Oligomycins are macrolides created by Streptomyces that can be poisonous to other organisms.

Function

They have use as antibiotics.

In addition, oligomycin inhibits ATP synthase by blocking its proton channel, which is necessary for oxidative phosphorylation of ADP to ATP (energy production). Electron transport stops but there is an increase in the proton gradient, and electron transport soon stops because of the difficulty of pumping any more protons against the steep gradient.

Administering oligomycin to an individual can result in very high levels of lactate accumulating in the blood and urine.

Oligomycin is an inhibitor of ATP synthase. In oxidative phosphorylation research, it is used to prevent state 3 (phosphorylating) respiration.

Oligomycins^[1]

	R1	R2	R3	R4	R5
Oligomycin A	CH3	H	OH	H,H	CH3
Oligomycin B	CH3	H	OH	O	CH3
Oligomycin C	CH3	H	H	H,H	CH3
Oligomycin D (Rutamycin A)	H	H	OH	H,H	CH3
Oligomycin E	CH3	OH	OH	O	CH3
Oligomycin F	CH3	H	OH	H,H	CH2CH3
Rutamycin B	H	H	H	H,H	CH3
44-Homooligomycin A	CH2CH3	H	OH	H,H	CH3
44-Homooligomycin B	CH2CH3	H	OH	O	CH3

References

ca:Oligomicina hu:Oligomicin pt:Oligomicina