A protein kinase inhibitor is a type of enzyme inhibitor which specifically blocks the action of protein kinase.

Kinase inhibitors such as dasatinib are often used in the treatment of cancer and inflammation.

Some of the kinase inhibitors used in treating cancer are inhibitors of tyrosine kinase.^[1]

They can interfere with the repair of DNA double-strand breaks.^[2]

Examples

Currently there are several drugs launched that target protein kinases and the receptors that activate them:

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| Bevacizumab 

|- 
| BIBW 2992 

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| Cetuximab 

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| Imatinib 

|- 
| Trastuzumab 

|- 
| Gefitinib 

|- 
| Ranibizumab 

|- 
| Pegaptanib 

|- 
| Sorafenib 

|- 
| Dasatinib 

|- 
| Sunitinib 

|- 
| Erlotinib 

|- 
| Nilotinib 

|- 
| Lapatinib 

|- 
| Panitumumab 

References

External links

• IC50 values for common inhibitors
• KinaseCentral.com

de:Tyrosinkinase-Inhibitor

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