The Protein Structure Initiative (PSI) is a federal, university, and industry effort aimed at dramatically reducing the costs and lessening the time it takes to determine a three-dimensional protein structure. The long-range goal of the PSI is to make the three-dimensional atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences. Funding is provided by the U.S. National Institute of General Medical Sciences (NIGMS), and information is available on the website describing the Centers in the U.S. that are performing structural genomics and PSI-related technology development, as well as PSI meeting reports.

An information portal, the PSI SGKB (Knowledgebase), provides general information and search features, such as protein sequence and keyword searching, and modules describing target selection, experimental details, models, annotation, metrics, and technology. This information portal is based out of the Rutgers University, New Brusnwisck at the Protein Data Bank (PDB).

A PSI Materials Repository at the Harvard Institute of Proteomics has been funded to provide easy access to the many thousands of clones produced by PSI-funded Centers since 2000. Clones will be available starting in 2008.