtdIns(4,5)P₂ forming inositol 1,4,5-triphosphate (InsP₃) and diacylglycerol (DAG).

PtdIns(4,5)P2₂ is formed primarily by the type I phosphatidylinositol 4 phosphate 5 kinases from PI(4)P.

Class I PI 3-kinases phosphorylate PtdIns(4,5)P₂ forming phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P₃). Both PtdIns(3,4,5)P₃ and PtdIns(4,5)P₂ not only act as substrates for enzymes but also serve as docking phospholipids that bind specific domains that promote the recruitment of proteins to the plasma membrane and subsequent activation of signaling cascades.

Additional images

<gallery> Image:PIP2 cleavage to IP3 and DAG.jpg|PIP2 cleavage to IP3 and DAG initiates intracellular calcium release and PKC activation. </gallery>

References

1. ↑

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