OSD is a three letter acronym that may stand for:

• Åre Östersund Airport (OSD is the IATA airport code), in Sweden
• Office of the Secretary of Defense, the principal staff element of the U.S. Secretary of Defense
• On-screen display, a feature of visual devices like VCRs and DVD players that displays program, position, and setting data on a connected TV or computer display
• Osgood-Schlatter Disease, an inflammation of the growth plate at the tibial tuberosity which occurs mostly in teenage boys
• Open Source Definition, criteria used by the Open Source Initiative to determine whether or not a software license can be considered open source
• Oklahoma School for the Deaf, a K-12 residential school for the deaf or hard-hearing students
• Object storage device
• One Shot Deal, a live album by Frank Zappa posthumously released in 2008.
• Optimal shape design, a part of the field of optimal control theory

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