Major League or major league, first coined by Major League Baseball, can refer to a number of things.

Team Sports

• Major Indoor Soccer League the highest level of play in professional indoor soccer in the U.S.
• Major League Baseball, the highest level of play in professional baseball in N. America.
• Major League Cricket, unofficially, the highest level of play in professional cricket in the U.S.
• Major League Hockey, formerly the Ontario Hockey Association (OHA) Senior league; the top level of amateur men's ice hockey in Canada.
• Major League Lacrosse, the highest level of play in professional field lacrosse in the U.S.
• Major League Soccer, the highest level of play in professional soccer in the U.S. and Canada
• Major League Volleyball, formerly, the highest level of play in women's professional volleyball in the U.S.
• Tonga Major League, the highest level of Association football in Tonga.
• Major North American professional sports leagues, an overview of major league sports in Canada and the United States.

Other Sports and Competitions

• Major League Eating, designates all top-level competitive eaters, eating events, television specials and merchandise in the U.S.
• Major League Gaming, a professional league dedicated to competition in console gaming in the U.S.
• Major League Online, an online computer gaming league.
• Major League Wrestling, was a popular professional wrestling promotion that described itself as hybrid wrestling.

Music

• Major League, A song from Pavement's their 1999 album Terror Twilight
• Major Leagues (EP), Pavement's final EP
• Major League, is an alias used by the co-production of DJ Tiësto and Armin van Buuren.

Film

• Major League (film), a 1989 baseball movie
• Major League II, a 1994 baseball movie, the second installment in the series
• Major League: Back to the Minors, a 1998 baseball movie, the third installment in the series

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