Piperacillin is an extended spectrum beta-lactam antibiotic of the ureidopenicillin class. It is normally used together with a beta-lactamase inhibitor such as tazobactam, which is commercially available as Tazocin, Zobactin or Zosyn. The combination has activity against many Gram-positive and Gram-negative pathogens and anaerobes, including Pseudomonas aeruginosa.

Piperacillin is not absorbed orally, and must therefore be given by intravenous or intramuscular injection; piperacillin/tazobactam is administered intravenously every 6 or 8 hours; the drug may also be given by continuous infusion, but this has not been shown to be superior.^[1] Its main uses are in intensive care medicine (pneumonia, peritonitis), some diabetes-related foot infections and empirical therapy in febrile neutropenia (e.g. after chemotherapy).

Trade names and preparations

Piperacillin alone:

• Pipracil (U.S. only)

Piperacillin/tazobactam:

• Tazocin (UK, marketed by Wyeth)
• Tazocin (Japan, marketed by Toyama)
• Tazocin (New Zealand, marketed by Wyeth)
• Zosyn (U.S., marketed by Wyeth)
• Zobactin (India, marketed by GSK)

References

External links

• Zosyn (piperacillin/tazobactam combination) - information for U.S.
• Tazocin data sheet for New Zealand

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