McCool can refer to:

• McCool, Mississippi
• Colin McCool — an Australian Test cricketer
• Courtney McCool — an American gymnast
• Fionn mac Cumhail — a character from Irish mythology
• McCool — a bar in One Night at McCool's, a 2001 dark comedy film
• Robert McCool — the author of the original NCSA HTTPd web server, later known as the Apache HTTP Server
• Michelle McCool — professional wrestler and diva for WWE.
• William C. McCool — Pilot of the Space Shuttle Columbia when it disintegrated