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IRF3

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.[1]

It is a member of the interferon regulatory transcription factor (IRF) family.[1] IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.[2] This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.[3]

Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations
Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations

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Source: Wikipedia | The above article is available under the GNU FDL. | Edit this article


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