Chemical structure of sn-1-stearoyl-2-arachidonoyl phosphatidylinositol (3,5)-bisphosphate

Phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P₂) is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns(3,5)P₂ in internal membranes by the lipid kinase PIKfyve recruits a number of important proteins involved in regulating intracellular trafficking.

PtdIns(3,5)P₂ is dephophosphorylated by members of the myotubularin lipid phosphatase family on the 3 position of the inositol ring generating Phosphatidylinositol 5-phosphate (PtdIns5P).

The phosphoinositide-binding domain in a number of proteins binds to PtdIns(3,5)P₂, including the PH domain in centaurin-?2, the PX domain of SNX1, and a novel domain in Atg18p.

References

• Michell RH, Heath VL, Lemmon MA, Dove SK. (2006) Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Trends Biochem Sci. 31(1):52-63. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCV-4HVDYKK-1&_coverDate=01%2F31%2F2006&_alid=379389085&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=5180&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=85744e07280c8bce926a48329b8edd5e

External links

es:Fosfatidilinositol 3,5-bifosfato pl:3,5-bisfosforan fosfatydyloinozytolu

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