James Otis may refer to:

• James Otis, Sr. (1702?1778), Massachusetts lawyer and public official
• James Otis, Jr. (1725–1783), American revolutionary politician from Massachusetts
• James Otis, pen name of James Otis Kaler (1848–1912), American journalist and author of children?s literature
• James Otis (politician) (1826–1875), mayor of San Francisco, California
• James Otis (actor), American film and television actor
• Jim Otis, American football player

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