Francisco Pradilla Ortiz's painting "Cortejo del bautizo del Príncipe Don Juan, hijo de los Reyes Católicos, por las calles de Sevilla" (Retinue of the Baptism of Don Juan, son of the Catholic Monarchs, Along the Streets of Seville), 1910
At the age of 18 Juan married Margaret of Austria (1480-1530) in the Cathedral of Burgos in April, 1497. Six months later, on the way to the wedding of his older sister in Portugal, he died in Salamanca, possibly from tuberculosis. His wife was left pregnant and later gave birth to a stillborn child. Juan's death led to the inheritance of the Spanish kingdoms by the Habsburgs, after his sister married Philip the Handsome.
In 1492, Columbus named the newly discovered island of CubaIsla Juana in deference to Prince Juan, at that time the heir apparent.[1]