Prothesis may mean one of the following:

• Prothesis (liturgy) is part of the Divine Liturgy of the Eastern Orthodox Church. Also the chapel within the sanctuary where this part of the service takes place

The term prothesis is sometimes used for prosthesis; also see:

• Prosthesis (linguistics), an addition of phoneme or syllable at the beginning of word
• Prosthetic group (chemistry), a nonprotein component of a conjugated protein

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