Otter Creek may refer to some places in the United States:

• Otter Creek, Florida, a town
• Otter Creek (Vermont), a tributary of Lake Champlain
  • Otter Creek Brewing located in Middlebury, Vermont
• Otter Creek, Eau Claire County, Wisconsin, a town
• Otter Creek, Dunn County, Wisconsin, a town
• Otter Creek Park near Louisville, Kentucky
• Otter Creek Township, LaSalle County, Illinois, a township located near Streator, Illinois
• Otter Creek, Tennessee, a tributary of the Little Harpeth River
• Otter Creek Wilderness, a wilderness area in West Virginia