It was his answer to those who had publicly challenged him to give an explanation for the causes of gravity rather than just the mathematical principles of kinetics. Along with Occam's Razor, the term can be seen as a departure from the Aristotelian hypothetic-deductive method of natural philosophy.
Here is a translation of the passage containing this famous remark:
I have not as yet been able to discover the reason for these properties of gravity from phenomena, and I do not feign hypotheses. For whatever is not deduced from the phenomena must be called a hypothesis; and hypotheses, whether metaphysical or physical, or based on occult qualities, or mechanical, have no place in experimental philosophy. In this philosophy particular propositions are inferred from the phenomena, and afterwards rendered general by induction.[1]