Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.

It is formed from ribose 5-phosphate by the enzyme ribose-phosphate diphosphokinase.

It plays a role in transferring phosphate groups in several reactions:

|- 
| adenine phosphoribosyltransferase  

|- 
| hypoxanthine-guanine phosphoribosyltransferase  

|- 
| hypoxanthine-guanine phosphoribosyltransferase  

|- 
| orotate phosphoribosyltransferase 

|- 
| uracil phosphoribosyltransferase 

In de novo generation of purines, the enzyme amidophosphoribosyltransferase acts upon PRPP to create phosphoribosylamine.

See also

• Pyrimidine biosynthesis

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